ω-3多不飽和脂肪酸對胃腸道惡性腫瘤患者術后炎癥反應和營養狀態的影響_《中國普外基礎與臨床雜志》

作者：

劉流 ¹ , 莊文 ¹ , 陳忠 ²

1.四川大學華西醫院胃腸外科中心（成都　610041）;;
2.四川大學華西第二醫院兒科（成都　610041）;

關鍵詞：

ω-3多不飽和脂肪酸胃癌結直腸癌炎癥反應營養

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的研究ω-3多不飽和脂肪酸對胃腸道惡性腫瘤患者術后炎癥反應和營養狀態的影響。方法將華西醫院胃腸外科中心2009年2月1日至6月1日收治的40例胃腸道惡性腫瘤患者隨機分為對照組和實驗組各20例。術后2組連續行7 d腸外營養支持治療,實驗組每天加用ω-3多不飽和脂肪酸10 g。術前、術后第2天及術后第8天分別抽血檢測炎癥反應指標(包括白細胞、中性粒細胞和C反應蛋白水平)和營養狀態指標(包括總蛋白、白蛋白、前白蛋白、轉鐵蛋白和淋巴細胞水平)以及手術前、后體重變化(體重差)。結果 2組患者的基線一致，具有可比性(P gt;0.05)。術后第2天2組患者各項炎癥反應指標和營養狀態指標水平比較，差異均無統計學意義(P gt;0.05)；至術后第8天，實驗組的中性粒細胞和C反應蛋白水平均明顯低于對照組，淋巴細胞水平明顯高于對照組，差異有統計學意義(P lt;0.05)。2組患者的體重差比較差異無統計學意義(P gt;0.05)。結論 ω-3多不飽和脂肪酸能夠有效減輕胃腸道惡性腫瘤患者術后的炎癥反應，改善患者的術后營養狀態。

引用本文： 劉流,莊文,陳忠. ω-3多不飽和脂肪酸對胃腸道惡性腫瘤患者術后炎癥反應和營養狀態的影響. 中國普外基礎與臨床雜志, 2009, 16(12): 964-967. doi: 復制

1.	Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [Ｊ]. CA Cancer J Clin, 2005; 55(2): 74-108.
2.	Boyle P, Leon ME. Epidemiology of colorectal cancer [Ｊ]. Br Med Bull, 2002; 64: 1-25.
3.	Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma [Ｊ]. Ann Surg, 2004; 239(4): 553-560.
4.	任成山，陸海華, 杜曉鋒，等. 重度創傷后全身炎癥反應綜合征和多器官功能障礙綜合征 [Ｊ]. 中國危重病急救醫學, 2001； 13(11): 690-693.
5.	Richards GA. Lipid nutrients in critical illness [Ｊ]. Clin Pulm Med， 2009； 16(5): 265-269.
6.	Pacht ER. Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come [Ｊ]. Crit Care Med, 2006; 34(9): 2492-2493.
7.	黃莚庭. 大腸癌診治現狀與展望 [Ｊ]. 中國普外基礎與臨床雜志, 2000； 7(1): 44-45.
8.	陳威佐, 陳文元, 羅好曾. 武威市2001~2005 年胃癌發病率分析 [Ｊ]. 中國腫瘤, 2007； 16(5): 309-310.
9.	賈云鶴, 江志偉, 佴永軍, 等. 胃癌術后感染和排空障礙與術前營養不良及營養指標的相關研究 [Ｊ]. 腸外與腸內營養, 2005； 12(3)： 143-145.
10.	Evangelista V, Dell’Elba G, Celardo A, et al. TxA2-mediated myocardial ischemia as a consequence of an acute lung inflammatory reaction in the rabbit [Ｊ]. J Thromb Haemost, 2003; 1(2): 314-319.
11.	Wu GH, Zhang YW, Wu ZH. Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients [Ｊ]. World J Gastroenterol, 2001; 7(3): 357-362.
12.	Lin MT, Yeh SL, Yeh CL, et al. Parenteral ω-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy [Ｊ]. Shock, 2006; 25(1): 56-60.
13.	Calder PC. ω-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic [Ｊ]. Lipids, 2003; 38(4): 343-352.
14.	Calder PC. ω-3 polyunsaturated fatty acids and cytokine production in health and disease [Ｊ]. Ann Nutr Metab, 1997; 41(4): 203-234.
15.	Li Q, Wang M, Tan L, et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts [Ｊ]. J Lipid Res, 2005; 46(9): 1904-1913.
16.	Huber TB, Simons M, Hartleben B, et al. Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains [Ｊ]. Hum Mol Genet, 2003; 12(24): 3397-3405.
17.	Zhao Y, Joshi-Barve S, Barve S, et al. Eicosapentaenoic acid prevents LPS-induced TNF-α expression by preventing NF-κB activation [Ｊ]. J Am Coll Nutr, 2004; 23(1): 71-78.
18.	Li H, Ruan XZ, Powis SH, et al. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism [Ｊ]. Kidney Int, 2005; 67(3): 867-874.
19.	王新穎, 李維勤, 李寧, 等. ω-3多不飽和脂肪酸對重癥急性胰腺炎病人早期炎性反應的影響 [Ｊ]. 腸外與腸內營養, 2008； 15(4): 214-217.
20.	Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery [Ｊ]. Clin Nutr, 2004; 23(3): 325-330.
21.	Heys SD, Walker LG, Smith I, et al. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials [Ｊ]. Ann Surg, 1999; 229(4): 467-477.
22.	劉流，莊文，陳忠. ω-3不飽和脂肪酸促進胃腸道惡性腫瘤患者術后康復的療效研究 [Ｊ]. 中國普外基礎與臨床雜志，2009； 16(11): 895-899.

1. Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [Ｊ]. CA Cancer J Clin, 2005; 55(2): 74-108.
2. Boyle P, Leon ME. Epidemiology of colorectal cancer [Ｊ]. Br Med Bull, 2002; 64: 1-25.
3. Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma [Ｊ]. Ann Surg, 2004; 239(4): 553-560.
4. 任成山，陸海華, 杜曉鋒，等. 重度創傷后全身炎癥反應綜合征和多器官功能障礙綜合征 [Ｊ]. 中國危重病急救醫學, 2001； 13(11): 690-693.
5. Richards GA. Lipid nutrients in critical illness [Ｊ]. Clin Pulm Med， 2009； 16(5): 265-269.
6. Pacht ER. Enteral therapy to decrease morbidity and improve survival in acute respiratory distress syndrome: its time has come [Ｊ]. Crit Care Med, 2006; 34(9): 2492-2493.
7. 黃莚庭. 大腸癌診治現狀與展望 [Ｊ]. 中國普外基礎與臨床雜志, 2000； 7(1): 44-45.
8. 陳威佐, 陳文元, 羅好曾. 武威市2001~2005 年胃癌發病率分析 [Ｊ]. 中國腫瘤, 2007； 16(5): 309-310.
9. 賈云鶴, 江志偉, 佴永軍, 等. 胃癌術后感染和排空障礙與術前營養不良及營養指標的相關研究 [Ｊ]. 腸外與腸內營養, 2005； 12(3)： 143-145.
10. Evangelista V, Dell’Elba G, Celardo A, et al. TxA2-mediated myocardial ischemia as a consequence of an acute lung inflammatory reaction in the rabbit [Ｊ]. J Thromb Haemost, 2003; 1(2): 314-319.
11. Wu GH, Zhang YW, Wu ZH. Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients [Ｊ]. World J Gastroenterol, 2001; 7(3): 357-362.
12. Lin MT, Yeh SL, Yeh CL, et al. Parenteral ω-3 fatty acids modulate inflammatory and immune response in rats undergoing total gastrectomy [Ｊ]. Shock, 2006; 25(1): 56-60.
13. Calder PC. ω-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic [Ｊ]. Lipids, 2003; 38(4): 343-352.
14. Calder PC. ω-3 polyunsaturated fatty acids and cytokine production in health and disease [Ｊ]. Ann Nutr Metab, 1997; 41(4): 203-234.
15. Li Q, Wang M, Tan L, et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts [Ｊ]. J Lipid Res, 2005; 46(9): 1904-1913.
16. Huber TB, Simons M, Hartleben B, et al. Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains [Ｊ]. Hum Mol Genet, 2003; 12(24): 3397-3405.
17. Zhao Y, Joshi-Barve S, Barve S, et al. Eicosapentaenoic acid prevents LPS-induced TNF-α expression by preventing NF-κB activation [Ｊ]. J Am Coll Nutr, 2004; 23(1): 71-78.
18. Li H, Ruan XZ, Powis SH, et al. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism [Ｊ]. Kidney Int, 2005; 67(3): 867-874.
19. 王新穎, 李維勤, 李寧, 等. ω-3多不飽和脂肪酸對重癥急性胰腺炎病人早期炎性反應的影響 [Ｊ]. 腸外與腸內營養, 2008； 15(4): 214-217.
20. Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery [Ｊ]. Clin Nutr, 2004; 23(3): 325-330.
21. Heys SD, Walker LG, Smith I, et al. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials [Ｊ]. Ann Surg, 1999; 229(4): 467-477.
22. 劉流，莊文，陳忠. ω-3不飽和脂肪酸促進胃腸道惡性腫瘤患者術后康復的療效研究 [Ｊ]. 中國普外基礎與臨床雜志，2009； 16(11): 895-899.

《中國普外基礎與臨床雜志》

ω-3多不飽和脂肪酸對胃腸道惡性腫瘤患者術后炎癥反應和營養狀態的影響

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

ω-3多不飽和脂肪酸對胃腸道惡性腫瘤患者術后炎癥反應和營養狀態的影響

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料