Analysis of the disease burden of migraine in children and adolescents in Donghe District of Baotou_West China Medical Journal

Authors：

WANG Yabin ^1,2 ,  PAN Xiaohua ³

1. Central Clinical Medical College, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014040, P. R. China;
2. Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia 014040, P. R. China;
3. Geriatric Department, Baotou Mongolian and Chinese Medicine Hospital, Baotou, Inner Mongolia 014040, P. R. China;

Corresponding?author：

PAN Xiaohua, Email: 88088647@qq.com

Keywords：

Migraine; children; adolescents; disease burden

DOI：

10.7507/1002-0179.202604008

Video：

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Objective To investigate the disease burden of migraine in children and adolescents in Donghe District of Baotou, analyze the influencing factors of functional disability and life quality in migraine patients, and provide data support for precise prevention, education, and clinical intervention of migraine in children and adolescents. Methods From October 2024 to October 2025, a survey was conducted among in-school children and adolescents aged 6 to 18 in Donghe District of Baotou. Subjects with migraines were selected, baseline data and headache characteristics were collected, and scale assessments were completed for statistical analysis. Results This survey showed that among 9247 respondents, a total of 806 children and adolescents were diagnosed with migraine, with a migraine prevalence rate of 8.72%. After adjusting for gender and age, the prevalence rate was 6.67%. Multivariate logistic regression analysis showed that allergic rhinitis, sleep, headache frequency, and headache duration were influencing factors for functional disabilities in migraine patients (P<0.05). Age, academic pressure, frequency and severity of headaches, premonitory symptoms, and ethnicity were factors affecting quality of life (P<0.05). Conclusion The prevalence of migraine in children and adolescents in Donghe District is relatively high. Modifiable factors including insufficient sleep, academic pressure and allergic rhinitis are closely associated with migraine disease burden.

Citation： WANG Yabin, PAN Xiaohua. Analysis of the disease burden of migraine in children and adolescents in Donghe District of Baotou. West China Medical Journal, 2026, 41(5): 736-741. doi: 10.7507/1002-0179.202604008 Copy

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2.	Ertas M, Baykan B, Orhan EK, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults. J Headache Pain, 2012, 13(2): 147-157.
3.	Torres-Ferrus M, Vila-Sala C, Quintana M, et al. Headache, comorbidities and lifestyle in an adolescent population (the TEENs Study). Cephalalgia, 2019, 39(1): 91-99.
4.	Maiga Y, Souma?la B, N’Drainy Cissoko L, et al. Epidemiology of migraine among students in Mali. eNeurologicalSci, 2017, 7: 32-36.
5.	Lipton RB, Dodick D, Sadovsky R, et al. A self-administered screener for migraine in primary care: the ID migraine validation study. Neurology, 2003, 61(3): 375-382.
6.	Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 2018, 38(1): 1-211.
7.	Guidetti V, Faedda N. From 0° to 18°: how headache changes over time. Neurol Sci, 2017, 38(Suppl 1): 103-106.
8.	嚴云鶴. 社會工作介入大學生學習焦慮情緒的個案研究. 北京: 北京工業大學, 2019.
9.	Mutlu V, Karac? R, Yüksek MA, et al. Effect of bariatric surgery on headache frequency, duration and severity. BMC Surg, 2026, 26(1): 174.
10.	Caminero AB, Sánchez Del Río González M. Migraine as a cerebrovascular risk factor. Neurologia, 2012, 27(2): 103-111.
11.	張悅, 婁宇軒, 王藝斐, 等. 偏頭痛患者合并中量右向左分流卵圓孔未閉行介入封堵術的療效分析. 南京醫科大學學報(自然科學版), 2024, 44(2): 191-196.
12.	Ursitti F, Valeriani M. Migraine in childhood: gender differences. Eur J Paediatr Neurol, 2023, 42: 122-125.
13.	劉晨宇, 陳艷, 張曉杰, 等. 性激素及神經遞質對月經性偏頭痛的影響. 中國疼痛醫學雜志, 2025, 31(10): 780-785.
14.	W?ber C, W?ber-Bing?l ?, Uluduz D, et al. Undifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkey. J Headache Pain, 2018, 19(1): 18.
15.	Karaaslan Z, Uyguno?lu U, ?a?maz T, et al. The prevalence of headache disorders in children and adolescents in istanbul: a school-based study. Pediatr Neurol, 2023, 149: 100-107.
16.	Moschiano F, D'Amico D, Ramusino MC, et al. The role of diet and lifestyle in adolescents with headache: a review. Neurol Sci, 2013, 34(Suppl 1): S187-S190.
17.	Tiseo C, Vacca A, Felbush A, et al. Migraine and sleep disorders: a systematic review. J Headache Pain, 2020, 21(1): 126.
18.	Rudolf R, Lee J. School climate, academic performance, and adolescent well-being in Korea: the roles of competition and cooperation. Child Indic Res, 2023, 16(3): 917-940.
19.	GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1789-1858.
20.	于英英, 潘曉華, 劉國榮, 等. 偏頭痛患者殘疾程度影響因素分析. 華西醫學, 2024, 39(5): 717-722.
21.	Walter K. What Is Migraine?. JAMA, 2022, 327(1): 93.
22.	Zhang X, Levy D, Noseda R, et al. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci, 2010, 30(26): 8807-8814.
23.	Karatas H, Erdener SE, Gursoy-Ozdemir Y, et al. Spreading depression triggers headache by activating neuronal Panx1 channels. Science, 2013, 339(6123): 1092-1095.

1. GBD 2016 Headache Collaborators. Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol, 2018, 17(11): 954-976.
2. Ertas M, Baykan B, Orhan EK, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults. J Headache Pain, 2012, 13(2): 147-157.
3. Torres-Ferrus M, Vila-Sala C, Quintana M, et al. Headache, comorbidities and lifestyle in an adolescent population (the TEENs Study). Cephalalgia, 2019, 39(1): 91-99.
4. Maiga Y, Souma?la B, N’Drainy Cissoko L, et al. Epidemiology of migraine among students in Mali. eNeurologicalSci, 2017, 7: 32-36.
5. Lipton RB, Dodick D, Sadovsky R, et al. A self-administered screener for migraine in primary care: the ID migraine validation study. Neurology, 2003, 61(3): 375-382.
6. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 2018, 38(1): 1-211.
7. Guidetti V, Faedda N. From 0° to 18°: how headache changes over time. Neurol Sci, 2017, 38(Suppl 1): 103-106.
8. 嚴云鶴. 社會工作介入大學生學習焦慮情緒的個案研究. 北京: 北京工業大學, 2019.
9. Mutlu V, Karac? R, Yüksek MA, et al. Effect of bariatric surgery on headache frequency, duration and severity. BMC Surg, 2026, 26(1): 174.
10. Caminero AB, Sánchez Del Río González M. Migraine as a cerebrovascular risk factor. Neurologia, 2012, 27(2): 103-111.
11. 張悅, 婁宇軒, 王藝斐, 等. 偏頭痛患者合并中量右向左分流卵圓孔未閉行介入封堵術的療效分析. 南京醫科大學學報(自然科學版), 2024, 44(2): 191-196.
12. Ursitti F, Valeriani M. Migraine in childhood: gender differences. Eur J Paediatr Neurol, 2023, 42: 122-125.
13. 劉晨宇, 陳艷, 張曉杰, 等. 性激素及神經遞質對月經性偏頭痛的影響. 中國疼痛醫學雜志, 2025, 31(10): 780-785.
14. W?ber C, W?ber-Bing?l ?, Uluduz D, et al. Undifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkey. J Headache Pain, 2018, 19(1): 18.
15. Karaaslan Z, Uyguno?lu U, ?a?maz T, et al. The prevalence of headache disorders in children and adolescents in istanbul: a school-based study. Pediatr Neurol, 2023, 149: 100-107.
16. Moschiano F, D'Amico D, Ramusino MC, et al. The role of diet and lifestyle in adolescents with headache: a review. Neurol Sci, 2013, 34(Suppl 1): S187-S190.
17. Tiseo C, Vacca A, Felbush A, et al. Migraine and sleep disorders: a systematic review. J Headache Pain, 2020, 21(1): 126.
18. Rudolf R, Lee J. School climate, academic performance, and adolescent well-being in Korea: the roles of competition and cooperation. Child Indic Res, 2023, 16(3): 917-940.
19. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159): 1789-1858.
20. 于英英, 潘曉華, 劉國榮, 等. 偏頭痛患者殘疾程度影響因素分析. 華西醫學, 2024, 39(5): 717-722.
21. Walter K. What Is Migraine?. JAMA, 2022, 327(1): 93.
22. Zhang X, Levy D, Noseda R, et al. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci, 2010, 30(26): 8807-8814.
23. Karatas H, Erdener SE, Gursoy-Ozdemir Y, et al. Spreading depression triggers headache by activating neuronal Panx1 channels. Science, 2013, 339(6123): 1092-1095.

West China Medical Journal

Analysis of the disease burden of migraine in children and adolescents in Donghe District of Baotou

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