飲用咖啡與子宮內膜癌發病風險相關性的系統評價_《中國循證醫學雜志》

作者：

黃世金 ,  徐紅 , 韋瑋

廣西醫科大學第一附屬醫院婦科（南寧 530000）;

關鍵詞：

子宮內膜癌咖啡，咖啡因系統評價 Meta分析隊列研究

DOI：

10.7507/1672-2531.20130054

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　系統評價飲用咖啡與子宮內膜癌發病風險的相關性。
方法　計算機檢索CBM、CNKI、WanFang Data、PubMed、EMbase和The Cochrane Library（2012年第5期）數據庫，收集國內外發表的關于子宮內膜癌發病風險與飲用咖啡相關性的前瞻性隊列研究，檢索時間截至2012年5月，并追溯所獲文獻的參考文獻。由2位評價者按照納入與排除標準獨立篩選文獻、提取資料并評價質量后，采用Stata 12.0軟件進行統計分析。
結果　最終納入10個隊列研究，包括4 484例子宮內膜癌患者。Meta分析結果顯示，與飲用咖啡量最少或不飲用咖啡的婦女相比，飲用咖啡量最多的婦女罹患子宮內膜癌的風險降低［RR=0.69，95% CI（0.62，0.78）］，經常飲用咖啡的婦女罹患子宮內膜癌的風險降低［RR=0.83，95% CI（0.77，0.89）］。劑量–效應分析結果顯示，婦女飲用咖啡每增加2杯/ d，患子宮內膜癌的風險降低12%。
結論　婦女經常飲用咖啡（2杯/ d以上）可降低子宮內膜癌的發病風險，大量飲用咖啡（5 杯/ d以上）可更明顯降低子宮內膜癌發病風險。

引用本文： 黃世金,徐紅,韋瑋. 飲用咖啡與子宮內膜癌發病風險相關性的系統評價. 中國循證醫學雜志, 2013, 13(3): 313-319. doi: 10.7507/1672-2531.20130054 復制

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3.	Yu X, Bao Z, Zou J, et al. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer, 2011, 11(1): 96.
4.	Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev, 2002, 11(12): 1531-1543.
5.	Je Y, Giovannucci E. Coffee consumption and risk of endometrial cancer: Findings from a large up-to-date meta-analysis. Int J Cancer, 2012, 131(7): 1700-1710.
6.	Bravi F, Scotti L, Bosetti C, et al. Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies. American Journal of Obstetrics and Gynecology, 2009, 200(2): 130-135.
7.	Wells G, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2010. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
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11.	Friberg E, Orsini N, Mantzoros CS, et al. Coffee drinking and risk of endometrial cancer-A population-based cohort study. International Journal of Cancer, 2009, 125(10): 2413-2417.
12.	Je Y, Hankinson SE, Tworoger SS, et al. A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up. Cancer Epidemiology Biomarkers & Prevention, 2011, 20(12): 2487-2495.
13.	Stensvold I, Jacobsen BK. Coffee and cancer: a prospective study of 43,000 Norwegian men and women. Cancer Causes Control, 1994, 5(5): 401-408.
14.	Uccella S, Mariani A, Wang A, et al. Coffee consumption and the risk of endometrial cancer in postmenopausal women. Gynecol Oncol, 2010, 116(3): S75-S76.
15.	Jacobsen BK, Bjelke E, Kvale G, et al. Coffee drinking, mortality, and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst, 1986, 76(5): 823-831.
16.	Gavrilyuk O, Braaten T, Skeie G, et al. Coffee consumption and endometrial cancer risk among postmenopausal women in the norwegian women and cancer (NOWAC) study. International Journal of Gynecological Cancer, 2011, 21(12 SUPPL. 3): S509.
17.	Shimazu T, Inoue M, Sasazuki S, et al. Coffee consumption and risk of endometrial cancer: A prospective study in Japan. International Journal of Cancer, 2008, 123(10): 2406-2410.
18.	Nilsson LM, Johansson I, Lenner P, et al. Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes & Control, 2010, 21(10): 1533-1544.
19.	Giri A, Sturgeon SR, Luisi N, et al. Caffeinated Coffee, Decaffeinated Coffee and Endometrial Cancer Risk: A Prospective Cohort Study among US Postmenopausal Women. Nutrients, 2011, 3(11): 937-950.
20.	Gunter MJ, Schaub JA, Xue X, et al. A prospective investigation of coffee drinking and endometrial cancer incidence. International Journal of Cancer, 2012, 131(4): E530-E536.
21.	Goto A, Song Y, Chen BH, et al. Coffee and Caffeine Consumption in Relation to Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women. Diabetes, 2010, 60(1): 269-275.
22.	van Dieren S, Uiterwaal CS, van der Schouw YT, et al. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia, 2009, 52(12): 2561-2569.
23.	Cavin C, Holzhaeuser D, Scharf G, et al. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food and Chemical Toxicology, 2002, 40(8): 1155-1163.
24.	Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr, 2011, 51(4): 363-373.
25.	Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal, 2008, 10(3): 475-510.
26.	McCusker RR, Fuehrlein B, Goldberger BA, et al. Caffeine content of decaffeinated coffee. J Anal Toxicol, 2006, 30(8): 611-613.
27.	Moore SC, Gierach GL, Schatzkin A, et al. Physical activity, sedentary behaviours, and the prevention of endometrial cancer. British Journal of Cancer, 2010, 103(7): 933-938.
28.	Zhou B, Yang L, Sun Q, et al. Cigarette Smoking and the Risk of Endometrial Cancer: A Meta-Analysis. The American Journal of Medicine, 2008, 121(6): 501-508.e503.

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA: A Cancer Journal for Clinicians, 2011, 61(2): 69-90.
2. Akhmedkhanov A, Zeleniuch-Jacquotte A, Toniolo P. Role of Exogenous and Endogenous Hormones in Endometrial Cancer. Annals of the New York Academy of Sciences, 2001, 943(1): 296-315.
3. Yu X, Bao Z, Zou J, et al. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer, 2011, 11(1): 96.
4. Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev, 2002, 11(12): 1531-1543.
5. Je Y, Giovannucci E. Coffee consumption and risk of endometrial cancer: Findings from a large up-to-date meta-analysis. Int J Cancer, 2012, 131(7): 1700-1710.
6. Bravi F, Scotti L, Bosetti C, et al. Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies. American Journal of Obstetrics and Gynecology, 2009, 200(2): 130-135.
7. Wells G, Shea B, O’Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2010. Available from: URL: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
8. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA, 2000, 283(15): 2008-2012.
9. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol, 1992, 135(11): 1301-1309.
10. Orsini N, Bellocco R, Greenland S. Generalized least squares for trend estimation of summarized dose-response data. The Stata Journal, 2006, 6(1): 40-57.
11. Friberg E, Orsini N, Mantzoros CS, et al. Coffee drinking and risk of endometrial cancer-A population-based cohort study. International Journal of Cancer, 2009, 125(10): 2413-2417.
12. Je Y, Hankinson SE, Tworoger SS, et al. A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up. Cancer Epidemiology Biomarkers & Prevention, 2011, 20(12): 2487-2495.
13. Stensvold I, Jacobsen BK. Coffee and cancer: a prospective study of 43,000 Norwegian men and women. Cancer Causes Control, 1994, 5(5): 401-408.
14. Uccella S, Mariani A, Wang A, et al. Coffee consumption and the risk of endometrial cancer in postmenopausal women. Gynecol Oncol, 2010, 116(3): S75-S76.
15. Jacobsen BK, Bjelke E, Kvale G, et al. Coffee drinking, mortality, and cancer incidence: results from a Norwegian prospective study. J Natl Cancer Inst, 1986, 76(5): 823-831.
16. Gavrilyuk O, Braaten T, Skeie G, et al. Coffee consumption and endometrial cancer risk among postmenopausal women in the norwegian women and cancer (NOWAC) study. International Journal of Gynecological Cancer, 2011, 21(12 SUPPL. 3): S509.
17. Shimazu T, Inoue M, Sasazuki S, et al. Coffee consumption and risk of endometrial cancer: A prospective study in Japan. International Journal of Cancer, 2008, 123(10): 2406-2410.
18. Nilsson LM, Johansson I, Lenner P, et al. Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes & Control, 2010, 21(10): 1533-1544.
19. Giri A, Sturgeon SR, Luisi N, et al. Caffeinated Coffee, Decaffeinated Coffee and Endometrial Cancer Risk: A Prospective Cohort Study among US Postmenopausal Women. Nutrients, 2011, 3(11): 937-950.
20. Gunter MJ, Schaub JA, Xue X, et al. A prospective investigation of coffee drinking and endometrial cancer incidence. International Journal of Cancer, 2012, 131(4): E530-E536.
21. Goto A, Song Y, Chen BH, et al. Coffee and Caffeine Consumption in Relation to Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women. Diabetes, 2010, 60(1): 269-275.
22. van Dieren S, Uiterwaal CS, van der Schouw YT, et al. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia, 2009, 52(12): 2561-2569.
23. Cavin C, Holzhaeuser D, Scharf G, et al. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food and Chemical Toxicology, 2002, 40(8): 1155-1163.
24. Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr, 2011, 51(4): 363-373.
25. Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal, 2008, 10(3): 475-510.
26. McCusker RR, Fuehrlein B, Goldberger BA, et al. Caffeine content of decaffeinated coffee. J Anal Toxicol, 2006, 30(8): 611-613.
27. Moore SC, Gierach GL, Schatzkin A, et al. Physical activity, sedentary behaviours, and the prevention of endometrial cancer. British Journal of Cancer, 2010, 103(7): 933-938.
28. Zhou B, Yang L, Sun Q, et al. Cigarette Smoking and the Risk of Endometrial Cancer: A Meta-Analysis. The American Journal of Medicine, 2008, 121(6): 501-508.e503.

《中國循證醫學雜志》

飲用咖啡與子宮內膜癌發病風險相關性的系統評價

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《中國循證醫學雜志》

飲用咖啡與子宮內膜癌發病風險相關性的系統評價

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