泛凋亡在呼吸系統疾病中的研究進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

陳雪怡 ,  張景鴻

廣西醫科大學第二附屬醫院急診科（廣西南寧 530021）;

Corresponding?author：

張景鴻, Email: gxzhangjinghong@163.com

Keywords：

DOI：

10.7507/1671-6205.202309043

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Citation： 陳雪怡, 張景鴻. 泛凋亡在呼吸系統疾病中的研究進展. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(5): 375-380. doi: 10.7507/1671-6205.202309043 Copy

1.	Yan WT, Yang YD, Hu XM, et al. Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies. Neural Regen Res, 2022, 17(8): 1761-1768.
2.	Zhu P, Ke ZR, Chen JX, et al. Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment. Front Immunol, 2023, 14: 1120034.
3.	Sharma A, Ahmad Farouk I, Lal SK. COVID-19: a review on the novel coronavirus disease evolution, transmission, detection, control and prevention. Viruses, 2021, 13(2): 202.
4.	Malireddi RKS, Tweedell RE, Kanneganti TD. PANoptosis components, regulation, and implications. Aging (Albany NY), 2020, 12(12): 11163-11164.
5.	Malik A, Kanneganti TD. Inflammasome activation and assembly at a glance. J Cell Sci, 2017, 130(23): 3955-3963.
6.	Levine AJ. p53, the cellular gatekeeper for growth and division. Cell, 1997, 88(3): 323-331.
7.	Fan TJ, Han LH, Cong RS, et al. Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai), 2005, 37(11): 719-927.
8.	Kiraz Y, Adan A, Kartal Yandim M, et al. Major apoptotic mechanisms and genes involved in apoptosis. Tumour Biol, 2016, 37(7): 8471-8486.
9.	Yuan J, Amin P, Ofengeim D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nat Rev Neurosci, 2019, 20(1): 19-33.
10.	Jiang W, Deng Z, Dai X, et al. PANoptosis: a new insight into oral infectious diseases. Front Immunol, 2021, 12: 789610.
11.	Tsuchiya K, Nakajima S, Hosojima S, et al. Caspase-1 initiates apoptosis in the absence of gasdermin D. Nat Commun, 2019, 10(1): 2091.
12.	Kang S, Fernandes-Alnemri T, Rogers C, et al. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun, 2015, 6: 7515.
13.	Guo CH, Fu R, Zhou MJ, et al. Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation. J Autoimmun, 2019, 103: 102286.
14.	Shi CX, Cao P, Wang YK, et al. PANoptosis: a cell death characterized by pyroptosis, apoptosis, and necroptosis. J Inflamm Res, 2023, 16: 1523-1532.
15.	Wang Y, Pandian N, Han JH, et al. Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method. Cell Mol Life Sci, 2022, 79(10): 531.
16.	Zheng M, Karki R, Vogel P, Kanneganti TD. Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. Cell, 2020, 181(3): 674-687.
17.	Samir P, Malireddi RKS, Kanneganti TD. The PANoptosome: a deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis). Front Cell Infect Microbiol, 2020, 10: 238.
18.	Kuriakose T, Kanneganti TD. ZBP1: innate sensor regulating cell death and inflammation. Trends Immunol, 2018, 39(2): 123-134.
19.	Kesavardhana S, Malireddi RKS, Burton AR, et al. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. J Biol Chem, 2020, 295(24): 8325-8330.
20.	Banoth B, Tuladhar S, Karki R, et al. ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis). J Biol Chem, 2020, 295(52): 18276-18283.
21.	Kanneganti TD, Body-Malapel M, Amer A, et al. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem, 2006, 281(48): 36560-36568.
22.	Zheng M, Kanneganti TD. The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunol Rev, 2020, 297(1): 26-38.
23.	Sundaram B, Pandian N, Mall R, et al. NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs. Cell, 2023, 186(13): 2783-2801.
24.	Sharma BR, Karki R, Kanneganti TD. Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. Eur J Immunol, 2019, 49(11): 1998-2011.
25.	Lee S, Karki R, Wang YQ, et al. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature, 2021, 597(7876): 415-419.
26.	Arrázola MS, Court FA. Commentary on "PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons". Neural Regen Res, 2023, 18(2): 341.
27.	Wei X, Xie F, Zhou XX, et al. Role of pyroptosis in inflammation and cancer. Cell Mol Immunol, 2022, 19(9): 971-992.
28.	Zheng M, Williams EP, Malireddi RKS, et al. Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. J Biol Chem, 2020, 295(41): 14040-14052.
29.	Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 1997, 91(4): 479-489.
30.	Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet, 2021, 398(10300): 622-637.
31.	Huppert LA, Matthay MA, Ware LB. Pathogenesis of acute respiratory distress syndrome. Semin Respir Crit Care Med, 2019, 40(1): 31-39.
32.	Messaoud-Nacer Y, Culerier E, Rose S, et al. STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS). Cell Death Dis, 2022, 13(3): 269.
33.	Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med, 2020, 382(18): 1708-1720.
34.	Heinen N, Kl?hn M, Steinmann E, et al. In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease. Viruses, 2021, 13(5): 792.
35.	Puelles VG, Lütgehetmann M, Lindenmeyer MT, et al. Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med, 2020, 383(6): 590-592.
36.	Xu JC, Xu XY, Jiang LN, et al. SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis. Respir Res, 2020, 21(1): 182.
37.	Zhao FXN, Ma QW, Yue Q, et al. SARS-CoV-2 infection and lung regeneration. Clin Microbiol Rev, 2022, 35(2): e0018821.
38.	Karki R, Sharma BR, Tuladhar S, et al. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell, 2021, 184(1): 149-168.
39.	He WT, Wan H, Hu L, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1βsecretion. Cell Res, 2015, 25(12): 1285-1298.
40.	Newton K, Wickliffe KE, Dugger DL, et al. Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature, 2019, 574(7778): 428-431.
41.	Jose RJ, Manuel A. COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir Med, 2020, 8(6): e46-e47.
42.	Lee JW, Chun W, Lee HJ, et al. The role of macrophages in the development of acute and chronic inflammatory lung diseases. Cells, 2021, 10(4): 897.
43.	Robb CT, Regan KH, Dorward DA, et al. Key mechanisms governing resolution of lung inflammation. Semin Immunopathol, 2016, 38(4): 425-448.
44.	Cicco S, Cicco G, Racanelli V, et al. Neutrophil extracellular traps (NETs) and damage-associated molecular patterns (DAMPs): two potential targets for COVID-19 treatment. Mediators Inflamm, 2020, 2020: 7527953.
45.	Schifanella L, Anderson J, Wieking G, et al. The defenders of the alveolus succumb in COVID-19 pneumonia to SARS-CoV-2 and necroptosis, pyroptosis, and PANoptosis. J Infect Dis, 2023, 227(11): 1245-1254.
46.	Ruaro B, Salton F, Braga L, et al. The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung. Int J Mol Sci, 2021, 22(5): 2566.
47.	Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 2021, 71(3): 209-249.
48.	Ruiz-Cordero R, Devine WP. Targeted therapy and checkpoint immunotherapy in lung cancer. Surg Pathol Clin, 2020, 13(1): 17-33.
49.	Bade BC, Dela Cruz CS. Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med, 2020, 41(1): 1-24.
50.	Gómez-Angelats M, Cidlowski JA. Molecular evidence for the nuclear localization of FADD. Cell Death Differ, 2003, 10(7): 791-797.
51.	Wei S, Chen Z, Ling X, et al. Comprehensive analysis illustrating the role of PANoptosis-related genes in lung cancer based on bioinformatic algorithms and experiments. Front Pharmacol, 2023, 14: 1115221.
52.	Hartl D, Tirouvanziam R, Laval J, et al. Innate immunity of the lung: from basic mechanisms to translational medicine. J Innate Immun, 2018, 10(5-6): 487-501.
53.	Kruger P, Saffarzadeh M, Weber AN, et al. Neutrophils: between host defence, immune modulation, and tissue injury. PLoS Pathog, 2015, 11(3): e1004651.
54.	Tang AC, Turvey SE, Alves MP, et al. Current concepts: host-pathogen interactions in cystic fibrosis airways disease. Eur Respir Rev, 2014, 23(133): 320-332.
55.	Regamey N, Tsartsali L, Hilliard TN, et al. Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis. Thorax, 2012, 67(2): 164-170.
56.	Van Opdenbosch N, Lamkanfi M. Caspases in cell death, inflammation, and disease. Immunity, 2019, 50(6): 1352-1364.
57.	趙鵬躍, 姚人騏, 杜曉輝, 等. 泛凋亡在人類疾病中的作用研究進展. 中華醫學雜志, 2022, 102(32): 2549-2554.
58.	Sun X, Yang YP, Meng XN, et al. PANoptosis: mechanisms, biology, and role in disease[J/OL]. Immunol Rev, [2023-10-12].
59.	Cui YH, Wang XQ, Lin FY, et al. MiR-29a-3p improves acute lung injury by reducing alveolar epithelial cell PANoptosis. Aging Dis, 2022, 13(3): 899-909.
60.	Christgen S, Zheng M, Kesavardhana S, et al. Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis). Front Cell Infect Microbiol, 2020, 10: 237.
61.	Karki R, Sundaram B, Sharma BR, et al. ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Cell Rep, 2021, 37(3): 109858.
62.	Malireddi RKS, Kesavardhana S, Kanneganti TD. ZBP1 and TAK1: master regulators of NLRP3 inflammasome/pyroptosis, apoptosis, and necroptosis (PAN-optosis). Front Cell Infect Microbiol, 2019, 9: 406.
63.	Oh S, Lee S. Recent advances in ZBP1-derived PANoptosis against viral infections. Front Immunol, 2023, 14: 1148727.

1. Yan WT, Yang YD, Hu XM, et al. Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies. Neural Regen Res, 2022, 17(8): 1761-1768.
2. Zhu P, Ke ZR, Chen JX, et al. Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment. Front Immunol, 2023, 14: 1120034.
3. Sharma A, Ahmad Farouk I, Lal SK. COVID-19: a review on the novel coronavirus disease evolution, transmission, detection, control and prevention. Viruses, 2021, 13(2): 202.
4. Malireddi RKS, Tweedell RE, Kanneganti TD. PANoptosis components, regulation, and implications. Aging (Albany NY), 2020, 12(12): 11163-11164.
5. Malik A, Kanneganti TD. Inflammasome activation and assembly at a glance. J Cell Sci, 2017, 130(23): 3955-3963.
6. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell, 1997, 88(3): 323-331.
7. Fan TJ, Han LH, Cong RS, et al. Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai), 2005, 37(11): 719-927.
8. Kiraz Y, Adan A, Kartal Yandim M, et al. Major apoptotic mechanisms and genes involved in apoptosis. Tumour Biol, 2016, 37(7): 8471-8486.
9. Yuan J, Amin P, Ofengeim D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nat Rev Neurosci, 2019, 20(1): 19-33.
10. Jiang W, Deng Z, Dai X, et al. PANoptosis: a new insight into oral infectious diseases. Front Immunol, 2021, 12: 789610.
11. Tsuchiya K, Nakajima S, Hosojima S, et al. Caspase-1 initiates apoptosis in the absence of gasdermin D. Nat Commun, 2019, 10(1): 2091.
12. Kang S, Fernandes-Alnemri T, Rogers C, et al. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun, 2015, 6: 7515.
13. Guo CH, Fu R, Zhou MJ, et al. Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation. J Autoimmun, 2019, 103: 102286.
14. Shi CX, Cao P, Wang YK, et al. PANoptosis: a cell death characterized by pyroptosis, apoptosis, and necroptosis. J Inflamm Res, 2023, 16: 1523-1532.
15. Wang Y, Pandian N, Han JH, et al. Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method. Cell Mol Life Sci, 2022, 79(10): 531.
16. Zheng M, Karki R, Vogel P, Kanneganti TD. Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. Cell, 2020, 181(3): 674-687.
17. Samir P, Malireddi RKS, Kanneganti TD. The PANoptosome: a deadly protein complex driving pyroptosis, apoptosis, and necroptosis (PANoptosis). Front Cell Infect Microbiol, 2020, 10: 238.
18. Kuriakose T, Kanneganti TD. ZBP1: innate sensor regulating cell death and inflammation. Trends Immunol, 2018, 39(2): 123-134.
19. Kesavardhana S, Malireddi RKS, Burton AR, et al. The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. J Biol Chem, 2020, 295(24): 8325-8330.
20. Banoth B, Tuladhar S, Karki R, et al. ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis). J Biol Chem, 2020, 295(52): 18276-18283.
21. Kanneganti TD, Body-Malapel M, Amer A, et al. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem, 2006, 281(48): 36560-36568.
22. Zheng M, Kanneganti TD. The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunol Rev, 2020, 297(1): 26-38.
23. Sundaram B, Pandian N, Mall R, et al. NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs. Cell, 2023, 186(13): 2783-2801.
24. Sharma BR, Karki R, Kanneganti TD. Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. Eur J Immunol, 2019, 49(11): 1998-2011.
25. Lee S, Karki R, Wang YQ, et al. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature, 2021, 597(7876): 415-419.
26. Arrázola MS, Court FA. Commentary on "PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons". Neural Regen Res, 2023, 18(2): 341.
27. Wei X, Xie F, Zhou XX, et al. Role of pyroptosis in inflammation and cancer. Cell Mol Immunol, 2022, 19(9): 971-992.
28. Zheng M, Williams EP, Malireddi RKS, et al. Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. J Biol Chem, 2020, 295(41): 14040-14052.
29. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 1997, 91(4): 479-489.
30. Meyer NJ, Gattinoni L, Calfee CS. Acute respiratory distress syndrome. Lancet, 2021, 398(10300): 622-637.
31. Huppert LA, Matthay MA, Ware LB. Pathogenesis of acute respiratory distress syndrome. Semin Respir Crit Care Med, 2019, 40(1): 31-39.
32. Messaoud-Nacer Y, Culerier E, Rose S, et al. STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS). Cell Death Dis, 2022, 13(3): 269.
33. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med, 2020, 382(18): 1708-1720.
34. Heinen N, Kl?hn M, Steinmann E, et al. In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease. Viruses, 2021, 13(5): 792.
35. Puelles VG, Lütgehetmann M, Lindenmeyer MT, et al. Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med, 2020, 383(6): 590-592.
36. Xu JC, Xu XY, Jiang LN, et al. SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis. Respir Res, 2020, 21(1): 182.
37. Zhao FXN, Ma QW, Yue Q, et al. SARS-CoV-2 infection and lung regeneration. Clin Microbiol Rev, 2022, 35(2): e0018821.
38. Karki R, Sharma BR, Tuladhar S, et al. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell, 2021, 184(1): 149-168.
39. He WT, Wan H, Hu L, et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1βsecretion. Cell Res, 2015, 25(12): 1285-1298.
40. Newton K, Wickliffe KE, Dugger DL, et al. Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature, 2019, 574(7778): 428-431.
41. Jose RJ, Manuel A. COVID-19 cytokine storm: the interplay between inflammation and coagulation. Lancet Respir Med, 2020, 8(6): e46-e47.
42. Lee JW, Chun W, Lee HJ, et al. The role of macrophages in the development of acute and chronic inflammatory lung diseases. Cells, 2021, 10(4): 897.
43. Robb CT, Regan KH, Dorward DA, et al. Key mechanisms governing resolution of lung inflammation. Semin Immunopathol, 2016, 38(4): 425-448.
44. Cicco S, Cicco G, Racanelli V, et al. Neutrophil extracellular traps (NETs) and damage-associated molecular patterns (DAMPs): two potential targets for COVID-19 treatment. Mediators Inflamm, 2020, 2020: 7527953.
45. Schifanella L, Anderson J, Wieking G, et al. The defenders of the alveolus succumb in COVID-19 pneumonia to SARS-CoV-2 and necroptosis, pyroptosis, and PANoptosis. J Infect Dis, 2023, 227(11): 1245-1254.
46. Ruaro B, Salton F, Braga L, et al. The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung. Int J Mol Sci, 2021, 22(5): 2566.
47. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 2021, 71(3): 209-249.
48. Ruiz-Cordero R, Devine WP. Targeted therapy and checkpoint immunotherapy in lung cancer. Surg Pathol Clin, 2020, 13(1): 17-33.
49. Bade BC, Dela Cruz CS. Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med, 2020, 41(1): 1-24.
50. Gómez-Angelats M, Cidlowski JA. Molecular evidence for the nuclear localization of FADD. Cell Death Differ, 2003, 10(7): 791-797.
51. Wei S, Chen Z, Ling X, et al. Comprehensive analysis illustrating the role of PANoptosis-related genes in lung cancer based on bioinformatic algorithms and experiments. Front Pharmacol, 2023, 14: 1115221.
52. Hartl D, Tirouvanziam R, Laval J, et al. Innate immunity of the lung: from basic mechanisms to translational medicine. J Innate Immun, 2018, 10(5-6): 487-501.
53. Kruger P, Saffarzadeh M, Weber AN, et al. Neutrophils: between host defence, immune modulation, and tissue injury. PLoS Pathog, 2015, 11(3): e1004651.
54. Tang AC, Turvey SE, Alves MP, et al. Current concepts: host-pathogen interactions in cystic fibrosis airways disease. Eur Respir Rev, 2014, 23(133): 320-332.
55. Regamey N, Tsartsali L, Hilliard TN, et al. Distinct patterns of inflammation in the airway lumen and bronchial mucosa of children with cystic fibrosis. Thorax, 2012, 67(2): 164-170.
56. Van Opdenbosch N, Lamkanfi M. Caspases in cell death, inflammation, and disease. Immunity, 2019, 50(6): 1352-1364.
57. 趙鵬躍, 姚人騏, 杜曉輝, 等. 泛凋亡在人類疾病中的作用研究進展. 中華醫學雜志, 2022, 102(32): 2549-2554.
58. Sun X, Yang YP, Meng XN, et al. PANoptosis: mechanisms, biology, and role in disease[J/OL]. Immunol Rev, [2023-10-12].
59. Cui YH, Wang XQ, Lin FY, et al. MiR-29a-3p improves acute lung injury by reducing alveolar epithelial cell PANoptosis. Aging Dis, 2022, 13(3): 899-909.
60. Christgen S, Zheng M, Kesavardhana S, et al. Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis). Front Cell Infect Microbiol, 2020, 10: 237.
61. Karki R, Sundaram B, Sharma BR, et al. ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Cell Rep, 2021, 37(3): 109858.
62. Malireddi RKS, Kesavardhana S, Kanneganti TD. ZBP1 and TAK1: master regulators of NLRP3 inflammasome/pyroptosis, apoptosis, and necroptosis (PAN-optosis). Front Cell Infect Microbiol, 2019, 9: 406.
63. Oh S, Lee S. Recent advances in ZBP1-derived PANoptosis against viral infections. Front Immunol, 2023, 14: 1148727.

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泛凋亡在呼吸系統疾病中的研究進展

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