Application of Kartogenin in cartilage tissue engineering_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

JIANG Jinhang ,  ZHANG Shujiang ,  LU Weijie

Department of Orthopedics, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Guangdong, 510120, P. R. China;

Corresponding?author：

ZHANG Shujiang, Email: drzhangsj@gzhmu.edu.cn; LU Weijie, Email: 13902280296@139.com

Keywords：

Kartogenin; tissue engineering; cartilage injury; cartilage regeneration

DOI：

10.7507/1002-1892.202510025

Video：

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Objective To review the research progress and application prospects of Kartogenin (KGN) in cartilage repair and tissue engineering. Methods Through a literature review, the mechanisms of KGN in cartilage repair, biomaterial composite strategies, and the resulting repair effectivenes were sorted out. Results KGN regulates multiple signaling pathways to induce mesenchymal stem cells differentiation into chondrocytes, maintain chondrocyte phenotypes, inhibit chondrocyte senescence, and promote the secretion of extracellular matrix. KGN also forms high-efficiency scaffolds with various materials, suitable for tissue engineering scaffolds of different anatomical sites and defect types, and exhibits significant cartilage regenerative effectiveness in vitro and small animal models. Conclusion Overall, KGN shows great application potential in cartilage tissue engineering. However, clinical translation still faces many challenges, which represents a key direction for future research.

Citation： JIANG Jinhang, ZHANG Shujiang, LU Weijie. Application of Kartogenin in cartilage tissue engineering. Chinese Journal of Reparative and Reconstructive Surgery, 2026, 40(3): 502-510. doi: 10.7507/1002-1892.202510025 Copy

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Chinese Journal of Reparative and Reconstructive Surgery

Application of Kartogenin in cartilage tissue engineering

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