目的:初步探討體外血漿脂蛋白過濾器（DELP）對急性腦梗死患者的臨床療效及安全性。方法:采用隨機、基礎治療平行對照試驗設計，將符合入選標準的患者隨機分為兩組:試驗組3例，發病48 h內和間隔一天上午接受DELP治療，對照組2例，僅給予基礎治療。用NIHSS量表，Barthel指數和改良Rankin評分評價神經功能恢復狀況。結果:治療后14 d治療組NIHSS降低趨勢明顯優于對照組，治療后90 d治療組mRS良好預后的患者比例顯著高于對照組。兩組均未發現明顯不良反應，治療前后兩組的實驗室指標無顯著變化。結論:DELP治療急性腦梗死所致的神經功能缺損效果及安全性良好，為臨床急性腦梗死的治療提供了一條新的途徑。
引用本文：
郭建,周沐科,李其富,楊蓉,陳靜,何俐. DELP治療急性腦梗死療效初步觀察. 華西醫學, 2009, 24(1): 7-8. doi:
復制
| 1. |
Katzan IL，Hammer MD，Hixson ED，et al.Utilization of intravenous tissue plasminogen activator for acute ischemic stroke[J].Arch Neurol.2004，61:346-350..
|
| 2. |
THE NINDS TPA STROKE STUDY GROUP.Generalized efficacy of tPA for acute stroke.Subgroup analysis of the NINDS tPA Stroke Trial[J].Stroke，1997，28 （11）:2119-2125..
|
| 3. |
Zhu YC，Cui LY，Hua BL，et al.Correlation between fibrinogen level and cerebral infarction[J].Chin Med Sci J，2006，21（3）:167-170..
|
| 4. |
Zhang X，Hu Y，Hong M，et al.Plasma thrombomodulin，fibrinogen，and activity of tissue factor as risk factors for acute cerebral infarction[J].Am J Clin Pathol，2007，128（2）:287292..
|
| 5. |
Guo Y，Zuo YF，Wang QZ，et al.Metaanalysis of defibrase in treatment of acute cerebral infarction[J].Chin Med J，2006，119（8）:662-668.
|
- 1. Katzan IL，Hammer MD，Hixson ED，et al.Utilization of intravenous tissue plasminogen activator for acute ischemic stroke[J].Arch Neurol.2004，61:346-350..
- 2. THE NINDS TPA STROKE STUDY GROUP.Generalized efficacy of tPA for acute stroke.Subgroup analysis of the NINDS tPA Stroke Trial[J].Stroke，1997，28 （11）:2119-2125..
- 3. Zhu YC，Cui LY，Hua BL，et al.Correlation between fibrinogen level and cerebral infarction[J].Chin Med Sci J，2006，21（3）:167-170..
- 4. Zhang X，Hu Y，Hong M，et al.Plasma thrombomodulin，fibrinogen，and activity of tissue factor as risk factors for acute cerebral infarction[J].Am J Clin Pathol，2007，128（2）:287292..
- 5. Guo Y，Zuo YF，Wang QZ，et al.Metaanalysis of defibrase in treatment of acute cerebral infarction[J].Chin Med J，2006，119（8）:662-668.
1/5
微信公眾號