TNF-α-G308A基因多態性與風濕性心臟病相關性的Meta分析_《中國循證醫學雜志》

作者：

張瑤俊 , 李明慧 , 楊少華 , 田乃亮 , 賈海波 ,  陳紹良

南京市第一醫院/南京市心血管病研究所（南京 210006）;

關鍵詞：

風濕性心臟病腫瘤壞死因子α 基因多態性 Meta分析

DOI：

10.7507/1672-2531.20120188

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　采用Meta分析方法評價腫瘤壞死因子α（TNF-α） G308A基因多態性與風濕性心臟病（RHD）的相關性。
方法　計算機檢索PubMed、EMbase、CNKI、WanFang Data中關于TNF-α基因多態性與風濕性心臟病相關性的病例-對照研究，檢索時限均從1990年1月至2011年6月。由2名評價者按照納入和排除標準獨立選擇文獻、提取資料和評價質量后，采用RevMan 5.1和SPSS 16.0軟件進行Meta分析。
結果　共納入5個研究，539例風濕性心臟病患者和624例對照人群。以TNF-α-G308A基因隱性遺傳模式計算的Meta分析結果顯示，AA基因型攜帶者患風濕性心臟病的危險與GA+GG基因型攜帶者的差異有統計學意義［OR=5.06，95%CI（2.15，11.89），P=0.000 2］。以TNF-α-G308A基因顯性遺傳模式計算的Meta分析結果也顯示，AA基因型攜帶者患風濕性心臟病的危險與GA+GG基因型攜帶者的差異有統計學意義［OR=3.14，95%CI（1.05，9.38），P=0.04］。
結論　現有證據顯示，TNF-α-G308A基因多態性與風濕性心臟病相關，AA等位基因攜帶者患風濕性心臟病的危險有增高趨勢。但由于納入研究數量有限，尚不清楚不同人種TNF-α-G308A基因多態性是否與風濕性心臟病相關。上述結論仍需開展更多高質量、大樣本的臨床試驗加以證實。

引用本文： 張瑤俊,李明慧,楊少華,田乃亮,賈海波,陳紹良. TNF-α-G308A基因多態性與風濕性心臟病相關性的Meta分析. 中國循證醫學雜志, 2012, 12(10): 1209-1212. doi: 10.7507/1672-2531.20120188 復制

1.	Kaplan EL. Pathogenesis of acute rheumatic fever and rheumatic heart disease: evasive after half a century of clinical, epidemiological, and laboratory investigation. Heart, 2005, 91(1): 3-4.
2.	McDonald M, Currie BJ, Carapetis JR. Acute rheumatic fever: a chink in the chain that links the heart to the throat. Lancet Infect Dis, 2004, 4(4): 240-245.
3.	Carapetis JR, Steer AC, Mulholland EK, et al. The global burden of group A streptococcal diseases. Lancet Infect Dis, 2005, 5(11): 685-694.
4.	Bhat MS, Wani BA, Koul PA, et al. HLA antigen pattern of Kashmiri patients with rheumatic heart disease. Indian J Med Res, 1997, 105(32): 271-274.
5.	Hua R, Xu JB, Wang JC, et al. Association of TNFAIP3 polymorphism with rheumatic heart disease in Chinese Han population. Immunogenetics, 2009, 61(11-12): 739-744.
6.	Berdeli A, Tabel Y, Celik HA, et al. Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. Scand J Rheumatol, 2006, 35(1): 44-47.
7.	Settin A, Abdel-Hady H, El-Baz R, et al. Gene polymorphisms of TNF-alpha (-308), IL-10 (-1082), IL-6 (-174), and IL-1Ra (VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol, 2007, 28(5): 363-371.
8.	Hernandez-Pacheco G, Flores-Dominguez C, Rodriguez-Perez JM, et al. Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease. J Autoimmun, 2003, 21(1): 59-63.
9.	Sallakci N, Akcurin G, Koksoy S, et al. TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production. J Autoimmun, 2005, 25(2): 150-154.
10.	Chou H, Tsai F. Tumor Necrosis Factor-alpha Gene G-308A and G-238A polymorphisms are not associated with Rheumatic Heart Disease in Taiwan. Mid-Taiwan Journal of Medicine, 2006, 11(3): 149-154.
11.	Mohamed AA, Rashed LA, Shaker SM, et al. Association of tumor necrosis factor-alpha polymorphisms with susceptibility and clinical outcomes of rheumatic heart disease. Saudi Med J, 2010, 31(6): 644-649.
12.	Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med, 1990, 323(4): 236-241.
13.	Kaplan MH, Meyeserian M. An immunological cross-reaction between group-A streptococcal cells and human heart tissue. Lancet, 1962, 1(7232): 706-710.

1. Kaplan EL. Pathogenesis of acute rheumatic fever and rheumatic heart disease: evasive after half a century of clinical, epidemiological, and laboratory investigation. Heart, 2005, 91(1): 3-4.
2. McDonald M, Currie BJ, Carapetis JR. Acute rheumatic fever: a chink in the chain that links the heart to the throat. Lancet Infect Dis, 2004, 4(4): 240-245.
3. Carapetis JR, Steer AC, Mulholland EK, et al. The global burden of group A streptococcal diseases. Lancet Infect Dis, 2005, 5(11): 685-694.
4. Bhat MS, Wani BA, Koul PA, et al. HLA antigen pattern of Kashmiri patients with rheumatic heart disease. Indian J Med Res, 1997, 105(32): 271-274.
5. Hua R, Xu JB, Wang JC, et al. Association of TNFAIP3 polymorphism with rheumatic heart disease in Chinese Han population. Immunogenetics, 2009, 61(11-12): 739-744.
6. Berdeli A, Tabel Y, Celik HA, et al. Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. Scand J Rheumatol, 2006, 35(1): 44-47.
7. Settin A, Abdel-Hady H, El-Baz R, et al. Gene polymorphisms of TNF-alpha (-308), IL-10 (-1082), IL-6 (-174), and IL-1Ra (VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol, 2007, 28(5): 363-371.
8. Hernandez-Pacheco G, Flores-Dominguez C, Rodriguez-Perez JM, et al. Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease. J Autoimmun, 2003, 21(1): 59-63.
9. Sallakci N, Akcurin G, Koksoy S, et al. TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production. J Autoimmun, 2005, 25(2): 150-154.
10. Chou H, Tsai F. Tumor Necrosis Factor-alpha Gene G-308A and G-238A polymorphisms are not associated with Rheumatic Heart Disease in Taiwan. Mid-Taiwan Journal of Medicine, 2006, 11(3): 149-154.
11. Mohamed AA, Rashed LA, Shaker SM, et al. Association of tumor necrosis factor-alpha polymorphisms with susceptibility and clinical outcomes of rheumatic heart disease. Saudi Med J, 2010, 31(6): 644-649.
12. Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med, 1990, 323(4): 236-241.
13. Kaplan MH, Meyeserian M. An immunological cross-reaction between group-A streptococcal cells and human heart tissue. Lancet, 1962, 1(7232): 706-710.

《中國循證醫學雜志》

TNF-α-G308A基因多態性與風濕性心臟病相關性的Meta分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

《中國循證醫學雜志》

TNF-α-G308A基因多態性與風濕性心臟病相關性的Meta分析

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

上一篇

下一篇

Format

Content

摘要全文圖表視頻參考文獻施引文獻補充材料