以非驚厥性癲癇持續狀態為首發表現的FLAMES綜合征一例_Journal of Epilepsy

Authors：

周輝 ^1,2,3 , 馬小丹 ^1,3,4 , 羅媛媛 ^1,3 , 黃宏燕 ^1,3 ,  郝曉婷 ^1,3

1. ;
2. ;
3. ;
4. ;

Corresponding?author：

郝曉婷, Email: sherryhao@wchscu.cn

Keywords：

非驚厥性癲癇持續狀態; 髓鞘少突膠質細胞糖蛋白; 癲癇

DOI：

10.7507/2096-0247.202509011

Video：

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Citation： 周輝, 馬小丹, 羅媛媛, 黃宏燕, 郝曉婷. 以非驚厥性癲癇持續狀態為首發表現的FLAMES綜合征一例. Journal of Epilepsy, 2025, 11(6): 519-523. doi: 10.7507/2096-0247.202509011 Copy

1.	Ramanathan S, Dale R, Brilot F. Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmun rev, 2016, 15(4): 307-324.
2.	Jarius S, Paul F, Aktas O, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. J neuroinflamm, 2018, 15(1): 134.
3.	Vega E, Arrambide G, Olivé G, et al. Non-ADEM encephalitis in patients with myelin oligodendrocyte glycoprotein antibodies: a systematic review. Eur J neurol, 2023, 30(5): 1515-1527.
4.	Takegami N, Murai H, Mori H, et al. Multiple cortical lesions with grainy enhancement of magnetic resonance imaging in anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis with seizures (FLAMES). J neurol sci, 2023, 451: 120729.
5.	Ogawa R, Nakashima I, Takahashi T, et al. MOG antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy. Neurol-neuroimmunol neuroinflammation, 2017, 4(2): 322.
6.	Budhram A, Mirian A, Sharma M. Meningo-cortical manifestations of myelin oligodendrocyte glycoprotein antibody-associated disease: Review of a novel clinico-radiographic spectrum. Front neurol, 2022, 13: 1044642.
7.	李波, 王展航. 抗髓鞘少突膠質細胞糖蛋白免疫球蛋白G抗體相關疾病(MOGAD)的診斷. 中國神經免疫學和神經病學雜志, 2025, 32(2): 89-94.
8.	劉康, 王薇, 靳梅, 等. 以癲癇發作為首發癥狀的MOG抗體相關疾病患者臨床分析. 中國神經免疫學和神經病學雜志, 2022, 29(5): 386-392.
9.	李尚茹, 常旭婷, 張捷, 等. 兒童MOGAD中急性癥狀性癲癇發作及繼發癲癇的相關因素分析. 中華兒科雜志, 2024, 62(7): 655-660.
10.	張敏, 馬煦, 楊春曉, 等. 成人非驚厥性癲癇持續狀態患者的臨床及腦電圖特征. 中國醫藥導報, 2018, 15(2): 62-66.
11.	楊丹, 王向波, 閆鶴立, 等. 髓鞘少突膠質細胞糖蛋白抗體相關疾病臨床及影像分析. 中國神經精神疾病雜志, 2023, 49(6): 331-339.
12.	戴雨薇, 尹晴, 楊利. 癲癇的自身免疫性病因研究進展概述. 中華神經科雜志, 2024, 57(5): 511-518.
13.	Liu K, Wang W, Jin M, et al. FLAIR hyperintense cortical lesions in myelin oligodendrocyte glycoprotein-associated encephalitis with seizures in children: a retrospective single-center case series. Front immunol, 2025, 16: 1563481.
14.	Misu T. Myelin oligodendrocyte glycoprotein antibody-associated disease: pathophysiology, clinical patterns, and therapeutic challenges of intractable and severe forms. Int J mol sci, 2025, 26(17): 8538.
15.	尹翮翔, 張遙, 徐雁, 等. MOG抗體相關腦炎臨床特點與預后分析. 中國神經免疫學和神經病學雜志, 2021, 28(4): 288-292, 322.

1. Ramanathan S, Dale R, Brilot F. Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmun rev, 2016, 15(4): 307-324.
2. Jarius S, Paul F, Aktas O, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. J neuroinflamm, 2018, 15(1): 134.
3. Vega E, Arrambide G, Olivé G, et al. Non-ADEM encephalitis in patients with myelin oligodendrocyte glycoprotein antibodies: a systematic review. Eur J neurol, 2023, 30(5): 1515-1527.
4. Takegami N, Murai H, Mori H, et al. Multiple cortical lesions with grainy enhancement of magnetic resonance imaging in anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis with seizures (FLAMES). J neurol sci, 2023, 451: 120729.
5. Ogawa R, Nakashima I, Takahashi T, et al. MOG antibody-positive, benign, unilateral, cerebral cortical encephalitis with epilepsy. Neurol-neuroimmunol neuroinflammation, 2017, 4(2): 322.
6. Budhram A, Mirian A, Sharma M. Meningo-cortical manifestations of myelin oligodendrocyte glycoprotein antibody-associated disease: Review of a novel clinico-radiographic spectrum. Front neurol, 2022, 13: 1044642.
7. 李波, 王展航. 抗髓鞘少突膠質細胞糖蛋白免疫球蛋白G抗體相關疾病(MOGAD)的診斷. 中國神經免疫學和神經病學雜志, 2025, 32(2): 89-94.
8. 劉康, 王薇, 靳梅, 等. 以癲癇發作為首發癥狀的MOG抗體相關疾病患者臨床分析. 中國神經免疫學和神經病學雜志, 2022, 29(5): 386-392.
9. 李尚茹, 常旭婷, 張捷, 等. 兒童MOGAD中急性癥狀性癲癇發作及繼發癲癇的相關因素分析. 中華兒科雜志, 2024, 62(7): 655-660.
10. 張敏, 馬煦, 楊春曉, 等. 成人非驚厥性癲癇持續狀態患者的臨床及腦電圖特征. 中國醫藥導報, 2018, 15(2): 62-66.
11. 楊丹, 王向波, 閆鶴立, 等. 髓鞘少突膠質細胞糖蛋白抗體相關疾病臨床及影像分析. 中國神經精神疾病雜志, 2023, 49(6): 331-339.
12. 戴雨薇, 尹晴, 楊利. 癲癇的自身免疫性病因研究進展概述. 中華神經科雜志, 2024, 57(5): 511-518.
13. Liu K, Wang W, Jin M, et al. FLAIR hyperintense cortical lesions in myelin oligodendrocyte glycoprotein-associated encephalitis with seizures in children: a retrospective single-center case series. Front immunol, 2025, 16: 1563481.
14. Misu T. Myelin oligodendrocyte glycoprotein antibody-associated disease: pathophysiology, clinical patterns, and therapeutic challenges of intractable and severe forms. Int J mol sci, 2025, 26(17): 8538.
15. 尹翮翔, 張遙, 徐雁, 等. MOG抗體相關腦炎臨床特點與預后分析. 中國神經免疫學和神經病學雜志, 2021, 28(4): 288-292, 322.

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以非驚厥性癲癇持續狀態為首發表現的FLAMES綜合征一例

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