Pathological and clinical festures of 51 patients with focal cortical dysplasia_Journal of Epilepsy

Authors：

 CHU Xia , BAI Ganggang , ZHOU Xiaojing

Department of Pathology, the 988th Hospital of the Joint Logistics Support Force, PLA, 602^#, Zhengzhou 450042, China;

Corresponding?author：

CHU Xia, Email: ccchuxia@126.com

Keywords：

Focal cortical dysplasia; Eepilepsy; Pathology; Clinic

DOI：

10.7507/2096-0247.20210066

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the microscopic character and clinical pathological feature of focal cortical dysplasia (FCD).Methods 51 cases were collected from January 2015 to September 2018 in the 988th Hospital of the Joint Logistics Support Force of the People’s Libereation Army. Pathology with FCD of their diseased brain tissue was classified according to the classification standard by the International Anti-Epilepsy Union (ILAE) in 2011. Epileptic seizure characteristics were analysed in different types.Results FCD I was 23 cases (45.1%). FCD II was 11 (21.6%). FCD III was 17 (33.3%). Ia was the most common type (23.5%, 12/51). Neurons were arranged into microcolumnar structures in Ia. NF expression in immunohistochemistry was characteristic. It was close to the neuron like line or waterfall. The second type was Ⅲa (15.7%, 8/51). Hippocampal sclerosis was given priority to CA4 area pyramidal cells to reduce or disappear. Three types all happened in bilateral cerebral hemisphere. There was no statistical difference. Temporal lobe was significantly more than frontal lobe. More than 50% of the cases occurredepilepsy before the age of 18. The main manifestation was partial onset seizures and secondary body stiffness clonus. The onset age and history of epilepsy in patients with FCD Ⅲ were earlier than those in the other two types. On image the positive rate of I type was 78.3% and that of Ⅱ and Ⅲ was both 100%.Conclusion FCD is a common pathological feature of epilepsy patients. Carefully pathologic examination is the premise of accurate classification of each subtype. Ⅲ type is different from Ⅰ and Ⅱ type in epileptic seizures.

Citation： CHU Xia, BAI Ganggang, ZHOU Xiaojing. Pathological and clinical festures of 51 patients with focal cortical dysplasia. Journal of Epilepsy, 2021, 7(5): 406-410. doi: 10.7507/2096-0247.20210066 Copy

1.	Taylor DC, Falconer MA, Ruton CJ, et al. Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry, 1971, 34(4): 369-387.
2.	Michael Wong. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation. Epilepsia, 2008, 49(1): 8-21.
3.	Blǔmcke I, Thom M, Aronica E, et al. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia, 2011, 52(1): 158-174.
4.	樸月善, 陳莉, 付永娟, 等. 癲癇相關局灶性皮質發育不良的臨床病理學研究. 中華病理學雜志, 2007, 36(3): 150-154.
5.	Lerner JT, Salamon N, Hauptman JS, et al. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia, 2009, 50(6): 1310-1335.
6.	劉長青, 陳凱, 欒國明. 81例局灶性皮質發育不良Ⅱ型的臨床及預后分析. 中華神經外科雜志, 2014, 30(5): 493-496.
7.	馮占輝, 高勤, 徐祖才. 難治性癲癇伴局灶性大腦皮質發育障礙15例患者的臨床特點及病理學分析. 癲癇與神經電生理學雜, 2018, 27(4): 202-205.
8.	Cendes F, Cook MJ, Watson C, et al. Frequency and characteristics of dualpathology in patients with lesional pilepsy. Neurology, 1995, 45(11): 2058-2064.
9.	Morales C L, Estupi?án B, Lorigados P L, et al. Microscopic mild focal cortical dysplasia In temporal lobe dual pathology: an electrocorticography study. Seizure, 2009, 18(8): 593-600.
10.	Maria T. Hippocampal sclerosis in epilepsy: a neuropathology review. Neuropathol Appl Neurobiol, 2014, 40(5): 520-543.
11.	李超, 汪寅, 鐘平, 等. 腦節細胞膠質瘤27例臨床分析. 中華神經外科雜志, 2008, 24(4): 249-251.
12.	遇濤, 張國君, 李勇杰, 等. 導致難治性癲癇的顳葉腫瘤特點分析. 臨床神經外科雜志, 2013, 10(6): 329-331.
13.	Luyken C, Blümcke I, Fimmers R, et al. Supratentorial gangliogliomas: Histopathologic grading and tumor recurrence in 184 patients witha median follow-up of 8 years. Cancer, 2004, 101(1): 146-155.
14.	孫康健, 周曉平, 史繼新, 等. 18例罕見胚胎發育不良性神經上皮腫瘤的治療. 臨床神經外科雜志, 2008, 5(1): 40-42.
15.	Pasquier B, Peoch M, Fabre-Bocquentin B, et al. Surgical pathologyof drug-resistent partial epilepsy: a 10-year experience with a seriesof 327 consecutive resections. Epileptic Disorder, 2002, 4(2): 99-119.
16.	王美萍, 肖波. 皮質發育畸形與癲癇的研究現狀. 神經損傷與功能重建, 2012, 7(1): 64-67.
17.	程莉鵬, 張國君, 楊小楓. 局灶性皮質發育不良致癇的電生理機制研究現狀. 中華醫學雜志, 2018, 98(31): 2530-2532.
18.	Koul R, Aithala GR, Joshi RM, et al. Lamotrigene and vigabatrin in intractable seizures in children. Neurol India, 1998, 46(2): 130-133.
19.	Aldenkamp AP, Bodde N. Behaviour, cognition and epilepsy. Acta Neurol Scand Suppl, 2005, (182): 19-25.

1. Taylor DC, Falconer MA, Ruton CJ, et al. Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry, 1971, 34(4): 369-387.
2. Michael Wong. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation. Epilepsia, 2008, 49(1): 8-21.
3. Blǔmcke I, Thom M, Aronica E, et al. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia, 2011, 52(1): 158-174.
4. 樸月善, 陳莉, 付永娟, 等. 癲癇相關局灶性皮質發育不良的臨床病理學研究. 中華病理學雜志, 2007, 36(3): 150-154.
5. Lerner JT, Salamon N, Hauptman JS, et al. Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia, 2009, 50(6): 1310-1335.
6. 劉長青, 陳凱, 欒國明. 81例局灶性皮質發育不良Ⅱ型的臨床及預后分析. 中華神經外科雜志, 2014, 30(5): 493-496.
7. 馮占輝, 高勤, 徐祖才. 難治性癲癇伴局灶性大腦皮質發育障礙15例患者的臨床特點及病理學分析. 癲癇與神經電生理學雜, 2018, 27(4): 202-205.
8. Cendes F, Cook MJ, Watson C, et al. Frequency and characteristics of dualpathology in patients with lesional pilepsy. Neurology, 1995, 45(11): 2058-2064.
9. Morales C L, Estupi?án B, Lorigados P L, et al. Microscopic mild focal cortical dysplasia In temporal lobe dual pathology: an electrocorticography study. Seizure, 2009, 18(8): 593-600.
10. Maria T. Hippocampal sclerosis in epilepsy: a neuropathology review. Neuropathol Appl Neurobiol, 2014, 40(5): 520-543.
11. 李超, 汪寅, 鐘平, 等. 腦節細胞膠質瘤27例臨床分析. 中華神經外科雜志, 2008, 24(4): 249-251.
12. 遇濤, 張國君, 李勇杰, 等. 導致難治性癲癇的顳葉腫瘤特點分析. 臨床神經外科雜志, 2013, 10(6): 329-331.
13. Luyken C, Blümcke I, Fimmers R, et al. Supratentorial gangliogliomas: Histopathologic grading and tumor recurrence in 184 patients witha median follow-up of 8 years. Cancer, 2004, 101(1): 146-155.
14. 孫康健, 周曉平, 史繼新, 等. 18例罕見胚胎發育不良性神經上皮腫瘤的治療. 臨床神經外科雜志, 2008, 5(1): 40-42.
15. Pasquier B, Peoch M, Fabre-Bocquentin B, et al. Surgical pathologyof drug-resistent partial epilepsy: a 10-year experience with a seriesof 327 consecutive resections. Epileptic Disorder, 2002, 4(2): 99-119.
16. 王美萍, 肖波. 皮質發育畸形與癲癇的研究現狀. 神經損傷與功能重建, 2012, 7(1): 64-67.
17. 程莉鵬, 張國君, 楊小楓. 局灶性皮質發育不良致癇的電生理機制研究現狀. 中華醫學雜志, 2018, 98(31): 2530-2532.
18. Koul R, Aithala GR, Joshi RM, et al. Lamotrigene and vigabatrin in intractable seizures in children. Neurol India, 1998, 46(2): 130-133.
19. Aldenkamp AP, Bodde N. Behaviour, cognition and epilepsy. Acta Neurol Scand Suppl, 2005, (182): 19-25.

Journal of Epilepsy

Pathological and clinical festures of 51 patients with focal cortical dysplasia

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content