Application and progress of intelligent responsive hydrogels in articular cartilage injury repair_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

XU Qingyu , ZHANG Baojian , LI Hongri , LIU Chengri , BI Shuhao , YANG Zhixiang ,  LIU Yanqun

Orthopedic Diagnosis and Treatment Center, Yanbian University Hospital (Yanbian Hospital), Yanji Jilin, 133000, P. R. China;

Corresponding?author：

LIU Yanqun, Email: 13844312816@163.com

Keywords：

Intelligent responsive hydrogel; response principle; cartilage injury; repair

DOI：

10.7507/1002-1892.202411015

Video：

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Objective To review clinical application and research progress of different types of intelligent responsive hydrogels in repairing articular cartilage injury. Methods The animal experiments and clinical studies of different types of intelligent responsive hydrogels for repairing articular cartilage injury were summarized by reviewing relevant literature at home and abroad. Results The intrinsic regenerative capacity of articular cartilage following injury is limited. Intelligent responsive hydrogels, including those that are temperature-sensitive, light-sensitive, enzyme-responsive, pH-sensitive, and other stimuli-responsive hydrogels, can undergo phase transitions in response to specific stimuli, thereby achieving optimal functionality. These hydrogels can fill the injured cartilage area, promote the proliferation and differentiation of chondrocytes, and expedite the repair of the damaged site. With advancements in cartilage tissue engineering materials research, intelligent responsive hydrogels offer a novel approach and promising potential for the treatment of cartilage injuries. Conclusion Intelligent responsive hydrogel is a kind of flexible, controllable, efficient, and stable polymer, which has similar structure and functional properties to articular cartilage, and has become one of the important biomaterials for cartilage repair. However, there is still a lack of unified treatment standards and simple and efficient preparation technology.

Citation： XU Qingyu, ZHANG Baojian, LI Hongri, LIU Chengri, BI Shuhao, YANG Zhixiang, LIU Yanqun. Application and progress of intelligent responsive hydrogels in articular cartilage injury repair. Chinese Journal of Reparative and Reconstructive Surgery, 2025, 39(2): 250-256. doi: 10.7507/1002-1892.202411015 Copy

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1. 蔣寧, 徐桂軍, 李浩民, 等. 距骨骨軟骨損傷的外科治療進展. 中國修復重建外科雜志, 2024, 38(3): 373-379.
2. Whyte GP, Bizzoco L, Gobbi A. One-step cartilage repair of full-thickness knee chondral lesions using a hyaluronic acid-based scaffold embedded with bone marrow aspirate concentrate: Long-term outcomes after mean follow-up duration of 14 years. Am J Sports Med, 2024, 52(14): 3561-3568.
3. Brittberg M. Treatment of knee cartilage lesions in 2024: From hyaluronic acid to regenerative medicine. J Exp Orthop, 2024, 11(2): e12016. doi: 10.1002/jeo2.12016.
4. Sharma V, Sakhalkar U, Nadkarni P, et al. Cytoprotective effect of growth factors derived from platelets on corticosteroid-treated primary anterior cruciate ligament-derived stromal cells and chondrocytes. Cureus, 2024, 16(7): e65566. doi: 10.7759/cureus.65566.
5. 楊星, 周明旺, 王曉萍, 等. 干細胞修復軟骨損傷治療膝骨關節炎的機制與臨床研究進展. 中國骨質疏松雜志, 2024, 30(10): 1466-1471.
6. Rahvar TP, Abdekhodaie JM, Jooybar E, et al. An enzymatically crosslinked collagen type Ⅱ/hyaluronic acid hybrid hydrogel: A biomimetic cell delivery system for cartilage tissue engineering. Int J Biol Macromol, 2024, 279(P1): 134614. doi: 10.1016/j.ijbiomac.2024.134614.
7. Yuan X, Wan J, Yang Y, et al. Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogenin. Carbohydr Polym, 2023, 304: 120492. doi: 10.1016/j.carbpol.2022.120492.
8. Ross AK, Ferati RS, Alaia JM, et al. Current and emerging techniques in articular cartilage repair. Bull Hosp Jt Dis (2013), 2024, 82(1): 91-99.
9. Khajouei S, Ravan H, Ebrahimi A. DNA hydrogel-empowered biosensing. Adv Colloid Interface Sci, 2020, 275: 102060. doi: 10.1016/j.cis.2019.102060.
10. Cao H, Duan LX, Zhang Y, et al. Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity. Signal Transduct Target Ther, 2021, 6(1): 426-426.
11. Cheng W, Ding Z, Zheng X, et al. Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration. Biomater Sci, 2020, 8(9): 2537-2548.
12. 陸怡雨, 李昊. 智能水凝膠在口腔醫學領域的應用. 南京醫科大學學報 (自然科學版), 2022, 42(8): 1192-1196,1200.
13. 楊躍娜, 胡旭芳, 劉玉珊, 等. 智能水凝膠世界. 大學化學, 2024, 39(5): 172-183.
14. Hoang Thi TT, Sinh LH, Huynh DP, et al. Self-assemblable polymer smart-blocks for temperature-induced injectable hydrogel in biomedical applications. Front Chem, 2020, 8: 19. doi: 10.3389/fchem.2020.00019.
15. Mahinroosta M, Farsangi JZ, Allahverdi A, et al. Hydrogels as intelligent materials: A brief review of synthesis, properties and applications. Materials Today Chemistry, 2018, 8: 42-55.
16. 朱本舜, 鄭睿夫, 周亞坤, 等. 醫用自剝離水凝膠敷料的研究進展. 現代化工, 2024, 44(4): 34-39, 44.
17. Tang Y, Wang J, Qiu H, et al. The chondrogenic differentiation of BMSCs in collagen hydrogels and the effect of MMPs among cell-material interactions. Collagen and Leather, 2024, 6(1): 31-46.
18. 王勇, 姚子昂, 吳海歌. 殼聚糖溫敏水凝膠在骨組織工程中的研究進展. 化工新型材料, 2022, 50(S1): 13-19.
19. 郭偉成, 廖元太, 張洪玉. 潤滑水凝膠涂層研究進展. 清華大學學報(自然科學版), 2024, 64(3): 381-392.
20. Jiang Z, Qin S, Wang W, et al. Investigating the anti-inflammatory and bone repair-promoting effects of an injectable porous hydrogel containing magnesium ions in a rat periodontitis mode. Smart Materials in Medicine, 2024, 5(2): 207-220.
21. Shi F, Xiao D, Zhang C, et al. The effect of macropore size of hydroxyapatite scaffold on the osteogenic differentiation of bone mesenchymal stem cells under perfusion culture. Regen Biomater, 2021, 8(6): rbab050. doi: 10.1093/rb/rbab050.
22. Elsheikh M, Kishida R, Hayashi K, et al. Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks. Regen Biomater, 2022, 9(1): rbac010. doi: 10.1093/rb/rbac010.
23. Huang Z, Liu C, Zheng G, et al. Articular cartilage regeneration via induced chondrocyte autophagy by sustained release of leptin inhibitor from thermo-sensitive hydrogel through STAT3/REDD1/mTORC1 cascade. Adv Healthc Mater, 2023, 12(30): e2302181. doi: 10.1002/adhm.202302181.
24. Hasani-Sadrabadi MM, Sarrion P, Pouraghaei S, et al. An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats. Sci Transl Med, 2020, 12(534): eaay6853. doi: 10.1126/scitranslmed.aay6853.
25. Ao Y, Tang W, Tan H, et al. Hydrogel composed of type Ⅱ collagen, chondroitin sulfate and hyaluronic acid for cartilage tissue engineering. Biomed Mater Eng, 2022, 33(6): 515-523.
26. 張新威. 3D打印rGO復合水凝膠支架用于多細胞遞送和骨修復的研究. 長春: 吉林大學, 2023.
27. Tian Y, Cui Y, Ren G, et al. Dual-functional thermosensitive hydrogel for reducing infection and enhancing bone regeneration in infected bone defects. Mater Today Bio, 2024, 25: 100972. doi: 10.1016/j.mtbio.2024.100972.
28. Hafezi M, Nouri Khorasani S, Zare M, et al. Advanced hydrogels for cartilage tissue engineering: Recent progress and future directions. Polymers (Basel), 2021, 13(23): 4199. doi: 10.3390/polym13234199.
29. Chen Z, Yang X, Liu X, et al. A thermodynamic theory coupling photo-chemo-mechano interactions for light-responsive hydrogel. Journal of the Mechanics and Physics of Solids, 2024, 188: 105677-105693.
30. Liu XY, Yang QS, Rao W. A photo-mechanical coupling theory for photoisomerization hydrogel considering the distribution state of molecular chains. International Journal of Solids and Structures, 2023, 283: 112474-112489.
31. 張恒杰, 柳坤銳, 陳顯春, 等. 光響應智能生物粘附材料的設計與應用. 化學學報, 2023, 81(12): 1739-1753.
32. Tsegay F, Elsherif M, Butt H. Smart 3D printed hydrogel skin wound bandages: A review. Polymers (Basel), 2022, 14(5): 1012. doi: 10.3390/polym14051012.
33. Zhang W, Xue W, Jia Z, et al. Photo-driven dynamic hydrogel modulates bone marrow mesenchymal stem cells behavior for enhanced cartilage regeneration. Chemical Engineering Journal, 2024, 484: 149689-149699.
34. 劉曉雨, 張辛芮, 張燁華, 等. 自黏附、近紅外光響應水凝膠的制備及藥物釋放性能研究. 化學通報, 2024, 87(7): 850-856.
35. Diego T, Lorenzo V, Elena G, et al. Visible light-mediated cross-linking of injectable gellan gum hydrogels embedding human chondrocytes. Carbohydrate Polymer Technologies and Applications, 2023, 6: 100382-100396.
36. 薛春宇, 陳國強, 袁俊虎, 等. 應用天然水凝膠修復關節軟骨損傷的研究進展. 生物骨科材料與臨床研究, 2024, 21(1): 56-60, 70.
37. Zhao X, Javed B, Tian F, et al. Hydrogel on a smart nanomaterial interface to carry therapeutics for digitalized glioma treatment. Gels, 2022, 8(10): 664. doi: 10.3390/gels8100664.
38. Gao L, Beninatto R, Oláh T, et al. A photopolymerizable biocompatible hyaluronic acid hydrogel promotes early articular cartilage repair in a minipig model in vivo. Adv Healthc Mater, 2023, 12(26): e2300931. doi: 10.1002/adhm.202300931.
39. 王澤文, 李陳致, 劉家河, 等. 軟骨支架材料的制備方法及優缺點. 中國組織工程研究, 2024, 28(15): 2404-2409.
40. Khanmohammadi M, Jalessi M, Asghari A. Biomimetic hydrogel scaffolds via enzymatic reaction for cartilage tissue engineering. BMC Res Notes, 2022, 15(1): 174. doi: 10.1186/s13104-022-06060-w.
41. Kim J, Park S, Park YJ, et al. Dual-phase blocks for regeneration of critical-sized bone defects. Nano Today, 2024, 54: 102120-102133.
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Chinese Journal of Reparative and Reconstructive Surgery

Application and progress of intelligent responsive hydrogels in articular cartilage injury repair

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