遺傳對兒童精神健康發育影響的雙生子研究_《中國循證醫學雜志》

作者：

1. 重慶醫科大學附屬第一醫院心理衛生中心（重慶 400016）；2. 四川大學華西醫院心理衛生中心（成都 610041）;

關鍵詞：

雙生子精神健康遺傳發育和健康狀況評定（DAWBA）

DOI：

10.7507/1672-2531.20100403

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目的　了解遺傳因素對兒童雙生子精神健康發育的影響。
方法　通過教委和學校募集6 ～ 16 歲在同一家庭中撫養并就讀于同一所學校的雙生子。簽署知情同意書后，用發育和健康狀況評定量表（Development andWell-Bing Assessment, DAWBA）中文版向雙生子父母調查雙生子的精神健康發育狀況。同時采集雙生子的頰粘膜標本提取DNA 進行卵型鑒定。
結果　共募集到雙生子102 對，完成問卷調查93 對，其中同卵雙生子（MZ）50 對，異卵雙生子（DZ）43 對。在DAWBA 的情緒、行為癥狀及其癥狀產生的影響部分，計算機診斷結果顯示情緒障礙中的分離性焦慮（MZ 組相關系數（r）=0.821，P lt;0.01；DZ 組r =0.348，P lt;0.01）、廣泛性焦慮(MZ 組r =0.546，P lt;0.01；DZ 組r =0.309，P lt;0.01)、特殊恐怖癥狀（MZ 組r =0.849，P lt;0.01；DZ 組r =0.726，P lt;0.01）及對立/ 品行障礙（MZ組r =0.237，P lt;0.01；DZ 組r =0.163，P lt;0.01）、注意力缺陷- 多動障礙（MZ 組r =0.640，P lt;0.01；DZ 組r =0.198，P lt;0.01），孤獨癥癥狀（MZ 組r =0.680，P lt;0.01；DZ 組r =0.372，P lt;0.01），MZ 組r 大于DZ 組。
結論　在影響兒童雙生子精神健康發育的因素中，遺傳因素起重要作用。

引用本文： 覃青,傅一笑,蒙華慶,李濤,羅慶華,歐穎,陳品紅,杜蓮,邱海棠,高玉峰,鄭玉萍,邱田. 遺傳對兒童精神健康發育影響的雙生子研究. 中國循證醫學雜志, 2010, 10(3): 311-315. doi: 10.7507/1672-2531.20100403 復制

1.	郭蘭婷, 單友荷, 周在東, 等. 學齡兒童的抑郁. 中國心理衛生雜志, 1998, 12(3): 151-154.
2.	李晶, 陳莉, 賈娜, 等. 兒童個性特征的雙生子研究. 中國行為醫學科學, 1998, 7(3): 198-199.
3.	Moya T, Fleitlich-Bilyk B, Goodman R, et al. The Eating Disorders Section of the Development and Well-Being Assessment (DAWBA): development and validation. Rev Bras Psiquiatr, 2005, 27(1): 25-31.
4.	Goodman R, Ford T, Richards H, et al. The development and wellbeing assessment: description and initial validation of an integrated assessment of child and adolescent psychopathology. J Child Psychiatry, 2000, 41(5): 645-655.
5.	Fombonne E, Simmons H, Ford T, et al. Prevalence of pervasive developmental disorders in the british nationwide survey of child mental health. J Am Child Adolesc Psychiatry, 2001, 40(7): 820-827.
6.	Fleitlich-Bilyk B, Goodman R. Prevalence of child and adolescent psychiatric disorders in southeast brazil. J Am Acad Child Adolesc Psychiatry, 2004, 43(6): 727-734.
7.	何鑫, 朱鼎良. 應用微星DNA基因分型技術進行雙生子卵型鑒定. 中華醫學遺傳學雜志, 2001, 12(18): 421-425.
8.	Yang MJ, Tzeng CH, Tseng JY, et al. Determination of twin zygosity using a commercially available STR analysis of 15 unlinked loci and the gender-determining marker amelogenin-apreliminary report. Human Reprod, 2006, 21(8): 2175-2179.
9.	黃志碧, 梁秋萍. 直線回歸與檢驗統計分析方法. 廣西醫學, 1999, 21(4): 656-662.
10.	Gilmour J, Hill B, Place M, et al. Social communication deficits in conduct disorder: a clinical and community survey. J Child Psychol Psychiatry, 2004, 45(5): 967-978.
11.	Scourfiled J, Martin N, Eley TC, et al. The genetic relationship between social cognitionand conduct problems. Behav Genet, 2004, 34(4): 377-383.
12.	Goldsmith HH, Gottesman II. Heritable variability and variable heritability in developmental psychopathology: Frontiers of developmental psychopathology. Oxford University Press: NewYork. 1996.
13.	Galton F. The history of twins, as a criterion of the relative powers of nuture and nuture: The Journal of the Anthropological Institute of Great Britain and Ireland. RAS: London, 1876.
14.	Siemens HW. The Diagnosis of Identity in Twins. J Hered, 1927, 18(5): 201-209.
15.	黃愛群, 胡永華. 雙生子方法在遺傳流行病學研究中的應用及進展. 國際遺傳學雜志, 2006, 29(5): 346-351.
16.	劉書君. 長處和困難問卷（SDQ）中文版的信度和效度研究. 四川大學碩士論文集. 2006. 6-7.
17.	Hudziak JJ, Derks EM, Althoff RR, et al. The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the conners’ rating scales. Am J Psychiatry, 2005, 162(9): 1614-1620.
18.	Rahman A, Harrington R, Freeman C, et al. Research in child and adolescent psychiatry:Research Methods in Psychiatry. 3rd edition. Gaskell: London, 2006.
19.	Bolton D, Eley TC, O’Connor TG, et al. Prevalence and genetic and environmental influences on anxiety disorders in 6-year-old twins. Psychol Med, 2006, (3): 335-344.

1. 郭蘭婷, 單友荷, 周在東, 等. 學齡兒童的抑郁. 中國心理衛生雜志, 1998, 12(3): 151-154.
2. 李晶, 陳莉, 賈娜, 等. 兒童個性特征的雙生子研究. 中國行為醫學科學, 1998, 7(3): 198-199.
3. Moya T, Fleitlich-Bilyk B, Goodman R, et al. The Eating Disorders Section of the Development and Well-Being Assessment (DAWBA): development and validation. Rev Bras Psiquiatr, 2005, 27(1): 25-31.
4. Goodman R, Ford T, Richards H, et al. The development and wellbeing assessment: description and initial validation of an integrated assessment of child and adolescent psychopathology. J Child Psychiatry, 2000, 41(5): 645-655.
5. Fombonne E, Simmons H, Ford T, et al. Prevalence of pervasive developmental disorders in the british nationwide survey of child mental health. J Am Child Adolesc Psychiatry, 2001, 40(7): 820-827.
6. Fleitlich-Bilyk B, Goodman R. Prevalence of child and adolescent psychiatric disorders in southeast brazil. J Am Acad Child Adolesc Psychiatry, 2004, 43(6): 727-734.
7. 何鑫, 朱鼎良. 應用微星DNA基因分型技術進行雙生子卵型鑒定. 中華醫學遺傳學雜志, 2001, 12(18): 421-425.
8. Yang MJ, Tzeng CH, Tseng JY, et al. Determination of twin zygosity using a commercially available STR analysis of 15 unlinked loci and the gender-determining marker amelogenin-apreliminary report. Human Reprod, 2006, 21(8): 2175-2179.
9. 黃志碧, 梁秋萍. 直線回歸與檢驗統計分析方法. 廣西醫學, 1999, 21(4): 656-662.
10. Gilmour J, Hill B, Place M, et al. Social communication deficits in conduct disorder: a clinical and community survey. J Child Psychol Psychiatry, 2004, 45(5): 967-978.
11. Scourfiled J, Martin N, Eley TC, et al. The genetic relationship between social cognitionand conduct problems. Behav Genet, 2004, 34(4): 377-383.
12. Goldsmith HH, Gottesman II. Heritable variability and variable heritability in developmental psychopathology: Frontiers of developmental psychopathology. Oxford University Press: NewYork. 1996.
13. Galton F. The history of twins, as a criterion of the relative powers of nuture and nuture: The Journal of the Anthropological Institute of Great Britain and Ireland. RAS: London, 1876.
14. Siemens HW. The Diagnosis of Identity in Twins. J Hered, 1927, 18(5): 201-209.
15. 黃愛群, 胡永華. 雙生子方法在遺傳流行病學研究中的應用及進展. 國際遺傳學雜志, 2006, 29(5): 346-351.
16. 劉書君. 長處和困難問卷（SDQ）中文版的信度和效度研究. 四川大學碩士論文集. 2006. 6-7.
17. Hudziak JJ, Derks EM, Althoff RR, et al. The genetic and environmental contributions to attention deficit hyperactivity disorder as measured by the conners’ rating scales. Am J Psychiatry, 2005, 162(9): 1614-1620.
18. Rahman A, Harrington R, Freeman C, et al. Research in child and adolescent psychiatry:Research Methods in Psychiatry. 3rd edition. Gaskell: London, 2006.
19. Bolton D, Eley TC, O’Connor TG, et al. Prevalence and genetic and environmental influences on anxiety disorders in 6-year-old twins. Psychol Med, 2006, (3): 335-344.

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遺傳對兒童精神健康發育影響的雙生子研究

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《中國循證醫學雜志》

遺傳對兒童精神健康發育影響的雙生子研究

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