TNF-α-308位點多態性與中國系統性紅斑狼瘡相關性的Meta分析_《中國循證醫學雜志》

作者：

高香 ¹ ,  呂玲 ¹ , 王小欽 ²

1. 復旦大學附屬華山醫院風濕科（上海 200040）；2. 復旦大學附屬華山醫院血液科（上海 200040）;

關鍵詞：

Meta分析 TNF-α基因系統性紅斑狼瘡基因多態性中國人群

DOI：

10.7507/1672-2531.20100544

視頻：

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目的　評價TNF-α-308位點多態性與中國系統性紅斑狼瘡的相關性。
方法　檢索PubMed、EBSCO、中國學術期刊全文數據庫（CNKI）、中國生物醫學文獻數據庫（CBM）、萬方數據庫，收集TNF-α-308位點多態性與中國系統性紅斑狼瘡（SLE）相關性的文獻。檢索時間為建庫至2010年3月。用Meta分析的方法檢測基因型AA vs. GG、GA vs. GG、AA vs. GG + GA、GA + AA vs. GG和A vs. G在SLE組與對照組中是否有差異。
結果　共納入8篇文獻，共有SLE患者731例，健康對照901例。對總體人群進行Meta分析，未發現等位基因A與SLE相關［OR=1.42，95%CI（0.97，2.09），P=0.07］；將人群按地域分層，未發現-308A與中國臺灣人群SLE相關［OR=1.04，95%CI（0.77，1.40），P=0.82］。基因型AA vs. GG、GA vs. GG、AA vs. GG + GA、GA + AA vs. GG在SLE組與對照組中無顯著差異。
結論　本研究未鑒定出TNF-α-308位點等位基因和基因型與中國SLE相關。

引用本文： 高香,呂玲,王小欽. TNF-α-308位點多態性與中國系統性紅斑狼瘡相關性的Meta分析. 中國循證醫學雜志, 2010, 10(9): 1053-1057. doi: 10.7507/1672-2531.20100544 復制

1.	Harley JB, Moser KL, Gaffney PM, et al. The genetics of human systemic lupus erythematosus. Curr Opin Immunol, 1998, 10(6): 690-696.
2.	Vyse TJ, Kotzin BL. Genetic basis of systemic lupus erythematosus. Curr Opin Immunol, 1996, 8(6): 843-851.
3.	Wilson AG, de Vries N, Pociot F, et al. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med, 1993, 177(2): 557-560.
4.	Fedczyna TO, Lutz J, Pachman LM. Expression of TNF alpha by muscle fibers in biopsies from children with untreated juvenile dermatomyositis: association with the TNFalpha-308A allele. Clin Immunol, 2001, 100(2): 236-239.
5.	Studnicka-Benke A, Steiner G, Petera P, et al. Tumour necrosis factor alpha and its soluble receptors parallel clinical disease and autoimmune activity in systemic lupus erythematosus. Br J Rheumatol, 1996, 35(11): 1067-1074.
6.	Rood MJ, van Krugten MV, Zanelli E, et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum, 2000, 43(1): 129-134.
7.	van der Linden MW, van der Slik AR, Zanelli E, et al. Six microsatellite markers on the short arm of chromosome in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus. Genes Immun, 2001, 2(7): 373-380.
8.	May LA, Huang Q, Morris D, et al. Relationship of tumour necrosis factor alpha gene polymorphisms and neuropsychiatric lupus. Lupus, 2002, 11(2): 114-118.
9.	Parks CG, Pandey JP, Dooley MA, et al. Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a populationbased study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism. Hum Immunol, 2004, 65(6): 622-631.
10.	Bayley JP, de Rooij H, van den Elsen PJ, et al. Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. Cytokine, 2001, 14(6): 316-323.
11.	吳曉梅, 時玥, 時景璞, 等. 中國漢族人群腦出血患者血管緊張素轉換酶基因插入/缺失多態性的Meta分析. 中國循證醫學雜志, 2009, 9(12): 1323-1327.
12.	李靜, 康德英. 系統評價與meta分析. 見: 王家良, 主編. 臨床流行病學: 臨床科研設計、測量與評價. 上海: 上海科學技術出版社, 2009. 264-268.
13.	Lin YJ, Chen RH, Wan L, et al. Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus, 2009, 18(11): 974-979.
14.	Tsai LJ, Hsiao SH, Tsai LM, et al. The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modiWer gene in SLE. Tissue Antigens, 2008, 71(2): 114-126.
15.	Lu LY, Cheng HH, Sung PK, et al. Tumor necrosis factor-beta +252A polymorphism is associated with systemic lupus erythematosus in Taiwan. J Formos Med Assoc, 2005, 104(8): 563-570.
16.	付朝偉, 沈福民, 江峰, 等. 腫瘤壞死因子A基因多態性與系統性紅斑狼瘡的相關研究. 中華醫學遺傳學雜志, 2002, 19(6): 532-533.
17.	劉稚然, 唐坤, 施為, 等. 系統性紅斑狼瘡患者腫瘤壞死因子α基因多態性研究. 中華皮膚科雜志, 2001, 34(1): 56.
18.	王敏, 董怡, 黃尚志, 等. 腫瘤壞死因子α基因多態性及其與系統性紅斑狼瘡的相關性. 中華內科雜志, 1999, 38(6): 393-396.
19.	王育新, 章友康, 朱世樂, 等. 腫瘤壞死因子的基因多態性與系統性紅斑狼瘡的相關性分析. 中華醫學雜志, 1998, 78(2): 111-114.
20.	Chen CJ, Yen JH, Tsai WC, et al. The TNF2 allele does not contribute towards susceptibility to systemic lupus erythematosus. Immunol Lett, 1997, 55(1): 1-3.
21.	Huizinga TW, Westendorp RG, Bollen EL, et al. TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol, 1997, 72(2): 149-153.
22.	Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter –308A/G polymorphism and SLE susceptibility. Eur J Hum Genet, 2006, 14(3): 364-371.
23.	Zou YF, Feng XL, Tao JH, et al. Meta-analysis of TNF-alpha promoter -308A/G polymorphism and SLE susceptibility in Asian populations. Rheumatol Int, 2010 Mar 24. [Epub ahead of print]:.
24.	Fong KY, Howe HS, Tin SK, et al. Polymorphism of the regulatory region of tumour necrosis factor alpha gene in patients with systemic lupus erythematosus. Ann Acad Med Singapore, 1996, 25(1): 90-93.
25.	Azizah MR, Kuak SH, Ainol SS, et al. Association of the tumor necrosis factor alpha gene polymorphism with susceptibility and clinical-immunological Wndings of systemic lupus erythematosus. Asian Pac J Allergy Immunol, 2004, 22(2-3): 159-163.
26.	沈洪兵. 循證醫學. 見: 姜慶五, 主編. 臨床流行病學. 北京: 高等教育出版社, 2007, 240-250.

1. Harley JB, Moser KL, Gaffney PM, et al. The genetics of human systemic lupus erythematosus. Curr Opin Immunol, 1998, 10(6): 690-696.
2. Vyse TJ, Kotzin BL. Genetic basis of systemic lupus erythematosus. Curr Opin Immunol, 1996, 8(6): 843-851.
3. Wilson AG, de Vries N, Pociot F, et al. An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med, 1993, 177(2): 557-560.
4. Fedczyna TO, Lutz J, Pachman LM. Expression of TNF alpha by muscle fibers in biopsies from children with untreated juvenile dermatomyositis: association with the TNFalpha-308A allele. Clin Immunol, 2001, 100(2): 236-239.
5. Studnicka-Benke A, Steiner G, Petera P, et al. Tumour necrosis factor alpha and its soluble receptors parallel clinical disease and autoimmune activity in systemic lupus erythematosus. Br J Rheumatol, 1996, 35(11): 1067-1074.
6. Rood MJ, van Krugten MV, Zanelli E, et al. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus. Arthritis Rheum, 2000, 43(1): 129-134.
7. van der Linden MW, van der Slik AR, Zanelli E, et al. Six microsatellite markers on the short arm of chromosome in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus. Genes Immun, 2001, 2(7): 373-380.
8. May LA, Huang Q, Morris D, et al. Relationship of tumour necrosis factor alpha gene polymorphisms and neuropsychiatric lupus. Lupus, 2002, 11(2): 114-118.
9. Parks CG, Pandey JP, Dooley MA, et al. Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a populationbased study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism. Hum Immunol, 2004, 65(6): 622-631.
10. Bayley JP, de Rooij H, van den Elsen PJ, et al. Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter. Cytokine, 2001, 14(6): 316-323.
11. 吳曉梅, 時玥, 時景璞, 等. 中國漢族人群腦出血患者血管緊張素轉換酶基因插入/缺失多態性的Meta分析. 中國循證醫學雜志, 2009, 9(12): 1323-1327.
12. 李靜, 康德英. 系統評價與meta分析. 見: 王家良, 主編. 臨床流行病學: 臨床科研設計、測量與評價. 上海: 上海科學技術出版社, 2009. 264-268.
13. Lin YJ, Chen RH, Wan L, et al. Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus, 2009, 18(11): 974-979.
14. Tsai LJ, Hsiao SH, Tsai LM, et al. The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modiWer gene in SLE. Tissue Antigens, 2008, 71(2): 114-126.
15. Lu LY, Cheng HH, Sung PK, et al. Tumor necrosis factor-beta +252A polymorphism is associated with systemic lupus erythematosus in Taiwan. J Formos Med Assoc, 2005, 104(8): 563-570.
16. 付朝偉, 沈福民, 江峰, 等. 腫瘤壞死因子A基因多態性與系統性紅斑狼瘡的相關研究. 中華醫學遺傳學雜志, 2002, 19(6): 532-533.
17. 劉稚然, 唐坤, 施為, 等. 系統性紅斑狼瘡患者腫瘤壞死因子α基因多態性研究. 中華皮膚科雜志, 2001, 34(1): 56.
18. 王敏, 董怡, 黃尚志, 等. 腫瘤壞死因子α基因多態性及其與系統性紅斑狼瘡的相關性. 中華內科雜志, 1999, 38(6): 393-396.
19. 王育新, 章友康, 朱世樂, 等. 腫瘤壞死因子的基因多態性與系統性紅斑狼瘡的相關性分析. 中華醫學雜志, 1998, 78(2): 111-114.
20. Chen CJ, Yen JH, Tsai WC, et al. The TNF2 allele does not contribute towards susceptibility to systemic lupus erythematosus. Immunol Lett, 1997, 55(1): 1-3.
21. Huizinga TW, Westendorp RG, Bollen EL, et al. TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol, 1997, 72(2): 149-153.
22. Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter –308A/G polymorphism and SLE susceptibility. Eur J Hum Genet, 2006, 14(3): 364-371.
23. Zou YF, Feng XL, Tao JH, et al. Meta-analysis of TNF-alpha promoter -308A/G polymorphism and SLE susceptibility in Asian populations. Rheumatol Int, 2010 Mar 24. [Epub ahead of print]:.
24. Fong KY, Howe HS, Tin SK, et al. Polymorphism of the regulatory region of tumour necrosis factor alpha gene in patients with systemic lupus erythematosus. Ann Acad Med Singapore, 1996, 25(1): 90-93.
25. Azizah MR, Kuak SH, Ainol SS, et al. Association of the tumor necrosis factor alpha gene polymorphism with susceptibility and clinical-immunological Wndings of systemic lupus erythematosus. Asian Pac J Allergy Immunol, 2004, 22(2-3): 159-163.
26. 沈洪兵. 循證醫學. 見: 姜慶五, 主編. 臨床流行病學. 北京: 高等教育出版社, 2007, 240-250.

《中國循證醫學雜志》

TNF-α-308位點多態性與中國系統性紅斑狼瘡相關性的Meta分析

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《中國循證醫學雜志》

TNF-α-308位點多態性與中國系統性紅斑狼瘡相關性的Meta分析

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