Research progress on the role and mechanism of magnesium element and magnesium materials in tendon-bone interface healing_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YUE Hao ^1,2,3 , ZHU Xinke ^1,2,3 ,  SUN Zhengming ^1,2,3 , MENG Jiamin ⁴ , HAO Shuai ^1,2 , DONG Xianghui ^2,3 , GAO Zhengchao ^2,3

1. Graduate School Office, Xi’an Medical University, Xi’an Shaanxi, 710021, P. R. China;
2. Department of Orthopedics, Shaanxi Provincial People’s Hospital, Xi’an Shaanxi, 710068, P. R. China;
3. Key Laboratory of Basic and Clinical Translation for Bone and Joint Diseases in Shaanxi Province, Xi’an Shaanxi, 710068, P. R. China;
4. Department of Ophthalmology, the First Affiliated Hospital of Northwestern University, Xi’an Shaanxi, 710002, P. R. China;

Corresponding?author：

SUN Zhengming, Email: 13891984927@163.com

Keywords：

Magnesium element; magnesium material; tendon-bone interface; repair and reconstruction; mechanism

DOI：

10.7507/1002-1892.202601024

Video：

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Objective To review the research progress on the application of magnesium element and magnesium materials in the repair and reconstruction of tendon-bone interface injuries. Methods Relevant research literature at home and abroad in recent years was retrieved. Focusing on the physiological functions of magnesium element, the classification and advantages of magnesium materials, the core mechanisms of magnesium element in regulating the proliferation and differentiation of stem cells, up-regulating the expression of healing markers, activating key signaling pathways, and regulating the inflammatory response were systematically analyzed. At the same time, the current application status and challenges of non-alloyed magnesium materials and magnesium alloys in tendon-bone interface healing were summarized. Results As an essential element in the human body, the elastic modulus of magnesium is close to that of natural bone. The magnesium ions released during degradation can promote the healing of the tendon-bone interface through multiple pathways. Non-alloyed magnesium materials can promote the formation of fibrocartilage and regulate the inflammatory microenvironment. Magnesium alloys have further optimized the mechanical properties and biocompatibility through alloying, surface coating and modification techniques. Both of them have shown good effects in promoting tendon-bone interface healing in animal experiments and preliminary clinical studies. Conclusion Magnesium element and magnesium materials have significant advantages and application potential in the repair of tendon-bone interface injuries. However, it is still necessary to optimize their mechanical strength and degradation behavior through material design, clarify the molecular mechanism, and carry out large-scale long-term clinical trials to further promote their clinical transformation and wide application.

Citation： YUE Hao, ZHU Xinke, SUN Zhengming, MENG Jiamin, HAO Shuai, DONG Xianghui, GAO Zhengchao. Research progress on the role and mechanism of magnesium element and magnesium materials in tendon-bone interface healing. Chinese Journal of Reparative and Reconstructive Surgery, 2026, 40(5): 832-838. doi: 10.7507/1002-1892.202601024 Copy

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Chinese Journal of Reparative and Reconstructive Surgery

Research progress on the role and mechanism of magnesium element and magnesium materials in tendon-bone interface healing

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