Factors influencing comorbid sleep disorders in adolescents with epilepsy: a scoping review_Journal of Epilepsy

Authors：

XIA Sijie ^1,2,3,4 , ZHANG Nan ^1,2,3,4 ,  CUI Cui ^1,2,3,4

1. Nursing Department, Children's Hospital Affiliated to Chongqing Medical University, Chongqing 400014, China;
2. National Clinical Research Center for Child Health and Disorders, Chongqing 400014, China;
3. Key Laboratory of Child Development and Disorders, Ministry of Education, Chongqing 400014, China;
4. Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing 400014, China;

Corresponding?author：

CUI Cui, Email: cuicui17@126.com

Keywords：

Epilepsy; Adolescents; Sleep disorders; Influencing factors; Scoping review

DOI：

10.7507/2096-0247.202509003

Video：

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Objective To conduct a scoping review on the influencing factors of comorbid sleep disorders in adolescents with epilepsy, so as to provide a reference basis for clinical prevention and early intervention. Methods Following the methodological framework of scoping review, relevant studies were systematically searched in PubMed, Web of Science, Cochrane Library, Embase, Chinese Biomedical Literature Database, CNKI, Wanfang, and VIP Database. The retrieval time limit was from the establishment of each database to April 30, 2025. The included literatures were summarized and analyzed. Results A total of 17 literatures were included, and 17 influencing factors related to comorbid sleep disorders in adolescents with epilepsy were identified, which were mainly divided into six categories: demographic factors, characteristics and severity of epilepsy, treatment-related factors, psychiatric comorbidities, organic neurological damage and neurocognitive development and psychosocial and environmental factors. Conclusion Sleep disorders are relatively common in adolescents with epilepsy, and their influencing factors are multifaceted.There is a lack of large-sample research on this population in our country, especially the lack of discussion of the causal relationship between influencing factors and sleep disorders, resulting in a lack of basis for early intervention. Future research urgently needs to systematically identify key influencing factors and explore their internal mechanisms through large-sample surveys, so as to lay a solid scientific foundation for the construction of evidence-based intervention programs.

Citation： XIA Sijie, ZHANG Nan, CUI Cui. Factors influencing comorbid sleep disorders in adolescents with epilepsy: a scoping review. Journal of Epilepsy, 2025, 11(6): 508-514. doi: 10.7507/2096-0247.202509003 Copy

1.	路蟬伊, 劉立雄, 張云峰. 癲癇發病機制的研究進展. 解放軍醫學院學報, 2014, 35(8): 876-881.
2.	Sateia MJ. International classification of sleep disorders-third edition. Chest, 2014, 146(5): 1387-1394.
3.	朱登納, 牛國輝. 兒童癲癇的長程管理. 臨床兒科雜志, 2023, 41(3): 235-240.
4.	黃路遙, 丁晶, 汪昕. 癲癇與睡眠障礙共病的研究進展. 中國臨床醫學, 2025, 32(3): 505-511.
5.	胡盼, 肖爭. 癲癇共病失眠的研究進展. 癲癇與神經電生理學雜志, 2024, 33(4): 237-242.
6.	麥子峰, 許鴻燕, 馬寧. 急性睡眠剝奪對認知與情緒功能的影響及其神經機制的研究進展. 中國全科醫學, 2021, 24(29): 3653-3659.
7.	Craig L, Kelli Borgess DS, Robin P. Practical guidance for knowledge synthesis: scoping review methods. Asian Nurs Res (Korean Soc Nurs Sci), 2019, 13(5): 287-294.
8.	Proost R, Cleeren E, Jansen B, et al. Factors associated with poor sleep in children with drug-resistant epilepsy. Epilepsia, 2024, 65(11): 3335-3349.
9.	Byars A, Byars K, Johnson C, et al. The relationship between sleep problems and neuropsychological functioning in children with first recognized seizures. Epilepsy behav, 2008, 13(4): 607-613.
10.	Ekinci O, Isik U, Gunes S, et al. Understanding sleep problems in children with epilepsy: associations with quality of life, attention-deficit hyperactivity disorder and maternal emotional symptoms. Seizure, 2016, 40: 108-113.
11.	Ong L, Yang W, Wong S, et al. Sleep habits and disturbances in Malaysian children with epilepsy. J paediatr child health, 2010, 46(3): 80-84.
12.	Düken M, Zengin M. The mediating role of social support in the relationship between psychosocial problems and sleep patterns of adolescents with epilepsy. Epilepsy behav, 2024, 152: 109656.
13.	Neto F, Nunes M. Evaluation of sleep organization in patients with attention deficit hyperactivity disorder (ADHD) and ADHD as a comorbidity of epilepsy. Sleep med, 2017, 33: 91-96.
14.	Hansen B, Alfstad K, van Roy B, et al. Sleep problems in children and adolescents with epilepsy: Associations with psychiatric comorbidity. Epilepsy behav, 2016, 62: 14-19.
15.	張萌萌, 周農. 學齡期癲癇兒童睡眠問題及其影響因素分析. 安徽醫科大學學報, 2017, 52(4): 579-584.
16.	蔡曉唐, 羅蓉, 康琳敏, 等. 7~14歲癲癇患兒睡眠習慣調查及分析. 中國實用兒科雜志, 2010, 25(11): 868-870.
17.	郭柳, 金春華, 楊淑霞, 等. 癲癇患兒睡眠質量問卷調查. 世界睡眠醫學雜志, 2014(1): 39-41.
18.	毛云青, 董恩恒, 李多多, 等. 伴中央顳區棘波自限性癲癇患兒睡眠狀況及影響因素分析. 新鄉醫學院學報, 2024, 41(4): 348-352.
19.	楊曉輝, 董耀榮. 抗癇治療對睡眠相關性癲癇患兒睡眠結構的影響作用. 貴州醫藥, 2016, 40(1): 45-47.
20.	鄧瑤, 周潔蘭, 喻韜. 440例癲癇兒童睡眠問題及其影響因素分析. 現代臨床醫學, 2021, 47(6): 401-403,418.
21.	黃娟, 萬方銳. 丙戊酸鈉對伴中央顳區棘波的兒童良性癲癇睡眠結構的影響. 江西醫藥, 2016, 51(10): 1090-1091.
22.	黎西, 周農. 臨床下發作的原發性癲癇兒童睡眠結構特點及其影響因素. 安徽醫科大學學報, 2012, 47(2): 164-166.
23.	劉文超, 張開慧, 徐小蓮, 等. 青少年癲癇共病焦慮抑郁患者的睡眠特點研究及相關性分析. 癲癇與神經電生理學雜志, 2025, 34(1): 27-32.
24.	曾錦英. 兒童良性癲癇發作間期癲癇樣放電對睡眠結構的影響. 實用心腦肺血管病雜志, 2014, 22(4): 114-115.
25.	Sivertsen B, Harvey A, Pallesen S, et al. Trajectories of sleep problems from childhood to adolescence: a population-based longitudinal study from Norway. J Sleep Res, 2017, 26(1): 55-63.
26.	Hadjimarkou M, Benham R, Schwarz J, et al. Estradiol suppresses rapid eye movement sleep and activation of sleep-active neurons in the ventrolateral preoptic area. Eur J Neurosci, 2008, 27(7): 1780-1792.
27.	Paul K, Laposky A, Turek F. Reproductive hormone replacement alters sleep in mice. Neurosci Lett, 2009, 463(3): 239-243.
28.	Perucca E, Perucca P, White H, et al. Drug resistance in epilepsy. Lancet Neurol, 2023, 22(8): 723-734.
29.	Lee S, Choi E, Jeon J, et al. Insomnia moderates the association between recurrent seizures and emotional instability in persons with epilepsy. Epilepsy behav, 2021, 125: 108414.
30.	Atrooz F, Liu H, Kochi C, et al. Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes. Neuroscience, 2019, 406: 22-37.
31.	王輝. 拉莫三嗪聯合丙戊酸鈉對兒童福利院內兒童癲癇發作控制情況、發作頻率、睡眠質量的影響分析. 醫藥衛生, 2025(4): 48-51.
32.	王敏涵, 李琦, 黃曉瓊, 等. 工娛療法對青少年癲癇病人自尊水平及生活質量的影響. 全科護理, 2023, 21(30): 4254-4257.
33.	陳麗花. 心理康復護理對癲癇兒童睡眠及家長心理狀況的改善效果. 黑龍江中醫藥, 2022, 51(5): 146-147.
34.	池海珊. 健康教育干預對小兒癲癇患兒睡眠質量的效果研究. 世界睡眠醫學雜志, 2024, 11(10): 2235-2237,2241.

1. 路蟬伊, 劉立雄, 張云峰. 癲癇發病機制的研究進展. 解放軍醫學院學報, 2014, 35(8): 876-881.
2. Sateia MJ. International classification of sleep disorders-third edition. Chest, 2014, 146(5): 1387-1394.
3. 朱登納, 牛國輝. 兒童癲癇的長程管理. 臨床兒科雜志, 2023, 41(3): 235-240.
4. 黃路遙, 丁晶, 汪昕. 癲癇與睡眠障礙共病的研究進展. 中國臨床醫學, 2025, 32(3): 505-511.
5. 胡盼, 肖爭. 癲癇共病失眠的研究進展. 癲癇與神經電生理學雜志, 2024, 33(4): 237-242.
6. 麥子峰, 許鴻燕, 馬寧. 急性睡眠剝奪對認知與情緒功能的影響及其神經機制的研究進展. 中國全科醫學, 2021, 24(29): 3653-3659.
7. Craig L, Kelli Borgess DS, Robin P. Practical guidance for knowledge synthesis: scoping review methods. Asian Nurs Res (Korean Soc Nurs Sci), 2019, 13(5): 287-294.
8. Proost R, Cleeren E, Jansen B, et al. Factors associated with poor sleep in children with drug-resistant epilepsy. Epilepsia, 2024, 65(11): 3335-3349.
9. Byars A, Byars K, Johnson C, et al. The relationship between sleep problems and neuropsychological functioning in children with first recognized seizures. Epilepsy behav, 2008, 13(4): 607-613.
10. Ekinci O, Isik U, Gunes S, et al. Understanding sleep problems in children with epilepsy: associations with quality of life, attention-deficit hyperactivity disorder and maternal emotional symptoms. Seizure, 2016, 40: 108-113.
11. Ong L, Yang W, Wong S, et al. Sleep habits and disturbances in Malaysian children with epilepsy. J paediatr child health, 2010, 46(3): 80-84.
12. Düken M, Zengin M. The mediating role of social support in the relationship between psychosocial problems and sleep patterns of adolescents with epilepsy. Epilepsy behav, 2024, 152: 109656.
13. Neto F, Nunes M. Evaluation of sleep organization in patients with attention deficit hyperactivity disorder (ADHD) and ADHD as a comorbidity of epilepsy. Sleep med, 2017, 33: 91-96.
14. Hansen B, Alfstad K, van Roy B, et al. Sleep problems in children and adolescents with epilepsy: Associations with psychiatric comorbidity. Epilepsy behav, 2016, 62: 14-19.
15. 張萌萌, 周農. 學齡期癲癇兒童睡眠問題及其影響因素分析. 安徽醫科大學學報, 2017, 52(4): 579-584.
16. 蔡曉唐, 羅蓉, 康琳敏, 等. 7~14歲癲癇患兒睡眠習慣調查及分析. 中國實用兒科雜志, 2010, 25(11): 868-870.
17. 郭柳, 金春華, 楊淑霞, 等. 癲癇患兒睡眠質量問卷調查. 世界睡眠醫學雜志, 2014(1): 39-41.
18. 毛云青, 董恩恒, 李多多, 等. 伴中央顳區棘波自限性癲癇患兒睡眠狀況及影響因素分析. 新鄉醫學院學報, 2024, 41(4): 348-352.
19. 楊曉輝, 董耀榮. 抗癇治療對睡眠相關性癲癇患兒睡眠結構的影響作用. 貴州醫藥, 2016, 40(1): 45-47.
20. 鄧瑤, 周潔蘭, 喻韜. 440例癲癇兒童睡眠問題及其影響因素分析. 現代臨床醫學, 2021, 47(6): 401-403,418.
21. 黃娟, 萬方銳. 丙戊酸鈉對伴中央顳區棘波的兒童良性癲癇睡眠結構的影響. 江西醫藥, 2016, 51(10): 1090-1091.
22. 黎西, 周農. 臨床下發作的原發性癲癇兒童睡眠結構特點及其影響因素. 安徽醫科大學學報, 2012, 47(2): 164-166.
23. 劉文超, 張開慧, 徐小蓮, 等. 青少年癲癇共病焦慮抑郁患者的睡眠特點研究及相關性分析. 癲癇與神經電生理學雜志, 2025, 34(1): 27-32.
24. 曾錦英. 兒童良性癲癇發作間期癲癇樣放電對睡眠結構的影響. 實用心腦肺血管病雜志, 2014, 22(4): 114-115.
25. Sivertsen B, Harvey A, Pallesen S, et al. Trajectories of sleep problems from childhood to adolescence: a population-based longitudinal study from Norway. J Sleep Res, 2017, 26(1): 55-63.
26. Hadjimarkou M, Benham R, Schwarz J, et al. Estradiol suppresses rapid eye movement sleep and activation of sleep-active neurons in the ventrolateral preoptic area. Eur J Neurosci, 2008, 27(7): 1780-1792.
27. Paul K, Laposky A, Turek F. Reproductive hormone replacement alters sleep in mice. Neurosci Lett, 2009, 463(3): 239-243.
28. Perucca E, Perucca P, White H, et al. Drug resistance in epilepsy. Lancet Neurol, 2023, 22(8): 723-734.
29. Lee S, Choi E, Jeon J, et al. Insomnia moderates the association between recurrent seizures and emotional instability in persons with epilepsy. Epilepsy behav, 2021, 125: 108414.
30. Atrooz F, Liu H, Kochi C, et al. Early Life Sleep Deprivation: Role of Oxido-Inflammatory Processes. Neuroscience, 2019, 406: 22-37.
31. 王輝. 拉莫三嗪聯合丙戊酸鈉對兒童福利院內兒童癲癇發作控制情況、發作頻率、睡眠質量的影響分析. 醫藥衛生, 2025(4): 48-51.
32. 王敏涵, 李琦, 黃曉瓊, 等. 工娛療法對青少年癲癇病人自尊水平及生活質量的影響. 全科護理, 2023, 21(30): 4254-4257.
33. 陳麗花. 心理康復護理對癲癇兒童睡眠及家長心理狀況的改善效果. 黑龍江中醫藥, 2022, 51(5): 146-147.
34. 池海珊. 健康教育干預對小兒癲癇患兒睡眠質量的效果研究. 世界睡眠醫學雜志, 2024, 11(10): 2235-2237,2241.

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