非甾體類抗炎藥抗腫瘤機理的研究進展_《中國普外基礎與臨床雜志》

作者：

李權林 ,  任明揚

川北醫學院第二臨床醫學院胃腸外科（四川南充 637000）;

關鍵詞：

非甾體類抗炎藥腫瘤環氧合酶-2

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　總結非甾體類抗炎藥抗腫瘤機理的研究進展。
方法　查閱近年來國內外關于非甾體類抗炎藥抗腫瘤機理的相關文獻，就其研究進展進行綜述。
結果　非甾體類抗炎藥抗腫瘤的機理是多層次、多位點的。
結論　非甾體類抗炎藥有望成為結直腸癌高危人群的預防用藥和結直腸癌根治術后的化療輔助用藥，用于預防術后腫瘤的復發。

引用本文： 李權林,任明揚. 非甾體類抗炎藥抗腫瘤機理的研究進展. 中國普外基礎與臨床雜志, 2012, 19(12): 1368-1371. doi: 復制

1.	Ruder EH， Laiyemo AO， Graubard BI， et al. Non-steroidal anti-inflammatory drugs and colorectal cancer risk in a large， prospective cohort[J]. Am J Gastroenterol， 2011， 106(7)：1340-1350.
2.	Coghill AE， Newcomb PA， Campbell PT， et al. Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer[J]. Gut， 2011， 60(4)：491-498.
3.	Burn J， Bishop DT， Chapman PD， et al. A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis[J]. Cancer Prev Res (Phila)， 2011， 4(5)：655-665.
4.	Liao LM， Vaughan TL， Corley DA， et al. Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis[J]. Gastroenterology， 2012， 142(3)： 442-452.
5.	Mccormack VA， Hung RJ， Brenner DR， et al. Aspirin and NSAID use and lung cancer risk： a pooled analysis in the International Lung Cancer Consortium (ILCCO)[J]. Cancer Causes Control， 2011， 22(12)： 1709-1720.
6.	Mahmud SM， Franco EL， Turner D， et al. Use of non-steroidal anti-inflammatory drugs and prostate cancer risk： a population-based nested case-control study[J]. PLoS One， 2011， 6(1)： e16412.
7.	Takkouche B， Regueira-Méndez C， Etminan M. Breast Cancer and use of nonsteroidal anti-inflammatory drugs： a meta-analysis[J]. J Natl Cancer Inst， 2008， 100(20)： 1439-1447.
8.	Hossain MA， Kim DH， Jang JY， et al. Aspirin induces apoptosisin vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model[J]. Int J Oncol， 2012， 40(4)： 1298-1304.
9.	Tomoda C， Moatamed F， Naeim F， et al. Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase[J]. Exp Biol Med， 2008， 233(11)： 1433-1440.
10.	Ghosh N， Chaki R， Mandal V， et al. COX-2 as a target for cancerchemotherapy[J]. Pharmacol Rep， 2010， 62(2)：233-244.
11.	Chen XL， Su BS， Sun RQ， et al. Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in humangastric adenocarcinoma[J]. World J Gastroenterol， 2005， 11(8)：1228-1231.
12.	Kim BH， Kim CI， Chang HS， et al. Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia：is it related to apoptosis and angiogenesis of prostate cancer?[J]. Korean J Urol， 2011， 52(4)：253-259.
13.	Leung E， McArthur D， Morris A， et al. Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression[J]. Dis Colon Rectum， 2008， 51(3)：342-347.
14.	Fang C， Bourdette D， Banker G， et al. Oxidative stress inhibits axonal transport：implication for neurodegenerative diseases[J]. Mol Neurodegener， 2012， 7： 29.
15.	Wang Y， Yu Q， Fan D， et al. Coronary heart disease in Type 2 diabetes： mechanisms and comprehensive prevention strategies[J]. Expert Rev Cardiovasc Ther， 2012， 10(8)： 1051-1060.
16.	Chen W， Zhu H， Jia ZQ， et al. Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations：implications for cancer intervention[J]. Biochem Biophys Res Commun， 2009， 390(1)：142-147.
17.	Goel A， Chang DK， Ricciardiello L， et al. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells[J]. Clin Cancer Res， 2003， 9(1)：383-390.
18.	Dibra HK， Brown JE， Hooley P， et al. Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line[J]. Oncol Rep， 2010， 24(1)：37-46.
19.	He H， Xia HH， Wang JD， et al. Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma[J]. Cancer， 2006， 106(6)：1243-1249.
20.	Raza H， John A， Benedict S. Acetylsalicylic acid-induced oxidative stress， cell cycle arrest， apoptosis and mitochondrialdysfunction in human hepatoma HepG2 cells[J]. Eur J Pharmacol，2011， 668(1-2)：15-24.
21.	Bank A， Yu J， Zhang L. NSAIDs downregulate bcl-X(L) and dissociate BAX and bcl-X(L) to induce apoptosis in colon cancer cells[J]. Nutr Cancer， 2008， 60(Suppl 1)：98-103.
22.	Liu HF， Hsiao PW， Chao JI. Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells[J]. Chem Biol Interact， 2008， 176(1)：48-57.
23.	Uddin S， Ahmed M， Hussain A， et al. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer[J]. Int J Cancer， 2010， 126(2)：382-394.
24.	Zhang ZQ， Huang LQ， Zhao WP， et al. Annexin 1 induced by anti-inflammatory drugs binds to NF-κB inhibiting its activation：anticancer effects in vitro and in vivo[J]. Cancer Res， 2010， 70(6)：2379-2388.
25.	Chattopadhyay M， Goswami S， Rodes DB， et al. No-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo throughS-nitrosylation[J]. Cancer Lett， 2010， 298(2)：204-211.
26.	Tinsley HN， Gary BD， Thaiparambil J， et al. Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition[J]. Cancer Prev Res (Phila)， 2010， 3(10)：1303-1313.
27.	Brunelli C， Amici C， Angelini M， et al. The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR， causing a translational block in human colorectal cancer cells[J]. Biochem J， 2012， 443(2)：379-386.
28.	Réti A， Pap E， Adleff V， et al. Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase[J]. Cancer Chemother Pharmacol， 2010， 66(2)：219-227.

1. Ruder EH， Laiyemo AO， Graubard BI， et al. Non-steroidal anti-inflammatory drugs and colorectal cancer risk in a large， prospective cohort[J]. Am J Gastroenterol， 2011， 106(7)：1340-1350.
2. Coghill AE， Newcomb PA， Campbell PT， et al. Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer[J]. Gut， 2011， 60(4)：491-498.
3. Burn J， Bishop DT， Chapman PD， et al. A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis[J]. Cancer Prev Res (Phila)， 2011， 4(5)：655-665.
4. Liao LM， Vaughan TL， Corley DA， et al. Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis[J]. Gastroenterology， 2012， 142(3)： 442-452.
5. Mccormack VA， Hung RJ， Brenner DR， et al. Aspirin and NSAID use and lung cancer risk： a pooled analysis in the International Lung Cancer Consortium (ILCCO)[J]. Cancer Causes Control， 2011， 22(12)： 1709-1720.
6. Mahmud SM， Franco EL， Turner D， et al. Use of non-steroidal anti-inflammatory drugs and prostate cancer risk： a population-based nested case-control study[J]. PLoS One， 2011， 6(1)： e16412.
7. Takkouche B， Regueira-Méndez C， Etminan M. Breast Cancer and use of nonsteroidal anti-inflammatory drugs： a meta-analysis[J]. J Natl Cancer Inst， 2008， 100(20)： 1439-1447.
8. Hossain MA， Kim DH， Jang JY， et al. Aspirin induces apoptosisin vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model[J]. Int J Oncol， 2012， 40(4)： 1298-1304.
9. Tomoda C， Moatamed F， Naeim F， et al. Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase[J]. Exp Biol Med， 2008， 233(11)： 1433-1440.
10. Ghosh N， Chaki R， Mandal V， et al. COX-2 as a target for cancerchemotherapy[J]. Pharmacol Rep， 2010， 62(2)：233-244.
11. Chen XL， Su BS， Sun RQ， et al. Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in humangastric adenocarcinoma[J]. World J Gastroenterol， 2005， 11(8)：1228-1231.
12. Kim BH， Kim CI， Chang HS， et al. Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia：is it related to apoptosis and angiogenesis of prostate cancer?[J]. Korean J Urol， 2011， 52(4)：253-259.
13. Leung E， McArthur D， Morris A， et al. Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression[J]. Dis Colon Rectum， 2008， 51(3)：342-347.
14. Fang C， Bourdette D， Banker G， et al. Oxidative stress inhibits axonal transport：implication for neurodegenerative diseases[J]. Mol Neurodegener， 2012， 7： 29.
15. Wang Y， Yu Q， Fan D， et al. Coronary heart disease in Type 2 diabetes： mechanisms and comprehensive prevention strategies[J]. Expert Rev Cardiovasc Ther， 2012， 10(8)： 1051-1060.
16. Chen W， Zhu H， Jia ZQ， et al. Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations：implications for cancer intervention[J]. Biochem Biophys Res Commun， 2009， 390(1)：142-147.
17. Goel A， Chang DK， Ricciardiello L， et al. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells[J]. Clin Cancer Res， 2003， 9(1)：383-390.
18. Dibra HK， Brown JE， Hooley P， et al. Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line[J]. Oncol Rep， 2010， 24(1)：37-46.
19. He H， Xia HH， Wang JD， et al. Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma[J]. Cancer， 2006， 106(6)：1243-1249.
20. Raza H， John A， Benedict S. Acetylsalicylic acid-induced oxidative stress， cell cycle arrest， apoptosis and mitochondrialdysfunction in human hepatoma HepG2 cells[J]. Eur J Pharmacol，2011， 668(1-2)：15-24.
21. Bank A， Yu J， Zhang L. NSAIDs downregulate bcl-X(L) and dissociate BAX and bcl-X(L) to induce apoptosis in colon cancer cells[J]. Nutr Cancer， 2008， 60(Suppl 1)：98-103.
22. Liu HF， Hsiao PW， Chao JI. Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells[J]. Chem Biol Interact， 2008， 176(1)：48-57.
23. Uddin S， Ahmed M， Hussain A， et al. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer[J]. Int J Cancer， 2010， 126(2)：382-394.
24. Zhang ZQ， Huang LQ， Zhao WP， et al. Annexin 1 induced by anti-inflammatory drugs binds to NF-κB inhibiting its activation：anticancer effects in vitro and in vivo[J]. Cancer Res， 2010， 70(6)：2379-2388.
25. Chattopadhyay M， Goswami S， Rodes DB， et al. No-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo throughS-nitrosylation[J]. Cancer Lett， 2010， 298(2)：204-211.
26. Tinsley HN， Gary BD， Thaiparambil J， et al. Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition[J]. Cancer Prev Res (Phila)， 2010， 3(10)：1303-1313.
27. Brunelli C， Amici C， Angelini M， et al. The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR， causing a translational block in human colorectal cancer cells[J]. Biochem J， 2012， 443(2)：379-386.
28. Réti A， Pap E， Adleff V， et al. Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase[J]. Cancer Chemother Pharmacol， 2010， 66(2)：219-227.

《中國普外基礎與臨床雜志》

非甾體類抗炎藥抗腫瘤機理的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

《中國普外基礎與臨床雜志》

非甾體類抗炎藥抗腫瘤機理的研究進展

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料