微塑料暴露與呼吸系統疾病關聯研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

陳晨 , 郭忠良 , 季穎群 ,  王娜

同濟大學附屬上海市東方醫院呼吸與危重癥醫學科（上海 200120）;

Corresponding?author：

王娜, Email: Stefanie_wangyi@163.com

Keywords：

DOI：

10.7507/1671-6205.202604043

Video：

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Abstract Full text Figures/Tables Video References Cited by

1.	Landrigan PJ, Raps H, Cropper M, et al. The minderoo-monaco commission on plastics and human health[J]. Ann Glob Health, 2023, 89(1): 23.
2.	Thompson RC, Olsen Y, Mitchell RP , et al. Lost at sea: Where is all the plastic[J]? Science, 2004, 304(5672): 838-838.
3.	Napper IE, Thompson R. Plastic debris in the marine environment: history and future challenges[J]. Glob Chall, 2020, 4(6): 1900081.
4.	World Health Organization. Dietary and inhalation exposure to nano- and microplastic particles and potential implications for human health. (World Health Organization, Geneva, 2022).
5.	Khan A, Jia ZQ. Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts[J]. Iscience, 2023, 26(2): 106061.
6.	Wootton N, Reis-Santos P, Gillanders BM. Microplastic in fish - A global synthesis[J]. Rev Fish Biol Fisher, 2021, 31(4): 753-771.
7.	O?mann BE, Sarau G, Holtmannsp?tter H , et al. Small-sized microplastics and pigmented particles in bottled mineral water[J]. Water Res, 2018, 141: 307-316.
8.	Akhbarizadeh R, Dobaradaran S, Schmidt TC , et al. Worldwide bottled water occurrence of emerging contaminants: a review of the recent scientific literature[J]. J Hazard Mater, 2020, 392: 122271.
9.	Danopoulos E, Twiddy M, Rotchell JM. Microplastic contamination of drinking water: a systematic review[J]. PLoS One, 2020, 15(7): e0236838.
10.	Cox KD, Covernton GA, Davies HL , et al. Human consumption of microplastics[J]. Environ Sci Technol, 2019, 53(12): 7068-7074.
11.	Jenner LC, Rotchell JM, Bennett RT , et al. Detection of microplastics in human lung tissue using μFTIR spectroscopy[J]. Sci Total Environ, 2022, 831: 154907.
12.	Zhang Q, Xu EG, Li JN , et al. A review of microplastics in table salt, drinking water, and air: direct human exposure[J]. Environ Sci Technol, 2020, 54(7): 3740-3751.
13.	Kacprzak S, Tijing LD. Microplastics in indoor environment: Sources, mitigation and fate[J]. J Environ Chem Eng, 2022, 10(2): 107359.
14.	Guerranti C, Martellini T, Perra G , et al. Microplastics in cosmetics: environmental issues and needs for global bans[J]. Environ Toxicol Pharmacol, 2019, 68: 75-79.
15.	Hernandez LM, Yousefi N, Tufenkji N. Are there nanoplastics in your personal care products?[J]. Environ Sci Technol Lett, 2017, 4(7): 280-285.
16.	Wright SL, Kelly FJ. Plastic and human health: a micro issue?[J]. Environ Sci Technol, 2017, 51(12): 6634-6647.
17.	Yee MSL, Hii LW, Looi CK , et al. Impact of microplastics and nanoplastics on human health[J]. Nanomaterials, 2021, 11(2): 496.
18.	Weng Y, Yan H, Nan X , et al. Potential health risks of microplastic fibres release from disposable surgical masks: impact of repeated wearing and handling[J]. J Hazard Mater, 2024, 470: 134219.
19.	Liu S, Yang YX, Du ZY , et al. Percutaneous coronary intervention leads to microplastics entering the blood: interventional devices are a major source[J]. J Hazard Mater, 2024, 476: 135054.
20.	Yang YX, Xie EZH, Du ZY , et al. Detection of various microplastics in patients undergoing cardiac surgery[J]. Environ Sci Technol, 2023, 57(30): 10911-10918.
21.	Zheng X, Feng Q, Guo L. Quantitative analysis of microplastics and nanoplastics released from disposable PVC infusion tubes[J]. J Hazard Mater, 2024, 465: 133246.
22.	Mou L, Wu CL, Li R , et al. Rapid detection of microplastics/nanoplastics directly exposed to blood during intravenous injections via mie scattering spectra[J]. J Hazard Mater, 2024, 480: 136193.
23.	Ruenraroengsak P, Tetley TD. Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells[J]. Part Fibre Toxicol, 2015, 12: 19.
24.	Lu K, Lai KP, Stoeger T, et al. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology[J]. J Hazard Mater, 2021, 416: 126069.
25.	Rudolph J, V?lkl M, Jér?me V , et al. Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells[J]. Sci Rep, 2021, 11(1): 15702.
26.	Champion JA, Walker A, Mitragotri S. Role of particle size in phagocytosis of polymeric microspheres[J]. Pharm Res, 2008, 25(8): 1815-1821.
27.	Delaney S, Rodriguez C, Sarrett SM , et al. Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging[J]. Sci Total Environ, 2023, 904: 166320.
28.	Xu MM, Chen JY, Gao L , et al. Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway[J]. Ecotoxicol Environ Saf, 2025, 291: 117828.
29.	Dong CD, Chen CW, Chen Y C , et al. Polystyrene microplastic particles: in vitro pulmonary toxicity assessment[J]. J Hazard Mater, 2020, 385: 121575.
30.	Gosselink IF, van Schooten FJ, Drittij MJ , et al. Assessing toxicity of amorphous nanoplastics in airway- and lung epithelial cells using air-liquid interface models[J]. Chemosphere, 2024, 368: 143702.
31.	Luo HJ, Xiao T, Sun XX, et al. The regulation of circRNA_kif26b on alveolar epithelial cell senescence via miR-346-3p is involved in microplastics-induced lung injuries[J]. Sci Total Environ, 2023, 882: 163512.
32.	Shahzadi C, Di Serafino A, Aruffo E , et al. A549 as an in vitro model to evaluate the impact of microplastics in the air[J]. Biology-Basel, 2023, 12(9): 1243.
33.	Goodman KE, Hare JT, Khamis ZI , et al. Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes[J]. Chem Res Toxicol, 2021, 34(4): 1069-1081.
34.	Yang S, Zhang T, Ge Y, et al. Sentinel supervised lung-on-a-chip: A new environmental toxicology platform for nanoplastic-induced lung injury[J]. J Hazard Mater, 2023, 458: 131962.
35.	呂垚, 張瑞, 崔慧杰, 等. 慢性阻塞性肺疾病風險因素的研究進展[J]. 中國呼吸與危重監護雜志, 2026, 25(2): 142-147.
36.	Lu WF, Li XL, Wang SG , et al. New evidence of microplastics in the lower respiratory tract: inhalation through smoking[J]. Environ Sci Technol, 2023, 57(23): 8496-8505.
37.	Qiu L, Lu WF, Tu CL , et al. Evidence of microplastics in bronchoalveolar lavage fluid among never-smokers: a prospective case series[J]. Environ Sci Technol, 2023, 57(6): 2435-2444.
38.	Chen C, Liu F, Quan S, et al. Microplastics in the bronchoalveolar lavage fluid of Chinese children: associations with age, city development, and disease features[J]. Environ Sci Technol, 2023, 57(34): 12594-12601.
39.	Tuna A, Ta? BM, Ba?aran Kank?l?? G , et al. Detection of microplastics in patients with allergic rhinitis[J]. Eur Arch Otorhinolaryngol, 2023, 280(12): 5363-5367.
40.	Han Q, Gao X, Wang SW , et al. Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway[J]. Toxicol Lett, 2023, 384: 73-85.
41.	Hu JQ, Wang CC, Ma RX, et al. Co-exposure to polyethylene microplastics and house dust mites aggravates airway epithelial barrier dysfunction and airway inflammation via CXCL1 signaling pathway in a mouse model[J]. Int Immunopharmacol, 2025, 146: 113921.
42.	Paplińska-Goryca M, Misiukiewicz-St?pień P, Wróbel M , et al. The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD[J]. Sci Rep, 2025, 15(1): 4242.
43.	Wu Q, Li R, You Y, et al. Lung microbiota participated in fibrous microplastics (MPs) aggravating OVA-induced asthma disease in mice[J]. Food Chem Toxicol, 2024, 190: 114776.
44.	Lim D, Jeong J, Song KS, et al. Inhalation toxicity of polystyrene micro(nano)plastics using modified OECD TG 412[J]. Chemosphere, 2021, 262: 128330.
45.	Li X, Zhang T, Lv W, et al. Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice[J]. Ecotoxicol Environ Saf, 2022, 232: 113238.
46.	Li YT, Shi T, Li X, et al. Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement[J]. Environ Int, 2022, 164: 107257.
47.	Cao J, Xu R, Geng Y, et al. Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-kappaB signal in mice[J]. Environ Pollut, 2023, 320: 121068.
48.	Zhang JM, Du JZ, Liu DY , et al. Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling[J]. Ecotoxicol Environ Saf, 2024, 277: 116357.
49.	Pauly JL, Stegmeier SJ, Allaart HA , et al. Inhaled cellulosic and plastic fibers found in human lung tissue[J]. Cancer Epidemiol Biomarkers Prev, 1998, 7(5): 419-428.
50.	Chen Q, Gao J, Yu H, et al. An emerging role of microplastics in the etiology of lung ground glass nodules[J]. Environ Sci Eur, 2022, 34(1): 25.
51.	Deng X, Gui Y, Zhao L. The micro(nano)plastics perspective: exploring cancer development and therapy[J]. Mol Cancer, 2025, 24(1): 30.
52.	Gutiérrez-García J, Egea R, Barguilla I , et al. Long-term exposure to real-life polyethylene terephthalate nanoplastics induces carcinogenesis in vitro[J]. Environ Sci Technol, 2025, 59(22): 10891-10904.
53.	Lee Y, Heo SE, Park K, et al. Amplified lung cancer hazards from surface defects in aged polypropylene microplastics[J]. Chem Eng J, 2025, 514: 163302.
54.	Oraee S, Alinejadfard M, Mahdavi S, et al. The association between micro- and nano-plastics and cardiovascular outcomes: a comprehensive review[J]. Toxicol Environ Health Sci, 2025, 17(2): 203-218.
55.	Rajendran D, Chandrasekaran N. Journey of micronanoplastics with blood components[J]. RSC Adv, 2023, 13(45): 31435-31459.
56.	Wang TT, Yi ZH, Liu XQ , et al. Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites[J]. EBioMedicine, 2024, 103: 105118.

1. Landrigan PJ, Raps H, Cropper M, et al. The minderoo-monaco commission on plastics and human health[J]. Ann Glob Health, 2023, 89(1): 23.
2. Thompson RC, Olsen Y, Mitchell RP , et al. Lost at sea: Where is all the plastic[J]? Science, 2004, 304(5672): 838-838.
3. Napper IE, Thompson R. Plastic debris in the marine environment: history and future challenges[J]. Glob Chall, 2020, 4(6): 1900081.
4. World Health Organization. Dietary and inhalation exposure to nano- and microplastic particles and potential implications for human health. (World Health Organization, Geneva, 2022).
5. Khan A, Jia ZQ. Recent insights into uptake, toxicity, and molecular targets of microplastics and nanoplastics relevant to human health impacts[J]. Iscience, 2023, 26(2): 106061.
6. Wootton N, Reis-Santos P, Gillanders BM. Microplastic in fish - A global synthesis[J]. Rev Fish Biol Fisher, 2021, 31(4): 753-771.
7. O?mann BE, Sarau G, Holtmannsp?tter H , et al. Small-sized microplastics and pigmented particles in bottled mineral water[J]. Water Res, 2018, 141: 307-316.
8. Akhbarizadeh R, Dobaradaran S, Schmidt TC , et al. Worldwide bottled water occurrence of emerging contaminants: a review of the recent scientific literature[J]. J Hazard Mater, 2020, 392: 122271.
9. Danopoulos E, Twiddy M, Rotchell JM. Microplastic contamination of drinking water: a systematic review[J]. PLoS One, 2020, 15(7): e0236838.
10. Cox KD, Covernton GA, Davies HL , et al. Human consumption of microplastics[J]. Environ Sci Technol, 2019, 53(12): 7068-7074.
11. Jenner LC, Rotchell JM, Bennett RT , et al. Detection of microplastics in human lung tissue using μFTIR spectroscopy[J]. Sci Total Environ, 2022, 831: 154907.
12. Zhang Q, Xu EG, Li JN , et al. A review of microplastics in table salt, drinking water, and air: direct human exposure[J]. Environ Sci Technol, 2020, 54(7): 3740-3751.
13. Kacprzak S, Tijing LD. Microplastics in indoor environment: Sources, mitigation and fate[J]. J Environ Chem Eng, 2022, 10(2): 107359.
14. Guerranti C, Martellini T, Perra G , et al. Microplastics in cosmetics: environmental issues and needs for global bans[J]. Environ Toxicol Pharmacol, 2019, 68: 75-79.
15. Hernandez LM, Yousefi N, Tufenkji N. Are there nanoplastics in your personal care products?[J]. Environ Sci Technol Lett, 2017, 4(7): 280-285.
16. Wright SL, Kelly FJ. Plastic and human health: a micro issue?[J]. Environ Sci Technol, 2017, 51(12): 6634-6647.
17. Yee MSL, Hii LW, Looi CK , et al. Impact of microplastics and nanoplastics on human health[J]. Nanomaterials, 2021, 11(2): 496.
18. Weng Y, Yan H, Nan X , et al. Potential health risks of microplastic fibres release from disposable surgical masks: impact of repeated wearing and handling[J]. J Hazard Mater, 2024, 470: 134219.
19. Liu S, Yang YX, Du ZY , et al. Percutaneous coronary intervention leads to microplastics entering the blood: interventional devices are a major source[J]. J Hazard Mater, 2024, 476: 135054.
20. Yang YX, Xie EZH, Du ZY , et al. Detection of various microplastics in patients undergoing cardiac surgery[J]. Environ Sci Technol, 2023, 57(30): 10911-10918.
21. Zheng X, Feng Q, Guo L. Quantitative analysis of microplastics and nanoplastics released from disposable PVC infusion tubes[J]. J Hazard Mater, 2024, 465: 133246.
22. Mou L, Wu CL, Li R , et al. Rapid detection of microplastics/nanoplastics directly exposed to blood during intravenous injections via mie scattering spectra[J]. J Hazard Mater, 2024, 480: 136193.
23. Ruenraroengsak P, Tetley TD. Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells[J]. Part Fibre Toxicol, 2015, 12: 19.
24. Lu K, Lai KP, Stoeger T, et al. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology[J]. J Hazard Mater, 2021, 416: 126069.
25. Rudolph J, V?lkl M, Jér?me V , et al. Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells[J]. Sci Rep, 2021, 11(1): 15702.
26. Champion JA, Walker A, Mitragotri S. Role of particle size in phagocytosis of polymeric microspheres[J]. Pharm Res, 2008, 25(8): 1815-1821.
27. Delaney S, Rodriguez C, Sarrett SM , et al. Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging[J]. Sci Total Environ, 2023, 904: 166320.
28. Xu MM, Chen JY, Gao L , et al. Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway[J]. Ecotoxicol Environ Saf, 2025, 291: 117828.
29. Dong CD, Chen CW, Chen Y C , et al. Polystyrene microplastic particles: in vitro pulmonary toxicity assessment[J]. J Hazard Mater, 2020, 385: 121575.
30. Gosselink IF, van Schooten FJ, Drittij MJ , et al. Assessing toxicity of amorphous nanoplastics in airway- and lung epithelial cells using air-liquid interface models[J]. Chemosphere, 2024, 368: 143702.
31. Luo HJ, Xiao T, Sun XX, et al. The regulation of circRNA_kif26b on alveolar epithelial cell senescence via miR-346-3p is involved in microplastics-induced lung injuries[J]. Sci Total Environ, 2023, 882: 163512.
32. Shahzadi C, Di Serafino A, Aruffo E , et al. A549 as an in vitro model to evaluate the impact of microplastics in the air[J]. Biology-Basel, 2023, 12(9): 1243.
33. Goodman KE, Hare JT, Khamis ZI , et al. Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes[J]. Chem Res Toxicol, 2021, 34(4): 1069-1081.
34. Yang S, Zhang T, Ge Y, et al. Sentinel supervised lung-on-a-chip: A new environmental toxicology platform for nanoplastic-induced lung injury[J]. J Hazard Mater, 2023, 458: 131962.
35. 呂垚, 張瑞, 崔慧杰, 等. 慢性阻塞性肺疾病風險因素的研究進展[J]. 中國呼吸與危重監護雜志, 2026, 25(2): 142-147.
36. Lu WF, Li XL, Wang SG , et al. New evidence of microplastics in the lower respiratory tract: inhalation through smoking[J]. Environ Sci Technol, 2023, 57(23): 8496-8505.
37. Qiu L, Lu WF, Tu CL , et al. Evidence of microplastics in bronchoalveolar lavage fluid among never-smokers: a prospective case series[J]. Environ Sci Technol, 2023, 57(6): 2435-2444.
38. Chen C, Liu F, Quan S, et al. Microplastics in the bronchoalveolar lavage fluid of Chinese children: associations with age, city development, and disease features[J]. Environ Sci Technol, 2023, 57(34): 12594-12601.
39. Tuna A, Ta? BM, Ba?aran Kank?l?? G , et al. Detection of microplastics in patients with allergic rhinitis[J]. Eur Arch Otorhinolaryngol, 2023, 280(12): 5363-5367.
40. Han Q, Gao X, Wang SW , et al. Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway[J]. Toxicol Lett, 2023, 384: 73-85.
41. Hu JQ, Wang CC, Ma RX, et al. Co-exposure to polyethylene microplastics and house dust mites aggravates airway epithelial barrier dysfunction and airway inflammation via CXCL1 signaling pathway in a mouse model[J]. Int Immunopharmacol, 2025, 146: 113921.
42. Paplińska-Goryca M, Misiukiewicz-St?pień P, Wróbel M , et al. The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD[J]. Sci Rep, 2025, 15(1): 4242.
43. Wu Q, Li R, You Y, et al. Lung microbiota participated in fibrous microplastics (MPs) aggravating OVA-induced asthma disease in mice[J]. Food Chem Toxicol, 2024, 190: 114776.
44. Lim D, Jeong J, Song KS, et al. Inhalation toxicity of polystyrene micro(nano)plastics using modified OECD TG 412[J]. Chemosphere, 2021, 262: 128330.
45. Li X, Zhang T, Lv W, et al. Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice[J]. Ecotoxicol Environ Saf, 2022, 232: 113238.
46. Li YT, Shi T, Li X, et al. Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement[J]. Environ Int, 2022, 164: 107257.
47. Cao J, Xu R, Geng Y, et al. Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-kappaB signal in mice[J]. Environ Pollut, 2023, 320: 121068.
48. Zhang JM, Du JZ, Liu DY , et al. Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling[J]. Ecotoxicol Environ Saf, 2024, 277: 116357.
49. Pauly JL, Stegmeier SJ, Allaart HA , et al. Inhaled cellulosic and plastic fibers found in human lung tissue[J]. Cancer Epidemiol Biomarkers Prev, 1998, 7(5): 419-428.
50. Chen Q, Gao J, Yu H, et al. An emerging role of microplastics in the etiology of lung ground glass nodules[J]. Environ Sci Eur, 2022, 34(1): 25.
51. Deng X, Gui Y, Zhao L. The micro(nano)plastics perspective: exploring cancer development and therapy[J]. Mol Cancer, 2025, 24(1): 30.
52. Gutiérrez-García J, Egea R, Barguilla I , et al. Long-term exposure to real-life polyethylene terephthalate nanoplastics induces carcinogenesis in vitro[J]. Environ Sci Technol, 2025, 59(22): 10891-10904.
53. Lee Y, Heo SE, Park K, et al. Amplified lung cancer hazards from surface defects in aged polypropylene microplastics[J]. Chem Eng J, 2025, 514: 163302.
54. Oraee S, Alinejadfard M, Mahdavi S, et al. The association between micro- and nano-plastics and cardiovascular outcomes: a comprehensive review[J]. Toxicol Environ Health Sci, 2025, 17(2): 203-218.
55. Rajendran D, Chandrasekaran N. Journey of micronanoplastics with blood components[J]. RSC Adv, 2023, 13(45): 31435-31459.
56. Wang TT, Yi ZH, Liu XQ , et al. Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites[J]. EBioMedicine, 2024, 103: 105118.

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