優化牙釉質輻射劑量重建方法中的電子順磁共振譜擬合程序_《華西醫學》

作者：

周莉 ¹ , 張文藝 ² , 于奡 ³ , 苑淑渝 ² , 戴光復 ² ,  張良安 ²

1 四川大學華西醫院放射物理技術中心;2 中國醫學科學院中國協和醫科大學放射醫學研究所;3 南開大學中心實驗室;

關鍵詞：

牙釉質電子順磁共振

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【摘要】　目的　優化牙釉質電子順磁共振（EPR）譜擬合程序。　方法　將牙釉質EPR譜擬合程序中的RIS-BGS偏移量設置為定參，取優化值；增加手動擬合功能，可以將參數初始值直接代入高斯模型得到擬合譜。　結果　將牙釉質EPR譜擬合程序中RIS-BGS偏移量設置為定參后，其優化值為0.529，減少了變參數量；采用手動擬合功能有助于調整參數初始值；在自動擬合程序對于個別樣品譜不能給出正確結果情況時，仍然可以通過手動擬合來得到一個近似的擬合結果。　結論　優化了EPR譜擬合程序的應用過程。
【Abstract】　Objective　 To optimize the enamel electron paramagnetic resonance (EPR) spectrum fitting procedure.　Methods　 RIS-BGS offset was set as a determined parameter in enamel EPR spectrum fitting program, and an optimized value was given for RIS-BGS offset. A manual fitting function was designed that can substite the initutial value into the Gaussian model function directly.　Results　 RIS-BGS offset was set as a determined parameter, the optimized value of which was 0.529. The number of parameters decreased; the manual fitting function maked it easier to select initial values for parameters. When the auto fitting program failed to give a correct result for some EPR spectrum, a fitting result could still be obtained with the manual fitting method.　Conclusion　 The application of the spectrum fitting procedure can be optimized.

引用本文： 周莉,張文藝,于奡,苑淑渝,戴光復,張良安. 優化牙釉質輻射劑量重建方法中的電子順磁共振譜擬合程序. 華西醫學, 2010, 25(12): 2160-2163. doi: 復制

1.	Chumak V, Ciesielski B, Sholom S, et al. Lessons of the 3rd international intercomparison on EPR dosimetry with teeth: similarities and differences of two successful techniques[J]. Radiat Prot Dosimetry, 2006, 120 (1-4): 197-201.
2.	Nakamura N, Miyazawa C, Sawada S, et al. A close correlation between electron spin resonance (ESR) dosimetry from tooth enamel and cytogenetic dosimetry from lymphocytes of Hiroshima atomic-bomb survivors[J]. Int J Radiat Biol, 1998, 73 (6): 619-27.
3.	Ikeya M, Miyajima J, Okajima S. ESR dosimetry for atomic bomb survivors using shell buttons and tooth enamel[J]. Jpn J Appl Phys, 1984(23): 697-699.
4.	Romanyukha AA, Ignatiev EA, Vasilenko EK, et al. EPR dose reconstruction for Russian nuclear workers[J]. Health Phys, 2000, 78 (1): 15-20.
5.	Wieser A, Romanyukha AA, Degteve MO, et al. Tooth enamel as a natural beta dosimeter for bone seeking radionuclides [J]. Radiat Prot Dosimetry, 1996, 65(1-4): 413-416.
6.	Romanyukha AA, Degteva MO, Kozheurov VP, et al. Pilot study of the Ural population by tooth electron paramagnetic resonance dosimetry[J]. Radiat Environ Biophys, 1996, 35(4): 305-310.
7.	Chumak V, Sholom S, Pasalkaya L. Application of high precision EPR dosimetry with teeth for reconstruction of doses to Chernobyl Populations[J]. Radiat Prot Dosimetry, 1999, 84(1-4): 515-520.
8.	Ishii H, Ikeya M, Okano M. ESR dosimetry of teeth of residents close to Chernobyl reactor accident[J]. J Nucl Sci Techonl, 1990, 27(12): 1153-1155.
9.	Chumak V, Sholom SV, Likhtarev IA. Some results of retrospective dose reconstructon for selected groups of exposed population in Ukraine. In: Proceedings of symposium on the radiological consequences of the chernobyl accident[R]. Report EUR 16544 EN, European Commission, Brussels, 1996, 1059-1062.
10.	Sevan’Katv AV, Lloyd DC, Edwards AA, et al. High exposures to radiation received by workers inside the Chernobyl Sargophagus[J]. Radiat Prot Dosimetryn. 1995, 59(2): 85-91.
11.	Ivannikov AI, Skvortsov VG, Stepanenko VF, et al. Wide scale EPR retrospective dosimetry. Results and problems[J]. Radiat Prot Dosimetry, 1997, 71(3): 175-180.
12.	丁艷秋. 牙釉質EPR劑量學方法應用于醫用診斷X射線工作者劑量重建的方法研究[J]. 中國輻射衛生, 2010, 19(1): 15-16.
13.	楊英杰. 2例嚴重的60Co放射事故受照人員的牙齒劑量估算[J]. 中國輻射衛生, 2010, 19(2): 150-151.
14.	吳偉章. 牙釉質電子順磁共振(EPR)譜擬合技術及其在劑量重建中的應用研究[D]. 中國協和醫科大學學位論文, 2005.
15.	周莉. 牙釉質EPR劑量測定方法的主要影響因素分析[J]. 國外醫學?放射醫學核醫學分冊, 2004, 28(3): 128-132.
16.	周莉, 于奡, 張文藝, 等. ETS對牙釉質EPR譜去卷積程序擬合結果的影響[J]. 中華放射醫學與防護, 2006, 26(6): 586-588.
17.	焦玲, 張文藝, 丁艷秋, 等. 日射量的估算及其對牙釉質電子自旋共振劑量學的影響[J]. 中華放射醫學與防護雜志, 2009 , 29(3): 306-309.
18.	焦玲, 張文藝, 潘志紅, 等. 牙釉質電子自旋共振(ESR)信號強度與質量關系的研究[J]. 中國輻射衛生, 2005, 14(3): 177-178.
19.	Ivannikov AI, Skvortsov VG, Stepanenko VF, et al. EPR tooth enamel dosimetry: optimization of the automated spectra deconvolution routine[J]. Health Phys, 2001, 81 (2): 124-137.

1. 　Chumak V, Ciesielski B, Sholom S, et al. Lessons of the 3rd international intercomparison on EPR dosimetry with teeth: similarities and differences of two successful techniques[J]. Radiat Prot Dosimetry, 2006, 120 (1-4): 197-201.
2. 　Nakamura N, Miyazawa C, Sawada S, et al. A close correlation between electron spin resonance (ESR) dosimetry from tooth enamel and cytogenetic dosimetry from lymphocytes of Hiroshima atomic-bomb survivors[J]. Int J Radiat Biol, 1998, 73 (6): 619-27.
3. 　Ikeya M, Miyajima J, Okajima S. ESR dosimetry for atomic bomb survivors using shell buttons and tooth enamel[J]. Jpn J Appl Phys, 1984(23): 697-699.
4. 　Romanyukha AA, Ignatiev EA, Vasilenko EK, et al. EPR dose reconstruction for Russian nuclear workers[J]. Health Phys, 2000, 78 (1): 15-20.
5. 　Wieser A, Romanyukha AA, Degteve MO, et al. Tooth enamel as a natural beta dosimeter for bone seeking radionuclides [J]. Radiat Prot Dosimetry, 1996, 65(1-4): 413-416.
6. 　Romanyukha AA, Degteva MO, Kozheurov VP, et al. Pilot study of the Ural population by tooth electron paramagnetic resonance dosimetry[J]. Radiat Environ Biophys, 1996, 35(4): 305-310.
7. 　Chumak V, Sholom S, Pasalkaya L. Application of high precision EPR dosimetry with teeth for reconstruction of doses to Chernobyl Populations[J]. Radiat Prot Dosimetry, 1999, 84(1-4): 515-520.
8. 　Ishii H, Ikeya M, Okano M. ESR dosimetry of teeth of residents close to Chernobyl reactor accident[J]. J Nucl Sci Techonl, 1990, 27(12): 1153-1155.
9. 　Chumak V, Sholom SV, Likhtarev IA. Some results of retrospective dose reconstructon for selected groups of exposed population in Ukraine. In: Proceedings of symposium on the radiological consequences of the chernobyl accident[R]. Report EUR 16544 EN, European Commission, Brussels, 1996, 1059-1062.
10. 　Sevan’Katv AV, Lloyd DC, Edwards AA, et al. High exposures to radiation received by workers inside the Chernobyl Sargophagus[J]. Radiat Prot Dosimetryn. 1995, 59(2): 85-91.
11. 　Ivannikov AI, Skvortsov VG, Stepanenko VF, et al. Wide scale EPR retrospective dosimetry. Results and problems[J]. Radiat Prot Dosimetry, 1997, 71(3): 175-180.
12. 　丁艷秋. 牙釉質EPR劑量學方法應用于醫用診斷X射線工作者劑量重建的方法研究[J]. 中國輻射衛生, 2010, 19(1): 15-16.
13. 　楊英杰. 2例嚴重的60Co放射事故受照人員的牙齒劑量估算[J]. 中國輻射衛生, 2010, 19(2): 150-151.
14. 　吳偉章. 牙釉質電子順磁共振(EPR)譜擬合技術及其在劑量重建中的應用研究[D]. 中國協和醫科大學學位論文, 2005.
15. 　周莉. 牙釉質EPR劑量測定方法的主要影響因素分析[J]. 國外醫學?放射醫學核醫學分冊, 2004, 28(3): 128-132.
16. 　周莉, 于奡, 張文藝, 等. ETS對牙釉質EPR譜去卷積程序擬合結果的影響[J]. 中華放射醫學與防護, 2006, 26(6): 586-588.
17. 　焦玲, 張文藝, 丁艷秋, 等. 日射量的估算及其對牙釉質電子自旋共振劑量學的影響[J]. 中華放射醫學與防護雜志, 2009 , 29(3): 306-309.
18. 　焦玲, 張文藝, 潘志紅, 等. 牙釉質電子自旋共振(ESR)信號強度與質量關系的研究[J]. 中國輻射衛生, 2005, 14(3): 177-178.
19. 　Ivannikov AI, Skvortsov VG, Stepanenko VF, et al. EPR tooth enamel dosimetry: optimization of the automated spectra deconvolution routine[J]. Health Phys, 2001, 81 (2): 124-137.

《華西醫學》

優化牙釉質輻射劑量重建方法中的電子順磁共振譜擬合程序

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《華西醫學》

優化牙釉質輻射劑量重建方法中的電子順磁共振譜擬合程序

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