- Department of Nephrology and Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
LIU Fang,
Email: liufangfh@163.com
Chronic kidney disease (CKD) is a global public health issue, with its prevalence and incidence increasing annually, imposing significant health and economic burdens on patients and society. A growing body of research indicates that both shortened and prolonged sleep duration, as well as poor sleep quality, are closely associated with the prevalence, progression, and adverse clinical outcomes of CKD. This article summarizes the relationship between sleep duration, sleep quality, and CKD, explores potential mechanisms by which sleep disturbances may contribute to the development and progression of CKD, analyzes the impact of CKD on sleep, and summarizes intervention measures targeting sleep problems in CKD patients. It aims to provide new insights for future clinical practice.
Citation： LANG Yanlin, LIU Fang. Research progress on sleep duration and quality in chronic kidney disease. West China Medical Journal, 2026, 41(6): 1045-1051. doi: 10.7507/1002-0179.202504016 Copy
Copyright ? the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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- 1. Kalantar-Zadeh K, Jafar TH, Nitsch D, et al. Chronic kidney disease. Lancet, 2021, 398(10302): 786-802.
- 2. Bello AK, Okpechi IG, Levin A, et al. An update on the global disparities in kidney disease burden and care across world countries and regions. Lancet Glob Health, 2024, 12(3): e382-e395.
- 3. Lyons OD. Sleep disorders in chronic kidney disease. Nat Rev Nephrol, 2024, 20(10): 690-700.
- 4. Koh JH, Yeo BSY, Tan TWE, et al. The association of sleep duration with the risk of chronic kidney disease: a systematic review and meta-analysis. Clin Kidney J, 2024, 17(8): sfae177.
- 5. Guo S, Yamagishi K, Kihara T, et al. Sleep duration and risk of mortality from chronic kidney disease among Japanese adults. Sleep Health, 2025, 11(1): 91-97.
- 6. Kadoya M, Morimoto A, Miyoshi A, et al. Sleep quality, autonomic dysfunction and renal function in diabetic patients with pre-CKD phase. Sci Rep, 2021, 11(1): 19048.
- 7. Chang W, Han Y, Song X, et al. Relationship between trajectory of sleep quality and short-term changes in residual renal function in stage 3-5 chronic kidney disease patients. Clin Exp Nephrol, 2020, 24(6): 557-564.
- 8. Castro-Diehl C, Diez Roux AV, Redline S, et al. Sleep duration and quality in relation to autonomic nervous system measures: the multi-ethnic study of atherosclerosis (MESA). Sleep, 2016, 39(11): 1927-1940.
- 9. Hering D, Esler MD, Schlaich MP. Chronic kidney disease: role of sympathetic nervous system activation and potential benefits of renal denervation. EuroIntervention, 2013, 9 (Suppl R): R127-R135.
- 10. Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry, 2016, 80(1): 40-52.
- 11. Kochi M, Kohagura K, Shiohira Y, et al. Inflammation as a risk of developing chronic kidney disease in rheumatoid arthritis. PLoS One, 2016, 11(8): e0160225.
- 12. Brady EM, Bodicoat DH, Hall AP, et al. Sleep duration, obesity and insulin resistance in a multi-ethnic UK population at high risk of diabetes. Diabetes Res Clin Pract, 2018, 139: 195-202.
- 13. Liu C, Zhang J, Wei X, et al. Effects of sleep duration and changes in body mass index on diabetic kidney disease: a prospective cohort study. Front Endocrinol (Lausanne), 2023, 14: 1278665.
- 14. Jiang L, Xu H. U-shaped relationship between sleep duration and CKD in US adults: data from national health and nutrition examination survey (NHANES) 2005-2014. Am J Nephrol, 2023, 54(7/8): 275-280.
- 15. Sun H, Qin K, Zou C, et al. The association of nighttime sleep duration and quality with chronic kidney disease in middle-aged and older Chinese: a cohort study. Sleep Med, 2021, 86: 25-31.
- 16. Franke FJ, Arzt M, Kroner T, et al. Daytime napping and diabetes-associated kidney disease. Sleep Med, 2019, 54: 205-212.
- 17. Kim CW, Chang Y, Sung E, et al. Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women. PLoS One, 2017, 12(4): e0175298.
- 18. Salifu I, Tedla F, Pandey A, et al. Sleep duration and chronic kidney disease: analysis of the national health interview survey. Cardiorenal Med, 2014, 4(3/4): 210-216.
- 19. Shen X, Wu Y, Zhang D. Nighttime sleep duration, 24-hour sleep duration and risk of all-cause mortality among adults: a meta-analysis of prospective cohort studies. Sci Rep, 2016, 6: 21480.
- 20. Jiang B, Tang D, Dai N, et al. Association of self-reported nighttime sleep duration with chronic kidney disease: China Health and Retirement Longitudinal Study. Am J Nephrol, 2023, 54(7/8): 249-257.
- 21. Yamamoto R, Shinzawa M, Isaka Y, et al. Sleep quality and sleep duration with CKD are associated with progression to ESKD. Clin J Am Soc Nephrol, 2018, 13(12): 1825-1832.
- 22. Park S, Lee S, Kim Y, et al. Short or long sleep duration and CKD: a Mendelian randomization study. J Am Soc Nephrol, 2020, 31(12): 2937-2947.
- 23. Wang Y, Huang W, O’Neil A, et al. Association between sleep duration and mortality risk among adults with type 2 diabetes:a prospective cohort study. Diabetologia, 2020, 63(11): 2292-2304.
- 24. Ricardo AC, Goh V, Chen J, et al. Association of sleep duration, symptoms, and disorders with mortality in adults with chronic kidney disease. Kidney Int Rep, 2017, 2(5): 866-873.
- 25. Petrov ME, Kim Y, Lauderdale DS, et al. Objective sleep, a novel risk factor for alterations in kidney function: the CARDIA study. Sleep Med, 2014, 15(9): 1140-1146.
- 26. Choi H, Kim HC, Lee JY, et al. Sleep duration and chronic kidney disease: the Korean Genome and Epidemiology Study (KoGES)-Kangwha study. Korean J Intern Med, 2017, 32(2): 323-334.
- 27. Krystal AD, Edinger JD. Measuring sleep quality. Sleep Med, 2008, 9 (Suppl 1): S10-S17.
- 28. Buysse DJ, Reynolds CF 3rd, Monk TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res, 1989, 28(2): 193-213.
- 29. Geng T, Li X, Ma H, et al. Adherence to a healthy sleep pattern and risk of chronic kidney disease: the UK biobank study. Mayo Clin Proc, 2022, 97(1): 68-77.
- 30. Meng L, Ding Y, Li J, et al. Impact of inflammatory markers on the relationship between sleep quality and diabetic kidney disease. Sleep Breath, 2022, 26(1): 157-165.
- 31. Ricardo AC, Knutson K, Chen J, et al. The association of sleep duration and quality with CKD progression. J Am Soc Nephrol, 2017, 28(12): 3708-3715.
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