多發性腦梗死與單發性腦梗死危險因素對比分析_《中國循證醫學雜志》

作者：

趙松耀 ,  劉鳴 , 劉志勤

四川大學華西醫院神經內科（成都 610041）;

關鍵詞：

多發性腦梗死單發性腦梗死危險因素

DOI：

10.7507/1672-2531.20080019

視頻：

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目的　比較多發性腦梗死（MCI）與單發性腦梗死（SCI）的危險因素，以利于對其進行針對性的防治。
方法　前瞻性連續登記神經內科缺血性腦卒中患者，根據臨床和影像學資料分為MCI和SCI組，對可能影響多發性腦梗死發病的24項因素先進行單因素分析，比較可能的危險因素在MCI與SCI組間有無差異，然后進行非條件logistic多元回歸分析，校正混雜因素的影響。
結果　年齡、性別、高血壓、糖尿病、心瓣膜病、吸煙、腦梗死史、入院首次收縮壓等危險因素在MCI與SCI組間有顯著差異，logistic多元回歸分析顯示，年齡[OR=1.014,95% CI 9(1.003,1.026)]、高血壓[OR=1.566,95% CI (1.185,2.068)]、吸煙[OR=1.473,95% CI (1.052,2.061)]、腦梗死史[OR=1.948,95% CI (1.326，2.864)]為MCI的獨立危險因素。
結論　與SCI相比，年齡、高血壓、吸煙、腦梗死史為MCI的獨立危險因素。

引用本文： 趙松耀,劉鳴,劉志勤. 多發性腦梗死與單發性腦梗死危險因素對比分析. 中國循證醫學雜志, 2008, 08(2): 75-78. doi: 10.7507/1672-2531.20080019 復制

1.	Roh JK, Kang DW, Lee SH, et al. Significance of acute multiple brain infarction on diffusion-weighted imaging. Stroke, 2000, 31(3): 688-694.
2.	Bernasconi A, Bogousslavsky J, Bassetti C, et al. Multiple acute infarcts in the posterior circulation. J Neurol Neurosurg Psychiatry. 1996, 60(3): 289-296.
3.	Bogousslavsky J, Bernasconi A, Kumral E. Acute multiple infarction involving the anterior circulation. Arch Neurol, 1996, 53(1): 50-57.
4.	Meng J, Meng C, Yang P, et al. Cognitive impairment in multiple cerebral infarction. Chinese Medical Journal, 1995, 108(4): 315.
5.	[No authors listed]. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
6.	周農, 高宗良. 多發性腦梗塞和單發性腦梗塞的對比分析. 安徽醫科大學學報, 1990, 25(4): 275-277.
7.	郭宗君, 袁桂芬, 劉學生, 等. 不同病程單發及多發腦梗塞對病人認知障礙的影響. 中國實用內科雜志, 2000, 20(9): 561-562.
8.	汪凱, 卞興華, 孟玉, 等. 多發梗塞性癡呆與多發性腦梗塞腦容積線性指標的對照研究. 安徽醫科大學學報, 2002, 37(6): 451-453.
9.	Jackson C, Sudlow C. Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts. Stroke, 2005, 36(4): 891-901.
10.	Arauz A, Murillo L, Cantú C, et al. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke, 2003, 34(10): 2453-2458.
11.	李軼男. 高血壓病患者并發缺血性腦卒中危險因素分析. 國外醫學神經病學神經外科學分冊, 1999, 2: 64.
12.	Vermeer SE, Den Heijer T, Koudstaal PJ, et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke, 2003, 34(2):392-396.
13.	Eguchi K, Kabino K, Hoshide S, et al. Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population. Hypertens Res, 2004, 27(10): 747-754.
14.	Yamagishi K, Iso H, Kitamura A, et al. Smoking raises the risk of total and ischemic strokes in hypertensive men. Hypertens Res, 2003, 26(3): 209–217.
15.	Halperin RO, Michael Gaziano J, Sesso HD, et al. Smoking and the Risk of Incident Hypertension in Middle-aged and Older Men. American Journal of Hypertension, 2008, Epub ahead of print.

1. Roh JK, Kang DW, Lee SH, et al. Significance of acute multiple brain infarction on diffusion-weighted imaging. Stroke, 2000, 31(3): 688-694.
2. Bernasconi A, Bogousslavsky J, Bassetti C, et al. Multiple acute infarcts in the posterior circulation. J Neurol Neurosurg Psychiatry. 1996, 60(3): 289-296.
3. Bogousslavsky J, Bernasconi A, Kumral E. Acute multiple infarction involving the anterior circulation. Arch Neurol, 1996, 53(1): 50-57.
4. Meng J, Meng C, Yang P, et al. Cognitive impairment in multiple cerebral infarction. Chinese Medical Journal, 1995, 108(4): 315.
5. [No authors listed]. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
6. 周農, 高宗良. 多發性腦梗塞和單發性腦梗塞的對比分析. 安徽醫科大學學報, 1990, 25(4): 275-277.
7. 郭宗君, 袁桂芬, 劉學生, 等. 不同病程單發及多發腦梗塞對病人認知障礙的影響. 中國實用內科雜志, 2000, 20(9): 561-562.
8. 汪凱, 卞興華, 孟玉, 等. 多發梗塞性癡呆與多發性腦梗塞腦容積線性指標的對照研究. 安徽醫科大學學報, 2002, 37(6): 451-453.
9. Jackson C, Sudlow C. Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts. Stroke, 2005, 36(4): 891-901.
10. Arauz A, Murillo L, Cantú C, et al. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke, 2003, 34(10): 2453-2458.
11. 李軼男. 高血壓病患者并發缺血性腦卒中危險因素分析. 國外醫學神經病學神經外科學分冊, 1999, 2: 64.
12. Vermeer SE, Den Heijer T, Koudstaal PJ, et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke, 2003, 34(2):392-396.
13. Eguchi K, Kabino K, Hoshide S, et al. Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population. Hypertens Res, 2004, 27(10): 747-754.
14. Yamagishi K, Iso H, Kitamura A, et al. Smoking raises the risk of total and ischemic strokes in hypertensive men. Hypertens Res, 2003, 26(3): 209–217.
15. Halperin RO, Michael Gaziano J, Sesso HD, et al. Smoking and the Risk of Incident Hypertension in Middle-aged and Older Men. American Journal of Hypertension, 2008, Epub ahead of print.

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《中國循證醫學雜志》

多發性腦梗死與單發性腦梗死危險因素對比分析

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《中國循證醫學雜志》

多發性腦梗死與單發性腦梗死危險因素對比分析

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