米諾地爾治療血液透析伴頑固性高血壓一例_《華西醫學》

作者：

田茂露 , 劉曉霞 ,  胡章學

四川大學華西醫院腎臟內科（成都，610041）;

關鍵詞：

米諾地爾頑固性高血壓血液透析

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【摘要】　目的　探討米諾地爾對血液透析伴頑固性高血壓的降壓價值。　方法　觀察1例血液透析伴頑固性高血壓患者米諾地爾的降壓療效，分析米諾地爾的臨床應用及不良反應。　結果　米諾地爾能快速高效地控制患者的頑固性高血壓狀態，且小劑量長期維持治療未發生明顯藥物相關副作用。　結論　米諾地爾降壓效果顯著、起效迅速，但鑒于使用米諾地爾的潛在毒副作用較多，該藥應該被嚴格限制到對足量傳統降壓藥無效或伴有不能接受的藥物并發癥患者。

引用本文： 田茂露,劉曉霞,胡章學. 米諾地爾治療血液透析伴頑固性高血壓一例. 華西醫學, 2011, 26(12): 1870-1871. doi: 復制

1.	Mahony JF, Gibson GR, Sheil AG, et al. Bilateral nephrectomy for malignant hypertension[J]. Lancet, 1972, 299(7759): 1036-1038.
2.	Pettinger WA, Mitchell HC. Minoxidil--an alternative to nephrectomy for refractory hypertension[J]. N Engl J Med, 1973, 289(4): 167-171.
3.	Black RN, Hunter SJ, Atkinson AB. Usefulness of the vasodilator minoxidil in resistant hypertension[J]. J Hypertens, 2007, 25(5): 1102-1103.
4.	Halling SE, Asling-Monemi K, Herthelius M, et al. Minoxidil therapy in children and young adult patients with renal disease and refractory hypertension: value when multidrug regimens have failed to achieve blood pressure control[J]. J Hum Hypertens, 2010, 24(8): 552-554.
5.	Black RNA, Hunter SJ, Atkinson AB. Refractory hypertension can often be helped by the use of the potent vasodilator minoxidil: results in 13 patients, 12 of whom were already receiving angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists[J]. Endocrine Abstracts, 2005, 9: 12.
6.	劉雙信, 史偉, 梁馨苓, 等. 米諾地爾在治療血液透析伴頑固性高血壓中的應用[J]. 中國血液凈化, 2004, 7(3): 355-357.
7.	Javier R, Dumler F, Park JH, et al. Long-term treatment with minoxidil in patients with severe renal failure[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): S149-S155.
8.	Luft FC, Bloch R, Szwed JJ, et al. Minoxidil treatment of malignant hypertension: Recovery of renal function[J]. JAMA, 1978, 240(18): 1985-1987.
9.	Gottlieb TB, Katz FH, Chidsey CA 3rd. Combined therapy with vasodilator drugs and beta-adrenergic blockade in hypertension: a comparative study of minoxidil and hydralazine[J]. Circulation, 1972, 45(3): 571-582.
10.	McChesney JA, Amend WJ Jr. Minoxidil in the treatment of refractory hypertension due to a spectrum of causes[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): 131-141.
11.	Mitchell HC, Pettinger WA. Long-term treatment of refractory hypertensive patients with minoxidil[J]. JAMA, 1978, 239(20): 2131-2138.
12.	Earhart RN, Ball J, Nuss DD, et al. Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory[J]. South Med J, 1977, 70(4): 442-443.
13.	Gilmore E, Weil J, Chidsey C. Treatment of essential hypertension with a new vasodilator in combination with beta adrenergic blockade [J]. N Engl J Med, 1970, 282(10): 521-527.
14.	Zarate A, Gelfand MC, Horton JD, et al. Pericardial effusion associated with minoxidil therapy in dialyzed patients[J]. Int J Artif Organs, 1980, 3(1): 15-17.
15.	Hall D, Froer DH, Loracher C. Treatment of severe hypertension with minoxidil and its effects on systemic and pulmonary haemodynamics[J]. Clin Sci Mol Med Suppl, 1976, 3: 587-589.

1. 　Mahony JF, Gibson GR, Sheil AG, et al. Bilateral nephrectomy for malignant hypertension[J]. Lancet, 1972, 299(7759): 1036-1038.
2. 　Pettinger WA, Mitchell HC. Minoxidil--an alternative to nephrectomy for refractory hypertension[J]. N Engl J Med, 1973, 289(4): 167-171.
3. 　Black RN, Hunter SJ, Atkinson AB. Usefulness of the vasodilator minoxidil in resistant hypertension[J]. J Hypertens, 2007, 25(5): 1102-1103.
4. 　Halling SE, Asling-Monemi K, Herthelius M, et al. Minoxidil therapy in children and young adult patients with renal disease and refractory hypertension: value when multidrug regimens have failed to achieve blood pressure control[J]. J Hum Hypertens, 2010, 24(8): 552-554.
5. 　Black RNA, Hunter SJ, Atkinson AB. Refractory hypertension can often be helped by the use of the potent vasodilator minoxidil: results in 13 patients, 12 of whom were already receiving angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists[J]. Endocrine Abstracts, 2005, 9: 12.
6. 　劉雙信, 史偉, 梁馨苓, 等. 米諾地爾在治療血液透析伴頑固性高血壓中的應用[J]. 中國血液凈化, 2004, 7(3): 355-357.
7. 　Javier R, Dumler F, Park JH, et al. Long-term treatment with minoxidil in patients with severe renal failure[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): S149-S155.
8. 　Luft FC, Bloch R, Szwed JJ, et al. Minoxidil treatment of malignant hypertension: Recovery of renal function[J]. JAMA, 1978, 240(18): 1985-1987.
9. 　Gottlieb TB, Katz FH, Chidsey CA 3rd. Combined therapy with vasodilator drugs and beta-adrenergic blockade in hypertension: a comparative study of minoxidil and hydralazine[J]. Circulation, 1972, 45(3): 571-582.
10. 　McChesney JA, Amend WJ Jr. Minoxidil in the treatment of refractory hypertension due to a spectrum of causes[J]. J Cardiovasc Pharmacol, 1980, 2(Suppl 2): 131-141.
11. 　Mitchell HC, Pettinger WA. Long-term treatment of refractory hypertensive patients with minoxidil[J]. JAMA, 1978, 239(20): 2131-2138.
12. 　Earhart RN, Ball J, Nuss DD, et al. Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory[J]. South Med J, 1977, 70(4): 442-443.
13. 　Gilmore E, Weil J, Chidsey C. Treatment of essential hypertension with a new vasodilator in combination with beta adrenergic blockade [J]. N Engl J Med, 1970, 282(10): 521-527.
14. 　Zarate A, Gelfand MC, Horton JD, et al. Pericardial effusion associated with minoxidil therapy in dialyzed patients[J]. Int J Artif Organs, 1980, 3(1): 15-17.
15. 　Hall D, Froer DH, Loracher C. Treatment of severe hypertension with minoxidil and its effects on systemic and pulmonary haemodynamics[J]. Clin Sci Mol Med Suppl, 1976, 3: 587-589.

《華西醫學》

米諾地爾治療血液透析伴頑固性高血壓一例

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《華西醫學》

米諾地爾治療血液透析伴頑固性高血壓一例

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