直腸癌術前放療的研究進展△_《中國普外基礎與臨床雜志》

作者：

杜冰清 , 鐘曉剛 , 麥威 ,  黃順榮

廣西壯族自治區人民醫院胃腸外科（廣西南寧 530021）;

關鍵詞：

直腸癌術前放療短程放療常規放療局部復發率放療敏感性基因表達譜

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　總結近年來直腸癌術前放化療的研究進展。
方法　復習近年來國內、外有關直腸癌術前放化療的相關文獻報道。
結果　術前放療的遠期局部復發率較術后放化療明顯降低，無瘤生存期明顯延長；在Ⅲ期直腸癌患者，術前短程放療比術前常規放療具有更高的局部復發率，而在Ⅱ期直腸癌患者二者的局部復發率差異無統計學意義；p53、CEA、Cox-2、EGFR、VEGF等生物學因子是判斷直腸癌術前放療效果的敏感指標。
結論　直腸癌的術前放療方案傾向于選擇術前常規放療，多種敏感因子的廣泛研究及基因表達譜、基因芯片的發展為直腸癌術前放療個體化方案的制定提供了更多的篩選指標。

引用本文： 杜冰清,鐘曉剛,麥威,黃順榮. 直腸癌術前放療的研究進展△. 中國普外基礎與臨床雜志, 2012, 19(12): 1357-1361. doi: 復制

1.	Nelson H， Petrelli N， Carlin A， et al. Guidelines 2000 for colon and rectal cancer surgery[J]. Natl Cancer Inst， 2001， 93(8)：583-596.
2.	Gastrointestinal Tumor Study Group. Prolongation of the disease-free interval in surgically treated rectal carcinoma[J]. N Engl J Med， 1985， 312(23)：1465-1472.
3.	Camma C， Giunta M， Fiorica F， et al. Preoperative radiotherapy for resectable rectal cancer： a meta-analysis[J]. JAMA， 2000， 284(8)：1008-1015.
4.	Engstrom PF， Arnoletti JP， Benson AB 3rd， et al. NCCN Clinical Practice Guidelines in Oncology： rectal cancer[J]. J Natl Compr Canc Netw， 2009， 7(8)：838-881.
5.	Yeh CH， Chen MF， Lai CH， et al. Comparison of treatmentresults between surgery alone， preoperative short course radiotherapy， or long-course concurrent chemoradiotherapy in locallyadvanced rectal cancer[J]. Int J Clin Oncol， 2012， 17(5)：482-490.
6.	Tiv M， Puyraveau M， Mineur L， et al. Long-term quality of life in patients with rectal cancer treated with preoperative-radiotherapywithin a randomized trial[J]. Cancer Radiother， 2010， 14(6-7)：530-534.
7.	Sauer R， Becker H， Hohenberger W， et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer[J]. N Engl J Med， 2004， 351(17)：1731-1740.
8.	van Giin W， Marijinen CA， Naqteqaal ID， et al. Preoperativeradiotherapy combined with total mesorectal excision for resectable rectal cancer：12-year follow-up of the multicentre， rando-mised controlled TME trial[J]. Lancet Oncol， 2011， 12(6)：575-582.
9.	Sebag-Montefiore D， Steele R， Quirke P， et al. Routine short course pre-op radiotherapy or selective post-op chemoradiotherapyfor resectable rectal cancer? Preliminary results of the MRC CR07randomised trial[J]. J Clin Oncol， 2006， 24(18)：3511-3514.
10.	Marijnen CA， Nagtegaal ID， Klein Kranenbarg E， et al. No downstaging after short-term preoperative radiotherapy in rectal cancer patients[J]. J Clin Oncol， 2001， 19(7)：1976-1984.
11.	Francois Y， Nemoz CJ， Baulieux J， et al. Infuence of the interval between preoperative radiation therapy and surgery on downstaging and the rate of sphincter sparing surgery for rectal cancer：the Lyon R9001 randomized trial[J]. J Clin Oncol， 1999， 17(8)：2396-2402.
12.	Pach R， Kuliq J， Richter P， et al. Randomized clinical trial on preoperative radiotherapy 25 Gy in rectal cancer-treatment results at 5-year follow-up[J]. Lanqenbecks Arch Surg， 2012， 397(5)：801-807.
13.	Pollack J， Holm T， Cedermark B， et al. Long-term effect ofpreoperative radiation therapy on anorectal function[J]. DisColon Rectum， 2006， 49(3)：345-352.
14.	Sauer R， Becker H， Hohenberger W， et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer[J]. N Engl J Med， 2004， 351(17)：1731-1740.
15.	Bujko K， Nowacki MP， Nasierowska-Guttmejer A， et al. Sphincterpreservation following preoperative radiotherapy for rectal cancer：report of a randomized trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy[J]. Radiother Oncol， 2004， 72(1)：15-24.
16.	Eitta MA， EI-Wahidi GF， Fouda MA， et al. Preoperativeradiotherapy in resectable rectal cancer：a prospective randomized study of two different approaches[J]. Jegypt Nati Canc Inst， 2010， 22(3)：155-164.
17.	Klenova A， Parvanova V， Georqiev R， et al. Preoperative radiotherapy in rectal cancer：treatment results of three different dose regimens[J]. J Buon， 2006， 11(2)：161-166.
18.	Bosset JF， Collette L， Calais G， et al. Chemothrapy with preoperative radiotherapy in rectal cancer[J]. N Engl J Med， 2006， 355(11)：1114-1123.
19.	Gerard JP， Bonnetain F， Conroy T， et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers：results of the FFCD9203[J]. Clin Oncol， 2006， 24(28)：4620-4625.
20.	Rouanet P， Rivoire M， Lelong B， et al. Sphincter preserving surgery after preoperative treatment for ultra-low rectal carcinoma. A French multicenter prospective trial： GRECCAR 1[J]. Proc Am Soc Clin Oncol， 2006， 24(18)：3527-3530.
21.	Stojanovic S， Popov I， Radosevic-Jelic L， et al. Preoperativeradiotherapy with capecitabine and mitomycin C in locallyadvanced rectal carcinoma[J]. Cancer Chemother Pharmacol， 2011， 68(3)：787-793.
22.	Das P， Skibber JM， Rodriquez-Bigas MA， et al. Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation[J]. Cancer， 2007， 109(9)：1750-1755.
23.	吳文銘，邱輝忠，吳斌，等. 臨床病理指標預測直腸癌新輔助治療效果初探[J]. 中華外科雜志， 2010，48(5)：348-352.
24.	Ishihara S， Watanabe T， Kiyomatsu T， et al. Prognostic signifi-cance of response to preoperative radiotherapy， lymph nodemetastasis， and CEA level in patients undergoing total mesorectal excision of rectal cancer[J]. Int J Colorectal Dis， 2010， 25(12)：1417-1425.
25.	Korkeila EA， Syrjanen K， Bendardaf R， et al. Preoperativeradiotherapy modulates ezrin expression and its value as apredictive marker in patients with rectal cancer[J]. Hum Pathol， 2011， 42(3)：384-392.
26.	Shinto E， Hashiquchi Y， Ueno H， et al. Pretreatment CD133 and cyclooxygenase-2 expression as the predictive markers of the pathological effect of chemoradiotherapy in rectal cancer patients[J]. Dis Colon Rectum， 2011， 54(9)：1006-1098.
27.	Min BS， Choi YJ， Pvo HR， et al. Cyclooxygenase-2 expression in pretreatment biopsy as a predictor of tumor responses afterpreoperative chemoradiation in rectal cancer[J]. Arch Surg， 2008， 143(11)：1091-1097.
28.	Zlobec L， Vuonq T， Compton CC， et al. Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy[J]. Br J Cancer， 2008， 98(2)：450-456.
29.	Unsal Kilic D， Uner A， Akyurek N， et al. Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy[J]. Int J Radiat Oncol Biol Phys， 2007， 67(1)：196-203.
30.	Moureau-Zabotto L， Farnault B， de Chaisemartin C， et al.Predictive factors of tumor response after neoadjuvant chemoradiation for locally advanced rectal cancer[J]. Int J Radiat Oncol Biol Phys， 2011， 80(2)：483-491.
31.	Yasuda K， Nirei T， Sunami E， et al. Density of CD4+ and CD8+ T lymphocytes in biopsy samples can be a predictor of pathologicalresponse to chemoradiotherapy (CRT) for rectal cancer[J]. RadiatOncol， 2011， 6：49.
32.	Kitayama J， Yasuda K， Kawai K， et al. Circulating lymphocyte is an important determinant of the effectiveness of preoperative rediotherapy in advanced rectal cancer[J]. BMC Cancer， 2011， 11：64.
33.	Chang GJ， Rodriguez-Bigas MA， Eng C， et al. Lymph node status after neoadjuvant radiotherapy for rectal cancer is a biologic predictor of outcome[J]. Cancer， 2009， 115(23)：5432-5440.
34.	Hu-Lieskovan S， Vallbohmer D， Zhang W， et al. EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients[J]. Clin Cancer Res， 2011， 17(15)：5161-5169.
35.	Kobunai T， Watanabe T， Fukusato T， et al. REG4， NEIL2， and BIRC5 gene expression correlates with gamma-radiation sensitivityin patients with rectal cancer receiving radiothrapy[J]. Anticancer， 2011， 31(12)：4147-4153.
36.	Watanabe T， Komuro Y， Kiyomatsu T， et al. Prediction ofsensitivity of rectal cancer cells in response to preoterativeradiotherapy by DNA microarray analysis of gene expressionprofiles[J]. Cancer Res， 2006， 66(7)：3370-3374.

1. Nelson H， Petrelli N， Carlin A， et al. Guidelines 2000 for colon and rectal cancer surgery[J]. Natl Cancer Inst， 2001， 93(8)：583-596.
2. Gastrointestinal Tumor Study Group. Prolongation of the disease-free interval in surgically treated rectal carcinoma[J]. N Engl J Med， 1985， 312(23)：1465-1472.
3. Camma C， Giunta M， Fiorica F， et al. Preoperative radiotherapy for resectable rectal cancer： a meta-analysis[J]. JAMA， 2000， 284(8)：1008-1015.
4. Engstrom PF， Arnoletti JP， Benson AB 3rd， et al. NCCN Clinical Practice Guidelines in Oncology： rectal cancer[J]. J Natl Compr Canc Netw， 2009， 7(8)：838-881.
5. Yeh CH， Chen MF， Lai CH， et al. Comparison of treatmentresults between surgery alone， preoperative short course radiotherapy， or long-course concurrent chemoradiotherapy in locallyadvanced rectal cancer[J]. Int J Clin Oncol， 2012， 17(5)：482-490.
6. Tiv M， Puyraveau M， Mineur L， et al. Long-term quality of life in patients with rectal cancer treated with preoperative-radiotherapywithin a randomized trial[J]. Cancer Radiother， 2010， 14(6-7)：530-534.
7. Sauer R， Becker H， Hohenberger W， et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer[J]. N Engl J Med， 2004， 351(17)：1731-1740.
8. van Giin W， Marijinen CA， Naqteqaal ID， et al. Preoperativeradiotherapy combined with total mesorectal excision for resectable rectal cancer：12-year follow-up of the multicentre， rando-mised controlled TME trial[J]. Lancet Oncol， 2011， 12(6)：575-582.
9. Sebag-Montefiore D， Steele R， Quirke P， et al. Routine short course pre-op radiotherapy or selective post-op chemoradiotherapyfor resectable rectal cancer? Preliminary results of the MRC CR07randomised trial[J]. J Clin Oncol， 2006， 24(18)：3511-3514.
10. Marijnen CA， Nagtegaal ID， Klein Kranenbarg E， et al. No downstaging after short-term preoperative radiotherapy in rectal cancer patients[J]. J Clin Oncol， 2001， 19(7)：1976-1984.
11. Francois Y， Nemoz CJ， Baulieux J， et al. Infuence of the interval between preoperative radiation therapy and surgery on downstaging and the rate of sphincter sparing surgery for rectal cancer：the Lyon R9001 randomized trial[J]. J Clin Oncol， 1999， 17(8)：2396-2402.
12. Pach R， Kuliq J， Richter P， et al. Randomized clinical trial on preoperative radiotherapy 25 Gy in rectal cancer-treatment results at 5-year follow-up[J]. Lanqenbecks Arch Surg， 2012， 397(5)：801-807.
13. Pollack J， Holm T， Cedermark B， et al. Long-term effect ofpreoperative radiation therapy on anorectal function[J]. DisColon Rectum， 2006， 49(3)：345-352.
14. Sauer R， Becker H， Hohenberger W， et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer[J]. N Engl J Med， 2004， 351(17)：1731-1740.
15. Bujko K， Nowacki MP， Nasierowska-Guttmejer A， et al. Sphincterpreservation following preoperative radiotherapy for rectal cancer：report of a randomized trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy[J]. Radiother Oncol， 2004， 72(1)：15-24.
16. Eitta MA， EI-Wahidi GF， Fouda MA， et al. Preoperativeradiotherapy in resectable rectal cancer：a prospective randomized study of two different approaches[J]. Jegypt Nati Canc Inst， 2010， 22(3)：155-164.
17. Klenova A， Parvanova V， Georqiev R， et al. Preoperative radiotherapy in rectal cancer：treatment results of three different dose regimens[J]. J Buon， 2006， 11(2)：161-166.
18. Bosset JF， Collette L， Calais G， et al. Chemothrapy with preoperative radiotherapy in rectal cancer[J]. N Engl J Med， 2006， 355(11)：1114-1123.
19. Gerard JP， Bonnetain F， Conroy T， et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers：results of the FFCD9203[J]. Clin Oncol， 2006， 24(28)：4620-4625.
20. Rouanet P， Rivoire M， Lelong B， et al. Sphincter preserving surgery after preoperative treatment for ultra-low rectal carcinoma. A French multicenter prospective trial： GRECCAR 1[J]. Proc Am Soc Clin Oncol， 2006， 24(18)：3527-3530.
21. Stojanovic S， Popov I， Radosevic-Jelic L， et al. Preoperativeradiotherapy with capecitabine and mitomycin C in locallyadvanced rectal carcinoma[J]. Cancer Chemother Pharmacol， 2011， 68(3)：787-793.
22. Das P， Skibber JM， Rodriquez-Bigas MA， et al. Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation[J]. Cancer， 2007， 109(9)：1750-1755.
23. 吳文銘，邱輝忠，吳斌，等. 臨床病理指標預測直腸癌新輔助治療效果初探[J]. 中華外科雜志， 2010，48(5)：348-352.
24. Ishihara S， Watanabe T， Kiyomatsu T， et al. Prognostic signifi-cance of response to preoperative radiotherapy， lymph nodemetastasis， and CEA level in patients undergoing total mesorectal excision of rectal cancer[J]. Int J Colorectal Dis， 2010， 25(12)：1417-1425.
25. Korkeila EA， Syrjanen K， Bendardaf R， et al. Preoperativeradiotherapy modulates ezrin expression and its value as apredictive marker in patients with rectal cancer[J]. Hum Pathol， 2011， 42(3)：384-392.
26. Shinto E， Hashiquchi Y， Ueno H， et al. Pretreatment CD133 and cyclooxygenase-2 expression as the predictive markers of the pathological effect of chemoradiotherapy in rectal cancer patients[J]. Dis Colon Rectum， 2011， 54(9)：1006-1098.
27. Min BS， Choi YJ， Pvo HR， et al. Cyclooxygenase-2 expression in pretreatment biopsy as a predictor of tumor responses afterpreoperative chemoradiation in rectal cancer[J]. Arch Surg， 2008， 143(11)：1091-1097.
28. Zlobec L， Vuonq T， Compton CC， et al. Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy[J]. Br J Cancer， 2008， 98(2)：450-456.
29. Unsal Kilic D， Uner A， Akyurek N， et al. Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy[J]. Int J Radiat Oncol Biol Phys， 2007， 67(1)：196-203.
30. Moureau-Zabotto L， Farnault B， de Chaisemartin C， et al.Predictive factors of tumor response after neoadjuvant chemoradiation for locally advanced rectal cancer[J]. Int J Radiat Oncol Biol Phys， 2011， 80(2)：483-491.
31. Yasuda K， Nirei T， Sunami E， et al. Density of CD4+ and CD8+ T lymphocytes in biopsy samples can be a predictor of pathologicalresponse to chemoradiotherapy (CRT) for rectal cancer[J]. RadiatOncol， 2011， 6：49.
32. Kitayama J， Yasuda K， Kawai K， et al. Circulating lymphocyte is an important determinant of the effectiveness of preoperative rediotherapy in advanced rectal cancer[J]. BMC Cancer， 2011， 11：64.
33. Chang GJ， Rodriguez-Bigas MA， Eng C， et al. Lymph node status after neoadjuvant radiotherapy for rectal cancer is a biologic predictor of outcome[J]. Cancer， 2009， 115(23)：5432-5440.
34. Hu-Lieskovan S， Vallbohmer D， Zhang W， et al. EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients[J]. Clin Cancer Res， 2011， 17(15)：5161-5169.
35. Kobunai T， Watanabe T， Fukusato T， et al. REG4， NEIL2， and BIRC5 gene expression correlates with gamma-radiation sensitivityin patients with rectal cancer receiving radiothrapy[J]. Anticancer， 2011， 31(12)：4147-4153.
36. Watanabe T， Komuro Y， Kiyomatsu T， et al. Prediction ofsensitivity of rectal cancer cells in response to preoterativeradiotherapy by DNA microarray analysis of gene expressionprofiles[J]. Cancer Res， 2006， 66(7)：3370-3374.

《中國普外基礎與臨床雜志》

直腸癌術前放療的研究進展△

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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《中國普外基礎與臨床雜志》

直腸癌術前放療的研究進展△

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料