【摘要】 目的 探討左氧氟沙星聯合阿奇霉素治療老年難治性呼吸道感染的療效及安全性。 方法 選擇2005年2月-2010年9月收治的高齡難治性呼吸道細菌感染患者68例，隨機分為治療組和對照組。治療組34例，給予左氧氟沙星聯合阿奇霉素；對照組34例，給予左氧氟沙星，兩組總療程皆為15 d。觀察兩組患者的臨床療效、細菌清除率和不良反應。 結果 治療組的總有效率為64.71%，對照組總有效率為32.35%，兩組差異有統計學意義（P lt;0.05） 。治療組細菌清除率為76.19%，對照組細菌清除率為36.36%，兩組差異有統計學意義（P lt;0.05） 。治療組和對照組的不良反應發生率分別為5.88%和8.82%，差異無統計學意義（P gt;0.05）。結論 左氧氟沙星聯合阿奇霉素治療老年難治性呼吸道感染療效高， 能有效清除細菌， 不良反應較少， 值得臨床推廣應用。
【Abstract】 Objective To evaluate the efficacy and safety of levofloxacin combined with azithromycin on refractory respiratory infections in elder patients. Methods A total of 68 elder patients with refractory respiratory infections in our hospital from February 2005 to September 2010 were randomly divided into two groups: treatment group (n=34) and control group (n=34). The patients in treatment group were treated with levofloxacin combined with azithromycin; while the patients in the control group were treated with levofloxacin alone. The total treatment periods of both groups were 15 days. The therapeutic efficacy, eradication rate of pathogens and the rate of aelverse reactions were observed. Results The therapeutic effect rate was 64.71% in the treatment group and 32.35% in the control group, and the difference between the two groups was statistically significant (P lt;0.05). The eradication rate of pathogens was 76.19% in the treatment group and 36.36% in the control group, and the difference was significant (P lt;0.05). The rate of the adverse reaction was 5.88% in the treatment group and 8.82% in the control group, and there were no significant differences between the two groups (P gt;0.05). Conclusion Levofloxacin combined with Azithromycin is effective on refractory respiratory tract infection in elder patients, which can effectively remove the bacteria with few adverse reaction.
引用本文： 李鴻雁,孫梅芹,肖欣榮,王煒,葉興蓉. 左氧氟沙星聯合阿奇霉素治療老年難治性呼吸道感染的臨床分析. 華西醫學, 2010, 25(12): 2174-2176. doi: 復制