Research progress of sleeve gastrectomy with jejunojejunal bypass_West China Medical Journal

Authors：

WANG Lang ¹ ,  DING Yinlu ²

1. Second Clinical College of Shandong University, Jinan, Shandong 250012, P. R. China;
2. Gastrointestinal Surgery Department, Second Hospital of Shandong University, Jinan, Shandong 250012, P. R. China;

Corresponding?author：

DING Yinlu, Email: dingyinlu@126.com

Keywords：

Sleeve gastrectomy; jejunojejunal bypass; Roux-en-Y gastric bypass; obesity

DOI：

10.7507/1002-0179.202407321

Video：

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Abstract Full text Figures/Tables Video References Cited by

With the swift evolution of bariatric and metabolic surgery, additional procedures building upon sleeve gastrectomy have consistently surfaced. Recent studies suggest that sleeve gastrectomy with jejunojejunal bypass (SG-JJB) yields superior short-term weight reduction outcomes compared to sleeve gastrectomy alone, with weight loss and glycemic control effects akin to Roux-en-Y gastric bypass, and without significant complications. As a result, SG-JJB is regarded as a safe and efficacious bariatric procedure, noted for its technical simplicity and reversibility, presenting substantial clinical utility. Nonetheless, high-quality, multicenter, large-sample, long-term follow-up randomized controlled trials are essential to further ascertain its long-term efficacy and safety, and to facilitate its standardized implementation. This article seeks to review the advancements in SG-JJB research, evaluate its effectiveness and safety in managing obesity and associated comorbidities, and explore its future developmental trajectory.

Citation： WANG Lang, DING Yinlu. Research progress of sleeve gastrectomy with jejunojejunal bypass. West China Medical Journal, 2025, 40(2): 305-312. doi: 10.7507/1002-0179.202407321 Copy

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2. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet, 2024, 403(10431): 1027-1050.
3. Okunogbe A, Nugent R, Spencer G, et al. Economic impacts of overweight and obesity: current and future estimates for 161 countries. BMJ Glob Health, 2022, 7(9): e009773.
4. GBD 2021 Risk Factors Collaborators. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet, 2024, 403(10440): 2162-2203.
5. Kloock S, Ziegler CG, Dischinger U. Obesity and its comorbidities, current treatment options and future perspectives: challenging bariatric surgery?. Pharmacol Ther, 2023, 251: 108549.
6. Brown WA, Liem R, Al-Sabah S, et al. Metabolic bariatric surgery across the IFSO chapters: key insights on the baseline patient demographics, procedure types, and mortality from the eighth IFSO global registry report. Obes Surg, 2024, 34(5): 1764-1777.
7. Biter LU, ’t Hart JW, Noordman BJ, et al. Long-term effect of sleeve gastrectomy vs Roux-en-Y gastric bypass in people living with severe obesity: a phase Ⅲ multicentre randomised controlled trial (SleeveBypass). Lancet Reg Health Eur, 2024, 38: 100836.
8. Dang JT, Vaughan T, Mocanu V, et al. Conversion of sleeve gastrectomy to Roux-en-Y gastric bypass: indications, prevalence, and safety. Obes Surg, 2023, 33(5): 1486-1493.
9. Nielsen HJ, Nedreb? BG, Foss? A, et al. Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy. Int J Obes (Lond), 2022, 46(4): 739-749.
10. Kim JC, Kim MG, Park JK, et al. Outcomes and adverse events after bariatric surgery: an updated systematic review and meta-analysis, 2013-2023. J Metab Bariatr Surg, 2023, 12(2): 76-88.
11. 王濤, 師振, 于飛. 不同手術方案治療重度肥胖合并 2 型糖尿病療效比較. 新鄉醫學院學報, 2022, 39(4): 371-375.
12. Huang CK, Mahendra R, Hsin MC, et al. Novel metabolic surgery: first Asia series and short-term results of laparoscopic proximal jejunal bypass with sleeve gastrectomy. Ann Laparosc Endosc Surg, 2016, 1: 37.
13. 李夢伊, 劉雁軍, 王桂琦, 等. 大中華減重與代謝手術數據庫 2023 年度報告. 中國實用外科雜志, 2024, 44(5): 552-563, 570.
14. 中國醫師協會外科醫師分會肥胖和代謝病外科專家工作組, 中國醫師協會外科醫師分會肥胖代謝外科綜合管理專家工作組, 中國肥胖代謝外科研究協作組. 中國肥胖代謝外科數據庫: 2023 年度報告. 中華肥胖與代謝病電子雜志, 2024, 10(2): 73-83.
15. Lin S, Li C, Guan W, et al. Three-year outcomes of sleeve gastrectomy plus jejunojejunal bypass: a retrospective case-matched study with sleeve gastrectomy and gastric bypass in Chinese patients with BMI ≥35 kg/m². Obes Surg, 2021, 31(8): 3525-3530.
16. Alamo Alamo M, Sepúlveda Torres C, Zapata Perez L. Vertical isolated gastroplasty with gastro-enteral bypass: preliminary results. Obes Surg, 2006, 16(3): 353-358.
17. de Menezes Ettinger JE, Azaro E, Mello CA, et al. Analysis of the vertical isolated gastroplasty: a new bariatric operation. Obes Surg, 2006, 16(9): 1261-1263.
18. Alamo M, Sepúlveda M, Gellona J, et al. Sleeve gastrectomy with jejunal bypass for the treatment of type 2 diabetes mellitus in patients with body mass index <35 kg/m². A cohort study. Obes Surg, 2012, 22(7): 1097-1103.
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