兒童良性癲癇伴中央顳區棘波藥物治療的研究進展_Journal of Epilepsy

Authors：

牛凱 ,  王小姍

南京醫科大學附屬腦科醫院　神經內科（南京 210029）;

Corresponding?author：

王小姍, Email: lidou2005@126.com

Keywords：

兒童良性癲癇伴中央顳區棘波; 抗癲癇藥物; 腦電圖; 認知功能; 功能磁共振

DOI：

10.7507/2096-0247.20210037

Video：

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兒童良性癲癇伴中央顳區棘波（Benign childhood epilepsy with centrotemporal spikes，BECT）是最常見的兒童局灶性癲癇綜合征，可導致患兒神經心理功能的廣泛受損。然而，BECT 的治療一直存在頗多爭議，抗癲癇藥物的使用時機缺乏統一結論，藥物治療的具體風險和收益尚未明了。本文就 BECT 藥物治療的相關研究進展進行綜述，著重從腦電圖、神經心理功能、大腦功能活動等方面討論藥物治療的影響，以供后續研究參考，進而為臨床治療提供意見。

Citation： 牛凱, 王小姍. 兒童良性癲癇伴中央顳區棘波藥物治療的研究進展. Journal of Epilepsy, 2021, 7(3): 241-245. doi: 10.7507/2096-0247.20210037 Copy

1.	Heijbel J, Blom S, Bergfors PG. Benign epilepsy of children with centrotemporal EEG foci. A study of incidence rate in outpatient care. Epilepsia, 1975, 16(5): 657-664.
2.	Garcia-Ramos C, Jackson DC, Lin JJ, et al. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia, 2015, 56(10): 1615-1622.
3.	Kirby A, Williams N, Koelewijn L, et al. Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder. Epilepsy Behav, 2017, 72: 122-126.
4.	Jiang S, Luo C, Huang Y, et al. Altered Static and Dynamic Spontaneous Neural Activity in Drug-Na?ve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes. Front Hum Neurosci, 2020, 14: 361.
5.	Jiang Y, Song L, Li X, et al. Dysfunctional white-matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes. Hum Brain Mapp, 2019, 40(10): 3113-3124.
6.	von Stülpnagel C, Kluger G, Leiz S, et al. Levetiracetam as add-on therapy in different subgroups of "benign" idiopathic focal epilepsies in childhood. Epilepsy Behav, 2010, 17(2): 193-198.
7.	Hughes JR. Benign epilepsy of childhood with centrotemporal spikes (BECTS): to treat or not to treat, that is the question. Epilepsy Behav, 2010, 19(3): 197-203.
8.	Mellish LC, Dunkley C, Ferrie CD, et al. Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility. Arch Dis Child, 2015, 100(1): 62-67.
9.	Liu MJ, Su XJ, Shi XY, et al. Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children. Medicine (Baltimore), 2017, 96(4): e5623.
10.	Gu W, Chen J, Tian W, et al. Outcome analysis of children with rolandic discharges on EEG: A real-world study. Seizure, 2020, 82: 105-108.
11.	Gkampeta A, Fidani L, Zafeiriou D, et al. Benign epilepsy with centrotemporal spikes: Relationship between type of seizures and response to medication in a Greek population. J Neurosci Rural Pract, 2015, 6(4): 545-548.
12.	Loiseau P, Duché B, Cordova S, et al. Prognosis of benign childhood epilepsy with centrotemporal spikes: a follow-up study of 168 patients. Epilepsia, 1988, 29(3): 229-235.
13.	Bouma PA, Bovenkerk AC, Westendorp RG, et al. The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology, 1997, 48(2): 430-437.
14.	Samaitien? R, Norkūnien? J, Jurkevi?ien? G, et al. Behavioral problems in children with benign childhood epilepsy with centrotemporal spikes treated and untreated with antiepileptic drugs. Medicina (Kaunas), 2012, 48(7): 338-344.
15.	Xiao F, An D, Deng H, et al. Evaluation of levetiracetam and valproic acid as low-dose monotherapies for children with typical benign childhood epilepsy with centrotemporal spikes (BECTS). Seizure, 2014, 23(9): 756-761.
16.	王衛星, 付淑芳, 陳鳳儀, 等. 不同類型抗癲癇藥物對伴中央顳區棘波兒童良性癲癇注意網絡損害及腦電圖癇樣放電的影響. 疑難病雜志, 2019, 18(9): 904-909.
17.	Grosso S, Balestri M, Di Bartolo RM, et al. Oxcarbazepine and atypical evolution of benign idiopathic focal epilepsy of childhood. Eur J Neurol, 2006, 13(10): 1142-1145.
18.	Verrotti A, D'Egidio C, Mohn A, et al. Antiepileptic drugs, sex hormones, and PCOS. Epilepsia, 2011, 52(2): 199-211.
19.	McNally MA, Kossoff EH. Incidental rolandic spikes: long-term outcomes and impact of treatment. Epilepsy Behav, 2015, 43: 135-138.
20.	Operto FF, Pastorino GMG, Mazza R, et al. Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up. Epilepsy Behav, 2019, 97: 187-191.
21.	Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
22.	Lee EH, You SJ. Factors associated with electroencephalographic and clinical remission of benign childhood epilepsy with centrotemporal spikes. Brain Dev, 2019, 41(2): 158-162.
23.	Kim H, Kim SY, Lim BC, et al. Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management. Brain Dev, 2018, 40(8): 693-698.
24.	Han JY, Choi SA, Chung YG, et al. Change of centrotemporal spikes from onset to remission in self-limited epilepsy with centrotemporal spikes (SLECTS). Brain Dev, 2020, 42(3): 270-276.
25.	Tacke M, Borggraefe I, Gerstl L, et al. Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial. Seizure, 2018, 56: 115-120.
26.	Tenney JR, Glauser T, Altaye M, et al. Longitudinal stability of interictal spikes in benign epilepsy with centrotemporal spikes. Epilepsia, 2016, 57(5): 805-811.
27.	Kanemura H, Sano F, Ohyama T, et al. Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy. Seizure, 2018, 62: 79-83.
28.	van Klink NE, van 't Klooster MA, Leijten FS, et al. Ripples on rolandic spikes: A marker of epilepsy severity. Epilepsia, 2016, 57(7): 1179-1189.
29.	Liu X, Han Q. Depression and anxiety in children with benign childhood epilepsy with centrotemporal spikes (BCECTS). BMC Pediatr, 2016, 16(1): 128.
30.	張靜, 陳芳, 靳梅, 等. 伴中央顳區棘波的兒童良性癲(癇)治療前后腦電圖與認知功能的對比分析. 國際兒科學雜志, 2016, 43(4): 329-332.
31.	Tacke M, Gerstl L, Heinen F, et al. Effect of anticonvulsive treatment on neuropsychological performance in children with BECTS. Eur J Paediatr Neurol, 2016, 20(6): 874-879.
32.	Han MJ, Kim SJ. Effects of Antiepileptic Drugs on Language Abilities in Benign Epilepsy of Childhood with Centrotemporal Spikes. J Clin Neurol, 2018, 14(4): 523-529.
33.	Liu WT, Yan XX, Cheng DZ, et al. Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life. Chin Med J (Engl), 2020, 133(14): 1649-1654.
34.	孫貴玉. 左乙拉西坦與丙戊酸鈉治療 BECTS 的療效及對患兒認知功能影響的臨床對比研究. 臨床和實驗醫學雜志, 2015, (14): 1189-1193.
35.	Wang X, Zhang Y, Long Z, et al. Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. J Psychiatr Res, 2017, 95: 68-75.
36.	Gohel SR, Biswal BB. Functional integration between brain regions at rest occurs in multiple-frequency bands. Brain Connect, 2015, 5(1): 23-34.
37.	Xu Q, Hu Z, Yang F, et al. Resting state signal latency assesses the propagation of intrinsic activations and estimates anti-epileptic effect of levetiracetam in Rolandic epilepsy. Brain Res Bull, 2020, 162: 125-131.
38.	Zhang Q, Yang F, Hu Z, et al. Antiepileptic Drug of Levetiracetam Decreases Centrotemporal Spike-Associated Activation in Rolandic Epilepsy. Front Neurosci, 2018, 12: 796.

1. Heijbel J, Blom S, Bergfors PG. Benign epilepsy of children with centrotemporal EEG foci. A study of incidence rate in outpatient care. Epilepsia, 1975, 16(5): 657-664.
2. Garcia-Ramos C, Jackson DC, Lin JJ, et al. Cognition and brain development in children with benign epilepsy with centrotemporal spikes. Epilepsia, 2015, 56(10): 1615-1622.
3. Kirby A, Williams N, Koelewijn L, et al. Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder. Epilepsy Behav, 2017, 72: 122-126.
4. Jiang S, Luo C, Huang Y, et al. Altered Static and Dynamic Spontaneous Neural Activity in Drug-Na?ve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes. Front Hum Neurosci, 2020, 14: 361.
5. Jiang Y, Song L, Li X, et al. Dysfunctional white-matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes. Hum Brain Mapp, 2019, 40(10): 3113-3124.
6. von Stülpnagel C, Kluger G, Leiz S, et al. Levetiracetam as add-on therapy in different subgroups of "benign" idiopathic focal epilepsies in childhood. Epilepsy Behav, 2010, 17(2): 193-198.
7. Hughes JR. Benign epilepsy of childhood with centrotemporal spikes (BECTS): to treat or not to treat, that is the question. Epilepsy Behav, 2010, 19(3): 197-203.
8. Mellish LC, Dunkley C, Ferrie CD, et al. Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility. Arch Dis Child, 2015, 100(1): 62-67.
9. Liu MJ, Su XJ, Shi XY, et al. Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children. Medicine (Baltimore), 2017, 96(4): e5623.
10. Gu W, Chen J, Tian W, et al. Outcome analysis of children with rolandic discharges on EEG: A real-world study. Seizure, 2020, 82: 105-108.
11. Gkampeta A, Fidani L, Zafeiriou D, et al. Benign epilepsy with centrotemporal spikes: Relationship between type of seizures and response to medication in a Greek population. J Neurosci Rural Pract, 2015, 6(4): 545-548.
12. Loiseau P, Duché B, Cordova S, et al. Prognosis of benign childhood epilepsy with centrotemporal spikes: a follow-up study of 168 patients. Epilepsia, 1988, 29(3): 229-235.
13. Bouma PA, Bovenkerk AC, Westendorp RG, et al. The course of benign partial epilepsy of childhood with centrotemporal spikes: a meta-analysis. Neurology, 1997, 48(2): 430-437.
14. Samaitien? R, Norkūnien? J, Jurkevi?ien? G, et al. Behavioral problems in children with benign childhood epilepsy with centrotemporal spikes treated and untreated with antiepileptic drugs. Medicina (Kaunas), 2012, 48(7): 338-344.
15. Xiao F, An D, Deng H, et al. Evaluation of levetiracetam and valproic acid as low-dose monotherapies for children with typical benign childhood epilepsy with centrotemporal spikes (BECTS). Seizure, 2014, 23(9): 756-761.
16. 王衛星, 付淑芳, 陳鳳儀, 等. 不同類型抗癲癇藥物對伴中央顳區棘波兒童良性癲癇注意網絡損害及腦電圖癇樣放電的影響. 疑難病雜志, 2019, 18(9): 904-909.
17. Grosso S, Balestri M, Di Bartolo RM, et al. Oxcarbazepine and atypical evolution of benign idiopathic focal epilepsy of childhood. Eur J Neurol, 2006, 13(10): 1142-1145.
18. Verrotti A, D'Egidio C, Mohn A, et al. Antiepileptic drugs, sex hormones, and PCOS. Epilepsia, 2011, 52(2): 199-211.
19. McNally MA, Kossoff EH. Incidental rolandic spikes: long-term outcomes and impact of treatment. Epilepsy Behav, 2015, 43: 135-138.
20. Operto FF, Pastorino GMG, Mazza R, et al. Cognitive profile in BECTS treated with levetiracetam: A 2-year follow-up. Epilepsy Behav, 2019, 97: 187-191.
21. Xiao F, An D, Lei D, et al. Real-time effects of centrotemporal spikes on cognition in rolandic epilepsy: An EEG-fMRI study. Neurology, 2016, 86(6): 544-551.
22. Lee EH, You SJ. Factors associated with electroencephalographic and clinical remission of benign childhood epilepsy with centrotemporal spikes. Brain Dev, 2019, 41(2): 158-162.
23. Kim H, Kim SY, Lim BC, et al. Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management. Brain Dev, 2018, 40(8): 693-698.
24. Han JY, Choi SA, Chung YG, et al. Change of centrotemporal spikes from onset to remission in self-limited epilepsy with centrotemporal spikes (SLECTS). Brain Dev, 2020, 42(3): 270-276.
25. Tacke M, Borggraefe I, Gerstl L, et al. Effects of Levetiracetam and Sulthiame on EEG in benign epilepsy with centrotemporal spikes: A randomized controlled trial. Seizure, 2018, 56: 115-120.
26. Tenney JR, Glauser T, Altaye M, et al. Longitudinal stability of interictal spikes in benign epilepsy with centrotemporal spikes. Epilepsia, 2016, 57(5): 805-811.
27. Kanemura H, Sano F, Ohyama T, et al. Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy. Seizure, 2018, 62: 79-83.
28. van Klink NE, van 't Klooster MA, Leijten FS, et al. Ripples on rolandic spikes: A marker of epilepsy severity. Epilepsia, 2016, 57(7): 1179-1189.
29. Liu X, Han Q. Depression and anxiety in children with benign childhood epilepsy with centrotemporal spikes (BCECTS). BMC Pediatr, 2016, 16(1): 128.
30. 張靜, 陳芳, 靳梅, 等. 伴中央顳區棘波的兒童良性癲(癇)治療前后腦電圖與認知功能的對比分析. 國際兒科學雜志, 2016, 43(4): 329-332.
31. Tacke M, Gerstl L, Heinen F, et al. Effect of anticonvulsive treatment on neuropsychological performance in children with BECTS. Eur J Paediatr Neurol, 2016, 20(6): 874-879.
32. Han MJ, Kim SJ. Effects of Antiepileptic Drugs on Language Abilities in Benign Epilepsy of Childhood with Centrotemporal Spikes. J Clin Neurol, 2018, 14(4): 523-529.
33. Liu WT, Yan XX, Cheng DZ, et al. Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life. Chin Med J (Engl), 2020, 133(14): 1649-1654.
34. 孫貴玉. 左乙拉西坦與丙戊酸鈉治療 BECTS 的療效及對患兒認知功能影響的臨床對比研究. 臨床和實驗醫學雜志, 2015, (14): 1189-1193.
35. Wang X, Zhang Y, Long Z, et al. Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. J Psychiatr Res, 2017, 95: 68-75.
36. Gohel SR, Biswal BB. Functional integration between brain regions at rest occurs in multiple-frequency bands. Brain Connect, 2015, 5(1): 23-34.
37. Xu Q, Hu Z, Yang F, et al. Resting state signal latency assesses the propagation of intrinsic activations and estimates anti-epileptic effect of levetiracetam in Rolandic epilepsy. Brain Res Bull, 2020, 162: 125-131.
38. Zhang Q, Yang F, Hu Z, et al. Antiepileptic Drug of Levetiracetam Decreases Centrotemporal Spike-Associated Activation in Rolandic Epilepsy. Front Neurosci, 2018, 12: 796.

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