PRDX6在呼吸系統疾病中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

常錦雯 ¹ , 陳琪文 ² , 楊蕊吉 ² , 孫媛淵 ¹ ,  趙利芳 ²

1. ;
2. ;

Corresponding?author：

趙利芳, Email: zhaolifang@sxmu.edu.cn

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DOI：

10.7507/1671-6205.202501036

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Citation： 常錦雯, 陳琪文, 楊蕊吉, 孫媛淵, 趙利芳. PRDX6在呼吸系統疾病中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2025, 24(11): 826-830. doi: 10.7507/1671-6205.202501036 Copy

1.	Rahaman H, Herojit K, Singh LR, et al. Structural and functional diversity of the peroxiredoxin 6 enzyme family. Antioxid Redox Signal, 2024, 40(13-15): 759-775.
2.	Patel P, Chatterjee S. Peroxiredoxin6 in endothelial signaling. Antioxidants(Basel), 2019, 8(3): 63.
3.	Kim KH, Lee W, Kim EE. Crystal structures of human peroxiredoxin 6 in different oxidation states. Biochem Biophys Res Commun, 2016, 477(4): 717-722.
4.	Chowhan RK, Hotumalani S, Rahaman H, et al. pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature. Sci Rep, 2021, 11(1): 9657.
5.	Ellison MA, Thurman GW, Ambruso DR. Phox activity of differentiated PLB-985 cells is enhanced, in an agonist specific manner, by the PLA₂ activity of Prdx6-PLA₂. Eur J Immunol, 2012, 42(6): 1609-1617.
6.	Jia W, Dong C, Li B. Anti-oxidant and pro-oxidant effects of peroxiredoxin 6: a potential target in respiratory diseases. Cells, 2023, 12(1): 181.
7.	Paluchova V, Cajka T, Durand T, et al. The role of peroxiredoxin 6 in biosynthesis of FAHFAs. Free Radic Biol Med, 2022, 193(Pt 2): 787-794.
8.	Arevalo JA, Vázquez-Medina JP. The role of peroxiredoxin 6 in cell signaling. Antioxidants(Basel), 2018, 7(12): 172.
9.	Chen JW, Dodia C, Feinstein SI, et al. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A₂ activities. J Biol Chem, 2000, 275(37): 28421-28427.
10.	Fisher AB, Dodia C, Chatterjee S. A peptide inhibitor of peroxiredoxin 6 phospholipase A₂ activity significantly protects against lung injury in a mouse model of ventilator induced lung injury(VILI). Antioxidants(Basel), 2021, 10(6): 925.
11.	Fisher AB, Dodia C, Yu K, et al. Lung phospholipid metabolism in transgenic mice overexpressing peroxiredoxin 6. Biochim Biophys Acta, 2006, 1761(7): 785-792.
12.	Fisher AB, Vasquez-Medina JP, Dodia C, et al. Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes. Redox Biol, 2018, 14: 41-46.
13.	Fisher AB. Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling. Arch Biochem Biophys, 2017, 617: 68-83.
14.	Salovska B, Kondelova A, Pimkova K, et al. Peroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape. Redox Biol, 2022, 49: 102212.
15.	Torres-Velarde JM, Allen KN, Salvador-Pascual A, et al. Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells. Free Radic Biol Med, 2024, 218: 82-93.
16.	Shen W, Yang L, Yang Y, et al. PRDX6 promotes fatty acid oxidation via PLA₂-dependent PPARαactivation in rats fed high-fat diet. Antioxid Redox Signal, 2023, 38(16-18): 1184-1200.
17.	Chatterjee S, Feinstein SI, Dodia C, et al. Peroxiredoxin 6 phosphorylation and subsequent phospholipase A₂ activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages. J Biol Chem, 2011, 286(13): 11696-11706.
18.	Fisher AB, Dodia C, Sorokina EM, et al. A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6. J Lipid Res, 2016, 57(4): 587-596.
19.	謝浩杰, 魯明麗, 張陳, 等. 基于深度學習的肺結核檢測綜述. 中國醫學物理學雜志, 2024, 41(07): 918-924.
20.	李繼榮, 王志堅, 陶保菊. 潛伏期結核感染研究進展. 醫學理論與實踐, 2023, 36(3): 394-396.
21.	楊華, 戈寶學. 結核性肉芽腫的代謝免疫調控機制研究進展. 生物醫學轉化, 2024, 5(02): 91-99.
22.	王鵬, 尹斌, 蘇映軍, 等. 結核分枝桿菌介導泡沫細胞形成機制的研究進展. 中華微生物學和免疫學雜志, 2020, 40(2): 154-159.
23.	應池清, 何暢, 徐凱進, 等. 結核潛伏感染診治進展. 浙江大學學報(醫學版), 2022, 51(6): 691-696.
24.	Schwab U, Rohde KH, Wang Z, et al. Transcriptional responses of Mycobacterium tuberculosis to lung surfactant. Microb Pathog, 2009, 46(4): 185-193.
25.	Lien YC, Feinstein SI, Dodia C, et al. The roles of peroxidase and phospholipase A₂ activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress. Antioxid Redox Signal, 2012, 16(5): 440-451.
26.	謝如眉, 李家康, 姚萌格, 等. PRDX6在心血管疾病中的研究進展. 中國動脈硬化雜志, 2024, 32(11): 932-938.
27.	肖雪瑩. MANF通過抑制PRDX6-ROS-GSDMD通路改善急性肺損傷. 安徽醫科大學, 2023.
28.	Russell DG, Huang L, VanderVen BC. Immunometabolism at the interface between macrophages and pathogens. Nat Rev Immunol, 2019, 19(5): 291-304.
29.	Wang X, An X, Wang X, et al. Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury. Int Immunopharmacol, 2019, 68: 252-258.
30.	Yang D, Song Y, Wang X, et al. Deletion of peroxiredoxin 6 potentiates lipopolysaccharide-induced acute lung injury in mice. Crit Care Med, 2011, 39(4): 756-764.
31.	Li HT, Tan F, Zhang TH, et al. Peroxiredoxin 6 mediates the protective function of curcumin pretreatment in acute lung injury induced by serum from patients undergoing one-lung ventilation in vitro. BMC Pulm Med, 2022, 22(1): 192.
32.	Vázquez-Medina JP, Tao JQ, Patel P, et al. Genetic inactivation of the phospholipase A₂ activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol, 2019, 316(4): L656-L668.
33.	Benipal B, Feinstein SI, Chatterjee S, et al. Inhibition of the phospholipase A₂ activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia. Redox Biol, 2015, 4: 321-327.
34.	Yang X, Xiao X, Zhou L, et al. Involvement of PRDX6 in the protective role of MANF in acute lung injury in rats. Exp Lung Res, 2025, 51(1): 1-10.
35.	Dong C, Li B, Yang D, et al. Peroxiredoxin 6-mediated negative regulation of MUC5AC hyper-production and secretion during asthma. American Thoracic Society International Conference, 2012, 185: 1.
36.	Kim SY, Jo HY, Kim MH, et al. H₂O₂-dependent hyperoxidation of peroxiredoxin 6(Prdx6)plays a role in cellular toxicity via up-regulation of iPLA₂ activity. J Biol Chem, 2008, 283(48): 33563-33568.
37.	Kwon HS, Bae YJ, Moon KA, et al. Hyperoxidized peroxiredoxins in peripheral blood mononuclear cells of asthma patients is associated with asthma severity. Life Sci, 2012, 90(13-14): 502-508.
38.	Shim HJ, Park SY, Kwon HS, et al. Oxidative stress modulates the expression pattern of peroxiredoxin-6 in peripheral blood mononuclear cells of asthmatic patients and bronchial epithelial cells. Allergy Asthma Immunol Res, 2020, 12(3): 523-536.
39.	Dong C, Li B, Yang D, et al. Over-expression of peroxiredoxin 6 protect mice from ovalbumin-induced airway inflammation and hypersecretion of MUC5AC by reducing ROS levels. Annual Congress of Chinese Thoracic Society, 2011, 38: 970.
40.	Wei T, Wang X, Lang K, et al. Peroxiredoxin 6 protects pulmonary epithelial cells from cigarette-related ferroptosis in chronic obstructive pulmonary disease. Inflammation, 2025, 48(2): 662-675.
41.	孫江, 高駿飛, 楊培草, 等. 外周血PRDX6與穩定期COPD患者臨床特征及頻繁急性加重的關系. 國際呼吸雜志, 2022, 42(17): 1306-1312.
42.	徐文雨, 朱默然, 徐春燕等. 過氧化還原蛋白6在慢性阻塞性肺疾病中的表達. 復旦學報(醫學版), 2022, 49(3): 466-468.
43.	Hewlett CJ, Kropski AJ, Blackwell ST. Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets. Matrix Biol, 2018, 71-72: 112-127.
44.	Wang Y, Feinstein SI, Fisher AB. Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H₂O₂-induced oxidative stress. J Cell Biochem, 2008, 104(4): 1274-1285.
45.	原銘貞, 高廣媛, 李波, 等. 過氧化物酶6與肺部炎癥性疾病關系的研究進展. 吉林大學學報(醫學版), 2014, 40(1): 210-214.
46.	Yun HM, Park KR, Park MH, et al. PRDX6 promotes tumor development via the JAK2/STAT3 pathway in a urethane-induced lung tumor model. Free Radic Biol Med, 2015, 80: 136-144.
47.	Marques RE, Guabiraba R, Russo RC, et al. Targeting CCL5 in inflammation. Expert Opin Ther Targets, 2013, 17(12): 1439-1460.
48.	Jo M, Yun HM, Park KR, et al. Lung tumor growth-promoting function of peroxiredoxin 6. Free Radic Biol Med, 2013, 61: 453-463.
49.	Li Z, Xiao J, Liu M, et al. Notch3 regulates ferroptosis via ROS-induced lipid peroxidation in NSCLC cells. FEBS Open Bio, 2022, 12(6): 1197-1205.
50.	Guo Q, Zhao M, Wang Q, et al. Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6-and caspase-3-mediated mitochondrial apoptosis. Biomed Pharmacother, 2024, 173: 116304.
51.	Jo M, Yun HM, Park KR, et al. Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6. PLoS One, 2014, 9(3): e91508.
52.	Chen C, Gong L, Liu X, et al. Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biol, 2021, 46: 102130.

1. Rahaman H, Herojit K, Singh LR, et al. Structural and functional diversity of the peroxiredoxin 6 enzyme family. Antioxid Redox Signal, 2024, 40(13-15): 759-775.
2. Patel P, Chatterjee S. Peroxiredoxin6 in endothelial signaling. Antioxidants(Basel), 2019, 8(3): 63.
3. Kim KH, Lee W, Kim EE. Crystal structures of human peroxiredoxin 6 in different oxidation states. Biochem Biophys Res Commun, 2016, 477(4): 717-722.
4. Chowhan RK, Hotumalani S, Rahaman H, et al. pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature. Sci Rep, 2021, 11(1): 9657.
5. Ellison MA, Thurman GW, Ambruso DR. Phox activity of differentiated PLB-985 cells is enhanced, in an agonist specific manner, by the PLA₂ activity of Prdx6-PLA₂. Eur J Immunol, 2012, 42(6): 1609-1617.
6. Jia W, Dong C, Li B. Anti-oxidant and pro-oxidant effects of peroxiredoxin 6: a potential target in respiratory diseases. Cells, 2023, 12(1): 181.
7. Paluchova V, Cajka T, Durand T, et al. The role of peroxiredoxin 6 in biosynthesis of FAHFAs. Free Radic Biol Med, 2022, 193(Pt 2): 787-794.
8. Arevalo JA, Vázquez-Medina JP. The role of peroxiredoxin 6 in cell signaling. Antioxidants(Basel), 2018, 7(12): 172.
9. Chen JW, Dodia C, Feinstein SI, et al. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A₂ activities. J Biol Chem, 2000, 275(37): 28421-28427.
10. Fisher AB, Dodia C, Chatterjee S. A peptide inhibitor of peroxiredoxin 6 phospholipase A₂ activity significantly protects against lung injury in a mouse model of ventilator induced lung injury(VILI). Antioxidants(Basel), 2021, 10(6): 925.
11. Fisher AB, Dodia C, Yu K, et al. Lung phospholipid metabolism in transgenic mice overexpressing peroxiredoxin 6. Biochim Biophys Acta, 2006, 1761(7): 785-792.
12. Fisher AB, Vasquez-Medina JP, Dodia C, et al. Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes. Redox Biol, 2018, 14: 41-46.
13. Fisher AB. Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling. Arch Biochem Biophys, 2017, 617: 68-83.
14. Salovska B, Kondelova A, Pimkova K, et al. Peroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape. Redox Biol, 2022, 49: 102212.
15. Torres-Velarde JM, Allen KN, Salvador-Pascual A, et al. Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells. Free Radic Biol Med, 2024, 218: 82-93.
16. Shen W, Yang L, Yang Y, et al. PRDX6 promotes fatty acid oxidation via PLA₂-dependent PPARαactivation in rats fed high-fat diet. Antioxid Redox Signal, 2023, 38(16-18): 1184-1200.
17. Chatterjee S, Feinstein SI, Dodia C, et al. Peroxiredoxin 6 phosphorylation and subsequent phospholipase A₂ activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages. J Biol Chem, 2011, 286(13): 11696-11706.
18. Fisher AB, Dodia C, Sorokina EM, et al. A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6. J Lipid Res, 2016, 57(4): 587-596.
19. 謝浩杰, 魯明麗, 張陳, 等. 基于深度學習的肺結核檢測綜述. 中國醫學物理學雜志, 2024, 41(07): 918-924.
20. 李繼榮, 王志堅, 陶保菊. 潛伏期結核感染研究進展. 醫學理論與實踐, 2023, 36(3): 394-396.
21. 楊華, 戈寶學. 結核性肉芽腫的代謝免疫調控機制研究進展. 生物醫學轉化, 2024, 5(02): 91-99.
22. 王鵬, 尹斌, 蘇映軍, 等. 結核分枝桿菌介導泡沫細胞形成機制的研究進展. 中華微生物學和免疫學雜志, 2020, 40(2): 154-159.
23. 應池清, 何暢, 徐凱進, 等. 結核潛伏感染診治進展. 浙江大學學報(醫學版), 2022, 51(6): 691-696.
24. Schwab U, Rohde KH, Wang Z, et al. Transcriptional responses of Mycobacterium tuberculosis to lung surfactant. Microb Pathog, 2009, 46(4): 185-193.
25. Lien YC, Feinstein SI, Dodia C, et al. The roles of peroxidase and phospholipase A₂ activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress. Antioxid Redox Signal, 2012, 16(5): 440-451.
26. 謝如眉, 李家康, 姚萌格, 等. PRDX6在心血管疾病中的研究進展. 中國動脈硬化雜志, 2024, 32(11): 932-938.
27. 肖雪瑩. MANF通過抑制PRDX6-ROS-GSDMD通路改善急性肺損傷. 安徽醫科大學, 2023.
28. Russell DG, Huang L, VanderVen BC. Immunometabolism at the interface between macrophages and pathogens. Nat Rev Immunol, 2019, 19(5): 291-304.
29. Wang X, An X, Wang X, et al. Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury. Int Immunopharmacol, 2019, 68: 252-258.
30. Yang D, Song Y, Wang X, et al. Deletion of peroxiredoxin 6 potentiates lipopolysaccharide-induced acute lung injury in mice. Crit Care Med, 2011, 39(4): 756-764.
31. Li HT, Tan F, Zhang TH, et al. Peroxiredoxin 6 mediates the protective function of curcumin pretreatment in acute lung injury induced by serum from patients undergoing one-lung ventilation in vitro. BMC Pulm Med, 2022, 22(1): 192.
32. Vázquez-Medina JP, Tao JQ, Patel P, et al. Genetic inactivation of the phospholipase A₂ activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol, 2019, 316(4): L656-L668.
33. Benipal B, Feinstein SI, Chatterjee S, et al. Inhibition of the phospholipase A₂ activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia. Redox Biol, 2015, 4: 321-327.
34. Yang X, Xiao X, Zhou L, et al. Involvement of PRDX6 in the protective role of MANF in acute lung injury in rats. Exp Lung Res, 2025, 51(1): 1-10.
35. Dong C, Li B, Yang D, et al. Peroxiredoxin 6-mediated negative regulation of MUC5AC hyper-production and secretion during asthma. American Thoracic Society International Conference, 2012, 185: 1.
36. Kim SY, Jo HY, Kim MH, et al. H₂O₂-dependent hyperoxidation of peroxiredoxin 6(Prdx6)plays a role in cellular toxicity via up-regulation of iPLA₂ activity. J Biol Chem, 2008, 283(48): 33563-33568.
37. Kwon HS, Bae YJ, Moon KA, et al. Hyperoxidized peroxiredoxins in peripheral blood mononuclear cells of asthma patients is associated with asthma severity. Life Sci, 2012, 90(13-14): 502-508.
38. Shim HJ, Park SY, Kwon HS, et al. Oxidative stress modulates the expression pattern of peroxiredoxin-6 in peripheral blood mononuclear cells of asthmatic patients and bronchial epithelial cells. Allergy Asthma Immunol Res, 2020, 12(3): 523-536.
39. Dong C, Li B, Yang D, et al. Over-expression of peroxiredoxin 6 protect mice from ovalbumin-induced airway inflammation and hypersecretion of MUC5AC by reducing ROS levels. Annual Congress of Chinese Thoracic Society, 2011, 38: 970.
40. Wei T, Wang X, Lang K, et al. Peroxiredoxin 6 protects pulmonary epithelial cells from cigarette-related ferroptosis in chronic obstructive pulmonary disease. Inflammation, 2025, 48(2): 662-675.
41. 孫江, 高駿飛, 楊培草, 等. 外周血PRDX6與穩定期COPD患者臨床特征及頻繁急性加重的關系. 國際呼吸雜志, 2022, 42(17): 1306-1312.
42. 徐文雨, 朱默然, 徐春燕等. 過氧化還原蛋白6在慢性阻塞性肺疾病中的表達. 復旦學報(醫學版), 2022, 49(3): 466-468.
43. Hewlett CJ, Kropski AJ, Blackwell ST. Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets. Matrix Biol, 2018, 71-72: 112-127.
44. Wang Y, Feinstein SI, Fisher AB. Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H₂O₂-induced oxidative stress. J Cell Biochem, 2008, 104(4): 1274-1285.
45. 原銘貞, 高廣媛, 李波, 等. 過氧化物酶6與肺部炎癥性疾病關系的研究進展. 吉林大學學報(醫學版), 2014, 40(1): 210-214.
46. Yun HM, Park KR, Park MH, et al. PRDX6 promotes tumor development via the JAK2/STAT3 pathway in a urethane-induced lung tumor model. Free Radic Biol Med, 2015, 80: 136-144.
47. Marques RE, Guabiraba R, Russo RC, et al. Targeting CCL5 in inflammation. Expert Opin Ther Targets, 2013, 17(12): 1439-1460.
48. Jo M, Yun HM, Park KR, et al. Lung tumor growth-promoting function of peroxiredoxin 6. Free Radic Biol Med, 2013, 61: 453-463.
49. Li Z, Xiao J, Liu M, et al. Notch3 regulates ferroptosis via ROS-induced lipid peroxidation in NSCLC cells. FEBS Open Bio, 2022, 12(6): 1197-1205.
50. Guo Q, Zhao M, Wang Q, et al. Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6-and caspase-3-mediated mitochondrial apoptosis. Biomed Pharmacother, 2024, 173: 116304.
51. Jo M, Yun HM, Park KR, et al. Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6. PLoS One, 2014, 9(3): e91508.
52. Chen C, Gong L, Liu X, et al. Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer. Redox Biol, 2021, 46: 102130.

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PRDX6在呼吸系統疾病中的研究進展

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