【摘要】 目的 研究合并2型糖尿病的冠心病患者冠狀動脈病變程度與血清視黃醇結合蛋白4（retinol-binding protein 4，RBP4）水平的相關性。 方法 2008年10月-2010年4月選擇性冠狀動脈造影確診的冠心病患者共120例，分為單純冠心病組（A組）60例和冠心病合并糖尿病組（B組）60例，檢測血糖、血脂、胰島素以及脂聯素、RBP4水平；根據冠狀動脈造影結果，以Gensini評分評判冠狀動脈病變程度。 結果 B組空腹血糖、胰島素、RBP4均顯著高于A組（P lt;0.05）；冠狀動脈病變程度更重（P lt;0.05）。相關性分析顯示RBP4水平與低密度脂蛋白膽固醇、胰島素抵抗和冠狀動脈病變積分呈正相關（r=0.312、0.322、0.314，P lt;0.05）。與脂聯素水平呈負相關（r=-0.362，P lt;0.01）。 結論 冠心病合并2型糖尿病患者RBP4明顯升高，且與冠狀動脈狹窄程度呈正相關。
【Abstract】 Objective To explore the relationship between the level of serum retinol-binding protein 4 (RBP4) and the extent of coronary lesions in coronary heart disease (CHD) patients accompanied with type 2 diabetes mellitus (T2DM). Methods A total of 120 patients with CHD diagnosed by coronary arteriongraphy between October 2008 and April 2010 were enrolled. The patients were divided into two groups: CHD group (60 patients); CHD accompanied with T2DM group (60 patients). The levels of serum insulin, adiponectin and RBP4 were measured. All the patients underwent coronary angiography and the extent of coronary lesions was assessed quantitatively based on the Gensini′s scoring system. Results The levels of serum insulin, plasma RBP4 and the extent of coronary artery stenosis in CHD accompanied with T2DM group were significantly higher than those in CHD group (P lt;0.05). Correlation analysis showed that the level of RBP4 was positively correlated with LDL-C, insulin resistance index and the coronary artery narrow degree（r=0.312, 0.322, 0.314; P lt;0.05); and negatively correlated with adiponectin (r=-0.362, P lt;0.01). Conclusion The significant elevated plasma RBP4 in CHD patients accompanied with T2DM is positively correlated with the extent of coronary artery lesion.
引用本文： 張敏,唐榮珍,曹曉紅,張維,辜曉惠,董巍. 冠心病合并2型糖尿病血清視黃醇結合蛋白4水平與冠狀動脈病變程度的相關性研究. 華西醫學, 2011, 26(12): 1818-1821. doi: 復制