白細胞介素1β與癲癇發作相關性的Meta分析\_《華西醫學》

作者：

魏統國 , 張冰麗 ,  葉紅濤

梅州市人民醫院癲癇專科（廣東梅州，514031）;

關鍵詞：

Meta分析白細胞介素1β 癲癇炎癥反應

DOI：

10.7507/1002-0179.20130580

視頻：

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目的　系統評價白細胞介素1β（IL-1β）與癲癇發作的相關性。方法　2012年5月－2013年10月檢索PubMed數據庫（1985年1月－2013年7月）、Medline數據庫（1985年1月－2013年7月）、中國知網（1998年1月－2013年7月）和萬方數據庫（1996年1月－2013年7月），并輔以谷歌學術搜索引擎進行手工檢索。由兩名研究者按照研究的納入與排除標準進行病例對照研究的選擇，對入選文獻的質量參照“非隨機對照臨床試驗質量評價標準與計分表”進行評價和計分，評估納入研究的方法學質量并對有效的信息進行數據提取。然后采用RevMan 5.0統計軟件進行Meta分析，以加權均數差（WMD）為效應指標。結果　共納入5個研究，包括82例癲癇發作的患者和471例正常對照。所納入的研究未描述詳細的抽樣方法及其檢測方法的特異性。Meta分析結果顯示：癲癇發作72 h以內的患者與正常對照人群之間血漿IL-1β的濃度差異無統計學意義[WMD=0.04 pg/mL，95%CI（?0.07，0.16）pg/mL，P=0.46]。結論　IL-1β可能沒有直接參與癲癇的發作，而是通過與其他炎性因子之間的相互作用來實現。因此，需要進一步的研究來證明IL-1β在癲癇發作中的作用。

引用本文： 魏統國,張冰麗,葉紅濤. 白細胞介素1β與癲癇發作相關性的Meta分析\. 華西醫學, 2013, 28(12): 1832-1836. doi: 10.7507/1002-0179.20130580 復制

1.	Baxendale S, O’Toole A. Epilepsy myths: alive and foaming in the 21st century[J]. Epilepsy Behav, 2007, 11(2): 192-196.
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7.	Sinha S, Patil S, Jayalekshmy V, et al. Do cytokines have any role in epilepsy?[J]. Epilepsy Res, 2008, 82(2-3): 171-176.
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9.	Pernot F, Heinrich C, Barbier L, et al. Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy[J]. Epilepsia, 2011, 52(12): 2315-2325.
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11.	Lehtimäki KA, Keränen T, Palmio J, et al. Increased plasma levels of cytokines after seizures in localization-related epilepsy[J]. Acta Neurol Scand, 2007, 116(4): 226-230.
12.	Hulkkonen J, Koskikallio E, Rainesalo S, et al. The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients[J]. Epilepsy Res, 2004, 59(2-3): 199-205.
13.	Peltola J, Palmio J, Korhonen L, et al. Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures[J]. Epilepsy Res, 2000, 41(3): 205-211.
14.	Bauer S, Cepok S, Todorova-Rudolph A, et al. Etiology and site of temporal lobe epilepsy influence postictal cytokine release[J]. Epilepsy Res, 2009, 86(1): 82-88.
15.	劉建平. 非隨機研究的系統評價方法[J]. 中國循證醫學, 2001, 1(4): 239-243.
16.	Choi J, Koh S. Role of brain inflammation in epileptogenesis[J]. Yonsei Med J, 2008, 49(1): 1-18.
17.	Peltola J, Hurme M, Miettinen A, et al. Elevated levels of interleukin-6 May occur in cerebrospinal fluid from patients with recent epileptic seizures[J]. Epilepsy Res, 1998, 31(2): 129-133.
18.	Fukuda M, Suzuki Y, Ishizaki Y, et al. Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats[J]. Seizure, 2009, 18(3): 211-214.
19.	Haspolat S, Baysal Y, Duman O, et al. Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures[J]. J Child Neurol, 2005, 20(7): 565-568.
20.	Tomoum HY, Badawy NM, Mostafa AA, et al. Plasma interleukin-1beta levels in children with febrile seizures[J]. J Child Neurol, 2007, 22(6): 689-692.
21.	Jauneau AC, Ischenko A, Chatagner A, et al. Interleukin-1beta and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes[J]. J Neuroinflammation, 2006, 3: 8.
22.	Bartfai T, Sanchez-Alavez M, Andell-Jonsson S, et al. Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma[J]. Ann N Y Acad Sci, 2007, 1113: 173-177.
23.	Rijkers K, Majoie HJ, Hoogland G, et al. The role of interleukin-1 in seizures and epilepsy: a critical review[J]. Exp Neurol, 2009, 216(2): 258-271.
24.	Steinman L. Elaborate interactions between the immune and nervous systems[J]. Nat Immunol, 2004, 5(6): 575-581.
25.	Vezzani A, Ravizza T, Balosso S, et al. Glia as a source of cytokines: implications for neuronal excitability and survival[J]. Epilepsia, 2008, 49(Suppl 2): 24-32.

1. 　Baxendale S, O’Toole A. Epilepsy myths: alive and foaming in the 21st century[J]. Epilepsy Behav, 2007, 11(2): 192-196.
2. 　Walker AE. Allergic phenomenon as basic mechanisms in epilepsy[M]//Jaspar HH, Ward AA Jr, Pope A. Basic mechanisms of the epilepsies. London: Churchill, 1969: 812-814.
3. 　Vezzani A, Janigro D. Leukocyte-endothelial adhesion mechanisms in epilepsy: cheers and jeers[J]. Epilepsy Curr, 2009, 9(4): 118-121.
4. 　Ravizza T, Gagliardi B, Noé F, et al. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy[J]. Neurobiol Dis, 2008, 29(1): 142-160.
5. 　Vezzani A, Balosso S, Ravizza T. The role of cytokines in the pathophysiology of epilepsy[J]. Brain Behav Immun, 2008, 22(6): 797-803.
6. 　江明慶. 癲癇患者血清中IL-1β、TNF-α含量變化研究[J]. 當代醫學, 2011, 17(33): 8-9.
7. 　Sinha S, Patil S, Jayalekshmy V, et al. Do cytokines have any role in epilepsy?[J]. Epilepsy Res, 2008, 82(2-3): 171-176.
8. 　Ravizza T, Boer K, Redeker S, et al. The IL-1beta system in epilepsy-associated malformations of cortical development[J]. Neurobiol Dis, 2006, 24(1): 128-143.
9. 　Pernot F, Heinrich C, Barbier L, et al. Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy[J]. Epilepsia, 2011, 52(12): 2315-2325.
10. 　Alapirtti T, Rinta S, Hulkkonen J, et al. Interleukin-6, interleukin-1 receptor antagonist and interleukin-1beta production in patients with focal epilepsy: a video-EEG study[J]. J Neurol Sci, 2009, 280(1-2): 94-97.
11. 　Lehtimäki KA, Keränen T, Palmio J, et al. Increased plasma levels of cytokines after seizures in localization-related epilepsy[J]. Acta Neurol Scand, 2007, 116(4): 226-230.
12. 　Hulkkonen J, Koskikallio E, Rainesalo S, et al. The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients[J]. Epilepsy Res, 2004, 59(2-3): 199-205.
13. 　Peltola J, Palmio J, Korhonen L, et al. Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures[J]. Epilepsy Res, 2000, 41(3): 205-211.
14. 　Bauer S, Cepok S, Todorova-Rudolph A, et al. Etiology and site of temporal lobe epilepsy influence postictal cytokine release[J]. Epilepsy Res, 2009, 86(1): 82-88.
15. 　劉建平. 非隨機研究的系統評價方法[J]. 中國循證醫學, 2001, 1(4): 239-243.
16. 　Choi J, Koh S. Role of brain inflammation in epileptogenesis[J]. Yonsei Med J, 2008, 49(1): 1-18.
17. 　Peltola J, Hurme M, Miettinen A, et al. Elevated levels of interleukin-6 May occur in cerebrospinal fluid from patients with recent epileptic seizures[J]. Epilepsy Res, 1998, 31(2): 129-133.
18. 　Fukuda M, Suzuki Y, Ishizaki Y, et al. Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats[J]. Seizure, 2009, 18(3): 211-214.
19. 　Haspolat S, Baysal Y, Duman O, et al. Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures[J]. J Child Neurol, 2005, 20(7): 565-568.
20. 　Tomoum HY, Badawy NM, Mostafa AA, et al. Plasma interleukin-1beta levels in children with febrile seizures[J]. J Child Neurol, 2007, 22(6): 689-692.
21. 　Jauneau AC, Ischenko A, Chatagner A, et al. Interleukin-1beta and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes[J]. J Neuroinflammation, 2006, 3: 8.
22. 　Bartfai T, Sanchez-Alavez M, Andell-Jonsson S, et al. Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma[J]. Ann N Y Acad Sci, 2007, 1113: 173-177.
23. 　Rijkers K, Majoie HJ, Hoogland G, et al. The role of interleukin-1 in seizures and epilepsy: a critical review[J]. Exp Neurol, 2009, 216(2): 258-271.
24. 　Steinman L. Elaborate interactions between the immune and nervous systems[J]. Nat Immunol, 2004, 5(6): 575-581.
25. 　Vezzani A, Ravizza T, Balosso S, et al. Glia as a source of cytokines: implications for neuronal excitability and survival[J]. Epilepsia, 2008, 49(Suppl 2): 24-32.

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《華西醫學》

白細胞介素1β與癲癇發作相關性的Meta分析\

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白細胞介素1β與癲癇發作相關性的Meta分析\

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