- 執筆（按姓氏筆畫排序，排名不分前后）：丁玎、虞培敏、洪震（復旦大學附屬華山醫院），丁美萍、郭誼（浙江大學醫學院附屬第二醫院），王濤（華中科技大學同濟醫學院附屬協和醫院），王群（北京天壇醫院），王荔、王蓓（山西醫科大學第二醫院），王贊（吉林大學第一醫院），孫新宇、孫洪強（北京大學第六醫院），孫美珍、李忻蓉（山西醫科大學第一醫院），劉學伍（山東省立醫院），劉永紅（空軍軍醫大學西京醫院），李勁梅、周東（四川大學華西醫院），李寧、詹淑琴、王玉平（首都醫科大學宣武醫院），李慶云（上海交通大學醫學院附屬瑞金醫院），李曉裔（貴州省人民醫院），李其富（海南醫科大學第一附屬醫院），吳原（廣西醫科大學第一附屬醫院），張潔（湖南省兒童醫院），趙忠新（海軍軍醫大學第二附屬醫院），鐘建民（江西省兒童醫院），姚麗芬，楊帆（哈爾濱醫科大學附屬第一醫院），宿長軍（西安市人民醫院?西安市第四醫院），謝涵（北京大學第一醫院），薛蓉（天津醫科大學總醫院）;
中國抗癲癇協會共患病專業委員會,
Email: sunmeizhen213@126.com
Citation： 中國抗癲癇協會共患病專業委員會. 癲癇共病睡眠障礙診斷與治療的中國專家共識. Journal of Epilepsy, 2025, 11(5): 369-378. doi: 10.7507/2096-0247.202506003 Copy
Copyright ? the editorial department of Journal of Epilepsy of West China Medical Publisher. All rights reserved
| 1. | Garg D, Charlesworth L, Shukla G. Sleep and temporal lobe epilepsy -associations, mechanisms and treatment implications. Front Hum Neurosci, 2022, 16: 849899. |
| 2. | Roliz AH , Kothare S. The relationship between sleep, epilepsy, and development: a review. Current Neurology and Neuroscience Reports, 2023, 23: 469–477. |
| 3. | Bergeyck RD, Geoffroy PA. Insomnia in neurological disorders: prevalence, mechanisms, impact and treatment approaches. Rev Neurol, 2023, 179(7): 767-781. |
| 4. | Roliz AH, Kothare S. The interaction between sleep and epilepsy. Curr Neurol Neurosci Rep, 2022, 22: 551-563. |
| 5. | Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55: 1002-1007. |
| 6. | Rashed HR, Tork MA, El-Nabil LM, et al. Refractory epilepsy and obstructive sleep apnea: is there an association? Egyp J Neurol, Psychiatry Neurosurg, 2019, 55: 1–6. |
| 7. | Khachatryan SG, Ghahramanyan L, Tavadyan Z, et al. Sleep-related movement disorders in a population of patients with epilepsy: prevalence and impact of restless legs syndrome and sleep bruxism. J Clin Sleep Med, 2020, 16(3): 409-414. |
| 8. | Geyer JD, Geyer EE, Fetterman Z, et al. Epilepsy and restless legs syndrome. Epilepsy & Behavior, 2017, 68: 41-44. |
| 9. | Jain SV, Kothare SV. Sleep and epilepsy. Seminars in Pediatric Neurology, 2015, 22(2): 86-92. |
| 10. | Nobili L, Beniczky S, Eriksson SH, et al. Expert Opinion: managing sleep disturbances in people with epilepsy. Epilepsy & Behavior, 2021, 124: 108341. |
| 11. | Vendrame M, Kaleyias J, Loddenkemper T, et al. Rapid eye movement sleep behavior disorder in children with epilepsy: a comorbid condition with significant neurological implications. Epilepsia, 2013, 54(8): e103-e107. |
| 12. | Baiardi S, VandiS, Pizza F, et al. Narcolepsy type 1 and idiopathic generalized epilepsy: diagnostic and therapeutic challenges in dual cases. J Clin Sleep Med, 2015, 11(11): 1257-1262. |
| 13. | Chakravarty K, Shukla G, Poornima S, et al. Effect of sleep quality on memory, executive function, and language performance in patients with refractory focal epilepsy and controlled epilepsy versus healthy controls-A prospective study. Epilepsy Behav, 2019, 92(3): 176-183. |
| 14. | Zhao F, Sun X, Wang Y, et al. Sleep disturbances in chinese children with epilepsy: associations with behavioral problems and quality of Life. Nat Sci Sleep, 2022, 14: 1225-1236. |
| 15. | Tio E, Culler GW, Bachman EM, et al. Ictal central apneas in temporal lobe epilepsies. Epilepsy Behav, 2020, 112: 107434. |
| 16. | Vilella L, Lacuey N, Hampson JP, et al. Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP). Neurology, 2019, 92(3): e171-e182. |
| 17. | Joyal KG, Kreitlow BL, Buchanan GF. The role of sleep state and time of day in modulating breathing in epilepsy: implications for sudden unexpected death in epilepsy. Front Neural Circuits, 2022, 16: 983211. |
| 18. | Zanzmera P, Shukla G, Gupta A, et al. Markedly disturbed sleep in medically refractory compared to controlled epilepsy-a clinical and polysomnography study. Seizure, 2012, 21(7): 487-490. |
| 19. | Nayak CS, Sinha S, Nagappa M, et al. Effect of carbamazepine on the sleep microtructure of temporal lobe epilepsy patients: a cyclic alternating pattern-based study. Sleep Medicine, 2016, 27-28: 80-85. |
| 20. | Roliz AH, Kothare S. The interaction between sleep and epilepsy. Curr Neurol Neurosci Rep, 2022, 22(9): 551-563. |
| 21. | Wu T, Avidan AY, Engel JJ. Sleep and epilepsy, clinical spectrum and updated review. Sleep Med Clin, 2021, 16(2): 389-408. |
| 22. | Petrucci AN, Joyal KG, Purnell BS, et al. Serotonin and sudden unexpected death in epilepsy. Exp Neurol, 2020, 325: 113145. |
| 23. | Harnod T, WangYC, Lin CL, et al. High risk of developing subsequent epilepsy in patients with sleep-disordered breathing. PLoS One, 2017, 12(3): e0173491. |
| 24. | Bonilla-Jaime H, Zeleke H, Rojas A, et al. Sleep disruption worsens seizures: neuroinflammation as a potential mechanistic link. Int J Mol Sci, 2021, 22(22): 12531. |
| 25. | Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res, 2010, 90: 171-177. |
| 26. | Goldberg-Stern H, Oren H, Peled N, et al. Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. Journal of Child Neurology, 2012, 27(12): 1524-1528. |
| 27. | Dell KL, Payne DE, Kremen V, et al. Seizure likelihood varies with day-to-day variations in sleep duration in patients with refractory focal epilepsy: a longitudinal electroencephalography investigation. EClinical Medicine, 2021, 5(37): 100934. |
| 28. | Zhong R, Li GJ, ZhaoT, et al. Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy. Epilepsia, 2024, 56(1): 1-10. |
| 29. | 李生慧, 金星明, 沈曉明, 等. 兒童睡眠習慣問卷中文版制定及測量性能考核. 中華兒科雜志, 2007, 45(3): 176-180. |
| 30. | Bruni O, Ottaviano S, Guidetti V, et a1. The sleep disturbance scale for Children(SDSC) construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence. J Sleep Res, 1996, 5(4): 251-261. |
| 31. | Mollayeva T, Thurairajah P, Burton K, et al. The pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: a systematic review and meta-analysis. Sleep Med Rev, 2016, 25: 52-73. |
| 32. | 趙忠新, 葉京英. 睡眠障礙(第二版). 北京: 人民衛生出版社出版, 2022. |
| 33. | Ramar K, Olson EJ. Management of common sleep disorders. American Family Physician, 2013, 88(4): 231-238. |
| 34. | Alex I. Parasomnias and sleep-related movement disorders in older adults. Sleep Med Clin, 2018, 13(1): 51-61. |
| 35. | Phillips NL, Moore T, Teng A, et al. Behavioral interventions for sleep disturbances in children with neurological and neurodevelopmental disorders: a systematic review and meta-analysis of randomized controlled trials. Sleep, 2020, 43(9): zsaa040. |
| 36. | 中國抗癲癇協會. 臨床診療指南?癲癇病分冊(2023修訂版). 北京: 人民衛生出版社, 2023. |
| 37. | Sateia MJ. International classification of sleep disorders-third edition. Chest, 2014, 146(5): 1387-1394. |
| 38. | Paruthi S, Brooks LJ, D'Ambrosio C, et al. Recommended amount of sleep for pediatric populations: a consensus statement of the american academy of sleep medicine. J Clin Sleep Med, 2016, 12(6): 785-786. |
| 39. | Thabet F, Tabarki B. Common sleep disorders in children: assessment and treatment. Neurosciences (Riyadh), 2023, 28(2): 85-90. |
| 40. | St Louis EK. Sleep and epilepsy: strange bedfellows no more. Minerva Pneumol, 2011, 50(3): 159-176. |
| 41. | Wirrell E, Tinuper P, Perucca E, et al. Introduction to the epilepsy syndrome papers. Epilepsia, 2022, 61(1): 1-3. |
| 42. | Kothare SV, Kaleyias J. Sleep and epilepsy in children and adolescents. Sleep Medicine, 2010, 11(7): 674-685. |
| 43. | ShenYR, Zhang MM, Wang Y, et al, Subjective sleep disturbance in chinese adults with epilepsy: associations with affective symptoms. Epilepsy Research, 2017, 135: 150–157. |
| 44. | Rocamora R, álvarez I, Chavarría B, et al. Perampanel effect on sleep architecture in patients with epilepsy. Seizure, 2020, 76: 137-142. |
| 45. | Lupo C, Fernandes M, Spanetta M, et al. The effect of lacosamide monotherapy on sleep architecture in patients with epilepsy: a preliminary evidence. Journal of Neural Transmission, 2023, 130: 87-95. |
| 46. | Schaefer NF, Mercante SN, Andrews N, et al. Wake up to sleep: the effects of lacosamide on daytime sleepiness in adults with epilepsy. Epilepsy & Behavior, 2017, 75: 176-182. |
| 47. | Furey SA, Hull SG, Leibowitz MT, et al. A randomized, double-blind, placebo-controlled, multicenter, 28-day, polysomnographic study of gabapentin in transient insomnia induced by sleep phase advance. J Clin Sleep Med, 2014, 10(10): 1101-1109. |
| 48. | Haas SD, Otte A, Weerd AD, et al. Exploratory polysomnographic evaluation of pregabalin on sleep disturbance in patients with epilepsy. J Clin Sleep Med, 2007, 3(5): 473-478. |
| 49. | 王一淇, 范秀琴, 王瓊, 等. 普瑞巴林單藥對局灶性癲癇患者睡眠的影響. 癲癇雜志, 2023, 9(3): 181-185. |
| 50. | Romigi A, Izzi F, Placidi F, et al. Effects of zonisamide as add-on therapy on sleep-wake cycle in focal epilepsy: a polysomnographic study. Epilepsy & Behavior, 2013, 26: 170-174. |
| 51. | Nayak CS, Sinha S, Nagappa M, et al. Effect of carbamazepine on the sleep microtructure of temporal lobe epilepsy patients: a cyclic alternating pattern-based study. Sleep Medicine, 2016, 27(2): 80-85. |
| 52. | 劉晨慧, 宿長軍. 睡眠障礙與癲癇. 中國臨床醫生雜志, 2018, 23(2): 134-137. |
| 53. | Jain SV, Glauser TA. Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia, 2014, 55(1): 26-37. |
| 54. | Nayak CS, Sinha S, Nagappa M, et al. Effect of valproate on the sleep microstructure of juvenile myoclonic epilepsy patienrs-a cross-scetional CAP based study. Sleep Medicine, 2016, 17: 129-133. |
| 55. | Romigi A, Izzi F, Marciani MG, et al. Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy: a polysomomnographic study. European Journal of Neurology, 2009, 16(1): 70-75. |
| 56. | Chaneva OG, Viteva EI, Effect of levetiracetam on nocturnal sleep in patients with epilepsy. Neurol Neurochir Pol, 2022, 56 (4): 357–364. |
| 57. | 張志揚, 徐祖才. 抗癲癇發作方案對癲癇共患睡眠障礙患者影響的研究進展. 癲癇雜志, 2025, 11(1): 63-68. |
| 58. | 中華醫學會神經病學會睡眠障礙學組. 中國成人失眠診斷與治療指南(2023版. 中華神經科雜志, 2024, 57(6): 560-584. |
| 59. | Rundfeldt C, Loscher W. The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. J CNS Drugs, 2014, 28(1): 29-43. |
| 60. | Hassinger AB, Bletnisky N, Dudekula R, et al. Selecting a pharmacotherapy regimen for patients with chronic insomnia. Expert Opin Pharmacother, 2020, 21(9): 1035-1043. |
| 61. | Dabak O, Altun D, Arslan M, et al. Evaluation of plasma melatonin levels in children with a febrile and febrile seizures. Pediatr Neurol, 2016, 57(4): 51-55. |
| 62. | Jiang J, WuYJ, Yan CH, et al. Efficacy and safety of agomelatine in epilepsy patients with sleep and mood disorders: an observational, retrospective cohort study. Epilepsy & Behavior, 2024, 152: 109641. |
| 63. | Roundtree HM, Simeone TA, Johnson C, et al. Orexin receptor antagonism improves sleep and reduces seizures in kcna1-null mice. J Sleep, 2016, 39(2): 357-368. |
| 64. | 神經系統疾病伴發抑郁焦慮障礙的診治專家共識組. 神經系統疾病伴發抑郁焦慮障礙的診斷治療專家共識(更新版). 中華內科雜志, 2011, 50(9): 799-805. |
| 65. | Edemann-Callesen H, Andersen HK, Ussing A, et al. Use of melatonin for children and adolescents with chronic insomnia attributable to disorders beyond indication: a systematic review, meta-analysis and clinical recommendation. EClinical Medicine, 2023, 61: 102049. |
| 66. | Thorpy MJ, Bogan RK. Update on the pharmacologic management of narcolepsy: mechanisms of action and clinical implications. Sleep Med, 2020, 68: 97-109. |
| 67. | Thorpy MJ, Shapiro C, Mayer G, et al. A randomized study of solriamfetol for excessive sleepiness in narcolepsy. Ann Neurol, 2019, 85(3): 359-370. |
| 68. | Powell J, Piszczatoski C, Garland S. Solriamfetol for excessive sleepiness in narcolepsy and obstructive sleep apnea. Ann Pharmacother, 2020, 54(10): 1016-1020. |
| 69. | Sivathamboo S, Perucca P, Velakoulis D, et al. Sleep-disordered breathing in epilepsy: epidemiology, mechanisms, and treatment. Sleep, 2018, 1: 41(4). |
| 70. | Liu F, Wang X. Diagnosis and treatment of epilepsy and sleep apnea comorbidity. Expert Review of Neurotherapeutics, 2016, 17(5): 1-11. |
| 71. | Garcia-Borreguero D, Ferini-Strambi L, Kohnen R, et al. European guidelines on management of restless legs syndrome: report of a joint task force by the european federation of neurological societies, the european neurological society and the european sleep research society. Eur J Neurol, 2012, 19(11): 1385-1396. |
| 72. | Aurora RN, Zak RS, Maganti RK, et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med, 2010, 6(1): 85-95. |
| 73. | 中華醫學會神經病學分會睡眠障礙組. 中國快速眼動睡眠行為障礙診斷與治療專家共識. 中華神經科雜志, 2017, 50(8): 567-571. |
| 74. | Kansagra S. Sleep disorders in adolescents. Pediatrics, 2020, 145(Suppl 2): S204-S209. |
| 75. | Lee SA, Han SH, No YJ, et al. Sleep hygiene and its association with mood and quality of life in people with epilepsy. Epilepsy Behav, 2015, 52(Pt A): 225-229. |
| 76. | Baranwal N, Yu PK, Siegel NS. Sleep physiology, pathophysiology, and sleep hygiene. Prog Cardiovasc Dis, 2023, 77: 59-69. |
| 77. | Bergmann M, Tschiderer L, Stefani A, et al. Sleep quality and daytime sleepiness in epilepsy: Systematic review and meta-analysis of 25 studies including 8, 196 individuals. Sleep Med Rev, 2021, 57: 101466. |
| 78. | Lin YY, Lee WT, Yang HL, et al. Screen time exposure and altered sleep in young children with epilepsy. J Nurs Scholarsh, 2020, 52(4): 352-359. |
| 79. | Morin CM, Benca R. Chronic insomnia. Lancet, 2012, 379: 1129-1141. |
| 80. | Annemieke van Straten, Tanja van der Zweerde, Kleiboer A, et al. Cognitive and behavioral therapies in the treatment of insomnia: a meta-analysis. Sleep Med Rev, 2017, 21(1): 1-14. |
| 81. | Spielman AJ, Caruso LS, Glovinsky PB. A behavioral perspective on insomnia treatment. Psychiatr Clin N Am, 1987, 10(4): 541-553. |
| 82. | Bootzin R. A stimulus control treatment for insomnia. Proceedings of the 80th Annual Convention of the American Psychological Association, 1972, 7(Pt.1): 395-396. |
| 83. | Khachatryan SG.Sleep-related movement disorders in a population of patients with epilepsy : prevalence and impact of restless legs syndrome and sleep bruxism. J Clin Sleep Med, 2020, 16(3) : 409-414. |
| 84. | Harvey AG. A cognitive theory and therapy for chronic insomnia. J Cogn Psychother, 2005, 19(1): 41-59. |
| 85. | Stepanski EJ, Wyatt JK. Use of sleep hygiene in the treatment of insomnia. Sleep Med Rv, 2003, 7(3): 215-225. |
| 86. | Nicassio P, Bootzin RR. A comparison of progressive relaxation and autogenic training as treatments for insomnia. J Abnorm Psychol, 1974, 83(3): 253-260. |
| 87. | Lee SA, Han SH, No YJ, et al. Sleep hygiene and its association with mood and quality of life in people with epilepsy. Epilepsy Behav, 2015, 52(Pt A): 225–229. |
| 88. | Manni R, Politini L, Ratti MT, et al. Sleep hygiene in adult epilepsy patients: a questionnaire-based survey. Acta Neurol Scand, 2000, 101(5): 301-304. |
| 89. | Lopez MR, Cheng JY, Kanner AM, et al. Insomnia symptoms in south florida military veterans with epilepsy. Epilepsy Behav, 2013, 27: 159-164. |
| 90. | Paardekooper D, Thayer Z, Miller L, et al. Group-based cognitive behavioral therapy program for improving poor sleep quality and quality of life in people with epilepsy: a pilot study. Epilepsy &Behavior, 2020, 104(Pt A): 106884. |
| 91. | Dewald-Kaufmann J, de Bruin E, Michael G. Cognitive behavioral therapy for insomnia (CBT-i) in school-aged children and adolescents. Sleep Medicine Clinics, 2019, 14(2): 155-165. |
| 92. | Hitomi T, Oga T, Tsuboi T, et al. Transient increase in epileptiform discharges after the introduction of nasal continuous positive airway pressure in a patient with obstructive sleep apnea and epilepsy. Intern Med, 2012, 51(17): 2453-2456. |
| 93. | Krone LB, Fehér KD, Rivero T, et al. Brain stimulation techniques as novel treatment options for insomnia: a systematic review. J Sleep Res, 2023, 32(6): e13927. |
| 94. | Chambe J, Reynaud E, Maruani J, et al. Light therapy in insomnia disorder: a systematic review and meta-analysis. J Sleep Res, 2023, 32(6): e13895. |
| 95. | Zhang S, Zhao Y, Qin Z, et al. Transcutaneous auricular vagus nerve stimulation for chronic insomnia disorder: a randomized clinical trial. JAMA Netw Open, 2024, 7(12): e2451217. |
| 96. | Yang HJ, Shi WX, Fan JJ, et al. Transcutaneous auricular vagus nerve stimulation (ta-VNS) for treatment of drug-resistant epilepsy: a randomized, double-blind clinical trial. Neurotherapeutics, 2023, 20(3): 870-880. |
| 97. | Xu ZYR, Fang JJ, Fan XQ, et al. Effectiveness and safety of transcutaneous auricular vagus nerve stimulation for depression in patients with epilepsy. Epilepsy Behav, 2025, 163: 110226. |
| 98. | Liu A, Rong P, Gong L, et al. Efficacy and safety of treatment with transcutaneous vagus nerve stimulation in 17 patients with refractory epilepsy evaluated by electroencephalogram, seizure frequency, and quality of life. Med Sci Monit, 2018, 24: 8439-8448. |
| 99. | Lovato N, Miller CB, Gordon CJ, et al. The efficacy of biofeedback for the treatment of insomnia: A critical review. Sleep Med, 2019, 56: 192-200. |
| 100. | Kremer S, Blue T. Biofeedback as an adjunct or alternative intervention to cognitive behavioral therapy for insomnia. Sleep Med Clin, 2023, 18(1): 85-93. |
- 1. Garg D, Charlesworth L, Shukla G. Sleep and temporal lobe epilepsy -associations, mechanisms and treatment implications. Front Hum Neurosci, 2022, 16: 849899.
- 2. Roliz AH , Kothare S. The relationship between sleep, epilepsy, and development: a review. Current Neurology and Neuroscience Reports, 2023, 23: 469–477.
- 3. Bergeyck RD, Geoffroy PA. Insomnia in neurological disorders: prevalence, mechanisms, impact and treatment approaches. Rev Neurol, 2023, 179(7): 767-781.
- 4. Roliz AH, Kothare S. The interaction between sleep and epilepsy. Curr Neurol Neurosci Rep, 2022, 22: 551-563.
- 5. Malow BA, Levy K, Maturen K, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology, 2000, 55: 1002-1007.
- 6. Rashed HR, Tork MA, El-Nabil LM, et al. Refractory epilepsy and obstructive sleep apnea: is there an association? Egyp J Neurol, Psychiatry Neurosurg, 2019, 55: 1–6.
- 7. Khachatryan SG, Ghahramanyan L, Tavadyan Z, et al. Sleep-related movement disorders in a population of patients with epilepsy: prevalence and impact of restless legs syndrome and sleep bruxism. J Clin Sleep Med, 2020, 16(3): 409-414.
- 8. Geyer JD, Geyer EE, Fetterman Z, et al. Epilepsy and restless legs syndrome. Epilepsy & Behavior, 2017, 68: 41-44.
- 9. Jain SV, Kothare SV. Sleep and epilepsy. Seminars in Pediatric Neurology, 2015, 22(2): 86-92.
- 10. Nobili L, Beniczky S, Eriksson SH, et al. Expert Opinion: managing sleep disturbances in people with epilepsy. Epilepsy & Behavior, 2021, 124: 108341.
- 11. Vendrame M, Kaleyias J, Loddenkemper T, et al. Rapid eye movement sleep behavior disorder in children with epilepsy: a comorbid condition with significant neurological implications. Epilepsia, 2013, 54(8): e103-e107.
- 12. Baiardi S, VandiS, Pizza F, et al. Narcolepsy type 1 and idiopathic generalized epilepsy: diagnostic and therapeutic challenges in dual cases. J Clin Sleep Med, 2015, 11(11): 1257-1262.
- 13. Chakravarty K, Shukla G, Poornima S, et al. Effect of sleep quality on memory, executive function, and language performance in patients with refractory focal epilepsy and controlled epilepsy versus healthy controls-A prospective study. Epilepsy Behav, 2019, 92(3): 176-183.
- 14. Zhao F, Sun X, Wang Y, et al. Sleep disturbances in chinese children with epilepsy: associations with behavioral problems and quality of Life. Nat Sci Sleep, 2022, 14: 1225-1236.
- 15. Tio E, Culler GW, Bachman EM, et al. Ictal central apneas in temporal lobe epilepsies. Epilepsy Behav, 2020, 112: 107434.
- 16. Vilella L, Lacuey N, Hampson JP, et al. Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP). Neurology, 2019, 92(3): e171-e182.
- 17. Joyal KG, Kreitlow BL, Buchanan GF. The role of sleep state and time of day in modulating breathing in epilepsy: implications for sudden unexpected death in epilepsy. Front Neural Circuits, 2022, 16: 983211.
- 18. Zanzmera P, Shukla G, Gupta A, et al. Markedly disturbed sleep in medically refractory compared to controlled epilepsy-a clinical and polysomnography study. Seizure, 2012, 21(7): 487-490.
- 19. Nayak CS, Sinha S, Nagappa M, et al. Effect of carbamazepine on the sleep microtructure of temporal lobe epilepsy patients: a cyclic alternating pattern-based study. Sleep Medicine, 2016, 27-28: 80-85.
- 20. Roliz AH, Kothare S. The interaction between sleep and epilepsy. Curr Neurol Neurosci Rep, 2022, 22(9): 551-563.
- 21. Wu T, Avidan AY, Engel JJ. Sleep and epilepsy, clinical spectrum and updated review. Sleep Med Clin, 2021, 16(2): 389-408.
- 22. Petrucci AN, Joyal KG, Purnell BS, et al. Serotonin and sudden unexpected death in epilepsy. Exp Neurol, 2020, 325: 113145.
- 23. Harnod T, WangYC, Lin CL, et al. High risk of developing subsequent epilepsy in patients with sleep-disordered breathing. PLoS One, 2017, 12(3): e0173491.
- 24. Bonilla-Jaime H, Zeleke H, Rojas A, et al. Sleep disruption worsens seizures: neuroinflammation as a potential mechanistic link. Int J Mol Sci, 2021, 22(22): 12531.
- 25. Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res, 2010, 90: 171-177.
- 26. Goldberg-Stern H, Oren H, Peled N, et al. Effect of melatonin on seizure frequency in intractable epilepsy: a pilot study. Journal of Child Neurology, 2012, 27(12): 1524-1528.
- 27. Dell KL, Payne DE, Kremen V, et al. Seizure likelihood varies with day-to-day variations in sleep duration in patients with refractory focal epilepsy: a longitudinal electroencephalography investigation. EClinical Medicine, 2021, 5(37): 100934.
- 28. Zhong R, Li GJ, ZhaoT, et al. Association of baseline sleep duration and sleep quality with seizure recurrence in newly treated patients with epilepsy. Epilepsia, 2024, 56(1): 1-10.
- 29. 李生慧, 金星明, 沈曉明, 等. 兒童睡眠習慣問卷中文版制定及測量性能考核. 中華兒科雜志, 2007, 45(3): 176-180.
- 30. Bruni O, Ottaviano S, Guidetti V, et a1. The sleep disturbance scale for Children(SDSC) construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence. J Sleep Res, 1996, 5(4): 251-261.
- 31. Mollayeva T, Thurairajah P, Burton K, et al. The pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: a systematic review and meta-analysis. Sleep Med Rev, 2016, 25: 52-73.
- 32. 趙忠新, 葉京英. 睡眠障礙(第二版). 北京: 人民衛生出版社出版, 2022.
- 33. Ramar K, Olson EJ. Management of common sleep disorders. American Family Physician, 2013, 88(4): 231-238.
- 34. Alex I. Parasomnias and sleep-related movement disorders in older adults. Sleep Med Clin, 2018, 13(1): 51-61.
- 35. Phillips NL, Moore T, Teng A, et al. Behavioral interventions for sleep disturbances in children with neurological and neurodevelopmental disorders: a systematic review and meta-analysis of randomized controlled trials. Sleep, 2020, 43(9): zsaa040.
- 36. 中國抗癲癇協會. 臨床診療指南?癲癇病分冊(2023修訂版). 北京: 人民衛生出版社, 2023.
- 37. Sateia MJ. International classification of sleep disorders-third edition. Chest, 2014, 146(5): 1387-1394.
- 38. Paruthi S, Brooks LJ, D'Ambrosio C, et al. Recommended amount of sleep for pediatric populations: a consensus statement of the american academy of sleep medicine. J Clin Sleep Med, 2016, 12(6): 785-786.
- 39. Thabet F, Tabarki B. Common sleep disorders in children: assessment and treatment. Neurosciences (Riyadh), 2023, 28(2): 85-90.
- 40. St Louis EK. Sleep and epilepsy: strange bedfellows no more. Minerva Pneumol, 2011, 50(3): 159-176.
- 41. Wirrell E, Tinuper P, Perucca E, et al. Introduction to the epilepsy syndrome papers. Epilepsia, 2022, 61(1): 1-3.
- 42. Kothare SV, Kaleyias J. Sleep and epilepsy in children and adolescents. Sleep Medicine, 2010, 11(7): 674-685.
- 43. ShenYR, Zhang MM, Wang Y, et al, Subjective sleep disturbance in chinese adults with epilepsy: associations with affective symptoms. Epilepsy Research, 2017, 135: 150–157.
- 44. Rocamora R, álvarez I, Chavarría B, et al. Perampanel effect on sleep architecture in patients with epilepsy. Seizure, 2020, 76: 137-142.
- 45. Lupo C, Fernandes M, Spanetta M, et al. The effect of lacosamide monotherapy on sleep architecture in patients with epilepsy: a preliminary evidence. Journal of Neural Transmission, 2023, 130: 87-95.
- 46. Schaefer NF, Mercante SN, Andrews N, et al. Wake up to sleep: the effects of lacosamide on daytime sleepiness in adults with epilepsy. Epilepsy & Behavior, 2017, 75: 176-182.
- 47. Furey SA, Hull SG, Leibowitz MT, et al. A randomized, double-blind, placebo-controlled, multicenter, 28-day, polysomnographic study of gabapentin in transient insomnia induced by sleep phase advance. J Clin Sleep Med, 2014, 10(10): 1101-1109.
- 48. Haas SD, Otte A, Weerd AD, et al. Exploratory polysomnographic evaluation of pregabalin on sleep disturbance in patients with epilepsy. J Clin Sleep Med, 2007, 3(5): 473-478.
- 49. 王一淇, 范秀琴, 王瓊, 等. 普瑞巴林單藥對局灶性癲癇患者睡眠的影響. 癲癇雜志, 2023, 9(3): 181-185.
- 50. Romigi A, Izzi F, Placidi F, et al. Effects of zonisamide as add-on therapy on sleep-wake cycle in focal epilepsy: a polysomnographic study. Epilepsy & Behavior, 2013, 26: 170-174.
- 51. Nayak CS, Sinha S, Nagappa M, et al. Effect of carbamazepine on the sleep microtructure of temporal lobe epilepsy patients: a cyclic alternating pattern-based study. Sleep Medicine, 2016, 27(2): 80-85.
- 52. 劉晨慧, 宿長軍. 睡眠障礙與癲癇. 中國臨床醫生雜志, 2018, 23(2): 134-137.
- 53. Jain SV, Glauser TA. Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia, 2014, 55(1): 26-37.
- 54. Nayak CS, Sinha S, Nagappa M, et al. Effect of valproate on the sleep microstructure of juvenile myoclonic epilepsy patienrs-a cross-scetional CAP based study. Sleep Medicine, 2016, 17: 129-133.
- 55. Romigi A, Izzi F, Marciani MG, et al. Pregabalin as add-on therapy induces REM sleep enhancement in partial epilepsy: a polysomomnographic study. European Journal of Neurology, 2009, 16(1): 70-75.
- 56. Chaneva OG, Viteva EI, Effect of levetiracetam on nocturnal sleep in patients with epilepsy. Neurol Neurochir Pol, 2022, 56 (4): 357–364.
- 57. 張志揚, 徐祖才. 抗癲癇發作方案對癲癇共患睡眠障礙患者影響的研究進展. 癲癇雜志, 2025, 11(1): 63-68.
- 58. 中華醫學會神經病學會睡眠障礙學組. 中國成人失眠診斷與治療指南(2023版. 中華神經科雜志, 2024, 57(6): 560-584.
- 59. Rundfeldt C, Loscher W. The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. J CNS Drugs, 2014, 28(1): 29-43.
- 60. Hassinger AB, Bletnisky N, Dudekula R, et al. Selecting a pharmacotherapy regimen for patients with chronic insomnia. Expert Opin Pharmacother, 2020, 21(9): 1035-1043.
- 61. Dabak O, Altun D, Arslan M, et al. Evaluation of plasma melatonin levels in children with a febrile and febrile seizures. Pediatr Neurol, 2016, 57(4): 51-55.
- 62. Jiang J, WuYJ, Yan CH, et al. Efficacy and safety of agomelatine in epilepsy patients with sleep and mood disorders: an observational, retrospective cohort study. Epilepsy & Behavior, 2024, 152: 109641.
- 63. Roundtree HM, Simeone TA, Johnson C, et al. Orexin receptor antagonism improves sleep and reduces seizures in kcna1-null mice. J Sleep, 2016, 39(2): 357-368.
- 64. 神經系統疾病伴發抑郁焦慮障礙的診治專家共識組. 神經系統疾病伴發抑郁焦慮障礙的診斷治療專家共識(更新版). 中華內科雜志, 2011, 50(9): 799-805.
- 65. Edemann-Callesen H, Andersen HK, Ussing A, et al. Use of melatonin for children and adolescents with chronic insomnia attributable to disorders beyond indication: a systematic review, meta-analysis and clinical recommendation. EClinical Medicine, 2023, 61: 102049.
- 66. Thorpy MJ, Bogan RK. Update on the pharmacologic management of narcolepsy: mechanisms of action and clinical implications. Sleep Med, 2020, 68: 97-109.
- 67. Thorpy MJ, Shapiro C, Mayer G, et al. A randomized study of solriamfetol for excessive sleepiness in narcolepsy. Ann Neurol, 2019, 85(3): 359-370.
- 68. Powell J, Piszczatoski C, Garland S. Solriamfetol for excessive sleepiness in narcolepsy and obstructive sleep apnea. Ann Pharmacother, 2020, 54(10): 1016-1020.
- 69. Sivathamboo S, Perucca P, Velakoulis D, et al. Sleep-disordered breathing in epilepsy: epidemiology, mechanisms, and treatment. Sleep, 2018, 1: 41(4).
- 70. Liu F, Wang X. Diagnosis and treatment of epilepsy and sleep apnea comorbidity. Expert Review of Neurotherapeutics, 2016, 17(5): 1-11.
- 71. Garcia-Borreguero D, Ferini-Strambi L, Kohnen R, et al. European guidelines on management of restless legs syndrome: report of a joint task force by the european federation of neurological societies, the european neurological society and the european sleep research society. Eur J Neurol, 2012, 19(11): 1385-1396.
- 72. Aurora RN, Zak RS, Maganti RK, et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med, 2010, 6(1): 85-95.
- 73. 中華醫學會神經病學分會睡眠障礙組. 中國快速眼動睡眠行為障礙診斷與治療專家共識. 中華神經科雜志, 2017, 50(8): 567-571.
- 74. Kansagra S. Sleep disorders in adolescents. Pediatrics, 2020, 145(Suppl 2): S204-S209.
- 75. Lee SA, Han SH, No YJ, et al. Sleep hygiene and its association with mood and quality of life in people with epilepsy. Epilepsy Behav, 2015, 52(Pt A): 225-229.
- 76. Baranwal N, Yu PK, Siegel NS. Sleep physiology, pathophysiology, and sleep hygiene. Prog Cardiovasc Dis, 2023, 77: 59-69.
- 77. Bergmann M, Tschiderer L, Stefani A, et al. Sleep quality and daytime sleepiness in epilepsy: Systematic review and meta-analysis of 25 studies including 8, 196 individuals. Sleep Med Rev, 2021, 57: 101466.
- 78. Lin YY, Lee WT, Yang HL, et al. Screen time exposure and altered sleep in young children with epilepsy. J Nurs Scholarsh, 2020, 52(4): 352-359.
- 79. Morin CM, Benca R. Chronic insomnia. Lancet, 2012, 379: 1129-1141.
- 80. Annemieke van Straten, Tanja van der Zweerde, Kleiboer A, et al. Cognitive and behavioral therapies in the treatment of insomnia: a meta-analysis. Sleep Med Rev, 2017, 21(1): 1-14.
- 81. Spielman AJ, Caruso LS, Glovinsky PB. A behavioral perspective on insomnia treatment. Psychiatr Clin N Am, 1987, 10(4): 541-553.
- 82. Bootzin R. A stimulus control treatment for insomnia. Proceedings of the 80th Annual Convention of the American Psychological Association, 1972, 7(Pt.1): 395-396.
- 83. Khachatryan SG.Sleep-related movement disorders in a population of patients with epilepsy : prevalence and impact of restless legs syndrome and sleep bruxism. J Clin Sleep Med, 2020, 16(3) : 409-414.
- 84. Harvey AG. A cognitive theory and therapy for chronic insomnia. J Cogn Psychother, 2005, 19(1): 41-59.
- 85. Stepanski EJ, Wyatt JK. Use of sleep hygiene in the treatment of insomnia. Sleep Med Rv, 2003, 7(3): 215-225.
- 86. Nicassio P, Bootzin RR. A comparison of progressive relaxation and autogenic training as treatments for insomnia. J Abnorm Psychol, 1974, 83(3): 253-260.
- 87. Lee SA, Han SH, No YJ, et al. Sleep hygiene and its association with mood and quality of life in people with epilepsy. Epilepsy Behav, 2015, 52(Pt A): 225–229.
- 88. Manni R, Politini L, Ratti MT, et al. Sleep hygiene in adult epilepsy patients: a questionnaire-based survey. Acta Neurol Scand, 2000, 101(5): 301-304.
- 89. Lopez MR, Cheng JY, Kanner AM, et al. Insomnia symptoms in south florida military veterans with epilepsy. Epilepsy Behav, 2013, 27: 159-164.
- 90. Paardekooper D, Thayer Z, Miller L, et al. Group-based cognitive behavioral therapy program for improving poor sleep quality and quality of life in people with epilepsy: a pilot study. Epilepsy &Behavior, 2020, 104(Pt A): 106884.
- 91. Dewald-Kaufmann J, de Bruin E, Michael G. Cognitive behavioral therapy for insomnia (CBT-i) in school-aged children and adolescents. Sleep Medicine Clinics, 2019, 14(2): 155-165.
- 92. Hitomi T, Oga T, Tsuboi T, et al. Transient increase in epileptiform discharges after the introduction of nasal continuous positive airway pressure in a patient with obstructive sleep apnea and epilepsy. Intern Med, 2012, 51(17): 2453-2456.
- 93. Krone LB, Fehér KD, Rivero T, et al. Brain stimulation techniques as novel treatment options for insomnia: a systematic review. J Sleep Res, 2023, 32(6): e13927.
- 94. Chambe J, Reynaud E, Maruani J, et al. Light therapy in insomnia disorder: a systematic review and meta-analysis. J Sleep Res, 2023, 32(6): e13895.
- 95. Zhang S, Zhao Y, Qin Z, et al. Transcutaneous auricular vagus nerve stimulation for chronic insomnia disorder: a randomized clinical trial. JAMA Netw Open, 2024, 7(12): e2451217.
- 96. Yang HJ, Shi WX, Fan JJ, et al. Transcutaneous auricular vagus nerve stimulation (ta-VNS) for treatment of drug-resistant epilepsy: a randomized, double-blind clinical trial. Neurotherapeutics, 2023, 20(3): 870-880.
- 97. Xu ZYR, Fang JJ, Fan XQ, et al. Effectiveness and safety of transcutaneous auricular vagus nerve stimulation for depression in patients with epilepsy. Epilepsy Behav, 2025, 163: 110226.
- 98. Liu A, Rong P, Gong L, et al. Efficacy and safety of treatment with transcutaneous vagus nerve stimulation in 17 patients with refractory epilepsy evaluated by electroencephalogram, seizure frequency, and quality of life. Med Sci Monit, 2018, 24: 8439-8448.
- 99. Lovato N, Miller CB, Gordon CJ, et al. The efficacy of biofeedback for the treatment of insomnia: A critical review. Sleep Med, 2019, 56: 192-200.
- 100. Kremer S, Blue T. Biofeedback as an adjunct or alternative intervention to cognitive behavioral therapy for insomnia. Sleep Med Clin, 2023, 18(1): 85-93.
-
Previous Article
COVER -
Next Article
院前緊急終止癲癇發作處理原則的專家共識