Nutritional Function of Enteral Immunonutrition for the Improvement of Immune Function and Nnutritional Status in Gastric Cancer Patients during and after Surgery_West China Medical Journal

Authors：

NING Zhichao.

Department of General Surgery, the Second People’s Hospital of Xindu District, Chengdu, Sichuan 610501, P. R. China;

Corresponding?author：

Keywords：

腸內營養; 胃癌; 免疫營養

DOI：

10.7507/1002-0179.20130526

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　探討圍手術期強化免疫營養素腸內營養支持對胃癌患者免疫功能和營養狀況的影響。方法　將2007年3月－2012年12月間24 例胃癌術后患者隨機分為腸內免疫營養組（研究組）和常規腸內營養組（對照組），每組12例，進行等氮等熱量營養支持，術前5 d至術后7 d。測定營養支持前后的血清白蛋白、前白蛋白、轉鐵蛋白、T淋巴細胞亞群及血清免疫球蛋白等指標變化。臨床觀察胃腸功能恢復時間。結果　術后兩組患者血清蛋白水平和免疫指標多有下降，但研究組術后8 d的血清前白蛋白水平和IgG、CD4/CD8比值較對照組明顯增加，研究組胃腸功能恢復時間早于對照組。結論　圍手術期應用強化免疫腸內營養支持可改善胃癌患者術后營養和免疫狀況，促進腸道功能恢復。

Citation： NING Zhichao.. Nutritional Function of Enteral Immunonutrition for the Improvement of Immune Function and Nnutritional Status in Gastric Cancer Patients during and after Surgery. West China Medical Journal, 2013, 28(11): 1662-1664. doi: 10.7507/1002-0179.20130526 Copy

1.	Wie GA, Cho YA, Kim SY, et al. Prevalence and risk factors of malnutrition among cancer patients according to tumor location and stage in the National Cancer Center in Korea[J]. Nutrition, 2010, 26(3): 263-268.
2.	張明鳴, 何濤, 達明緒, 等. 胃腸道腫瘤病人圍手術期營養支持[J]. 華西醫學, 2003, 18(3): 414-415.
3.	Klek S, Sierzega M, Szybinski P, et al. The immunomodulating enteral nutrition in malnourished surgical patients: a prospective, randomized, double-blind clinical trial[J]. Clin Nutr, 2011, 30(3): 282-288.
4.	吳佳, 張宇龍, 張璐, 等. 胃癌術后腸內免疫營養對胃癌患者近期療效的Meta分析[J]. 循證醫學, 2012, (5): 291-298.
5.	黎介壽. 腫瘤營養學的興起及臨床應用[J]. 腸外與腸內營養, 2004, 11(1): 1.
6.	Braga M. The Award for General Nutrition. Immunonutrition: from laboratory to clinical practice[J]. Nutrition, 2007, 23(4): 368-370.
7.	張明鳴, 程驚秋, 翟宏軍, 等. 添加特需營養素的營養支持對外科創傷后腸粘膜形態和屏障功能影響的實驗研究[J].中華胃腸外科雜志, 2009, 12(3): 306-309.
8.	Calder PC. Use of fish oil in parenteral nutrition: rationale and reality[J]. Proc Nutr Soc, 2006, 65(3): 264-277.
9.	Adjei AA, Jones JT, Enriquez FJ, et al. Dietary nucleosides and nucleotides reduce Cryptosporidium parvum infection in dexamethasone immunosuppressed adult mice[J]. Exp Parasitol, 1999, 92(3): 199-208.
10.	Azuma H, Mishima S, Oda J, et al. Enteral supplementation enriched with glutamine, fiber, and oligosaccharide prevents gut translocation in a bacterial overgrowth model[J]. J Trauma, 2009, 66(1): 110-114.
11.	黎介壽. 臨床營養支持的發展趨勢[J]. 腸外與腸內營養, 2010, 17(1): 1-4.
12.	伍曉汀, 陳博. 臨床營養支持策略的變遷[J]. 中國實用外科雜志, 2011, 31(1): 25-28.
13.	Braga M, Ljungqvist O, Soeters P, et al. ESPEN guidelines on parenteral nutrition: surgery[J]. Clin Nutr, 2009, 28(4): 378-386.
14.	Yoshida S, Matsui M, Shirouzu Y, et al. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer[J]. Ann Surg, 1998, 227(4): 485-491.

1. 　Wie GA, Cho YA, Kim SY, et al. Prevalence and risk factors of malnutrition among cancer patients according to tumor location and stage in the National Cancer Center in Korea[J]. Nutrition, 2010, 26(3): 263-268.
2. 　張明鳴, 何濤, 達明緒, 等. 胃腸道腫瘤病人圍手術期營養支持[J]. 華西醫學, 2003, 18(3): 414-415.
3. 　Klek S, Sierzega M, Szybinski P, et al. The immunomodulating enteral nutrition in malnourished surgical patients: a prospective, randomized, double-blind clinical trial[J]. Clin Nutr, 2011, 30(3): 282-288.
4. 　吳佳, 張宇龍, 張璐, 等. 胃癌術后腸內免疫營養對胃癌患者近期療效的Meta分析[J]. 循證醫學, 2012, (5): 291-298.
5. 　黎介壽. 腫瘤營養學的興起及臨床應用[J]. 腸外與腸內營養, 2004, 11(1): 1.
6. 　Braga M. The Award for General Nutrition. Immunonutrition: from laboratory to clinical practice[J]. Nutrition, 2007, 23(4): 368-370.
7. 　張明鳴, 程驚秋, 翟宏軍, 等. 添加特需營養素的營養支持對外科創傷后腸粘膜形態和屏障功能影響的實驗研究[J].中華胃腸外科雜志, 2009, 12(3): 306-309.
8. 　Calder PC. Use of fish oil in parenteral nutrition: rationale and reality[J]. Proc Nutr Soc, 2006, 65(3): 264-277.
9. 　Adjei AA, Jones JT, Enriquez FJ, et al. Dietary nucleosides and nucleotides reduce Cryptosporidium parvum infection in dexamethasone immunosuppressed adult mice[J]. Exp Parasitol, 1999, 92(3): 199-208.
10. 　Azuma H, Mishima S, Oda J, et al. Enteral supplementation enriched with glutamine, fiber, and oligosaccharide prevents gut translocation in a bacterial overgrowth model[J]. J Trauma, 2009, 66(1): 110-114.
11. 　黎介壽. 臨床營養支持的發展趨勢[J]. 腸外與腸內營養, 2010, 17(1): 1-4.
12. 　伍曉汀, 陳博. 臨床營養支持策略的變遷[J]. 中國實用外科雜志, 2011, 31(1): 25-28.
13. 　Braga M, Ljungqvist O, Soeters P, et al. ESPEN guidelines on parenteral nutrition: surgery[J]. Clin Nutr, 2009, 28(4): 378-386.
14. 　Yoshida S, Matsui M, Shirouzu Y, et al. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer[J]. Ann Surg, 1998, 227(4): 485-491.

West China Medical Journal

Nutritional Function of Enteral Immunonutrition for the Improvement of Immune Function and Nnutritional Status in Gastric Cancer Patients during and after Surgery

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content