目的對近年半月板組織工程研究進展進行綜述。 方法廣泛查閱近年國內外半月板組織工程的相關文獻，總結現狀及進展。 結果半月板組織工程研究主要集中在種子細胞選擇及其軟骨分化潛能研究，支架材料選擇及其機械力學性能研究，細胞培養過程中細胞因子作用機制研究等。 結論半月板組織工程研究已取得許多成果，尋找更符合生理過程、易于培養和定向軟骨分化能力強的種子細胞；探索促進種子細胞向軟骨，尤其是向纖維軟骨分化的細胞因子，并揭示分化過程中的作用機制；尋找可塑性強、無抗原性、可降解、力學性能接近正常半月板的支架材料是下一步研究重點。
引用本文： 符培亮,張雷,吳海山. 半月板組織工程研究進展. 中國修復重建外科雜志, 2013, 27(4): 486-491. doi: 10.7507/1002-1892.20130110 復制
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| 2. | Stärke C, Kopf S, Petersen W, et al. Meniscal repair. Arthroscopy, 2009, 25(9): 1033-1044. |
| 3. | Pereira H, Frias AM, Oliveira JM, et al. Tissue engineering and regenerative medicine strategies in meniscus lesions. Arthroscopy, 2011, 27(12): 1706-1719. |
| 4. | Ballyns JJ, Wright TM, Bonassar LJ. Effect of media mixing on ECM assembly and mechanical properties of anatomically-shaped tissue engineered meniscus. Biomaterials, 2010, 31(26): 6756-6763. |
| 5. | Makris EA, Hadidi P, Athanasiou KA. The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials, 2011, 32(30): 7411-7431. |
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| 7. | Van der Bracht H, Verdonk R, Verbruggen G, et al. Cell-Based Meniscus Tissue Engineering. E-Book: Topics in Tissue Engineering, vol3, 2007. |
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| 9. | Verdonk P, van Laer M, Verdonk R. Meniscus replacement: from allograft to tissue engineering. Sport Traumatologie, 2008, 24(2): 78-82. |
| 10. | Vanderploeg EJ, Imler SM, Brodkin KR, et al. Oscillatory tension differentially modulates matrix metabolism and cytoskeletal organization in chondrocytes and fibrochondrocytes. J Biomech, 2004, 37(12): 1941-1952. |
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| 17. | Johns DE, Athanasiou KA. Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage. Cell Tissue Res, 2008, 333(3): 439-447. |
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- 1. Malvankar SM, Khan WS. An overview of the different approaches used in the development of meniscal tissue engineering. Curr Stem Cell Res Ther, 2012, 7(2): 157-163.
- 2. Stärke C, Kopf S, Petersen W, et al. Meniscal repair. Arthroscopy, 2009, 25(9): 1033-1044.
- 3. Pereira H, Frias AM, Oliveira JM, et al. Tissue engineering and regenerative medicine strategies in meniscus lesions. Arthroscopy, 2011, 27(12): 1706-1719.
- 4. Ballyns JJ, Wright TM, Bonassar LJ. Effect of media mixing on ECM assembly and mechanical properties of anatomically-shaped tissue engineered meniscus. Biomaterials, 2010, 31(26): 6756-6763.
- 5. Makris EA, Hadidi P, Athanasiou KA. The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials, 2011, 32(30): 7411-7431.
- 6. Killian ML, Lepinski NM, Haut RC, et al. Regional and zonal histo-morphological characteristics of the lapine menisci. Anat Rec (Hoboken), 2010, 293(12): 1991-2000.
- 7. Van der Bracht H, Verdonk R, Verbruggen G, et al. Cell-Based Meniscus Tissue Engineering. E-Book: Topics in Tissue Engineering, vol3, 2007.
- 8. Li NG, Shi ZH, Tang YP, et al. New hope for the treatment of osteoarthritis through selective inhibition of MMP-13. J Curr Med Chem, 2011, 18(7): 977-1001.
- 9. Verdonk P, van Laer M, Verdonk R. Meniscus replacement: from allograft to tissue engineering. Sport Traumatologie, 2008, 24(2): 78-82.
- 10. Vanderploeg EJ, Imler SM, Brodkin KR, et al. Oscillatory tension differentially modulates matrix metabolism and cytoskeletal organization in chondrocytes and fibrochondrocytes. J Biomech, 2004, 37(12): 1941-1952.
- 11. Singh M, Pierpoint M, Mikos AG, et al. Chondrogenic differentiation of neonatal human dermal fibroblasts encapsulated in alginate beads with hydrostatic compression under hypoxic conditions in the presence of bone morphogenetic protein-2. J Biomed Mater Res A, 2011, 98(3): 412-424.
- 12. Forriol F. Growth factors in cartilage and meniscus repair. Injury, 2009, 40 Suppl 3: S12-16.
- 13. Gu Y, Wang Y, Dai H, et al. Chondrogenic differentiation of canine myoblasts induced by cartilage-derived morphogenetic protein-2 and transforming growth factor-β1 in vitro. Mol Med Report, 2012, 5(3): 767-772.
- 14. Riera KM, Rothfusz NE, Wilusz RE, et al. Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration. Arthritis Res Ther, 2011, 13(6): R187.
- 15. Minehara H, Urabe K, Naruse K, et al. A new technique for seeding chondrocytes onto solvent-preserved human meniscus using the chemokinetic effect of recombinant human bone morphogenetic protein-2. Cell Tissue Bank, 2011, 12(3): 199-207.
- 16. Fox DB, Warnock JJ, Stoker AM, et al. Effects of growth factors on equine synovial fibroblasts seeded on synthetic scaffolds for avascular meniscal tissue engineering. Res Vet Sci, 2010, 88(2): 326-332.
- 17. Johns DE, Athanasiou KA. Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage. Cell Tissue Res, 2008, 333(3): 439-447.
- 18. Zhang H, Leng P, Zhang J. Enhanced meniscal repair by overexpression of hIGF-1 in a full-thickness model. Clin Orthop Relat Res, 2009, 467(12): 3165-3174.
- 19. Morito T, Muneta T, Hara K, et al. Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans. Rheumatology (Oxford), 2008, 47(8): 1137-1143.
- 20. Zhang S, Muneta T, Morito T, et al. Autologous synovial fluid enhances migration of mesenchymal stem cells from synovium of osteoarthritis patients in tissue culture system. J Orthop Res, 2008, 26(10): 1413-1418.
- 21. De Bari C, Dell’Accio F, Tylzanowski P, et al. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum, 2001, 44(8): 1928-1942.
- 22. Djouad F, Bony C, Haupl T, et al. Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells. Arthritis Res Ther, 2005, 7(6): 1304-1315.
- 23. Jo CH, Ahn HJ, Kim HJ, et al. Surface characterization and chondrogenic differentiation of mesenchymal stromal cells derived from synovium. Cytotherapy, 2007, 9(7): 316-327.
- 24. Sakaguchi Y, Sekiya I, Yagishita K, et al. Comparison of human stem cells derived from various mesenchymal tissues. Arthritis Rheum, 2005, 52(8): 2521-2529.
- 25. Shirasawa S, Sekiya I, Sakaguchi Y, et al. In vitro chondrogenesis of human synovium-derived mesenchynlal stem cells: optimal condition and cmnparison with bone morrow-derived cells. J Cell Biochem, 2006, 97(1): 84-97.
- 26. Cheng NC, Estes BT, Awad HA, et al. Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. Tissue Eng Part A, 2009, 15(2): 231-241.
- 27. 李黎, 陳景祥, 朱崇濤. Sox9基因誘導脂肪肝細胞向軟骨細胞分化. 現代生物醫學進展, 2010, 10(20): 3851-3853.
- 28. 蔡增苗, 林昭靜, 任富亮. 脂肪干細胞在軟骨組織工程中的應用. 中國醫藥指南, 2011, 9(16): 217-218.
- 29. Mandal BB, Park SH, Gil ES, et al. Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials, 2011, 32(2): 639-651.
- 30. Zellner J, Mueller M, Berner A, et al. Role of mesenchymal stem cells in tissue engineering of meniscus. J Biomed Mater Res A, 2010, 94(4): 1150-1161.
- 31. Ionescu LC, Lee GC, Huang KL, et al. Growth factor supplementation improves native and engineered meniscus repair in vitro. Acta Biomater, 2012, 8(10): 3687-3694.
- 32. Hegert C, Kramer J, Hargus G, et al. Differentiation plasticity of chondrocytes derived from mouse embryonic stem cells. J Cell Sci, 2002, 115(Pt 23): 4617-4628.
- 33. Hwang NS, Varghese S, Zhang Z, et al. Chondrogenie differentiation of human embryonic stem cell-derived ceils in arginine-glycine-aspartate—modified hydrogels. Tissue Eng, 2006, 12(9): 2695-2706.
- 34. Nakajima M, Wakitani S, Harada Y, et al. In vivo mechanical condition plays an important role for appearance of cartilage tissue in ES cell transplanted joint. J Orthop Res, 2008, 26(1): 10-17.
- 35. Koay EJ, Hoben GM, Athanasiou KA. Tissue engineering with chondmgenically differentiated human embryonic stem cells. J Stem Cells, 2007, 25(9): 2183-2190.
- 36. Kramer J, Hegert C, Guan K, et al. Embryonic stem cell-derived chondrogenic differentiation in vitro: activation by BMP-2 and BMP-4. J Mech Dev, 2000, 92(2): 193-205.
- 37. Steiuert AF, Palmer GD, Capito R, et al. Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta1 complementary deoxyribonucleic acid. J Tissue Eng, 2007, 13(9): 2227-2237.
- 38. Steadman JR, Rodkey WG. Tissue-engeered collagen meniscus implants: 5- to 6- year feasibility study results. J Arthroscopy, 2005, 21(5): 515-525.
- 39. Martinek V, Ueblacker P, Braun K, et al. Second generation of meniscus transplantation: in-vivo study with tissue engineered meniscus replacement. Arch Orthop Trauma Surg, 2005, 126(4): 228-234.
- 40. Walsh CJ, Goodman D, Caplan AI, et al. Meniscus regeneration in a rabbit partial meniscectomy model. Tissue Eng, 1999, 5(4): 327-337.
- 41. Scotti C, Pozzi A, Mangiavini L, et al. Healing of meniscal tissue by cellular fibrin glue: an in vivo study. J Knee Surg Sports Traumatol Arthrosc, 2009, 17(6): 645-651.
- 42. Reckers LJ, Fagundes DJ, Cohen M. The ineffectiveness of fibrin glue and cyanoacrylate on fixation of meniscus transplants in rabbits. Knee, 2009, 16(4): 290-294.
- 43. Allman AJ, McPherson TB, Badylak SF, et al. Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation, 2001, 71(11): 1631-1640.
- 44. Sarikaya A, Record R, Wu CC, et al. Antimicrobial activity associated with extracellular matrices. Tissue Eng, 2002, 8(1): 63-71.
- 45. Grimes M, Pembroke JT, McGloughlin T. The effect of choice of sterilisation method on the biocompatibility and biodegradability of SIS (small intestinal submucosa). Biomed Mater Eng, 2005, 15(1-2): 65-71.
- 46. Roeder R, Wolfe J, Lianakis N, et al. Compliance, elastic modulus, and burst pressure of small-intestine submucosa (SIS) small-diameter vascular grafts. Boimed Mater Res, 1999, 47(1): 65-70.
- 47. Nihsen ES, Johnson CE, Hiles MC, et al. Bioactivity of small intestinal submucosa and oxidized regenerated cellulose/collagen. Adv Skin Wound Care, 2008, 21(10): 479-486.
- 48. Rosen M, Ponsky J, Petras R, et al. Small intestinal submucosa as a bioscaffold for biliary tract regeneration. Surgery, 2002, 132(3): 480-486.
- 49. Tan Y, Zhang Y, Pei M. Meniscus reconstruction through coculturing meniscus cells with synovium-derived stem cells on small intestine submucosa—a pilot study to engineer meniscus tissue constructs. Tissue Eng Part A, 2010, 16(1): 67-79.
- 50. Cook JL, Fox DB, Malaviya P, et al. Long-term outcome for large meniscal defects treated with small intestinal submucosa in a dog model. Am J Sports Med, 2006, 34(1): 32-42.
- 51. Tienen TG, Heijkants RG, de Groot JH, et al. Replacement of the knee meniscus by a porous polymer implant: a study in dogs. Am J Sports Med, 2006, 34(1): 64-71.
- 52. Aufderheide AC, Athanasiou KA. Comparison of scaffolds and culture conditions for tissue engineering of the knee meniscus. Tissue Eng, 2005, 11(7-8): 1095-1104.
- 53. Eli N, Oragui E, Khan W. Advances in meniscal tissue engineering. Ortop Traumatol Rehabil, 2011, 13(4): 319-326.
- 54. Stapleton TW, Ingram J, Fisher J, et al. Investigation of the regenerative capacity of an acellular porcine medial meniscus for tissue engineering applications. Tissue Eng Part A, 2011, 17(1-2): 231-242.
- 55. Mouzopoulos G, Siebold R. Partial meniscus substitution with tissue-engineered scaffold: an overview. Clin Sports Med, 2012, 31(1): 167-181.
- 56. Stabile KJ, Odom D, Smith TL, et al. An acellular, allograft-derived meniscus scaffold in an ovine model. Arthroscopy, 2010, 26(7): 936-948.
- 57. Sommerlath K, Gillquist J. The effect of meniscal prosthesis on knee biomechanics and cartilage. An experimental study in rabbits. Am J Sports Med, 1992, 20(1): 73-81.
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