Association between Interleukin-1α Polymorphisms and Risk of Intracranial Aaneurysm_West China Medical Journal

Authors：

SIMA Xiutian , LIU Hao , ZHOU Peizhi , HU Xin , ZHONG Weiying ,  YOUChao.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

YOUChao., Email: simaxiutian@163.com

Keywords：

白細胞介素1α; 多態性; 顱內動脈瘤

DOI：

10.7507/1002-0179.20130528

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目的　探討白細胞介素1α（IL-1α）基因多態性與顱內動脈瘤發生的關系。方法　以2010年6月－2012年3月145例顱內動脈瘤患者和181例正常對照者為研究對象，采用聚合酶鏈反應-限制性片段長度多態性檢測IL-1α-889C/T和+4845G/T多態性，統計分析基因多態性與顱內動脈瘤的相關性。結果　IL-1α-889C/T位點：CT/TT基因型在顱內動脈瘤組中的頻率為32.4%，顯著高于其在對照組中的頻率（21.5%），兩組相比差異有統計學意義（χ2=4.90，P＜0.05）；T等位基因在顱內動脈瘤組中的頻率為16.9%，顯著高于其在對照組中的頻率（10.8%），兩組相比差異有統計學意義（χ2=5.17，P＜0.05）。IL-1α+4845G/T多態性在兩組人群中的分布差異無統計學意義（P＞0.05）。結論　IL-1α -889C/T多態性與顱內動脈瘤的發病有關，-889T等位基因可能是顱內動脈瘤的遺傳易感基因。

Citation： SIMA Xiutian,LIU Hao,ZHOU Peizhi,HU Xin,ZHONG Weiying,YOUChao.. Association between Interleukin-1α Polymorphisms and Risk of Intracranial Aaneurysm. West China Medical Journal, 2013, 28(11): 1668-1670. doi: 10.7507/1002-0179.20130528 Copy

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1. 　張國忠, 馮文峰, 黃理金, 等. 白細胞介素-1β基因多態性與顱內動脈瘤的關系[J]. 廣東醫學, 2008, 29(12): 2016-2018.
2. 　Slowik A, Borratynska A, Turaj W, et al. Interleukin 1beta-511 C/T polymorphism and risk of aneurysmal subarachnoid haemorrhage[J]. J Neurol Neurosurg Psychiat, 2006, 77(2): 279-280.
3. 　Wang B, Zhou S, Wang J, et al. Lack of association between interleukin-1a gene (IL-1a) C(-889) T variant and polycystic ovary syndrome in Chinese women[J]. Endocrine, 2009, 35(2): 198-203.
4. 　Archana PM, Salman AA, Kumar TS, et al. Association between interleukin-1 gene polymorphism and severity of chronic periodontitis in a south Indian population group[J]. J Indian Soc Periodontol, 2012, 16(2): 174-178.
5. 　Li L, Sima X, Bai P, et al. Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm[J]. Clin Dev Immunol, 2012: 567-586.
6. 　Hendryk S, Jarzab B, Josko J. Increase of the IL-1 beta and IL-6 levels in CSF in patients with vasospasm following aneurysmal SAH[J]. Neuro Endocrinol Lett, 2004, 25(1-2): 141-147.
7. 　Fontanella M, Rubino E, Crobeddu E, et al. Brain arteriovenous malformations are associated with interleukin-1 cluster gene polymorphisms[J]. Neurosurgery, 2012, 70(1): 12-17.
8. 　Fontanella M, Rainero I, Gallone S, et al. Interleukin-1 cluster gene polymorphisms and aneurysmal subarachnoid hemorrhage[J]. Neurosurgery, 2010, 66(6): 1058-1062.

West China Medical Journal

Association between Interleukin-1α Polymorphisms and Risk of Intracranial Aaneurysm

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