Interpretation of the “2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care”: adult cardiopulmonary resuscitation_West China Medical Journal

Authors：

MA Wen ^1,2 , TANG Songling ^1,2 , WU Yang ^1,2 , XU Chongxi ^1,2 , WANG Zhiyuan ^1,2 , XIE Xuxin ^1,2 , PENG Haoran ^1,2 , LI Yuetao ^1,2 , DENG Yalu ^1,2 , YAO Peng ^1,2 , CHEN Yao ^1,2 , LIU Zhihao ^1,2 , GAN Lu ^1,2 ,  CAO Yu ^1,2

1. Department of Emergency Medicine, Institute of Disaster Medicine and Institute of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Disaster Medical Center, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

CAO Yu, Email: caoyu@wchscu.cn

Keywords：

2025 American Heart Association guidelines; cardiac arrest; cardiopulmonary resuscitation; survival chain; defibrillation; foreign-body airway obstruction

DOI：

10.7507/1002-0179.202511157

Video：

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The American Heart Association published the “2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care” in the journal Circulation in October 2025. The new guideline integrates the previously separate adult survival chains for different scenarios and populations into a unified “six-link survival chain” and provides updates and recommendations for multiple key components. Key updates emphasize the following contents: in basic life support, optimization of rescuers’ and patients’ positions, compression strategies for obese or prone patients, systematic management procedures for foreign-body airway obstruction, and details of automated external defibrillator application; in advanced life support, strengthening the core role of epinephrine and standardizing the use of vasoactive agents; updated resuscitation strategies for special situations (such as exposure to highly pathogenic respiratory pathogens and volatile hydrocarbon poisoning); in post-cardiac arrest care, further updates to respiratory and circulatory support, targeted temperature management, and neurological prognosis assessment; and recommendations at the system of care level, including public access to naloxone, video-based dispatch response, and the establishment of resuscitation centers. This article interprets the core recommendations of the guideline to offer references for clinical practice and education.

Citation： MA Wen, TANG Songling, WU Yang, XU Chongxi, WANG Zhiyuan, XIE Xuxin, PENG Haoran, LI Yuetao, DENG Yalu, YAO Peng, CHEN Yao, LIU Zhihao, GAN Lu, CAO Yu. Interpretation of the “2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care”: adult cardiopulmonary resuscitation. West China Medical Journal, 2025, 40(11): 1728-1737. doi: 10.7507/1002-0179.202511157 Copy

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West China Medical Journal

Interpretation of the “2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care”: adult cardiopulmonary resuscitation

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