ADAM33基因多態性及單體型與新疆維吾爾族慢性阻塞性肺疾病的相關性研究_《中國呼吸與危重監護雜志》

作者：

新疆醫科大學第一附屬醫院呼吸一科(烏魯木齊 830054);

關鍵詞：

慢性阻塞性肺疾病慢性阻塞性肺疾病綜合評估解整連蛋白和金屬蛋白33 單核苷酸多態性

DOI：

10.7507/1671-6205.2014034

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目的探討中國新疆地區維吾爾族慢性阻塞性肺疾病(簡稱慢阻肺)與解整連蛋白和金屬蛋白33(ADAM33)基因V4及F+1位點單核苷酸多態性的相關性。方法采用限制性片段長度多態性方法分析初次確診的維吾爾族慢阻肺患者100例(慢阻肺組)與同期健康體檢者140例(對照組)ADAM33 V4和F+1位點基因型,對所有研究對象進行肺功能檢查和慢阻肺流行病學調查,對慢阻肺組患者病情進行慢阻肺綜合評估。結果初次就診的維吾爾族慢阻肺患者經慢阻肺綜合評估,A組、B組和C組患者分別占22%、35%和30%。慢阻肺組和對照組間ADAM33基因V4和F+1位點基因型構成比差異均無統計學意義(P＞0.05),兩組ADAM33基因V4和F+1位點的3種基因型患者FEV₁%pred和FEV₁/FVC均值比較差異無統計學意義(P＞0.05)。慢阻肺組ADAM33基因V4、F+1位點不同基因型與慢阻肺綜合評估之間無顯著相關性(P＞0.05)。SHEsis在線軟件對V4、F+1位點進行單體型分析結果顯示4種單體型在慢阻肺組和對照組比較差異無統計學意義(P＞0.05)。結論初步就診的維吾爾族慢阻肺患者中,慢阻肺綜合評估B組及C組比例較大。ADAM33基因V4、F+1位點多態性與新疆維吾爾族慢阻肺不相關,與肺功能及病情程度不相關,不增加維吾爾族患者慢阻肺易感性。

引用本文： 王瓊, 夏宇, 胡昕, 王晶, 桑珂, 李雙, 齊曼古力·吾首爾. ADAM33基因多態性及單體型與新疆維吾爾族慢性阻塞性肺疾病的相關性研究. 中國呼吸與危重監護雜志, 2013, 12(2): 136-141. doi: 10.7507/1671-6205.2014034 復制

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13.	Dijkstra A,Postma DS,Noordhoek JA,et al.Expression of ADAMs in the human lung.Virchows Arch,2009,454:441-449.
14.	Drazen JM,Weiss ST.Genetics:inherit the wheeze.Nature,2002,418:383-384.
15.	van Diemen CC,Postma DS,Vonk JM,et al.A disintegrin and metalloprotease 33 Polymorphisms and lung function decline in the general population.Am J Respir Crit Care Med,2005,172:329-333.
16.	Gosman MM,Boezen HM,van Diemen CC,et al.A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology.Thorax,2007,62:242-247.
17.	Sadeghnejad A,Ohar JA,Zheng SL,et al.Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.Respir Res,2009,10:21.
18.	Pabst S,Pizarro Touron C,Gillissen A,et al.ADAM33 gene polymorphisms in chronic obstructive pulmonary disease.Eur J Med Res,2009,14 Suppl 4:182-186.
19.	Wang X,Li L,Xiao J,et al.Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population.BMC Med Genet,2009,10:132.
20.	秦睿君,王虹,郭長城,等.ADAM33基因單核苷酸多態性及單體型與慢性阻塞性肺疾病的關聯性研究.國際呼吸雜志,2012,32:182-187.

1. Zhong N,Wang C,Yao W,et al.Prevalence of chronic obstructive pulmonary disease in China:a large population-based survey.Am J Respir Crit Care Med,2007,176:753-760.
2. 凌敏,榮艷,茍安栓,等.新疆農村地區慢性阻塞性肺疾病的危險因素調查.中華結核和呼吸雜志,2011,34:666-668.
3. Bossé Y.Genetics of chronic obstructive pulmonary disease: a succinct review,future avenues and prospective clinical applications.Pharmacogenomics,2009,10:655-667.
4. Orie NG.The dutch hypothesis.Chest,2000,117(5 Suppl 1):299S.
5. Sluiter HJ,Koëter GH,de Monchy JG,et al.The Dutch hypothesis (chronic non-specific lung disease) revisited.Eur Respir J,1991,4:479-489.
6. Van Eerdewegh P,Little RD,Dupuis J,et al.Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.Nature,2002,418:426-430.
7. Drazen JM,Weiss ST.Genetics:inherit the wheeze.Nature,2002,418:383-384.
8. 柳濤,蔡柏薔.慢性阻塞性肺疾病診斷、處理和預防全球策略(2011年修訂版)介紹.中國呼吸與危重監護雜志,2012,11:1-12.
9. 周玉民,劉升明,呂嘉春,等.中國慢性阻塞性肺疾病患病率調查方法的研究設計.中華流行病學雜志,2006,27:814-818.
10. Anto JM,Vermeire P.Epidemiology of chronic obstructive pulmonary disease.Eur Respir J,2001,17:982-994.
11. Rabe KF,Hurd S,Anzueto A,et al.Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.Am J Respir Crit Care Med,2007,176:532-555.
12. 劉輝國,徐永健.慢性阻塞性肺疾病:從氣道慢性炎癥到全身慢性炎癥.中國呼吸與危重監護雜志,2007,6:410-412.
13. Dijkstra A,Postma DS,Noordhoek JA,et al.Expression of ADAMs in the human lung.Virchows Arch,2009,454:441-449.
14. Drazen JM,Weiss ST.Genetics:inherit the wheeze.Nature,2002,418:383-384.
15. van Diemen CC,Postma DS,Vonk JM,et al.A disintegrin and metalloprotease 33 Polymorphisms and lung function decline in the general population.Am J Respir Crit Care Med,2005,172:329-333.
16. Gosman MM,Boezen HM,van Diemen CC,et al.A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology.Thorax,2007,62:242-247.
17. Sadeghnejad A,Ohar JA,Zheng SL,et al.Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.Respir Res,2009,10:21.
18. Pabst S,Pizarro Touron C,Gillissen A,et al.ADAM33 gene polymorphisms in chronic obstructive pulmonary disease.Eur J Med Res,2009,14 Suppl 4:182-186.
19. Wang X,Li L,Xiao J,et al.Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population.BMC Med Genet,2009,10:132.
20. 秦睿君,王虹,郭長城,等.ADAM33基因單核苷酸多態性及單體型與慢性阻塞性肺疾病的關聯性研究.國際呼吸雜志,2012,32:182-187.

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ADAM33基因多態性及單體型與新疆維吾爾族慢性阻塞性肺疾病的相關性研究

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《中國呼吸與危重監護雜志》

ADAM33基因多態性及單體型與新疆維吾爾族慢性阻塞性肺疾病的相關性研究

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