正電子發射計算機斷層顯像/磁共振成像的臨床應用新進展_《華西醫學》

作者：

沈國華 , 周綠漪 , 賈志云 , 張文杰 , 王喬 ,  鄧候富

四川大學華西醫院核醫學科（成都，610041）;

關鍵詞：

正電子發射計算機斷層顯像磁共振成像分子影像學腫瘤學神經精神疾病多模式成像理

DOI：

10.7507/1002-0179.20130567

視頻：

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正電子發射計算機斷層顯像/磁共振成像這一新型設備和技術的出現，不僅為腫瘤學、神經精神疾病等的臨床應用開辟了新的道路，還為干細胞治療等基礎科研提供新的平臺。它不簡單是一種單一的技術變革，而是一種多模式成像理念的體現、多種技術的完美整合，它將給現代和將來的醫學發展模式帶來重大的影響。

引用本文： 沈國華,周綠漪,賈志云,張文杰,王喬,鄧候富. 正電子發射計算機斷層顯像/磁共振成像的臨床應用新進展. 華西醫學, 2013, 28(11): 1787-1790. doi: 10.7507/1002-0179.20130567 復制

1.	Drzezga A, Souvatzoglou M, Eiber M, et al. First clinical experience with integrated whole-body PET/Mr: comparison to PET/CT in patients with oncologic diagnoses[J]. J Nucl Med, 2012, 53(6): 845-855.
2.	Antoch G, Bockisch A. Combined PET/MRI: a new dimension in whole-body oncology imaging? [J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 113-120.
3.	Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis[J]. J Nucl Med, 2012, 53(6): 928-938.
4.	Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 2: bone tumors, soft-tissue tumors, melanoma, and lymphoma[J]. J Nucl Med, 2012, 53(8): 1244-1252.
5.	Boss A, Stegger L, Bisdas S, et al. Feasibility of simultaneous PET/MR imaging in the head and upper neck area[J]. Eur Radiol, 2011, 21(7): 1439-1446.
6.	Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646-674.
7.	Sauter AW, Wehrl HF, Kolb A, et al. Combined PET/MRI: one step further in multimodality imaging[J]. Trends Mol Med, 2010, 16(11): 508-515.
8.	Ng TS, Bading JR, Park R, et al. Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner[J]. J Nucl Med, 2012, 53(7): 1102-1109.
9.	Schreiter NF, Nogami M, Steffen I, et al. Evaluation of the potential of PET-MRI fusion for detection of liver metastases in patients with neuroendocrine tumours[J]. Eur Radiol, 2012, 22(2): 458-467.
10.	Nagarajah J, Jentzen W, Hartung V, et al. Diagnosis and dosimetry in differentiated thyroid carcinoma using 124I PET: comparison of PET/MRI vs PET/CT of the neck[J]. Eur J Nucl Med Mol Imaging, 2011, 38(10): 1862-1868.
11.	Estorch M, Carrio I. Future challenges of multimodality imaging[J]. Recent Results Cancer Res, 2013, 187: 403-415.
12.	Takasawa M, Jones PS, Guadagno JV, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET[J]. Stroke, 2008, 39(3): 870-877.
13.	Guadagno JV, Warburton EA, Jones PS, et al. How affected is oxygen metabolism in DWI lesions? A combined acute stroke PET-MR study[J]. Neurology, 2006, 67(5): 824-829.
14.	LoPinto-Khoury C, Sperling MR, Skidmore C, et al. Surgical outcome in PET-positive, MRI-negative patients with temporal lobe epilepsy[J]. Epilepsia, 2012, 53(2): 342-348.
15.	Zaidi H, Del Guerra A. An outlook on future design of hybrid PET/MRI systems[J]. Med Phys, 2011, 38(10): 5667-5689.
16.	Goffin K, Dedeurwaerdere S, Van Laere K, et al. Neuronuclear assessment of patients with epilepsy[J]. Semin Nucl Med, 2008, 38(4): 227-239.
17.	Chen W, Silverman DH. Advances in evaluation of primary brain tumors[J]. Semin Nucl Med, 2008, 38(4): 240.
18.	Gilman, S. Imaging the brain[J]. N Engl J Med, 1998, 338(12): 812-820.
19.	Yakushev I, Fellgiebel A. Horizontal versus longitudinal axis of the hippocampus: metabolic differentiation as measured with high-resolution PET/MRI[J]. J Nucl Med, 2011, 52(2): 329-330.
20.	Yakushev I, Müller MJ, Lorscheider M, et al. Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer’s disease[J]. Neuropsychologia, 2010, 48(5): 1447-1453.
21.	Behera D, Jacobs KE, Behera S, et al. (18) F-FDG PET/MRI can be used to identify injured peripheral nerves in a model of neuropathic pain[J]. J Nucl Med, 2011, 52(8): 1308-1312.
22.	Catana C, Drzezga A, Heiss WD, et al. PET/MRI for neurologic applications[J]. J Nucl Med, 2012, 53(12): 1916-1925.
23.	Heiss WD, Raab P, Lanfermann H. Multimodality assessment of brain tumors and tumor recurrence[J]. J Nucl Med, 2011, 52(10): 1585-1600.
24.	Nekolla SG, Martinez-Moeller A, Saraste A. PET and MRI in cardiac imaging: from validation studies to integrated applications[J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 121-130.
25.	Majmudar MD, Nahrendorf M. Cardiovascular molecular imaging: the road ahead[J]. J Nucl Med, 2012, 53(5): 673-676.
26.	Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction[J]. J Am Coll Cardiol, 2012, 59(2): 153-163.
27.	Bjorklund LM, Sánchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model[J]. Proc Natl Acad Sci USA, 2002, 99(4): 2344-2349.
28.	Glaudemans AM, Quintero AM, Signore A. PET/MRI in infectious and inflammatory diseases: will it be a useful improvement?[J]. Eur J Nucl Med Mol Imaging, 2012, 39(5):745-749.
29.	王強, 王榮福. 當代最先進分子影像新技術——PET/MRI[J]. 中國醫療器械信息, 2011, 17(4): 4-7.
30.	許震生, 譚海波, 管一暉. PET/MRI研制進展及展望[J]. 中國醫療器械信息, 2011, 17(4): 1-3, 26.

1. 　Drzezga A, Souvatzoglou M, Eiber M, et al. First clinical experience with integrated whole-body PET/Mr: comparison to PET/CT in patients with oncologic diagnoses[J]. J Nucl Med, 2012, 53(6): 845-855.
2. 　Antoch G, Bockisch A. Combined PET/MRI: a new dimension in whole-body oncology imaging? [J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 113-120.
3. 　Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 1: tumors of the brain, head and neck, chest, abdomen, and pelvis[J]. J Nucl Med, 2012, 53(6): 928-938.
4. 　Buchbender C, Heusner TA, Lauenstein TC, et al. Oncologic PET/MRI, part 2: bone tumors, soft-tissue tumors, melanoma, and lymphoma[J]. J Nucl Med, 2012, 53(8): 1244-1252.
5. 　Boss A, Stegger L, Bisdas S, et al. Feasibility of simultaneous PET/MR imaging in the head and upper neck area[J]. Eur Radiol, 2011, 21(7): 1439-1446.
6. 　Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646-674.
7. 　Sauter AW, Wehrl HF, Kolb A, et al. Combined PET/MRI: one step further in multimodality imaging[J]. Trends Mol Med, 2010, 16(11): 508-515.
8. 　Ng TS, Bading JR, Park R, et al. Quantitative, simultaneous PET/MRI for intratumoral imaging with an MRI-compatible PET scanner[J]. J Nucl Med, 2012, 53(7): 1102-1109.
9. 　Schreiter NF, Nogami M, Steffen I, et al. Evaluation of the potential of PET-MRI fusion for detection of liver metastases in patients with neuroendocrine tumours[J]. Eur Radiol, 2012, 22(2): 458-467.
10. 　Nagarajah J, Jentzen W, Hartung V, et al. Diagnosis and dosimetry in differentiated thyroid carcinoma using 124I PET: comparison of PET/MRI vs PET/CT of the neck[J]. Eur J Nucl Med Mol Imaging, 2011, 38(10): 1862-1868.
11. 　Estorch M, Carrio I. Future challenges of multimodality imaging[J]. Recent Results Cancer Res, 2013, 187: 403-415.
12. 　Takasawa M, Jones PS, Guadagno JV, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET[J]. Stroke, 2008, 39(3): 870-877.
13. 　Guadagno JV, Warburton EA, Jones PS, et al. How affected is oxygen metabolism in DWI lesions? A combined acute stroke PET-MR study[J]. Neurology, 2006, 67(5): 824-829.
14. 　LoPinto-Khoury C, Sperling MR, Skidmore C, et al. Surgical outcome in PET-positive, MRI-negative patients with temporal lobe epilepsy[J]. Epilepsia, 2012, 53(2): 342-348.
15. 　Zaidi H, Del Guerra A. An outlook on future design of hybrid PET/MRI systems[J]. Med Phys, 2011, 38(10): 5667-5689.
16. 　Goffin K, Dedeurwaerdere S, Van Laere K, et al. Neuronuclear assessment of patients with epilepsy[J]. Semin Nucl Med, 2008, 38(4): 227-239.
17. 　Chen W, Silverman DH. Advances in evaluation of primary brain tumors[J]. Semin Nucl Med, 2008, 38(4): 240.
18. 　Gilman, S. Imaging the brain[J]. N Engl J Med, 1998, 338(12): 812-820.
19. 　Yakushev I, Fellgiebel A. Horizontal versus longitudinal axis of the hippocampus: metabolic differentiation as measured with high-resolution PET/MRI[J]. J Nucl Med, 2011, 52(2): 329-330.
20. 　Yakushev I, Müller MJ, Lorscheider M, et al. Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer’s disease[J]. Neuropsychologia, 2010, 48(5): 1447-1453.
21. 　Behera D, Jacobs KE, Behera S, et al. (18) F-FDG PET/MRI can be used to identify injured peripheral nerves in a model of neuropathic pain[J]. J Nucl Med, 2011, 52(8): 1308-1312.
22. 　Catana C, Drzezga A, Heiss WD, et al. PET/MRI for neurologic applications[J]. J Nucl Med, 2012, 53(12): 1916-1925.
23. 　Heiss WD, Raab P, Lanfermann H. Multimodality assessment of brain tumors and tumor recurrence[J]. J Nucl Med, 2011, 52(10): 1585-1600.
24. 　Nekolla SG, Martinez-Moeller A, Saraste A. PET and MRI in cardiac imaging: from validation studies to integrated applications[J]. Eur J Nucl Med Mol Imaging, 2009, 36 (Suppl 1): 121-130.
25. 　Majmudar MD, Nahrendorf M. Cardiovascular molecular imaging: the road ahead[J]. J Nucl Med, 2012, 53(5): 673-676.
26. 　Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction[J]. J Am Coll Cardiol, 2012, 59(2): 153-163.
27. 　Bjorklund LM, Sánchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model[J]. Proc Natl Acad Sci USA, 2002, 99(4): 2344-2349.
28. 　Glaudemans AM, Quintero AM, Signore A. PET/MRI in infectious and inflammatory diseases: will it be a useful improvement?[J]. Eur J Nucl Med Mol Imaging, 2012, 39(5):745-749.
29. 　王強, 王榮福. 當代最先進分子影像新技術——PET/MRI[J]. 中國醫療器械信息, 2011, 17(4): 4-7.
30. 　許震生, 譚海波, 管一暉. PET/MRI研制進展及展望[J]. 中國醫療器械信息, 2011, 17(4): 1-3, 26.

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正電子發射計算機斷層顯像/磁共振成像的臨床應用新進展

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