Research Progress of The Relationship Between The Insulin Resistance, IGF-Ⅰ, IGF-Ⅱ, and Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CAILin-gang , LIQi-ju

Department of General Surgery, Central Hospital of Huangpu District, Shanghai 200002, China;

Corresponding?author：

CAILin-gang, Email: clg1980628@aliyun.com

Keywords：

Colorectal cancer; Insulin resistance; Insulin-like growth factor-Ⅰ; Insulin-like growth factor-Ⅱ

DOI：

10.7507/1007-9424.20150135

Video：

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Objective To review the research progress of the relationship between the insulin resistance, insulin-like growth factor-Ⅰ(IGF-Ⅰ), insulin-like growth factor-Ⅱ(IGF-Ⅱ), and colorectal cancer, and to explore the future research trends. Methods The related literatures in recent 5 years from abroad databases (PubMed, Web of Science, and EMBASE)and domestic databases (CNKI, WANFANG, and WEIPU)were collected and reviewed. Results The research on the correlation between the changes and colorectal cancer with insulin resistance and IGF-Ⅰand IGF-Ⅱlevels, epidemiological studies and the mechanism research, indicates that there are complex and close relationship between them. Conclusions The research about the relationship between the insulin resistance, IGF-Ⅰ, IGF-Ⅱ, and colorectal cancer is promising.However, many issues need to be further investigated.

Citation： CAILin-gang, LIQi-ju. Research Progress of The Relationship Between The Insulin Resistance, IGF-Ⅰ, IGF-Ⅱ, and Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(4): 509-512. doi: 10.7507/1007-9424.20150135 Copy

1.	Ali AT, Crowther NJ.Body fat distribution and insulin resistance.S Afr Med J, 2005, 95(11):878-880.
2.	Takahari D, Yamada Y, Okita NT, et al.Relationships of insulin like growth factor-1 receptor and epidermal growth factor receptor expression to clinical outcomes in patients with colorectal cancer.Oncology, 2009, 76(1):42-48.
3.	Sekharam M, Zhao H, Sun M, et al.Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway.Cancer Res, 2003, 63(22):7708-7716.
4.	李連第, 趙平, 孔靈芝.中國部分市、縣惡性腫瘤的發病與死亡(第3卷).北京:人民衛生出版社, 2007:250-251.
5.	Larsson SC, Giovannucci E, Wolk A.Diabetes and colorectal cancer incidence in the cohort of Swedish men.Diabetes Care, 2005, 28 (7):1805-1807.
6.	曾春平, 陳幼萍, 楊清水, 等.胰島素抵抗與結直腸癌患病關系的研究.南昌大學學報, 2014, 54(4):31-33.
7.	Chi F, Wu R, Zeng YC, et al.Circulation insulin-like growth factor peptides and colorectal cancer risk:an updated systematic review and meta-analysis.Mol Biol Rep, 2013, 40(5):3583-3590.
8.	文國容, 庹必光, 李娟, 等.胰島素和IGF-Ⅱ水平的變化與結直腸癌的關系.遵義醫學院學報, 2010, 33(3):205-207.
9.	Shiratsuchi I, Akagi Y, Kawahara A, et al.Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer.Anticancer Res, 2011, 31(7):2541-2545.
10.	Kuklińsk A, Kamocki Z, Cepowicz D, et al.Relationships between insulin-like growth factor i and selected clinico-morphological parameters in colorectal cancer patients.Pol Przegl Chir, 2011, 83(5):250-257.
11.	黃桂林, 吳毅平, 雷娜.胰島素樣生長因子-1在原發性結直腸癌中表達的研究.中國普外基礎與臨床雜志, 2009, 16(9):693-697.
12.	胡永澤, 烏新林.IGF-I和IGF-IR在結直腸癌組織中的表達及臨床意義.內蒙古醫科大學學報, 2013, 35(1):27-31.
13.	Carden CP, Molife LR, de Bono JS.predictive biomarkers for targeting insulin-like growth factor-1 (IGF-1) receptor.Mol Cancer Ther, 2009, 8(8):2077-2078.
14.	Hewish M, Chau I, Cunningham D.Insulin-like growth factor 1 receptor targeted therapeutics:novel compounds and novel treatment strategies for cancer medicine.Recent Pat Anticancer Drug Discov, 2009, 4(1):54-72.
15.	Ewing GP, Goff LW.The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma.Clin Colorectal Cancer, 2010, 9(4):219-223.
16.	鞠昕麗, 初蕾蕾, 楊閱樓, 等.IGF-Ⅱ和IGF-ⅠR及IGFBP-3在結直腸癌組織中的表達及其臨床意義.中國現代普通外科進展, 2013, 16(7):562-565.
17.	戚紅霞, 李曉虹, 胡海強.血清IGF-1、IGFBP-3、VEGF及多項白介素在結直腸癌轉移監測中的意義.海南醫學院學報, 2013, 19(2):176-179.
18.	胡倚玲, 王愛紅.結直腸癌患者血清中IGF-Ⅰ和IGF-BP3的水平及臨床意義.中國高等醫學教育, 2013, 9:132-133.
19.	陳權, 劉莉, 劉麗, 等.GHR、IGF-I在結直腸癌中的表達及其臨床意義.華中科技大學學報, 2012, 41(5):597-602.
20.	郝敬鵬.血清IGF-Ⅱ和TGF-α水平變化在結直腸癌中的臨床意義.中國現代醫學雜志, 2013, 23(1):48-51.
21.	Giovannucci E.Insulin and colon cancer.Cancer Causes Control, 1995, 6(2):164-179.
22.	吳青眉, 吳秋云, 張愛群.結直腸癌代謝紊亂與胰島素抵抗的研究.中華胃腸外科雜志, 2011, 14(4):261-263.
23.	黃云, 王治國, 王強.腹腔鏡與開放直腸乙狀結腸癌切除術術后胰島素抵抗的差異及其臨床意義.中國現代普通外科進展, 2011, 14(12):933-936.
24.	魏曉萍, 惠起源, 劉小蕓.糖尿病與惡性腫瘤.新醫學, 2009, 40 (1):56-58.
25.	Playford MP, Bicknell D, Bodmer W F, et al.Insulin like growth factor I regulates the location, stability, and transcriptional activity ofβ-catenin.Proc Natl Acid Sci USA, 2000, 97(22):12103-12108.
26.	Zha J, O'Brien C, Savage H, et al.Molecular predictors of response to a humanized anti-insulin like growth factor-I receptor monoclonal antibody in breast and colorectal cancer.Mol Cancer Ther, 2009, 8(8):2110-2121.
27.	Guo ST, Jiang CC, Wang GP, et al.MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.Oncogene, 2013, 32(15):1910-1920.
28.	Lim do Y, Cho HJ, Kim J, et al.Luteolin decreases IGF-Ⅱproduc-tion and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells.BMC Gastroenterol, 2012, 12:9.
29.	Flanigan SA, Pitts TM, Eckhardt SG, et al.The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.Clin Cancer Res, 2010, 16(22):5436-5446.
30.	李晴, 孔憲國, 郝杰民, 等.結直腸癌IGF-I mRNA表達與浸潤轉移的關系.癌癥, 2000, 9(2):153-155.
31.	Pechlivanis S, Wagner K, Chang-claude J, et al.Polymorphisms in the insulin like growth factor 1 and IGF bindingprotein 3 genes and risk of colorectal cancer.Cancer Detect Prev, 2007, 31(5):408-416.
32.	胡水清, 湯哲, 張玫.糖尿病與結直腸癌患病危險關系的調查分析.世界華人消化雜志, 2007, 15(1):88-91.
33.	Kasprzak A, Szaflarski W, Szmeja J, et al.Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer.Contemp Oncol (Pozn), 2012, 16(2):147-153.
34.	Cho YY, Kim JG, Chae YS, et al.No association of insulin-like growth factor gene polymorphisms with survival in patients with colorectal cancer.Cancer Res Treat, 2011, 43(3):189-194.
35.	甘德芳, 高天翼, 王書奎, 等.結直腸癌患者中IGF2 LOI以及表達的研究.現代生物醫學進展, 2013, (11):2090-2092.

1. Ali AT, Crowther NJ.Body fat distribution and insulin resistance.S Afr Med J, 2005, 95(11):878-880.
2. Takahari D, Yamada Y, Okita NT, et al.Relationships of insulin like growth factor-1 receptor and epidermal growth factor receptor expression to clinical outcomes in patients with colorectal cancer.Oncology, 2009, 76(1):42-48.
3. Sekharam M, Zhao H, Sun M, et al.Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway.Cancer Res, 2003, 63(22):7708-7716.
4. 李連第, 趙平, 孔靈芝.中國部分市、縣惡性腫瘤的發病與死亡(第3卷).北京:人民衛生出版社, 2007:250-251.
5. Larsson SC, Giovannucci E, Wolk A.Diabetes and colorectal cancer incidence in the cohort of Swedish men.Diabetes Care, 2005, 28 (7):1805-1807.
6. 曾春平, 陳幼萍, 楊清水, 等.胰島素抵抗與結直腸癌患病關系的研究.南昌大學學報, 2014, 54(4):31-33.
7. Chi F, Wu R, Zeng YC, et al.Circulation insulin-like growth factor peptides and colorectal cancer risk:an updated systematic review and meta-analysis.Mol Biol Rep, 2013, 40(5):3583-3590.
8. 文國容, 庹必光, 李娟, 等.胰島素和IGF-Ⅱ水平的變化與結直腸癌的關系.遵義醫學院學報, 2010, 33(3):205-207.
9. Shiratsuchi I, Akagi Y, Kawahara A, et al.Expression of IGF-1 and IGF-1R and their relation to clinicopathological factors in colorectal cancer.Anticancer Res, 2011, 31(7):2541-2545.
10. Kuklińsk A, Kamocki Z, Cepowicz D, et al.Relationships between insulin-like growth factor i and selected clinico-morphological parameters in colorectal cancer patients.Pol Przegl Chir, 2011, 83(5):250-257.
11. 黃桂林, 吳毅平, 雷娜.胰島素樣生長因子-1在原發性結直腸癌中表達的研究.中國普外基礎與臨床雜志, 2009, 16(9):693-697.
12. 胡永澤, 烏新林.IGF-I和IGF-IR在結直腸癌組織中的表達及臨床意義.內蒙古醫科大學學報, 2013, 35(1):27-31.
13. Carden CP, Molife LR, de Bono JS.predictive biomarkers for targeting insulin-like growth factor-1 (IGF-1) receptor.Mol Cancer Ther, 2009, 8(8):2077-2078.
14. Hewish M, Chau I, Cunningham D.Insulin-like growth factor 1 receptor targeted therapeutics:novel compounds and novel treatment strategies for cancer medicine.Recent Pat Anticancer Drug Discov, 2009, 4(1):54-72.
15. Ewing GP, Goff LW.The insulin-like growth factor signaling pathway as a target for treatment of colorectal carcinoma.Clin Colorectal Cancer, 2010, 9(4):219-223.
16. 鞠昕麗, 初蕾蕾, 楊閱樓, 等.IGF-Ⅱ和IGF-ⅠR及IGFBP-3在結直腸癌組織中的表達及其臨床意義.中國現代普通外科進展, 2013, 16(7):562-565.
17. 戚紅霞, 李曉虹, 胡海強.血清IGF-1、IGFBP-3、VEGF及多項白介素在結直腸癌轉移監測中的意義.海南醫學院學報, 2013, 19(2):176-179.
18. 胡倚玲, 王愛紅.結直腸癌患者血清中IGF-Ⅰ和IGF-BP3的水平及臨床意義.中國高等醫學教育, 2013, 9:132-133.
19. 陳權, 劉莉, 劉麗, 等.GHR、IGF-I在結直腸癌中的表達及其臨床意義.華中科技大學學報, 2012, 41(5):597-602.
20. 郝敬鵬.血清IGF-Ⅱ和TGF-α水平變化在結直腸癌中的臨床意義.中國現代醫學雜志, 2013, 23(1):48-51.
21. Giovannucci E.Insulin and colon cancer.Cancer Causes Control, 1995, 6(2):164-179.
22. 吳青眉, 吳秋云, 張愛群.結直腸癌代謝紊亂與胰島素抵抗的研究.中華胃腸外科雜志, 2011, 14(4):261-263.
23. 黃云, 王治國, 王強.腹腔鏡與開放直腸乙狀結腸癌切除術術后胰島素抵抗的差異及其臨床意義.中國現代普通外科進展, 2011, 14(12):933-936.
24. 魏曉萍, 惠起源, 劉小蕓.糖尿病與惡性腫瘤.新醫學, 2009, 40 (1):56-58.
25. Playford MP, Bicknell D, Bodmer W F, et al.Insulin like growth factor I regulates the location, stability, and transcriptional activity ofβ-catenin.Proc Natl Acid Sci USA, 2000, 97(22):12103-12108.
26. Zha J, O'Brien C, Savage H, et al.Molecular predictors of response to a humanized anti-insulin like growth factor-I receptor monoclonal antibody in breast and colorectal cancer.Mol Cancer Ther, 2009, 8(8):2110-2121.
27. Guo ST, Jiang CC, Wang GP, et al.MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.Oncogene, 2013, 32(15):1910-1920.
28. Lim do Y, Cho HJ, Kim J, et al.Luteolin decreases IGF-Ⅱproduc-tion and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells.BMC Gastroenterol, 2012, 12:9.
29. Flanigan SA, Pitts TM, Eckhardt SG, et al.The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.Clin Cancer Res, 2010, 16(22):5436-5446.
30. 李晴, 孔憲國, 郝杰民, 等.結直腸癌IGF-I mRNA表達與浸潤轉移的關系.癌癥, 2000, 9(2):153-155.
31. Pechlivanis S, Wagner K, Chang-claude J, et al.Polymorphisms in the insulin like growth factor 1 and IGF bindingprotein 3 genes and risk of colorectal cancer.Cancer Detect Prev, 2007, 31(5):408-416.
32. 胡水清, 湯哲, 張玫.糖尿病與結直腸癌患病危險關系的調查分析.世界華人消化雜志, 2007, 15(1):88-91.
33. Kasprzak A, Szaflarski W, Szmeja J, et al.Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer.Contemp Oncol (Pozn), 2012, 16(2):147-153.
34. Cho YY, Kim JG, Chae YS, et al.No association of insulin-like growth factor gene polymorphisms with survival in patients with colorectal cancer.Cancer Res Treat, 2011, 43(3):189-194.
35. 甘德芳, 高天翼, 王書奎, 等.結直腸癌患者中IGF2 LOI以及表達的研究.現代生物醫學進展, 2013, (11):2090-2092.

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Research Progress of The Relationship Between The Insulin Resistance, IGF-Ⅰ, IGF-Ⅱ, and Colorectal Cancer

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