通氣比在急性呼吸窘迫綜合征患者中的應用進展_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

王妍妍 , 江博 ,  方強

浙江大學醫學院附屬第一醫院重癥醫學科（浙江杭州 310000）;

Corresponding?author：

方強, Email: 1183005@zju.edu.cn

Keywords：

DOI：

10.7507/1671-6205.202308042

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Citation： 王妍妍, 江博, 方強. 通氣比在急性呼吸窘迫綜合征患者中的應用進展. Chinese Journal of Respiratory and Critical Care Medicine, 2024, 23(5): 365-369. doi: 10.7507/1671-6205.202308042 Copy

1.	Matthay MA, Arabi Y, Arroliga AC, et al. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med, 2024, 209(1): 37-47.
2.	Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA, 2016, 315(8): 788-800.
3.	錢穎, 謝永鵬, 沈葉菊, 等. 以機械功為導向的急性呼吸窘迫綜合征機械通氣新理念. 中國呼吸與危重監護雜志, 2020, 19: 418-421.
4.	Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers, 2019, 5(1): 18.
5.	Nuckton TJ, Alonso JA, Kallet RH, et al. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med, 2002, 346(17): 1281-1286.
6.	Lucangelo U, Bernabe F, Vatua S, et al. Prognostic value of different dead space indices in mechanically ventilated patients with acute lung injury and ARDS. Chest, 2008, 133(1): 62-71.
7.	Patel BV, Arachchillage DJ, Ridge CA, et al. Pulmonary angiopathy in severe COVID-19: physiologic, imaging, and hematologic observations. Am J Respir Crit Care Med, 2020, 202(5): 690-699.
8.	Torres A, Motos A, Riera J, et al. The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients. Crit Care, 2021, 25(1): 331.
9.	Sinha P, Calfee CS, Beitler JR, et al. Physiologic analysis and clinical performance of the ventilatory ratio in acute respiratory distress syndrome. Am J Respir Crit Care Med, 2019, 199(3): 333-341.
10.	Sinha P, Fauvel NJ, Singh S, et al. Ventilatory ratio: a simple bedside measure of ventilation. Br J Anaesth, 2009, 102(5): 692-697.
11.	Wang Z, Xia F, Dai H, et al. Early decrease of ventilatory ratio after prone position ventilation may predict successful weaning in patients with acute respiratory distress syndrome: a retrospective cohort study. Front Med (Lausanne), 2022, 9: 1057260.
12.	Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2000, 342(18): 1301-1308.
13.	Liu X, Liu X, Xu Y, et al. Ventilatory ratio in hypercapnic mechanically ventilated patients with COVID-19-associated acute respiratory distress syndrome. Am J Respir Crit Care Med, 2020, 201(10): 1297-1299.
14.	Zheng M. Dead space ventilation-related indices: bedside tools to evaluate the ventilation and perfusion relationship in patients with acute respiratory distress syndrome. Crit Care, 2023, 27(1): 46.
15.	Suarez-Sipmann F, Villar J, Ferrando C, et al. Monitoring expired CO₂ kinetics to individualize lung-protective ventilation in patients with the acute respiratory distress syndrome. Front Physiol, 2021, 12: 785014.
16.	Sinha P, Fauvel NJ, Singh P, et al. Analysis of ventilatory ratio as a novel method to monitor ventilatory adequacy at the bedside. Critical Care, 2013, 17(1): R34.
17.	Monteiro ACC, Vangala S, Wick KD, et al. The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial. Crit Care, 2022, 26(1): 297.
18.	Yang Y, Chi Y, Yuan S, et al. The relationship between ventilatory ratio (VR) and 28-day hospital mortality by restricted cubic splines (RCS) in 14, 328 mechanically ventilated ICU patients. BMC Pulm Med, 2022, 22(1): 229.
19.	Beloncle F, Studer A, Seegers V, et al. Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome. Crit Care, 2021, 25(1): 248.
20.	傅小云, 周厚榮, 葉賢偉, 等. 淺析新型冠狀病毒肺炎并發急性呼吸窘迫綜合征的病理及病理生理. 中國呼吸與危重監護雜志, 2022, 21(10): 756-760.
21.	Kaku N, Nakagama Y, Shirano M, et al. Longitudinal ventilatory ratio monitoring for COVID-19: its potential in predicting severity and assessing treatment response. Crit Care, 2021, 25(1): 366.
22.	Morales-Quinteros L, Neto AS, Artigas A, et al. Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS. Crit Care, 2021, 25(1): 171.
23.	Arrivé F, Coudroy R, Thille AW. Early identification and diagnostic approach in acute respiratory distress syndrome (ARDS). Diagnostics (Basel, Switzerland), 2021, 11(12): 2307.
24.	Grasselli G, Calfee CS, Camporota L, et al. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med, 2023, 49(7): 727-759.
25.	Constantin JM, Jabaudon M, Lefrant JY, et al. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial. Lancet Resp Med, 2019, 7(10): 870-880.
26.	See KC, Sahagun J, Taculod J. Identification of focal ARDS using PF ratio: a cross-sectional study. Crit Care, 2020, 24(1): 471.
27.	See KC, Estaras MT, Taculod JM. Identification of focal ARDS using ventilatory ratio. Crit Care, 2021, 25(1): 371.
28.	Guérin C, Reignier J, Richard JC, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med, 2013, 368(23): 2159-2168.
29.	Aoyama H, Uchida K, Aoyama K, et al. Assessment of therapeutic interventions and lung protective ventilation in patients with moderate to severe acute respiratory distress syndrome: a systematic review and network meta-analysis. JAMA Netw Open, 2019, 2(7): e198116.
30.	Albert RK, Keniston A, Baboi L, et al. Prone position-induced improvement in gas exchange does not predict improved survival in the acute respiratory distress syndrome. Am J Respir Crit Care Med, 2014, 189(4): 494-496.
31.	Proklou A, Papadakis E, Kondili E, et al. Ventilatory ratio threshold for unassisted breathing: a retrospective exploratory analysis. Respir Care, 2021, 66(11): 1699-1703.
32.	Morales-Quinteros L, Schultz MJ, Bringue J, et al. Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS. Ann Intensive Care, 2019, 9(1): 128.
33.	Maj R, Palermo P, Gattarello S, et al. Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome. Br J Anaesth, 2023, 130(3): 360-367.
34.	Madotto F, Rezoagli E, McNicholas BA, et al. Patterns and impact of arterial CO₂ management in patients with acute respiratory distress syndrome: insights from the LUNG SAFE Study. Chest, 2020, 158(5): 1967-1982.
35.	Vaporidi K, Akoumianaki E, Telias I, et al. Respiratory drive in critically ill patients. Pathophysiology and clinical implications. Am J Respir Crit Care Med, 2020, 201(1): 20-32.
36.	Bhalla AK, Dong J, Klein MJ, et al. The association between ventilatory ratio and mortality in children and young adults. Respir Care, 2021, 66(2): 205-212.

1. Matthay MA, Arabi Y, Arroliga AC, et al. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med, 2024, 209(1): 37-47.
2. Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA, 2016, 315(8): 788-800.
3. 錢穎, 謝永鵬, 沈葉菊, 等. 以機械功為導向的急性呼吸窘迫綜合征機械通氣新理念. 中國呼吸與危重監護雜志, 2020, 19: 418-421.
4. Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Primers, 2019, 5(1): 18.
5. Nuckton TJ, Alonso JA, Kallet RH, et al. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med, 2002, 346(17): 1281-1286.
6. Lucangelo U, Bernabe F, Vatua S, et al. Prognostic value of different dead space indices in mechanically ventilated patients with acute lung injury and ARDS. Chest, 2008, 133(1): 62-71.
7. Patel BV, Arachchillage DJ, Ridge CA, et al. Pulmonary angiopathy in severe COVID-19: physiologic, imaging, and hematologic observations. Am J Respir Crit Care Med, 2020, 202(5): 690-699.
8. Torres A, Motos A, Riera J, et al. The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients. Crit Care, 2021, 25(1): 331.
9. Sinha P, Calfee CS, Beitler JR, et al. Physiologic analysis and clinical performance of the ventilatory ratio in acute respiratory distress syndrome. Am J Respir Crit Care Med, 2019, 199(3): 333-341.
10. Sinha P, Fauvel NJ, Singh S, et al. Ventilatory ratio: a simple bedside measure of ventilation. Br J Anaesth, 2009, 102(5): 692-697.
11. Wang Z, Xia F, Dai H, et al. Early decrease of ventilatory ratio after prone position ventilation may predict successful weaning in patients with acute respiratory distress syndrome: a retrospective cohort study. Front Med (Lausanne), 2022, 9: 1057260.
12. Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med, 2000, 342(18): 1301-1308.
13. Liu X, Liu X, Xu Y, et al. Ventilatory ratio in hypercapnic mechanically ventilated patients with COVID-19-associated acute respiratory distress syndrome. Am J Respir Crit Care Med, 2020, 201(10): 1297-1299.
14. Zheng M. Dead space ventilation-related indices: bedside tools to evaluate the ventilation and perfusion relationship in patients with acute respiratory distress syndrome. Crit Care, 2023, 27(1): 46.
15. Suarez-Sipmann F, Villar J, Ferrando C, et al. Monitoring expired CO₂ kinetics to individualize lung-protective ventilation in patients with the acute respiratory distress syndrome. Front Physiol, 2021, 12: 785014.
16. Sinha P, Fauvel NJ, Singh P, et al. Analysis of ventilatory ratio as a novel method to monitor ventilatory adequacy at the bedside. Critical Care, 2013, 17(1): R34.
17. Monteiro ACC, Vangala S, Wick KD, et al. The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial. Crit Care, 2022, 26(1): 297.
18. Yang Y, Chi Y, Yuan S, et al. The relationship between ventilatory ratio (VR) and 28-day hospital mortality by restricted cubic splines (RCS) in 14, 328 mechanically ventilated ICU patients. BMC Pulm Med, 2022, 22(1): 229.
19. Beloncle F, Studer A, Seegers V, et al. Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome. Crit Care, 2021, 25(1): 248.
20. 傅小云, 周厚榮, 葉賢偉, 等. 淺析新型冠狀病毒肺炎并發急性呼吸窘迫綜合征的病理及病理生理. 中國呼吸與危重監護雜志, 2022, 21(10): 756-760.
21. Kaku N, Nakagama Y, Shirano M, et al. Longitudinal ventilatory ratio monitoring for COVID-19: its potential in predicting severity and assessing treatment response. Crit Care, 2021, 25(1): 366.
22. Morales-Quinteros L, Neto AS, Artigas A, et al. Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS. Crit Care, 2021, 25(1): 171.
23. Arrivé F, Coudroy R, Thille AW. Early identification and diagnostic approach in acute respiratory distress syndrome (ARDS). Diagnostics (Basel, Switzerland), 2021, 11(12): 2307.
24. Grasselli G, Calfee CS, Camporota L, et al. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med, 2023, 49(7): 727-759.
25. Constantin JM, Jabaudon M, Lefrant JY, et al. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial. Lancet Resp Med, 2019, 7(10): 870-880.
26. See KC, Sahagun J, Taculod J. Identification of focal ARDS using PF ratio: a cross-sectional study. Crit Care, 2020, 24(1): 471.
27. See KC, Estaras MT, Taculod JM. Identification of focal ARDS using ventilatory ratio. Crit Care, 2021, 25(1): 371.
28. Guérin C, Reignier J, Richard JC, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med, 2013, 368(23): 2159-2168.
29. Aoyama H, Uchida K, Aoyama K, et al. Assessment of therapeutic interventions and lung protective ventilation in patients with moderate to severe acute respiratory distress syndrome: a systematic review and network meta-analysis. JAMA Netw Open, 2019, 2(7): e198116.
30. Albert RK, Keniston A, Baboi L, et al. Prone position-induced improvement in gas exchange does not predict improved survival in the acute respiratory distress syndrome. Am J Respir Crit Care Med, 2014, 189(4): 494-496.
31. Proklou A, Papadakis E, Kondili E, et al. Ventilatory ratio threshold for unassisted breathing: a retrospective exploratory analysis. Respir Care, 2021, 66(11): 1699-1703.
32. Morales-Quinteros L, Schultz MJ, Bringue J, et al. Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS. Ann Intensive Care, 2019, 9(1): 128.
33. Maj R, Palermo P, Gattarello S, et al. Ventilatory ratio, dead space, and venous admixture in patients with acute respiratory distress syndrome. Br J Anaesth, 2023, 130(3): 360-367.
34. Madotto F, Rezoagli E, McNicholas BA, et al. Patterns and impact of arterial CO₂ management in patients with acute respiratory distress syndrome: insights from the LUNG SAFE Study. Chest, 2020, 158(5): 1967-1982.
35. Vaporidi K, Akoumianaki E, Telias I, et al. Respiratory drive in critically ill patients. Pathophysiology and clinical implications. Am J Respir Crit Care Med, 2020, 201(1): 20-32.
36. Bhalla AK, Dong J, Klein MJ, et al. The association between ventilatory ratio and mortality in children and young adults. Respir Care, 2021, 66(2): 205-212.

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