Expert consensus on perioperative pain management for lung cancer (2026 edition)_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 Expert Consensus Group on Perioperative Pain Management for Lung Cancer ,  National Center for Respiratory Medicine (Guangzhou) ,  National Research Center for Pain Diagnosis and Treatment ,  National Medical Quality Control Center for Pain Specialty

Corresponding?author：

Expert Consensus Group on Perioperative Pain Management for Lung Cancer, Email: xiuyizhi2015@163.com; National Center for Respiratory Medicine (Guangzhou), Email: chenchun-0428@163.com; National Research Center for Pain Diagnosis and Treatment, Email: fbfzryy@yeah.net; National Medical Quality Control Center for Pain Specialty, Email: drjianxing.he@gmail.com

Keywords：

Lung neoplasms; perioperative pain management; pain, postoperative; chronic pain; expert consensus

DOI：

10.7507/1007-4848.202512091

Video：

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This consensus was developed based on extensive evidence-based medicine, combination of an improved Delphi method and expert meeting discussions, and was jointly formulated by a multidisciplinary expert team in surgery, painology, anesthesiology, and oncology, ultimately establishing 14 recommendation statements. The content comprehensively covers the entire process of perioperative pain management for lung cancer, aiming to standardize clinical pain management pathways, improve the quality of postoperative recovery, and enhance long-term prognosis. This consensus provides comprehensive and systematic guidance for perioperative pain management in lung cancer, offering significant support for improving patients’ postoperative quality of life and promoting rapid recovery.

Citation： Expert Consensus Group on Perioperative Pain Management for Lung Cancer, National Center for Respiratory Medicine (Guangzhou), National Research Center for Pain Diagnosis and Treatment, National Medical Quality Control Center for Pain Specialty. Expert consensus on perioperative pain management for lung cancer (2026 edition). Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2026, 33(5): 659-673. doi: 10.7507/1007-4848.202512091 Copy

1.	Hyland SJ, Brockhaus KK, Vincent WR, et al. Perioperative pain management and opioid stewardship: a practical guide. Healthcare (Basel), 2021, 9(3): 333.
2.	Chen Y, Wang E, Sites BD, et al. Integrating mechanistic-based and classification-based concepts into perioperative pain management: an educational guide for acute pain physicians. Reg Anesth Pain Med, 2024, 49(8): 581-601.
3.	Mariano ER, Dickerson DM, Szokol JW, et al. A multisociety organizational consensus process to define guiding principles for acute perioperative pain management. Reg Anesth Pain Med, 2022, 47(2): 118-127.
4.	Liu Y, Xiao S, Yang H, et al. Postoperative pain-related outcomes and perioperative pain management in China: a population-based study. Lancet Reg Health West Pac, 2023, 39: 100822.
5.	Liu S, Li S, Tang Y, et al. Minimally invasive surgery vs. open thoracotomy for non-small-cell lung cancer with N2 disease: a systematic review and meta-analysis. Front Med (Lausanne), 2023, 10: 1152421.
6.	Yoon S, Hong WP, Joo H, et al. Long-term incidence of chronic postsurgical pain after thoracic surgery for lung cancer: a 10-year single-center retrospective study. Reg Anesth Pain Med, 2020, 45(5): 331-336.
7.	Gu Y, Li X, Zhou Q, et al. Uniportal video-assisted thoracic surgery versus open thoracotomy for chronic pain after surgery: a prospective cohort study. J Anesth, 2024, 38(4): 525-536.
8.	Keller DM, ?arczyński D, Rybacka A, et al. Fatal early-onset checkpoint inhibitor pneumonitis in a patient with advanced squamous-cell lung cancer with underlying pulmonary fibrosis: a case report and review of the literature. Front Oncol, 2025, 15: 1672093.
9.	Franqueiro AR, Wilson JM, He J, et al. Prospective study of preoperative negative affect and postoperative pain in patients undergoing thoracic surgery: the moderating role of sex. J Clin Med, 2024, 13(19): 5722.
10.	Brunelli A, Beretta E, Cassivi SD, et al. Consensus definitions to promote an evidence-based approach to management of the pleural space. A collaborative proposal by ESTS, AATS, STS, and GTSC. Eur J Cardiothorac Surg, 2011, 40(2): 291-297.
11.	Craig SR, Leaver HA, Yap PL, et al. Acute phase responses following minimal access and conventional thoracic surgery. Eur J Cardiothorac Surg, 2001, 20(3): 455-463.
12.	中華醫學會胸心血管外科學分會胸腔鏡外科學組, 中國醫師協會胸外科醫師分會微創外科專家委員會. 中國胸外科圍手術期疼痛管理專家共識(2018版). 中國胸心血管外科臨床雜志, 2018, 25(11): 921-928.Thoracoscopic Surgery Group of Chinese Socicty for Thoracic and Cardiovascular Surgery, Expert Committee of Mininally Invasive Thoracic Surgery of Chinese Association of Thoracic Surgeons. Chinese expert consensus statement on perioperative pain management of thoracic surgery (version 2018). Chin J Clin Thorac Cardiovasc Surg, 2018, 25(11): 921-928.
13.	邱翠玲, 李旭英, 歐陽取長, 等. 腫瘤科無痛病房管理規范專家共識. 腫瘤藥學, 2025, 15(2): 145-151.Qiu CL, Li XY, Ouyang QC, et al. Expert consensus on standardized management guidelines for pain-free wards in oncology departments. Oncol Pharm, 2025, 15(2): 145-151.
14.	Huskisson EC. Measurement of pain. Lancet, 1974, 2(7889): 1127-1131.
15.	Wong DL, Baker CM. Smiling faces as anchor for pain intensity scales. Pain, 2001, 89(2-3): 295-300.
16.	Farrar JT, Young JP, LaMoreaux L, et al. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain, 2001, 94(2): 149-158.
17.	Cleeland CS, Ryan KM. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singap, 1994, 23(2): 129-138.
18.	Melzack R, Torgerson WS. On the language of pain. Anesthesiology, 1971, 34(1): 50-59.
19.	Lindberg MF, Miaskowski C, Rust?en T, et al. Preoperative risk factors associated with chronic pain profiles following total knee arthroplasty. Eur J Pain, 2021, 25(3): 680-692.
20.	Louiselle AE, Niemiec SM, Zgheib C, et al. Macrophage polarization and diabetic wound healing. Transl Res, 2021, 236: 109-116.
21.	Zhang Z, Yu X, Peng X, et al. Single-port thoracoscopic surgery via areola approach for lung cancer: feasibility, safety, and initial experience with a novel technique. ANZ J Surg, 2025, 95(11): 2367-2372.
22.	Catelli C, Corzani R, Zanfrini E, et al. Robotic-assisted (RATS) versus video-assisted (VATS) lobectomy: a monocentric prospective randomized trial. Eur J Surg Oncol, 2023, 49(12): 107256.
23.	Bendixen M, J?rgensen OD, Kronborg C, et al. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol, 2016, 17(6): 836-844.
24.	Roszik J, Lee JJ, Wu YH, et al. Real-world studies link nonsteroidal anti-inflammatory drug use to improved overall lung cancer survival. Cancer Res Commun, 2022, 2(7): 590-601.
25.	Jiang W, Wang L, Zhang J, et al. Effects of postoperative non-steroidal anti-inflammatory drugs on long-term survival and recurrence of patients with non-small cell lung cancer. Medicine (Baltimore), 2018, 97(39): e12442.
26.	L?bel J, Danielsen AV, Sperling PK, et al. Intravenous dexamethasone in pain treatment after video-assisted thoracoscopic surgery. Dan Med J, 2024, 71(3): A05230317.
27.	Lin S, Zhang Y, Huang X, et al. Effects of combined use of salbutamol/budesonide in thoracic surgery on postoperative myocardial injury (MINS): a prospective randomized clinical trial. Drug Des Devel Ther, 2023, 17: 1025-1036.
28.	Sugimoto M, Takagi T, Suzuki R, et al. Mirogabalin vs pregabalin for chemotherapy-induced peripheral neuropathy in pancreatic cancer patients. BMC Cancer, 2021, 21(1): 1319.
29.	Misawa S, Denda T, Kodama S, et al. Efficacy and safety of mirogabalin for chemotherapy-induced peripheral neuropathy: a prospective single-arm trial (MiroCIP study). BMC Cancer, 2023, 23(1): 1098.
30.	Baba M, Kuroha M, Ohwada S, et al. Results of mirogabalin treatment for diabetic peripheral neuropathic pain in Asian subjects: a phase 2, double-blind, randomized, placebo-controlled, study. Pain Ther, 2020, 9(1): 261-278.
31.	Zhao Y, Li Y, Sun L, et al. Perioperative pregabalin reduced fatigue scores after thoracoscopic pneumonectomy in a RCT of NSCLC patients. Am J Cancer Res, 2023, 13(5): 2201-2212.
32.	Miyazaki T, Matsumoto K, Sato T, et al. Efficacy and safety of add-on mirogabalin to conventional therapy for the treatment of peripheral neuropathic pain after thoracic surgery: the multicenter, randomized, open-label ADMIT-NeP study. BMC Cancer, 2024, 24(1): 80.
33.	Tomaszek L, Fenikowski D, Maciejewski P, et al. Perioperative gabapentin in pediatric thoracic surgery patients-randomized, placebo-controlled, phase 4 trial. Pain Med, 2020, 21(8): 1562-1571.
34.	Doleman B, Mathiesen O, Sutton AJ, et al. Non-opioid analgesics for the prevention of chronic postsurgical pain: a systematic review and network meta-analysis. Br J Anaesth, 2023, 130(6): 719-728.
35.	Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol, 2015, 14(2): 162-173.
36.	Ferreira GE, Abdel-Shaheed C, Underwood M, et al. Efficacy, safety, and tolerability of antidepressants for pain in adults: overview of systematic reviews. BMJ, 2023, 380: e072415.
37.	Nikitas J, Yanagawa J, Sacks S, et al. Pathophysiology and management of chest wall pain after surgical and non-surgical local therapies for lung cancer. JTO Clin Res Rep, 2024, 5(7): 100690.
38.	Brown TJ, Keshvani N, Gupta A, et al. Rates of appropriate laxative prophylaxis for opioid-induced constipation in veterans with lung cancer: a retrospective cohort study. Support Care Cancer, 2020, 28(11): 5315-5321.
39.	Nakada T, Ohtsuka T. Impact of opioids on postoperative prognosis in lung cancer. J Thorac Dis, 2023, 15(10): 5272-5274.
40.	Nelson DB, Cata JP, Niu J, et al. Persistent opioid use is associated with worse survival after lobectomy for stage I non-small cell lung cancer. Pain, 2019, 160(10): 2365-2373.
41.	Nguyen J, Luk K, Vang D, et al. Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer. Br J Anaesth, 2014, 113(Suppl 1): i4-i13.
42.	Schwenk ES, Gupta RK. Mortality associated with long-term opioid use after lung cancer surgery: an infographic. Reg Anesth Pain Med, 2022, 47(11): 684.
43.	Yan H, Chen W, Chen Y, et al. Opioid-free versus opioid-based anesthesia on postoperative pain after thoracoscopic surgery: the use of intravenous and epidural esketamine. Anesth Analg, 2023, 137(2): 399-408.
44.	Feng CD, Xu Y, Chen S, et al. Opioid-free anaesthesia reduces postoperative nausea and vomiting after thoracoscopic lung resection: a randomised controlled trial. Br J Anaesth, 2024, 132(2): 267-276.
45.	Oh TK, Jeon JH, Lee JM, et al. Investigation of opioid use and long-term oncologic outcomes for non-small cell lung cancer patients treated with surgery. PLoS One, 2017, 12(7): e0181672.
46.	Dhillon S. Correction: Tegileridine: first approval. Drugs, 2024, 84(8): 1011.
47.	Wang Q, Zhao C, Hu J, et al. Efficacy of a modified cocktail for periarticular local infiltration analgesia in total knee arthroplasty: a prospective, double-blinded, randomized controlled trial. J Bone Joint Surg Am, 2023, 105(5): 354-362.
48.	Spaans LN, Dijkgraaf MGW, Susa D, et al. Intercostal or paravertebral block vs thoracic epidural in lung surgery: a randomized noninferiority trial. JAMA Surg, 2025, 160(8): 855-864.
49.	Chen JQ, Yang XL, Gu H, et al. The role of serratus anterior plane block during in video-assisted thoracoscopic surgery. Pain Ther, 2021, 10(2): 1051-1066.
50.	Chaudhary O, Baribeau Y, Urits I, et al. Use of erector spinae plane block in thoracic surgery leads to rapid recovery from anesthesia. Ann Thorac Surg, 2020, 110(4): 1153-1159.
51.	Xiang XB, Wu YY, Fang Z, et al. Stellate ganglion block for visceral pain in elderly patients undergoing video-assisted thoracoscopic lung cancer surgery: a randomized, controlled trial. Int J Surg, 2024, 110(11): 6996-7002.
52.	Qin J, Lei Z, Li R, et al. Intrapleural injection of bupivacaine liposome for pain management after thoracoscopic surgery. Sci Rep, 2025, 15(1): 24433.
53.	Chi Y, Su X, Liu S, et al. Liposomal bupivacaine intercostal nerve block for pain control in thoracoscopic surgery: a randomized controlled trial. Front Med (Lausanne), 2025, 12: 1647324.
54.	Dong L, Wang X, Fu L, et al. Efficacy and safety of bupivacaine liposomal in intercostal nerve block for postoperative pain management following uniportal thoracoscopy: a randomized trial. Pain Res Manag, 2025, 2025: 8816879.
55.	Coppens S, Hoogma DF, Dewinter G, et al. Erector spinae plane block versus intercostal nerve blocks in uniportal videoscopic-assisted thoracic surgery: a multicenter, double-blind, prospective randomized placebo-controlled trial. Anesthesiology, 2025, 143(4): 1015-1025.
56.	Ventham NT, Hughes M, O'Neill S, et al. Systematic review and meta-analysis of continuous local anaesthetic wound infiltration versus epidural analgesia for postoperative pain following abdominal surgery. Br J Surg, 2013, 100(10): 1280-1289.
57.	Fortier S, Hanna HA, Bernard A, et al. Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management. Eur J Anaesthesiol, 2012, 29(11): 524-530.
58.	Sztain JF, Gabriel RA, Said ET. Thoracic epidurals are associated with decreased opioid consumption compared to surgical infiltration of liposomal bupivacaine following video-assisted thoracoscopic surgery for lobectomy: a retrospective cohort analysis. J Cardiothorac Vasc Anesth, 2019, 33(3): 694-698.
59.	Zhao H, Wu Y, Zhang X, et al. The effect of preoperative serratus anterior muscle plane block on persistent postsurgical pain after video-assisted thoracic surgery: a retrospective cohort study. Clin J Pain, 2021, 37(10): 759-765.
60.	Shang LH, Xiao ZN, Zhao YL, et al. Analgesic effect of serratus anterior plane block after thoracoscopic surgery: a randomized controlled double-blinded study. Ther Clin Risk Manag, 2020, 16: 1257-1265.
61.	Leviel F, Fourdrain A, Delatre F, et al. Serratus anterior plane block alone, paravertebral block alone and their combination in video-assisted thoracoscopic surgery: the THORACOSOPIC double-blind, randomized trial. Eur J Cardiothorac Surg, 2024, 65(4): ezae082.
62.	Chen Z, Gao C, Zhang Y, et al. Effects of ultrasound-guided thoracic paravertebral nerve block combined with perineural or Ⅳ dexmedetomidine on acute and chronic pain after thoracoscopic resection of lung lesions: a double-blind randomized trial. Drug Des Devel Ther, 2024, 18: 2089-2101.
63.	Yang Z, Liu M, Wang C, et al. Thoracic paravertebral block with liposomal bupivacaine versus plain bupivacaine in patients undergoing thoracoscopic lung resection: a randomized controlled study. Drug Des Devel Ther, 2025, 19: 6955-6964.
64.	Wang LL, Zhu Y, Hui LY, et al. Liposomal bupivacaine in ultrasound-guided paravertebral block reduces opioid consumption and accelerates recovery after thoracic surgery: a randomized controlled trial. Drug Des Devel Ther, 2025, 19: 9137-9149.
65.	Xu X, Xie YX, Zhang M, et al. Comparison of thoracoscopy-guided thoracic paravertebral block and ultrasound-guided thoracic paravertebral block in postoperative analgesia of thoracoscopic lung cancer radical surgery: a randomized controlled trial. Pain Ther, 2024, 13(3): 577-588.
66.	Hu J, Zhou W, Zheng X, et al. Analgesic efficacy of continuous erector spinae plane block vs. opioid-based regimen for postoperative pain management following video-assisted thoracoscopic lung resection: a prospective, randomised, open-label, non-inferiority trial. Anaesthesia, 2025, 80(10): 1226-1236.
67.	Zhao H, Xin L, Feng Y. The effect of preoperative erector spinae plane vs. paravertebral blocks on patient-controlled oxycodone consumption after video-assisted thoracic surgery: a prospective randomized, blinded, non-inferiority study. J Clin Anesth, 2020, 62: 109737.
68.	Wei Y, Wei X, He F, et al. Effect of liposomal bupivacaine for preoperative thoracic paravertebral blockade on postoperative pain following video-assisted thoracoscopic lung surgery: a prospective, double-blind, randomized controlled trial. J Cardiothorac Vasc Anesth, 2026, 40(1): 281-289.
69.	Sung CS, Wei TJ, Hung JJ, et al. Comparisons in analgesic effects between ultrasound-guided erector spinae plane block and surgical intercostal nerve block after video-assisted thoracoscopic surgery: a randomized controlled trial. J Clin Anesth, 2024, 95: 111448.
70.	Li J, Pourrahmat MM, Vasilyeva E, et al. Efficacy and safety of patient-controlled analgesia compared with epidural analgesia after open hepatic resection: a systematic review and meta-analysis. Ann Surg, 2019, 270(2): 200-208.
71.	Huepenbecker SP, Cusworth SE, Kuroki LM, et al. Continuous epidural infusion in gynecologic oncology patients undergoing exploratory laparotomy: the new standard for decreased postoperative pain and opioid use. Gynecol Oncol, 2019, 153(2): 356-361.
72.	扶超, 胡渤, 周揚, 等. 比較全程硬膜外鎮痛和單次硬膜外阻滯聯合靜脈自控鎮痛對胸外科手術后急性與慢性疼痛的影響. 中華疼痛學雜志, 2021, 17(6): 638-644.Fu C, Hu B, Zhou Y, et al. The effect of comprehensive epidural analgesia and single epidural block plus intravenous analgesia on acute and chronic pain after thoracic surgery. Chin J Painol, 2021, 17(6): 638-644.
73.	Yabuki S, Kaiho Y, Tarasawa K, et al. Exploring the impact of perioperative analgesia on postoperative chronic analgesic prescriptions in patients with lung cancer undergoing minimally invasive thoracic surgery: a retrospective observational study. Eur J Pain, 2025, 29(2): e4774.
74.	McNicol ED, Ferguson MC, Hudcova J. Patient controlled opioid analgesia versus non-patient controlled opioid analgesia for postoperative pain. Cochrane Database Syst Rev, 2015, 2015(6): CD003348.
75.	von H?sslin T, Imboden P, Lüthi A, et al. Adverse events of postoperative thoracic epidural analgesia: a retrospective analysis of 7273 cases in a tertiary care teaching hospital. Eur J Anaesthesiol, 2016, 33(10): 708-714.
76.	劉浩, 賈延兵, 魏靜, 等. 重復外周磁刺激在康復治療中的應用及研究進展. 中國康復醫學雜志, 2021, 36(5): 631-637.Liu H, Jia YB, Wei J, et al. Application and research progress of repetitive peripheral magnetic stimulation in rehabilitation therapy. Chin J Rehabil Med, 2021, 36(5): 631-637.
77.	Lefaucheur JP, André-Obadia N, Antal A, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol, 2014, 125(11): 2150-2206.
78.	Bedder M, Parker L. Magnetic peripheral nerve stimulation (mPNS) for chronic pain. J Pain Res, 2023, 16: 2365-2373.
79.	Park S, Park R, Westwood D, et al. Effect of peripheral magnetic stimulation on acute and chronic pain after surgery: a systematic review and meta-analysis. J Pain, 2023, 24(7): 1151-1162.
80.	Wininger KL, Bester ML, Deshpande KK. Spinal cord stimulation to treat postthoracotomy neuralgia: non-small-cell lung cancer: a case report. Pain Manag Nurs, 2012, 13(1): 52-59.
81.	Sutanto YS, Ibrahim D, Septiawan D, et al. Effect of cognitive behavioral therapy on improving anxiety, depression, and quality of life in pre-diagnosed lung cancer patients. Asian Pac J Cancer Prev, 2021, 22(11): 3455-3460.
82.	Tsimopoulou I, Pasquali S, Howard R, et al. Psychological prehabilitation before cancer surgery: a systematic review. Ann Surg Oncol, 2015, 22(13): 4117-4123.
83.	Cheng JOS, Cheng ST. Effectiveness of physical and cognitive-behavioural intervention programmes for chronic musculoskeletal pain in adults: a systematic review and meta-analysis of randomised controlled trials. PLoS One, 2019, 14(10): e0223367.
84.	Lai Y, Huang J, Yang M, et al. Seven-day intensive preoperative rehabilitation for elderly patients with lung cancer: a randomized controlled trial. J Surg Res, 2017, 209: 30-36.
85.	Milkias M, Mekonnen S, Ahmed S, et al. Evidence-based guideline on chronic postsurgical pain management in adult patients in resource-restricted setting, 2023: systematic review and guideline. Ann Med Surg (Lond), 2023, 85(11): 5593-5603.
86.	Chen G, Lu J, Li B, et al. Efficacy and safety of Shenqi Fuzheng injection combined with chemotherapy for cancer: an overview of systematic reviews. Phytomedicine, 2024, 125: 155293.
87.	Park S, Lyu YR, Park SJ, et al. Electroacupuncture for post-thoracotomy pain: a systematic review and meta-analysis. PLoS One, 2021, 16(7): e0254093.
88.	Xu Y, Yang R, Xiao S, et al. Expert consensus on perioperative management of patients with lung cancer treated with co-ablation system therapy. Asia Pac J Oncol Nurs, 2025, 12: 100747.
89.	Wu D, Dai J, Sheng Y, et al. Evidence summary on pain management in thoracoscopic lung cancer surgery. Asia Pac J Oncol Nurs, 2025, 12: 100693.
90.	Zhao X, Cui L, Wang W, et al. Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery. Pak J Med Sci, 2016, 32(1): 155-159.
91.	Tian L, Wen Y, Li J, et al. Effects of remote web-based interventions on the physiological and psychological states of patients with cancer: systematic review with meta-analysis. JMIR Mhealth Uhealth, 2025, 13: e71196.
92.	Anderson D, Chen SA, Godoy LA, et al. Comprehensive review of chest tube management: a review. JAMA Surg, 2022, 157(3): 269-274.
93.	Bertoglio P, Guerrera F, Viti A, et al. Chest drain and thoracotomy for chest trauma. J Thorac Dis, 2019, 11(Suppl 2): S186-S191.
94.	Bassi M, Mottola E, Mantovani S, et al. Coaxial drainage versus standard chest tube after pulmonary lobectomy: a randomized controlled study. Curr Oncol, 2022, 29(7): 4455-4463.
95.	Rahman NM, Pepperell J, Rehal S, et al. Effect of opioids vs NSAIDs and larger vs smaller chest tube size on pain control and pleurodesis efficacy among patients with malignant pleural effusion: the TIME1 randomized clinical trial. JAMA, 2015, 314(24): 2641-2653.
96.	Rahman NM, Maskell NA, Davies CW, et al. The relationship between chest tube size and clinical outcome in pleural infection. Chest, 2010, 137(3): 536-543.
97.	Song L, Chen X, Zhu L, et al. Perioperative outcomes of bi-pigtail catheter drainage strategy versus conventional chest tube after uniportal video-assisted thoracic lung surgery. Eur J Cardiothorac Surg, 2023, 64(6): ezad411.
98.	Hart JM, Hussien AM, Tesfaye S, et al. Effectiveness of single chest tube vs double chest tube application postdecortication: prospective randomized controlled study. J Am Coll Surg, 2023, 236(6): 1217-1231.
99.	He J, Liang H, Wang W, et al. Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou). Transl Lung Cancer Res, 2021, 10(8): 3503-3519.
100.	Liu Z, Yang R, Sun Y. Tubeless uniportal thoracoscopic wedge resection with modified air leak test and chest tube drainage. BMC Surg, 2020, 20(1): 301.
101.	Li S, Jiang L, Ang KL, et al. New tubeless video-assisted thoracoscopic surgery for small pulmonary nodules. Eur J Cardiothorac Surg, 2017, 51(4): 689-693.
102.	Liao HC, Yang SM, Hung MH, et al. Thoracoscopic surgery without drainage tube placement for peripheral lung nodules. Ann Thorac Surg, 2020, 109(3): 887-893.
103.	Zhao Y, Shan L, Zhang W, et al. Minimally invasive lung surgery with an intraoperative completely or partially tubeless protocol: randomized clinical trial. BJS Open, 2024, 9(1): zrae132.
104.	Zhang JT, Dong S, Chu XP, et al. Randomized trial of an improved drainage strategy versus routine chest tube after lung wedge resection. Ann Thorac Surg, 2020, 109(4): 1040-1046.
105.	Zhang D, Wu J, Yang Y, et al. Comparison of non-intubated and intubated video-assisted thoracoscopic surgery for perioperative complications-a systematic review and meta-analysis. BMC Anesthesiol, 2025, 25(1): 272.
106.	Wang L, Wang D, Zhang Y. Comparison of postoperative pulmonary complications and intraoperative safety in thoracoscopic surgery under non-intubated versus intubated anesthesia: a randomized, controlled, double-blind non-inferiority trial. Updates Surg, 2024, 76(8): 2863-2873.
107.	Huang C, Huang Q, Shen Y, et al. General anaesthesia with double-lumen intubation compared to opioid-sparing strategies with laryngeal mask for thoracoscopic surgery: a randomised trial. Anaesth Crit Care Pain Med, 2022, 41(3): 101083.
108.	Treede RD, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain, 2019, 160(1): 19-27.
109.	Haroutiunian S, Nikolajsen L, Finnerup NB, et al. The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain, 2013, 154(1): 95-102.
110.	神經病理性疼痛診療專家組. 神經病理性疼痛診療專家共識. 中國疼痛醫學雜志, 2013, 19(12): 705-710.Expert Group for Diagnosis and Treatment of Neuropathic Pain. Expert consensus on the diagnosis and treatment of neuropathic pain. Chin J Pain Med, 2013, 19(12): 705-710.
111.	周圍神經病理性疼痛診療中國專家共識組. 周圍神經病理性疼痛診療中國專家共識. 中國疼痛醫學雜志, 2020, 26(5): 321-328.Chinese Expert Consensus Group on the Diagnosis and Treatment of Peripheral Neuropathic Pain. Chinese expert consensus on the diagnosis and treatment of peripheral neuropathic pain. Chin J Pain Med, 2020, 26(5): 321-328.
112.	Liu YM, Feng Y, Liu YQ, et al. Chinese Association for the Study of Pain: expert consensus on chronic postsurgical pain. World J Clin Cases, 2021, 9(9): 2090-2099.
113.	Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: from mechanisms to treatment. Physiol Rev, 2021, 101(1): 259-301.
114.	Varallo G, Giusti EM, Manna C, et al. Sleep disturbances and sleep disorders as risk factors for chronic postsurgical pain: a systematic review and meta-analysis. Sleep Med Rev, 2022, 63: 101630.
115.	盧振和, 呂巖, 吳士明, 等. 醫用紅外線熱成像技術在臨床醫學中應用的中國專家共識(2022版). 中華疼痛學雜志, 2022, 18(4): 449-455.Lu ZH, Lyu Y, Wu SM, et al. Consensus of Chinese experts on application of medical infrared themography in clinical medicine (2022 edition). Chin J Painol, 2022, 18(4): 449-455.

1. Hyland SJ, Brockhaus KK, Vincent WR, et al. Perioperative pain management and opioid stewardship: a practical guide. Healthcare (Basel), 2021, 9(3): 333.
2. Chen Y, Wang E, Sites BD, et al. Integrating mechanistic-based and classification-based concepts into perioperative pain management: an educational guide for acute pain physicians. Reg Anesth Pain Med, 2024, 49(8): 581-601.
3. Mariano ER, Dickerson DM, Szokol JW, et al. A multisociety organizational consensus process to define guiding principles for acute perioperative pain management. Reg Anesth Pain Med, 2022, 47(2): 118-127.
4. Liu Y, Xiao S, Yang H, et al. Postoperative pain-related outcomes and perioperative pain management in China: a population-based study. Lancet Reg Health West Pac, 2023, 39: 100822.
5. Liu S, Li S, Tang Y, et al. Minimally invasive surgery vs. open thoracotomy for non-small-cell lung cancer with N2 disease: a systematic review and meta-analysis. Front Med (Lausanne), 2023, 10: 1152421.
6. Yoon S, Hong WP, Joo H, et al. Long-term incidence of chronic postsurgical pain after thoracic surgery for lung cancer: a 10-year single-center retrospective study. Reg Anesth Pain Med, 2020, 45(5): 331-336.
7. Gu Y, Li X, Zhou Q, et al. Uniportal video-assisted thoracic surgery versus open thoracotomy for chronic pain after surgery: a prospective cohort study. J Anesth, 2024, 38(4): 525-536.
8. Keller DM, ?arczyński D, Rybacka A, et al. Fatal early-onset checkpoint inhibitor pneumonitis in a patient with advanced squamous-cell lung cancer with underlying pulmonary fibrosis: a case report and review of the literature. Front Oncol, 2025, 15: 1672093.
9. Franqueiro AR, Wilson JM, He J, et al. Prospective study of preoperative negative affect and postoperative pain in patients undergoing thoracic surgery: the moderating role of sex. J Clin Med, 2024, 13(19): 5722.
10. Brunelli A, Beretta E, Cassivi SD, et al. Consensus definitions to promote an evidence-based approach to management of the pleural space. A collaborative proposal by ESTS, AATS, STS, and GTSC. Eur J Cardiothorac Surg, 2011, 40(2): 291-297.
11. Craig SR, Leaver HA, Yap PL, et al. Acute phase responses following minimal access and conventional thoracic surgery. Eur J Cardiothorac Surg, 2001, 20(3): 455-463.
12. 中華醫學會胸心血管外科學分會胸腔鏡外科學組, 中國醫師協會胸外科醫師分會微創外科專家委員會. 中國胸外科圍手術期疼痛管理專家共識(2018版). 中國胸心血管外科臨床雜志, 2018, 25(11): 921-928.Thoracoscopic Surgery Group of Chinese Socicty for Thoracic and Cardiovascular Surgery, Expert Committee of Mininally Invasive Thoracic Surgery of Chinese Association of Thoracic Surgeons. Chinese expert consensus statement on perioperative pain management of thoracic surgery (version 2018). Chin J Clin Thorac Cardiovasc Surg, 2018, 25(11): 921-928.
13. 邱翠玲, 李旭英, 歐陽取長, 等. 腫瘤科無痛病房管理規范專家共識. 腫瘤藥學, 2025, 15(2): 145-151.Qiu CL, Li XY, Ouyang QC, et al. Expert consensus on standardized management guidelines for pain-free wards in oncology departments. Oncol Pharm, 2025, 15(2): 145-151.
14. Huskisson EC. Measurement of pain. Lancet, 1974, 2(7889): 1127-1131.
15. Wong DL, Baker CM. Smiling faces as anchor for pain intensity scales. Pain, 2001, 89(2-3): 295-300.
16. Farrar JT, Young JP, LaMoreaux L, et al. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain, 2001, 94(2): 149-158.
17. Cleeland CS, Ryan KM. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singap, 1994, 23(2): 129-138.
18. Melzack R, Torgerson WS. On the language of pain. Anesthesiology, 1971, 34(1): 50-59.
19. Lindberg MF, Miaskowski C, Rust?en T, et al. Preoperative risk factors associated with chronic pain profiles following total knee arthroplasty. Eur J Pain, 2021, 25(3): 680-692.
20. Louiselle AE, Niemiec SM, Zgheib C, et al. Macrophage polarization and diabetic wound healing. Transl Res, 2021, 236: 109-116.
21. Zhang Z, Yu X, Peng X, et al. Single-port thoracoscopic surgery via areola approach for lung cancer: feasibility, safety, and initial experience with a novel technique. ANZ J Surg, 2025, 95(11): 2367-2372.
22. Catelli C, Corzani R, Zanfrini E, et al. Robotic-assisted (RATS) versus video-assisted (VATS) lobectomy: a monocentric prospective randomized trial. Eur J Surg Oncol, 2023, 49(12): 107256.
23. Bendixen M, J?rgensen OD, Kronborg C, et al. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol, 2016, 17(6): 836-844.
24. Roszik J, Lee JJ, Wu YH, et al. Real-world studies link nonsteroidal anti-inflammatory drug use to improved overall lung cancer survival. Cancer Res Commun, 2022, 2(7): 590-601.
25. Jiang W, Wang L, Zhang J, et al. Effects of postoperative non-steroidal anti-inflammatory drugs on long-term survival and recurrence of patients with non-small cell lung cancer. Medicine (Baltimore), 2018, 97(39): e12442.
26. L?bel J, Danielsen AV, Sperling PK, et al. Intravenous dexamethasone in pain treatment after video-assisted thoracoscopic surgery. Dan Med J, 2024, 71(3): A05230317.
27. Lin S, Zhang Y, Huang X, et al. Effects of combined use of salbutamol/budesonide in thoracic surgery on postoperative myocardial injury (MINS): a prospective randomized clinical trial. Drug Des Devel Ther, 2023, 17: 1025-1036.
28. Sugimoto M, Takagi T, Suzuki R, et al. Mirogabalin vs pregabalin for chemotherapy-induced peripheral neuropathy in pancreatic cancer patients. BMC Cancer, 2021, 21(1): 1319.
29. Misawa S, Denda T, Kodama S, et al. Efficacy and safety of mirogabalin for chemotherapy-induced peripheral neuropathy: a prospective single-arm trial (MiroCIP study). BMC Cancer, 2023, 23(1): 1098.
30. Baba M, Kuroha M, Ohwada S, et al. Results of mirogabalin treatment for diabetic peripheral neuropathic pain in Asian subjects: a phase 2, double-blind, randomized, placebo-controlled, study. Pain Ther, 2020, 9(1): 261-278.
31. Zhao Y, Li Y, Sun L, et al. Perioperative pregabalin reduced fatigue scores after thoracoscopic pneumonectomy in a RCT of NSCLC patients. Am J Cancer Res, 2023, 13(5): 2201-2212.
32. Miyazaki T, Matsumoto K, Sato T, et al. Efficacy and safety of add-on mirogabalin to conventional therapy for the treatment of peripheral neuropathic pain after thoracic surgery: the multicenter, randomized, open-label ADMIT-NeP study. BMC Cancer, 2024, 24(1): 80.
33. Tomaszek L, Fenikowski D, Maciejewski P, et al. Perioperative gabapentin in pediatric thoracic surgery patients-randomized, placebo-controlled, phase 4 trial. Pain Med, 2020, 21(8): 1562-1571.
34. Doleman B, Mathiesen O, Sutton AJ, et al. Non-opioid analgesics for the prevention of chronic postsurgical pain: a systematic review and network meta-analysis. Br J Anaesth, 2023, 130(6): 719-728.
35. Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol, 2015, 14(2): 162-173.
36. Ferreira GE, Abdel-Shaheed C, Underwood M, et al. Efficacy, safety, and tolerability of antidepressants for pain in adults: overview of systematic reviews. BMJ, 2023, 380: e072415.
37. Nikitas J, Yanagawa J, Sacks S, et al. Pathophysiology and management of chest wall pain after surgical and non-surgical local therapies for lung cancer. JTO Clin Res Rep, 2024, 5(7): 100690.
38. Brown TJ, Keshvani N, Gupta A, et al. Rates of appropriate laxative prophylaxis for opioid-induced constipation in veterans with lung cancer: a retrospective cohort study. Support Care Cancer, 2020, 28(11): 5315-5321.
39. Nakada T, Ohtsuka T. Impact of opioids on postoperative prognosis in lung cancer. J Thorac Dis, 2023, 15(10): 5272-5274.
40. Nelson DB, Cata JP, Niu J, et al. Persistent opioid use is associated with worse survival after lobectomy for stage I non-small cell lung cancer. Pain, 2019, 160(10): 2365-2373.
41. Nguyen J, Luk K, Vang D, et al. Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer. Br J Anaesth, 2014, 113(Suppl 1): i4-i13.
42. Schwenk ES, Gupta RK. Mortality associated with long-term opioid use after lung cancer surgery: an infographic. Reg Anesth Pain Med, 2022, 47(11): 684.
43. Yan H, Chen W, Chen Y, et al. Opioid-free versus opioid-based anesthesia on postoperative pain after thoracoscopic surgery: the use of intravenous and epidural esketamine. Anesth Analg, 2023, 137(2): 399-408.
44. Feng CD, Xu Y, Chen S, et al. Opioid-free anaesthesia reduces postoperative nausea and vomiting after thoracoscopic lung resection: a randomised controlled trial. Br J Anaesth, 2024, 132(2): 267-276.
45. Oh TK, Jeon JH, Lee JM, et al. Investigation of opioid use and long-term oncologic outcomes for non-small cell lung cancer patients treated with surgery. PLoS One, 2017, 12(7): e0181672.
46. Dhillon S. Correction: Tegileridine: first approval. Drugs, 2024, 84(8): 1011.
47. Wang Q, Zhao C, Hu J, et al. Efficacy of a modified cocktail for periarticular local infiltration analgesia in total knee arthroplasty: a prospective, double-blinded, randomized controlled trial. J Bone Joint Surg Am, 2023, 105(5): 354-362.
48. Spaans LN, Dijkgraaf MGW, Susa D, et al. Intercostal or paravertebral block vs thoracic epidural in lung surgery: a randomized noninferiority trial. JAMA Surg, 2025, 160(8): 855-864.
49. Chen JQ, Yang XL, Gu H, et al. The role of serratus anterior plane block during in video-assisted thoracoscopic surgery. Pain Ther, 2021, 10(2): 1051-1066.
50. Chaudhary O, Baribeau Y, Urits I, et al. Use of erector spinae plane block in thoracic surgery leads to rapid recovery from anesthesia. Ann Thorac Surg, 2020, 110(4): 1153-1159.
51. Xiang XB, Wu YY, Fang Z, et al. Stellate ganglion block for visceral pain in elderly patients undergoing video-assisted thoracoscopic lung cancer surgery: a randomized, controlled trial. Int J Surg, 2024, 110(11): 6996-7002.
52. Qin J, Lei Z, Li R, et al. Intrapleural injection of bupivacaine liposome for pain management after thoracoscopic surgery. Sci Rep, 2025, 15(1): 24433.
53. Chi Y, Su X, Liu S, et al. Liposomal bupivacaine intercostal nerve block for pain control in thoracoscopic surgery: a randomized controlled trial. Front Med (Lausanne), 2025, 12: 1647324.
54. Dong L, Wang X, Fu L, et al. Efficacy and safety of bupivacaine liposomal in intercostal nerve block for postoperative pain management following uniportal thoracoscopy: a randomized trial. Pain Res Manag, 2025, 2025: 8816879.
55. Coppens S, Hoogma DF, Dewinter G, et al. Erector spinae plane block versus intercostal nerve blocks in uniportal videoscopic-assisted thoracic surgery: a multicenter, double-blind, prospective randomized placebo-controlled trial. Anesthesiology, 2025, 143(4): 1015-1025.
56. Ventham NT, Hughes M, O'Neill S, et al. Systematic review and meta-analysis of continuous local anaesthetic wound infiltration versus epidural analgesia for postoperative pain following abdominal surgery. Br J Surg, 2013, 100(10): 1280-1289.
57. Fortier S, Hanna HA, Bernard A, et al. Comparison between systemic analgesia, continuous wound catheter analgesia and continuous thoracic paravertebral block: a randomised, controlled trial of postthoracotomy pain management. Eur J Anaesthesiol, 2012, 29(11): 524-530.
58. Sztain JF, Gabriel RA, Said ET. Thoracic epidurals are associated with decreased opioid consumption compared to surgical infiltration of liposomal bupivacaine following video-assisted thoracoscopic surgery for lobectomy: a retrospective cohort analysis. J Cardiothorac Vasc Anesth, 2019, 33(3): 694-698.
59. Zhao H, Wu Y, Zhang X, et al. The effect of preoperative serratus anterior muscle plane block on persistent postsurgical pain after video-assisted thoracic surgery: a retrospective cohort study. Clin J Pain, 2021, 37(10): 759-765.
60. Shang LH, Xiao ZN, Zhao YL, et al. Analgesic effect of serratus anterior plane block after thoracoscopic surgery: a randomized controlled double-blinded study. Ther Clin Risk Manag, 2020, 16: 1257-1265.
61. Leviel F, Fourdrain A, Delatre F, et al. Serratus anterior plane block alone, paravertebral block alone and their combination in video-assisted thoracoscopic surgery: the THORACOSOPIC double-blind, randomized trial. Eur J Cardiothorac Surg, 2024, 65(4): ezae082.
62. Chen Z, Gao C, Zhang Y, et al. Effects of ultrasound-guided thoracic paravertebral nerve block combined with perineural or Ⅳ dexmedetomidine on acute and chronic pain after thoracoscopic resection of lung lesions: a double-blind randomized trial. Drug Des Devel Ther, 2024, 18: 2089-2101.
63. Yang Z, Liu M, Wang C, et al. Thoracic paravertebral block with liposomal bupivacaine versus plain bupivacaine in patients undergoing thoracoscopic lung resection: a randomized controlled study. Drug Des Devel Ther, 2025, 19: 6955-6964.
64. Wang LL, Zhu Y, Hui LY, et al. Liposomal bupivacaine in ultrasound-guided paravertebral block reduces opioid consumption and accelerates recovery after thoracic surgery: a randomized controlled trial. Drug Des Devel Ther, 2025, 19: 9137-9149.
65. Xu X, Xie YX, Zhang M, et al. Comparison of thoracoscopy-guided thoracic paravertebral block and ultrasound-guided thoracic paravertebral block in postoperative analgesia of thoracoscopic lung cancer radical surgery: a randomized controlled trial. Pain Ther, 2024, 13(3): 577-588.
66. Hu J, Zhou W, Zheng X, et al. Analgesic efficacy of continuous erector spinae plane block vs. opioid-based regimen for postoperative pain management following video-assisted thoracoscopic lung resection: a prospective, randomised, open-label, non-inferiority trial. Anaesthesia, 2025, 80(10): 1226-1236.
67. Zhao H, Xin L, Feng Y. The effect of preoperative erector spinae plane vs. paravertebral blocks on patient-controlled oxycodone consumption after video-assisted thoracic surgery: a prospective randomized, blinded, non-inferiority study. J Clin Anesth, 2020, 62: 109737.
68. Wei Y, Wei X, He F, et al. Effect of liposomal bupivacaine for preoperative thoracic paravertebral blockade on postoperative pain following video-assisted thoracoscopic lung surgery: a prospective, double-blind, randomized controlled trial. J Cardiothorac Vasc Anesth, 2026, 40(1): 281-289.
69. Sung CS, Wei TJ, Hung JJ, et al. Comparisons in analgesic effects between ultrasound-guided erector spinae plane block and surgical intercostal nerve block after video-assisted thoracoscopic surgery: a randomized controlled trial. J Clin Anesth, 2024, 95: 111448.
70. Li J, Pourrahmat MM, Vasilyeva E, et al. Efficacy and safety of patient-controlled analgesia compared with epidural analgesia after open hepatic resection: a systematic review and meta-analysis. Ann Surg, 2019, 270(2): 200-208.
71. Huepenbecker SP, Cusworth SE, Kuroki LM, et al. Continuous epidural infusion in gynecologic oncology patients undergoing exploratory laparotomy: the new standard for decreased postoperative pain and opioid use. Gynecol Oncol, 2019, 153(2): 356-361.
72. 扶超, 胡渤, 周揚, 等. 比較全程硬膜外鎮痛和單次硬膜外阻滯聯合靜脈自控鎮痛對胸外科手術后急性與慢性疼痛的影響. 中華疼痛學雜志, 2021, 17(6): 638-644.Fu C, Hu B, Zhou Y, et al. The effect of comprehensive epidural analgesia and single epidural block plus intravenous analgesia on acute and chronic pain after thoracic surgery. Chin J Painol, 2021, 17(6): 638-644.
73. Yabuki S, Kaiho Y, Tarasawa K, et al. Exploring the impact of perioperative analgesia on postoperative chronic analgesic prescriptions in patients with lung cancer undergoing minimally invasive thoracic surgery: a retrospective observational study. Eur J Pain, 2025, 29(2): e4774.
74. McNicol ED, Ferguson MC, Hudcova J. Patient controlled opioid analgesia versus non-patient controlled opioid analgesia for postoperative pain. Cochrane Database Syst Rev, 2015, 2015(6): CD003348.
75. von H?sslin T, Imboden P, Lüthi A, et al. Adverse events of postoperative thoracic epidural analgesia: a retrospective analysis of 7273 cases in a tertiary care teaching hospital. Eur J Anaesthesiol, 2016, 33(10): 708-714.
76. 劉浩, 賈延兵, 魏靜, 等. 重復外周磁刺激在康復治療中的應用及研究進展. 中國康復醫學雜志, 2021, 36(5): 631-637.Liu H, Jia YB, Wei J, et al. Application and research progress of repetitive peripheral magnetic stimulation in rehabilitation therapy. Chin J Rehabil Med, 2021, 36(5): 631-637.
77. Lefaucheur JP, André-Obadia N, Antal A, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol, 2014, 125(11): 2150-2206.
78. Bedder M, Parker L. Magnetic peripheral nerve stimulation (mPNS) for chronic pain. J Pain Res, 2023, 16: 2365-2373.
79. Park S, Park R, Westwood D, et al. Effect of peripheral magnetic stimulation on acute and chronic pain after surgery: a systematic review and meta-analysis. J Pain, 2023, 24(7): 1151-1162.
80. Wininger KL, Bester ML, Deshpande KK. Spinal cord stimulation to treat postthoracotomy neuralgia: non-small-cell lung cancer: a case report. Pain Manag Nurs, 2012, 13(1): 52-59.
81. Sutanto YS, Ibrahim D, Septiawan D, et al. Effect of cognitive behavioral therapy on improving anxiety, depression, and quality of life in pre-diagnosed lung cancer patients. Asian Pac J Cancer Prev, 2021, 22(11): 3455-3460.
82. Tsimopoulou I, Pasquali S, Howard R, et al. Psychological prehabilitation before cancer surgery: a systematic review. Ann Surg Oncol, 2015, 22(13): 4117-4123.
83. Cheng JOS, Cheng ST. Effectiveness of physical and cognitive-behavioural intervention programmes for chronic musculoskeletal pain in adults: a systematic review and meta-analysis of randomised controlled trials. PLoS One, 2019, 14(10): e0223367.
84. Lai Y, Huang J, Yang M, et al. Seven-day intensive preoperative rehabilitation for elderly patients with lung cancer: a randomized controlled trial. J Surg Res, 2017, 209: 30-36.
85. Milkias M, Mekonnen S, Ahmed S, et al. Evidence-based guideline on chronic postsurgical pain management in adult patients in resource-restricted setting, 2023: systematic review and guideline. Ann Med Surg (Lond), 2023, 85(11): 5593-5603.
86. Chen G, Lu J, Li B, et al. Efficacy and safety of Shenqi Fuzheng injection combined with chemotherapy for cancer: an overview of systematic reviews. Phytomedicine, 2024, 125: 155293.
87. Park S, Lyu YR, Park SJ, et al. Electroacupuncture for post-thoracotomy pain: a systematic review and meta-analysis. PLoS One, 2021, 16(7): e0254093.
88. Xu Y, Yang R, Xiao S, et al. Expert consensus on perioperative management of patients with lung cancer treated with co-ablation system therapy. Asia Pac J Oncol Nurs, 2025, 12: 100747.
89. Wu D, Dai J, Sheng Y, et al. Evidence summary on pain management in thoracoscopic lung cancer surgery. Asia Pac J Oncol Nurs, 2025, 12: 100693.
90. Zhao X, Cui L, Wang W, et al. Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery. Pak J Med Sci, 2016, 32(1): 155-159.
91. Tian L, Wen Y, Li J, et al. Effects of remote web-based interventions on the physiological and psychological states of patients with cancer: systematic review with meta-analysis. JMIR Mhealth Uhealth, 2025, 13: e71196.
92. Anderson D, Chen SA, Godoy LA, et al. Comprehensive review of chest tube management: a review. JAMA Surg, 2022, 157(3): 269-274.
93. Bertoglio P, Guerrera F, Viti A, et al. Chest drain and thoracotomy for chest trauma. J Thorac Dis, 2019, 11(Suppl 2): S186-S191.
94. Bassi M, Mottola E, Mantovani S, et al. Coaxial drainage versus standard chest tube after pulmonary lobectomy: a randomized controlled study. Curr Oncol, 2022, 29(7): 4455-4463.
95. Rahman NM, Pepperell J, Rehal S, et al. Effect of opioids vs NSAIDs and larger vs smaller chest tube size on pain control and pleurodesis efficacy among patients with malignant pleural effusion: the TIME1 randomized clinical trial. JAMA, 2015, 314(24): 2641-2653.
96. Rahman NM, Maskell NA, Davies CW, et al. The relationship between chest tube size and clinical outcome in pleural infection. Chest, 2010, 137(3): 536-543.
97. Song L, Chen X, Zhu L, et al. Perioperative outcomes of bi-pigtail catheter drainage strategy versus conventional chest tube after uniportal video-assisted thoracic lung surgery. Eur J Cardiothorac Surg, 2023, 64(6): ezad411.
98. Hart JM, Hussien AM, Tesfaye S, et al. Effectiveness of single chest tube vs double chest tube application postdecortication: prospective randomized controlled study. J Am Coll Surg, 2023, 236(6): 1217-1231.
99. He J, Liang H, Wang W, et al. Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou). Transl Lung Cancer Res, 2021, 10(8): 3503-3519.
100. Liu Z, Yang R, Sun Y. Tubeless uniportal thoracoscopic wedge resection with modified air leak test and chest tube drainage. BMC Surg, 2020, 20(1): 301.
101. Li S, Jiang L, Ang KL, et al. New tubeless video-assisted thoracoscopic surgery for small pulmonary nodules. Eur J Cardiothorac Surg, 2017, 51(4): 689-693.
102. Liao HC, Yang SM, Hung MH, et al. Thoracoscopic surgery without drainage tube placement for peripheral lung nodules. Ann Thorac Surg, 2020, 109(3): 887-893.
103. Zhao Y, Shan L, Zhang W, et al. Minimally invasive lung surgery with an intraoperative completely or partially tubeless protocol: randomized clinical trial. BJS Open, 2024, 9(1): zrae132.
104. Zhang JT, Dong S, Chu XP, et al. Randomized trial of an improved drainage strategy versus routine chest tube after lung wedge resection. Ann Thorac Surg, 2020, 109(4): 1040-1046.
105. Zhang D, Wu J, Yang Y, et al. Comparison of non-intubated and intubated video-assisted thoracoscopic surgery for perioperative complications-a systematic review and meta-analysis. BMC Anesthesiol, 2025, 25(1): 272.
106. Wang L, Wang D, Zhang Y. Comparison of postoperative pulmonary complications and intraoperative safety in thoracoscopic surgery under non-intubated versus intubated anesthesia: a randomized, controlled, double-blind non-inferiority trial. Updates Surg, 2024, 76(8): 2863-2873.
107. Huang C, Huang Q, Shen Y, et al. General anaesthesia with double-lumen intubation compared to opioid-sparing strategies with laryngeal mask for thoracoscopic surgery: a randomised trial. Anaesth Crit Care Pain Med, 2022, 41(3): 101083.
108. Treede RD, Rief W, Barke A, et al. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain, 2019, 160(1): 19-27.
109. Haroutiunian S, Nikolajsen L, Finnerup NB, et al. The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain, 2013, 154(1): 95-102.
110. 神經病理性疼痛診療專家組. 神經病理性疼痛診療專家共識. 中國疼痛醫學雜志, 2013, 19(12): 705-710.Expert Group for Diagnosis and Treatment of Neuropathic Pain. Expert consensus on the diagnosis and treatment of neuropathic pain. Chin J Pain Med, 2013, 19(12): 705-710.
111. 周圍神經病理性疼痛診療中國專家共識組. 周圍神經病理性疼痛診療中國專家共識. 中國疼痛醫學雜志, 2020, 26(5): 321-328.Chinese Expert Consensus Group on the Diagnosis and Treatment of Peripheral Neuropathic Pain. Chinese expert consensus on the diagnosis and treatment of peripheral neuropathic pain. Chin J Pain Med, 2020, 26(5): 321-328.
112. Liu YM, Feng Y, Liu YQ, et al. Chinese Association for the Study of Pain: expert consensus on chronic postsurgical pain. World J Clin Cases, 2021, 9(9): 2090-2099.
113. Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: from mechanisms to treatment. Physiol Rev, 2021, 101(1): 259-301.
114. Varallo G, Giusti EM, Manna C, et al. Sleep disturbances and sleep disorders as risk factors for chronic postsurgical pain: a systematic review and meta-analysis. Sleep Med Rev, 2022, 63: 101630.
115. 盧振和, 呂巖, 吳士明, 等. 醫用紅外線熱成像技術在臨床醫學中應用的中國專家共識(2022版). 中華疼痛學雜志, 2022, 18(4): 449-455.Lu ZH, Lyu Y, Wu SM, et al. Consensus of Chinese experts on application of medical infrared themography in clinical medicine (2022 edition). Chin J Painol, 2022, 18(4): 449-455.

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