氣管支氣管骨化癥合并慢性阻塞性肺疾病一例報告_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

石磊 , 夏茸 , 王丹 , 魏海東 ,  石軍年

蘭州大學第二醫院蘭州大學第二臨床醫學院（甘肅蘭州 730030）;

Corresponding?author：

石軍年, Email: shijn@lzu.edu.cn

Keywords：

DOI：

10.7507/1671-6205.202408040

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Citation： 石磊, 夏茸, 王丹, 魏海東, 石軍年. 氣管支氣管骨化癥合并慢性阻塞性肺疾病一例報告. Chinese Journal of Respiratory and Critical Care Medicine, 2026, 25(2): 125-130. doi: 10.7507/1671-6205.202408040 Copy

1.	Lim SY, Abu Samah MF, Pereirasamy L, et al. Tracheobronchopathia osteochondroplastica-stalactite of airways. Respirol Case Rep, 2021, 9(7): e00790.
2.	Lundgren R, Stjernberg N L. Tracheobronchopathia osteochondroplastica. A clinical bronchoscopic and spirometric study. Chest, 1981, 80(6): 706-709.
3.	Nair A A, Gupta R, Irodi A, et al. Tracheobronchopathia Osteochondroplastica - to Biopsy or not to Biopsy? A Relook at The Rare Disease. J Bronchology Interv Pulmonol, 2024, 31(1): 57-62.
4.	Dall'Amico GF, Sharma D, Ritchie L, et al. Severe tracheobronchopathia osteochondroplastica in an asymptomatic patient. BMJ Case Rep, 2023, 16(4): e249976.
5.	Sun J, Xie L, Su X, et al. Tracheobronchopathia osteochondroplastica: Case report and literature review. Respir Med Case Rep, 2015, 15: 14-17.
6.	Jabbardarjani HR, Radpey B, Kharabian S, et al. Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature. Lung, 2008, 186(5): 293-29.
7.	Li D, Jin F, Nan Y, et al. Multi-nodule of large airway: tracheobronchopathia osteochondroplastica. Ann Palliat Med, 2021, 10(2): 1115-1121.
8.	Prakash UB. Tracheobronchopathia osteochondroplastica. Semin Respir Crit Care Med, 2002, 23(2): 167-175.
9.	骨化性氣管支氣管病. 中華結核和呼吸雜志, 2001(7): 33-35+71.
10.	Zhu Y, Wu N, Huang H D, et al. A clinical study of tracheobronchopathia osteochondroplastica: findings from a large Chinese cohort. PLoS One, 2014, 9(7): e102068.
11.	Liu Q, Hu Y, Lei M, et al. Clinical Characteristics of Tracheobronchopathia Osteochondroplastica: A Retrospective Study of 33 Patients. Int J Gen Med, 2023, 16: 3447-3455.
12.	Simsek PO, Ozcelik U, Demirkazik F, et al. Tracheobronchopathia osteochondroplastica in a 9-year-old girl. Pediatr Pulmonol, 2006, 41(1): 95-97.
13.	馬靜, 孟晨, 張忠曉, 等. 兒童氣管和支氣管骨化癥1例病例報告. 中國循證兒科雜志, 2014, 9(3): 220-222,.
14.	Dumazet A, Launois C, Lebargy F, et al. Tracheobronchopathia osteochondroplastica: clinical, bronchoscopic, and comorbid features in a case series. BMC Pulm Med, 2022, 22(1): 423.
15.	Co?tmeur D, Bovyn G, Leroux P, et al. Tracheobronchopathia osteochondroplastica presenting at the time of a difficult intubation. Respir Med, 1997, 91(8): 496-498.
16.	Abu-Hijleh M, Lee D, Braman SS. Tracheobronchopathia osteochondroplastica: a rare large airway disorder. Lung, 2008, 186(6): 353-9.
17.	Toth C. [Tracheopathia osteoplastica. A 100-year-old mystery]. Pathologe, 2012, 33(2): 129-134.
18.	Ashley DJ. Bony metaplasia in trachea and bronchi. J Pathol, 1970, 102(3): 186-18.
19.	Heo JW, Lee E G, Gil B, et al. Tracheobronchopathia Osteochondroplastica Associated with Fibrotic Interstitial Lung Disease. Intern Med, 2021, 60(21): 3463-3467,.
20.	Tajima K, Yamakawa M, Katagiri T, et al. Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica. Virchows Arch, 1997, 431(5): 359-363.
21.	羅莉, 馮妮, 肖陽寶, 等. 骨化性氣管支氣管病36例回顧性分析. 湖南師范大學學報(醫學版), 2020, 17(03): 30-32.
22.	Barthwal MS, Chatterji R S, Mehta A. Tracheobronchopathia osteochondroplastica. Indian J Chest Dis Allied Sci, 2004, 46(1): 43-6.
23.	Jepsen O, Sorensen H. Tracheopathia osteoplastica and ozaena. Acta Otolaryngol, 1960, 51: 79-83.
24.	Magro P, Garand G, Cattier B, et al. [Association of tracheobronchopathia osteochondroplastica and ozène]. Rev Mal Respir, 2007, 24(7): 883-887.
25.	Hong Y, Shan S, Gu Y, et al. Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica. Nat Commun, 2022, 13(1): 1309.
26.	劉靜靜, 劉媛華, 羅瀟, 等. 骨化性氣管支氣管病33例臨床分析. 鄭州大學學報(醫學版), 2023, 58(01): 125-129.
27.	Morax LS, Breitenmoser I, Konrad C J. Tracheobronchopathia osteochondroplastica: a rare cause of tracheal tube cuff leak. Anaesth Rep, 2023, 11(2): e12240.
28.	Miller ME, Lina I, Sateri S, et al. Impact of Tracheobronchopathia Osteochondroplastica on Difficult Intubation. OTO Open, 2023, 7(3): e81.
29.	Datta A, Ghosh S, Mohapatra PR. A rare case of hemoptysis. Lung India, 2022, 39(1): 80-81.
30.	Patel P M, Jean ME, Reich K, et al. Tracheobronchopathia Osteochondroplastica: A Rare, Underrecognized Entity. Cureus, 2022, 14(9): e28832.
31.	Devaraja K, Sagar P, Chirom AS. Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management. BMJ Case Rep, 2017, 2017: bcr2017220567.
32.	Rodriguez NJV, Manto JT, Sydiongco-Inocencio P M M, et al. Tracheobronchopathia osteochondroplastica: a case report highlighting the importance of clinico-radiologic correlation. BJR Case Rep, 2023, 9(6): 20230062.
33.	García CA, Sangiovanni S, Zú?iga-Restrepo V, et al. Tracheobronchopathia Osteochondroplastica-Clinical, Radiological, and Endoscopic Correlation: Case Series and Literature Review. J Investig Med High Impact Case Rep, 2020, 8: 2324709620921609.
34.	朱瑩, 鄔盛昌, 胥武劍, 等. 骨化性氣管支氣管病臨床分析. 中國呼吸與危重監護雜志, 2012, 11(6): 592-595.
35.	李興勝, 曹德生. 高分辨率CT薄層檢查對骨化性氣管支氣管病的診斷價值. 實用醫學影像雜志, 2021, 22(1): 73-74.
36.	Chien YC, Wang HC, Chang YC, et al. Uncommon chronic cough caused by tracheobronchopathia osteochondroplastica. Thorax, 2012, 67(11): 1021-1022.
37.	黃曉輝, 陳玲, 王作和, 等. 骨化性氣管支氣管病CT表現. 中國醫學影像學雜志, 2012, 20(8): 594-595.
38.	Li YY, Hu CP, Yang HZ, et al. [The diagnostic value of flexible bronchoscopy in tracheobronchopathia osteochondroplastica]. Zhonghua Jie He He Hu Xi Za Zhi, 2009, 32(7): 489-492.
39.	Doshi H, Thankachen R, Philip MA, et al. Tracheobronchopathia osteochondroplastica presenting as an isolated nodule in the right upper lobe bronchus with upper lobe collapse. J Thorac Cardiovasc Surg, 2005, 130(3): 901-902.
40.	Kirba? G, Da?li CE, Tanrikulu A , et al. Unusual combination of tracheobronchopathia osteochondroplastica and AA amyloidosis. Yonsei Med J, 2009, 50(5): 721-724.
41.	Ihara H, Tajima K, Yoshikawa H, et al. Autofluorescence imaging bronchoscopy as a novel approach to the management of tracheobronchopathia osteochondroplastica: a case report. J Thorac Dis, 2016, 8(10): e1195-e1198.
42.	Newton R, Kemp S, Zoumot Z, et al. An unusual case of haemoptysis. Thorax, 2010, 65(4): 309, 353.
43.	陳婷, 柳廣南. 氣管支氣管骨化癥的臨床診治進展. 中國醫藥指南, 2020, 18(19): 30-31.
44.	Ulasli SS, Kupeli E. Tracheobronchopathia osteochondroplastica: a review of the literature. Clin Respir J, 2015, 9(4): 386-391.
45.	Chen C, Tang F, Herth FJF, et al. Building and validating an artificial intelligence model to identify tracheobronchopathia osteochondroplastica by using bronchoscopic images. Ther Adv Respir Dis, 2024, 18: 17534666241253694.
46.	Cho HK, Jeong BH, Kim H. Clinical course of tracheobronchopathia osteochondroplastica. J Thorac Dis, 2020, 12(10): 5571-5579.
47.	Devaraja K, Surendra VU. Clinicopathological Features and Management Principles of Tracheobronchopathia Osteochondroplastica - A Scoping Review. Indian J Otolaryngol Head Neck Surg, 2023, 75(4): 3798-3814.
48.	Song JY, Kim B G, Zo S, et al. Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA). Respir Med Case Rep, 2020, 31: 101158.
49.	Dharia I, Bielamowicz S. Surgical Management in Tracheobronchopathia Osteochondroplastica: A Case Study. Laryngoscope, 2021, 131(3): e911-e913.
50.	Wang Y, Li X, Zhang J, et al. Bronchoscopic Intervention for Tracheobronchopathia Osteochondroplastica: A Report of Two Cases. Laryngoscope, 2024, 134(7): 3093-3095.
51.	Hirsch M, Tovi F, Goldstein J, et al. Diagnosis of tracheopathia osteoplastica by computed tomography. Ann Otol Rhinol Laryngol, 1985, 94(2 Pt 1): 217-219.
52.	Al Omari A, Al-Qarqaz W, Khresat M, et al. Tracheobronchopathia osteochondroplastica in the setting of COVID-19. Ear Nose Throat J, 2024, 103(1suppl): 98s-101s.

1. Lim SY, Abu Samah MF, Pereirasamy L, et al. Tracheobronchopathia osteochondroplastica-stalactite of airways. Respirol Case Rep, 2021, 9(7): e00790.
2. Lundgren R, Stjernberg N L. Tracheobronchopathia osteochondroplastica. A clinical bronchoscopic and spirometric study. Chest, 1981, 80(6): 706-709.
3. Nair A A, Gupta R, Irodi A, et al. Tracheobronchopathia Osteochondroplastica - to Biopsy or not to Biopsy? A Relook at The Rare Disease. J Bronchology Interv Pulmonol, 2024, 31(1): 57-62.
4. Dall'Amico GF, Sharma D, Ritchie L, et al. Severe tracheobronchopathia osteochondroplastica in an asymptomatic patient. BMJ Case Rep, 2023, 16(4): e249976.
5. Sun J, Xie L, Su X, et al. Tracheobronchopathia osteochondroplastica: Case report and literature review. Respir Med Case Rep, 2015, 15: 14-17.
6. Jabbardarjani HR, Radpey B, Kharabian S, et al. Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature. Lung, 2008, 186(5): 293-29.
7. Li D, Jin F, Nan Y, et al. Multi-nodule of large airway: tracheobronchopathia osteochondroplastica. Ann Palliat Med, 2021, 10(2): 1115-1121.
8. Prakash UB. Tracheobronchopathia osteochondroplastica. Semin Respir Crit Care Med, 2002, 23(2): 167-175.
9. 骨化性氣管支氣管病. 中華結核和呼吸雜志, 2001(7): 33-35+71.
10. Zhu Y, Wu N, Huang H D, et al. A clinical study of tracheobronchopathia osteochondroplastica: findings from a large Chinese cohort. PLoS One, 2014, 9(7): e102068.
11. Liu Q, Hu Y, Lei M, et al. Clinical Characteristics of Tracheobronchopathia Osteochondroplastica: A Retrospective Study of 33 Patients. Int J Gen Med, 2023, 16: 3447-3455.
12. Simsek PO, Ozcelik U, Demirkazik F, et al. Tracheobronchopathia osteochondroplastica in a 9-year-old girl. Pediatr Pulmonol, 2006, 41(1): 95-97.
13. 馬靜, 孟晨, 張忠曉, 等. 兒童氣管和支氣管骨化癥1例病例報告. 中國循證兒科雜志, 2014, 9(3): 220-222,.
14. Dumazet A, Launois C, Lebargy F, et al. Tracheobronchopathia osteochondroplastica: clinical, bronchoscopic, and comorbid features in a case series. BMC Pulm Med, 2022, 22(1): 423.
15. Co?tmeur D, Bovyn G, Leroux P, et al. Tracheobronchopathia osteochondroplastica presenting at the time of a difficult intubation. Respir Med, 1997, 91(8): 496-498.
16. Abu-Hijleh M, Lee D, Braman SS. Tracheobronchopathia osteochondroplastica: a rare large airway disorder. Lung, 2008, 186(6): 353-9.
17. Toth C. [Tracheopathia osteoplastica. A 100-year-old mystery]. Pathologe, 2012, 33(2): 129-134.
18. Ashley DJ. Bony metaplasia in trachea and bronchi. J Pathol, 1970, 102(3): 186-18.
19. Heo JW, Lee E G, Gil B, et al. Tracheobronchopathia Osteochondroplastica Associated with Fibrotic Interstitial Lung Disease. Intern Med, 2021, 60(21): 3463-3467,.
20. Tajima K, Yamakawa M, Katagiri T, et al. Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica. Virchows Arch, 1997, 431(5): 359-363.
21. 羅莉, 馮妮, 肖陽寶, 等. 骨化性氣管支氣管病36例回顧性分析. 湖南師范大學學報(醫學版), 2020, 17(03): 30-32.
22. Barthwal MS, Chatterji R S, Mehta A. Tracheobronchopathia osteochondroplastica. Indian J Chest Dis Allied Sci, 2004, 46(1): 43-6.
23. Jepsen O, Sorensen H. Tracheopathia osteoplastica and ozaena. Acta Otolaryngol, 1960, 51: 79-83.
24. Magro P, Garand G, Cattier B, et al. [Association of tracheobronchopathia osteochondroplastica and ozène]. Rev Mal Respir, 2007, 24(7): 883-887.
25. Hong Y, Shan S, Gu Y, et al. Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica. Nat Commun, 2022, 13(1): 1309.
26. 劉靜靜, 劉媛華, 羅瀟, 等. 骨化性氣管支氣管病33例臨床分析. 鄭州大學學報(醫學版), 2023, 58(01): 125-129.
27. Morax LS, Breitenmoser I, Konrad C J. Tracheobronchopathia osteochondroplastica: a rare cause of tracheal tube cuff leak. Anaesth Rep, 2023, 11(2): e12240.
28. Miller ME, Lina I, Sateri S, et al. Impact of Tracheobronchopathia Osteochondroplastica on Difficult Intubation. OTO Open, 2023, 7(3): e81.
29. Datta A, Ghosh S, Mohapatra PR. A rare case of hemoptysis. Lung India, 2022, 39(1): 80-81.
30. Patel P M, Jean ME, Reich K, et al. Tracheobronchopathia Osteochondroplastica: A Rare, Underrecognized Entity. Cureus, 2022, 14(9): e28832.
31. Devaraja K, Sagar P, Chirom AS. Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management. BMJ Case Rep, 2017, 2017: bcr2017220567.
32. Rodriguez NJV, Manto JT, Sydiongco-Inocencio P M M, et al. Tracheobronchopathia osteochondroplastica: a case report highlighting the importance of clinico-radiologic correlation. BJR Case Rep, 2023, 9(6): 20230062.
33. García CA, Sangiovanni S, Zú?iga-Restrepo V, et al. Tracheobronchopathia Osteochondroplastica-Clinical, Radiological, and Endoscopic Correlation: Case Series and Literature Review. J Investig Med High Impact Case Rep, 2020, 8: 2324709620921609.
34. 朱瑩, 鄔盛昌, 胥武劍, 等. 骨化性氣管支氣管病臨床分析. 中國呼吸與危重監護雜志, 2012, 11(6): 592-595.
35. 李興勝, 曹德生. 高分辨率CT薄層檢查對骨化性氣管支氣管病的診斷價值. 實用醫學影像雜志, 2021, 22(1): 73-74.
36. Chien YC, Wang HC, Chang YC, et al. Uncommon chronic cough caused by tracheobronchopathia osteochondroplastica. Thorax, 2012, 67(11): 1021-1022.
37. 黃曉輝, 陳玲, 王作和, 等. 骨化性氣管支氣管病CT表現. 中國醫學影像學雜志, 2012, 20(8): 594-595.
38. Li YY, Hu CP, Yang HZ, et al. [The diagnostic value of flexible bronchoscopy in tracheobronchopathia osteochondroplastica]. Zhonghua Jie He He Hu Xi Za Zhi, 2009, 32(7): 489-492.
39. Doshi H, Thankachen R, Philip MA, et al. Tracheobronchopathia osteochondroplastica presenting as an isolated nodule in the right upper lobe bronchus with upper lobe collapse. J Thorac Cardiovasc Surg, 2005, 130(3): 901-902.
40. Kirba? G, Da?li CE, Tanrikulu A , et al. Unusual combination of tracheobronchopathia osteochondroplastica and AA amyloidosis. Yonsei Med J, 2009, 50(5): 721-724.
41. Ihara H, Tajima K, Yoshikawa H, et al. Autofluorescence imaging bronchoscopy as a novel approach to the management of tracheobronchopathia osteochondroplastica: a case report. J Thorac Dis, 2016, 8(10): e1195-e1198.
42. Newton R, Kemp S, Zoumot Z, et al. An unusual case of haemoptysis. Thorax, 2010, 65(4): 309, 353.
43. 陳婷, 柳廣南. 氣管支氣管骨化癥的臨床診治進展. 中國醫藥指南, 2020, 18(19): 30-31.
44. Ulasli SS, Kupeli E. Tracheobronchopathia osteochondroplastica: a review of the literature. Clin Respir J, 2015, 9(4): 386-391.
45. Chen C, Tang F, Herth FJF, et al. Building and validating an artificial intelligence model to identify tracheobronchopathia osteochondroplastica by using bronchoscopic images. Ther Adv Respir Dis, 2024, 18: 17534666241253694.
46. Cho HK, Jeong BH, Kim H. Clinical course of tracheobronchopathia osteochondroplastica. J Thorac Dis, 2020, 12(10): 5571-5579.
47. Devaraja K, Surendra VU. Clinicopathological Features and Management Principles of Tracheobronchopathia Osteochondroplastica - A Scoping Review. Indian J Otolaryngol Head Neck Surg, 2023, 75(4): 3798-3814.
48. Song JY, Kim B G, Zo S, et al. Tracheobronchopathia osteochondroplastica (TPO) associated with tracheobronchial amyloidosis (TBA). Respir Med Case Rep, 2020, 31: 101158.
49. Dharia I, Bielamowicz S. Surgical Management in Tracheobronchopathia Osteochondroplastica: A Case Study. Laryngoscope, 2021, 131(3): e911-e913.
50. Wang Y, Li X, Zhang J, et al. Bronchoscopic Intervention for Tracheobronchopathia Osteochondroplastica: A Report of Two Cases. Laryngoscope, 2024, 134(7): 3093-3095.
51. Hirsch M, Tovi F, Goldstein J, et al. Diagnosis of tracheopathia osteoplastica by computed tomography. Ann Otol Rhinol Laryngol, 1985, 94(2 Pt 1): 217-219.
52. Al Omari A, Al-Qarqaz W, Khresat M, et al. Tracheobronchopathia osteochondroplastica in the setting of COVID-19. Ear Nose Throat J, 2024, 103(1suppl): 98s-101s.

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氣管支氣管骨化癥合并慢性阻塞性肺疾病一例報告

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