愛普列特對前列腺5α-還原酶活性及雄激素受體水平的影響_《中國循證醫學雜志》

作者：

龔志勇 , 崔曙 , 鮮述彥 , 鄧顯忠 , 王繼忠

川北醫學院附屬醫院泌尿外科（四川南充 637000 ）;

關鍵詞：

愛普列特前列腺 5α- 還原酶雄激素受體

DOI：

10.7507/1672-2531.20080232

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目的　探索愛普列特對前列腺組織5α-還原酶活性及雄激素受體水平的影響。
方法　將40例確診為良性前列腺增生患者隨機分為兩組，每組各20例。試驗組服用愛普列特以及特拉唑嗪，對照組只服用特拉唑嗪。兩周后全部患者行手術取前列腺組織標本，用免疫組化的方法檢測40個前列腺標本中5α-還原酶的活性及雄激素受體水平。
結果　試驗組前列腺標本中5α-還原酶染色呈弱陽性或陰性，對照組前列腺標本中5α-還原酶染色呈強陽性。40例前列腺標本雄激素受體染色均呈強陽性。
結論　口服愛普列特可明顯抑制前列腺內5α-還原酶的活性，但對前列腺內雄激素受體水平無明顯影響。

引用本文： 龔志勇,崔曙,鮮述彥,鄧顯忠,王繼忠. 愛普列特對前列腺5α-還原酶活性及雄激素受體水平的影響. 中國循證醫學雜志, 2008, 08(12): 1047-1049. doi: 10.7507/1672-2531.20080232 復制

1.	Ranjan M, Diffley P, Stephen G, et al. Comparative study of human steroid 5alpha-reductase isoforms in prostate and female breast skin tissues: sensitivity to inhibition by finasteride and epristeride. Life Sci, 2002, 71(2): 115-126.
2.	Johnsonbaugh RE, Cohen BR, McCormack EM, et al. Effect of fourteen days treatment with epristeride, an uncompetitive 5α-reductase inhibitor, on serum and prostatic testosterone and dihydrotestosterone in men with benign prostatic hyperplasia. J Urol, 1993, 149: 423a.
3.	Marisa C, Eugene B, Eugenio F, et al. 5α-Reductase inhibitory and antiandrogenic activities of novel steroids in hamster seminal vesicles. Chem Pharm Bull, 2002, 50(11): 1447-1452.
4.	Baston E, Salem OI, Hartmann RW, et al. 6-Substituted 3,4-dihydronaphthalene-2-carboxylic acids: synthesis and structure-activity studies in a novel class of human 5-alpha-reductase inhibitors. J Enzyme Inhib Med Chem, 2002, 17(5): 303-320.
5.	Qian LH, Wang XL, Tu ZH, et al. Inhibition of regrowth of prostatic glandular cells by epristeride. Acta Pharmacol Sin, 2001, 22(9): 847-850.
6.	Bartsch G, Rittmaster RS, Klocker H, et al. Dihydrotestosterone and the concept of 5-alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol, 2002, 19(6): 413-425.
7.	Wang LG, Mencher SK, McCarron JP, et al. The biological basis for the use of an anti-androgen and a 5-alpha-reductase inhibitor in the treatment of recurrent prostate cancer: Case report and review. Oncol Rep, 2004, 11(6): 1325-1329.

1. Ranjan M, Diffley P, Stephen G, et al. Comparative study of human steroid 5alpha-reductase isoforms in prostate and female breast skin tissues: sensitivity to inhibition by finasteride and epristeride. Life Sci, 2002, 71(2): 115-126.
2. Johnsonbaugh RE, Cohen BR, McCormack EM, et al. Effect of fourteen days treatment with epristeride, an uncompetitive 5α-reductase inhibitor, on serum and prostatic testosterone and dihydrotestosterone in men with benign prostatic hyperplasia. J Urol, 1993, 149: 423a.
3. Marisa C, Eugene B, Eugenio F, et al. 5α-Reductase inhibitory and antiandrogenic activities of novel steroids in hamster seminal vesicles. Chem Pharm Bull, 2002, 50(11): 1447-1452.
4. Baston E, Salem OI, Hartmann RW, et al. 6-Substituted 3,4-dihydronaphthalene-2-carboxylic acids: synthesis and structure-activity studies in a novel class of human 5-alpha-reductase inhibitors. J Enzyme Inhib Med Chem, 2002, 17(5): 303-320.
5. Qian LH, Wang XL, Tu ZH, et al. Inhibition of regrowth of prostatic glandular cells by epristeride. Acta Pharmacol Sin, 2001, 22(9): 847-850.
6. Bartsch G, Rittmaster RS, Klocker H, et al. Dihydrotestosterone and the concept of 5-alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol, 2002, 19(6): 413-425.
7. Wang LG, Mencher SK, McCarron JP, et al. The biological basis for the use of an anti-androgen and a 5-alpha-reductase inhibitor in the treatment of recurrent prostate cancer: Case report and review. Oncol Rep, 2004, 11(6): 1325-1329.

《中國循證醫學雜志》

愛普列特對前列腺5α-還原酶活性及雄激素受體水平的影響

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《中國循證醫學雜志》

愛普列特對前列腺5α-還原酶活性及雄激素受體水平的影響

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