TGF基因多態性與高血壓遺傳易感性關系的Meta分析_《中國循證醫學雜志》

作者：

李敏 ^1,2 ,  時景璞 ^1,2

1. 中國醫科大學附屬第一醫院臨床流行病學教研室（沈陽?110001）；2. 遼寧省循證醫學中心（沈陽?110001）;

關鍵詞：

轉化生長因子基因多態性高血壓 Meta分析病例對照研究

DOI：

10.7507/1672-2531.20110235

視頻：

導出 下載 收藏 掃碼 引用

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

目的　綜合評價轉化生長因子β1（transforming growth factor β1，TGF β1）基因869T/C、915G/C多態性與高血壓遺傳易感性的關系。
方法　按照統一的檢索策略，在各大中英文數據庫中全面檢索相關文獻，獲取有關TGF β1基因多態性同高血壓遺傳易感性關系的病例-對照研究，而后按照納入與排除標準選擇文獻、提取資料和評價質量后，采用RevMan 5.1軟件進行Meta分析。
結果　共納入14個病例-對照研究。Meta分析結果顯示：TGF β1基因869總突變C等位基因與高血壓發病相關［OR=1.37，95%CI（1.21，1.54）］。攜帶CC、TT基因型的個體發生高血壓危險性的OR值分別為1.43（1.27，1.60）和0.64（0.53，0.78）。TGF β1基因915G/C多態性與高血壓關聯無統計學意義。對以中國人群為研究對象的研究進行綜合，該兩個多態性位點的結果與整體分析結果均相近。敏感性分析顯示結果穩定，Begg、Egger檢驗提示無發表偏倚。
結論　 TGF β1基因869T/C多態性能夠增加攜帶者患高血壓的發病風險，C等位基因可能是高血壓易感性的標記基因之一，暫未發現TGF β1基因915G/C多態性同高血壓發病相關。

引用本文： 李敏,時景璞. TGF基因多態性與高血壓遺傳易感性關系的Meta分析. 中國循證醫學雜志, 2011, 11(12): 1384-1390. doi: 10.7507/1672-2531.20110235 復制

1.	Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism typeⅡand a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension, 2005, 56(2): 295-300.
2.	Horwitz RI, Feinstein AR. Methodologic standards and contradictory result in case-control research. Am J Med, 1979, 66(4): 556-564.
3.	Colditz GA, Burdick E, Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am J Epidemiol, 1995, 142(4): 371-382.
4.	DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials, 2007, 28(2): 105-114.
5.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
6.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
7.	He F, Zhao D, Deng F, et al. Association of TGF-beta 1 gene polymorphisms in exon1 and blood levels with essential hypertension. Blood Press, 2010, 19(4): 225-233.
8.	趙丹, 胡清華, 鄧峰美, 等. 新疆哈薩克族轉化生長因子β1基因多態性及其血漿水平與原發性高血壓的關系. 中華醫學遺傳學雜志, 2010, 27(4): 463-468.
9.	唐任光, 韋葉生, 黃照河. 轉化生長因子β1基因+869T/C多態性與原發性高血壓的關系. 臨床檢驗雜志, 2009, 27(4): 270-271.
10.	Argano C, Duro G, Corrao S, et al. Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage. Blood Press, 2008, 17(4): 220-226.
11.	Ivanov VP, Solodilova MA, Polonnikov AV, et al. Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of Central Chernozem Region. Bull Exp Biol Med, 2007, 114(1): 66-68.
12.	陳慧生, 張七一, 王云英. 轉化生長因子β1基因多態性及其血清水平與高血壓病腎臟損害的關系. 臨床內科雜志, 2007, 24(1): 57-59.
13.	韋常麗, 吳延佳, 邱全, 等. 轉化生長因子β1 基因多態性與原發性高血壓關系的研究. 中國老年學雜志, 2007, 27(10): 962-964.
14.	呼邦傳, 初少莉, 王繼光, 等. 三個候選基因多態性與高血壓病關聯的研究. 中華內科雜志, 2006, 45(4): 281-284.
15.	張七一, 董海, 王云英, 等. 轉化生長因子β1 基因多態性及血清水平與高血壓左室肥厚的關系. 中華老年醫學雜志, 2006, 25(5): 358-360.
16.	韋葉生, 李壯, 藍景生. 轉化生長因子β1基因多態性與廣西壯族人原發性高血壓的遺傳易感性. 第四軍醫大學學報, 2005, 26(4): 341-344.
17.	Babel N, Cherepnev G, Kowalenko A, et al. Nonimmunologic complications and gene polymorphisms of immunoregulatory cytokines in long-term renal transplants. Kidney Int, 2004, 66(1): 428-432.
18.	Yamada Y, Fujisawa M, Ando F, et al. Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals. J Hum Genet, 2002, 4(5): 243-248.
19.	Frossard PM, Gupta A, Pravica V, et al. A study of five human cytokine genes in human essential hypertension. Mol Immunol, 2001, 38(12-13): 969-976.
20.	Li B, Khanna A, Sharma V, et al. TGF-beta1 DNA polymorphisms, protein levels, and blood pressure. Hypertension, 1999, 33(1Pt2): 271-275.
21.	Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet, 1997, 349(9062): 1353-1357.
22.	Stoll C, Mengsteab S, Stoll D, et al. Analysis of polymorphic TGFβ1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. BMC Med Genet, 2004, 5: 15.
23.	Quarmby S, Fakhoury H, Levine E, et al. Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol, 2003, 79(2): 137-143.
24.	Antonipillai I, Le TH, Soceneantu L, et al. Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. Am J Physiol, 1993, 265(4 Pt 2): F537-541.
25.	Kaizar EE. Metaanalyses are observational studies: how lack of randomization impacts analysis. Am J Gastroenterol, 2005, 100(6): 1233-1236.

1. Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism typeⅡand a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension, 2005, 56(2): 295-300.
2. Horwitz RI, Feinstein AR. Methodologic standards and contradictory result in case-control research. Am J Med, 1979, 66(4): 556-564.
3. Colditz GA, Burdick E, Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am J Epidemiol, 1995, 142(4): 371-382.
4. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials, 2007, 28(2): 105-114.
5. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
6. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
7. He F, Zhao D, Deng F, et al. Association of TGF-beta 1 gene polymorphisms in exon1 and blood levels with essential hypertension. Blood Press, 2010, 19(4): 225-233.
8. 趙丹, 胡清華, 鄧峰美, 等. 新疆哈薩克族轉化生長因子β1基因多態性及其血漿水平與原發性高血壓的關系. 中華醫學遺傳學雜志, 2010, 27(4): 463-468.
9. 唐任光, 韋葉生, 黃照河. 轉化生長因子β1基因+869T/C多態性與原發性高血壓的關系. 臨床檢驗雜志, 2009, 27(4): 270-271.
10. Argano C, Duro G, Corrao S, et al. Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage. Blood Press, 2008, 17(4): 220-226.
11. Ivanov VP, Solodilova MA, Polonnikov AV, et al. Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of Central Chernozem Region. Bull Exp Biol Med, 2007, 114(1): 66-68.
12. 陳慧生, 張七一, 王云英. 轉化生長因子β1基因多態性及其血清水平與高血壓病腎臟損害的關系. 臨床內科雜志, 2007, 24(1): 57-59.
13. 韋常麗, 吳延佳, 邱全, 等. 轉化生長因子β1 基因多態性與原發性高血壓關系的研究. 中國老年學雜志, 2007, 27(10): 962-964.
14. 呼邦傳, 初少莉, 王繼光, 等. 三個候選基因多態性與高血壓病關聯的研究. 中華內科雜志, 2006, 45(4): 281-284.
15. 張七一, 董海, 王云英, 等. 轉化生長因子β1 基因多態性及血清水平與高血壓左室肥厚的關系. 中華老年醫學雜志, 2006, 25(5): 358-360.
16. 韋葉生, 李壯, 藍景生. 轉化生長因子β1基因多態性與廣西壯族人原發性高血壓的遺傳易感性. 第四軍醫大學學報, 2005, 26(4): 341-344.
17. Babel N, Cherepnev G, Kowalenko A, et al. Nonimmunologic complications and gene polymorphisms of immunoregulatory cytokines in long-term renal transplants. Kidney Int, 2004, 66(1): 428-432.
18. Yamada Y, Fujisawa M, Ando F, et al. Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals. J Hum Genet, 2002, 4(5): 243-248.
19. Frossard PM, Gupta A, Pravica V, et al. A study of five human cytokine genes in human essential hypertension. Mol Immunol, 2001, 38(12-13): 969-976.
20. Li B, Khanna A, Sharma V, et al. TGF-beta1 DNA polymorphisms, protein levels, and blood pressure. Hypertension, 1999, 33(1Pt2): 271-275.
21. Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet, 1997, 349(9062): 1353-1357.
22. Stoll C, Mengsteab S, Stoll D, et al. Analysis of polymorphic TGFβ1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. BMC Med Genet, 2004, 5: 15.
23. Quarmby S, Fakhoury H, Levine E, et al. Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol, 2003, 79(2): 137-143.
24. Antonipillai I, Le TH, Soceneantu L, et al. Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. Am J Physiol, 1993, 265(4 Pt 2): F537-541.
25. Kaizar EE. Metaanalyses are observational studies: how lack of randomization impacts analysis. Am J Gastroenterol, 2005, 100(6): 1233-1236.

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《中國循證醫學雜志》

TGF基因多態性與高血壓遺傳易感性關系的Meta分析

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《中國循證醫學雜志》

TGF基因多態性與高血壓遺傳易感性關系的Meta分析

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