生長休止基因7及其產物的生理作用研究進展_《華西醫學》

作者：

徐臣利 ¹ ,  沈睿 ²

湖北醫藥學院（湖北十堰，442000）1 病理學教研室，2 附屬太和醫院骨科;

關鍵詞：

生長休止基因7 分化凋亡

DOI：

10.7507/1002-0179.20130409

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

生長休止基因7（gas7）及其產物參與神經細胞分化生長及腫瘤細胞生長、凋亡調控等過程，可通過穩定細胞骨骼并促使其延長誘導神經細胞的分化生長。另外，突變的gas7則參與腫瘤細胞的生長和凋亡的調節，但具體的分子調控機制仍不清楚，因此逐步研究gas7及其產物在這些調控過程中的作用就顯得尤為重要。

引用本文： 徐臣利,沈睿. 生長休止基因7及其產物的生理作用研究進展. 華西醫學, 2013, 28(8): 1299-1302. doi: 10.7507/1002-0179.20130409 復制

1.	Brenner DG, Lin-Chao S, Cohen SN. Analysis of mammalian cell genetic regulation in situ by using retrovirus-derived “portable exons” carrying the Escherichia coli lacZ gene[J]. PNAS, 1989, 86(14): 5517-5521.
2.	Lazakovitch EM, She BR, Lien CL, et al. The Gas7 gene encodes two protein isoforms differentially expressed within the brain[J]. Genomics, 1999, 61(3): 298-306.
3.	Ju YT, Chang AC, She BR, et al. gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation[J]. PNAS, 1998, 95(19):11423-11428.
4.	Moorthy PP, Kumar AA, Devaraj H. Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice[J]. Stem Cells Dev, 2005, 14(6): 664-670.
5.	Chao CC, Su LJ, Sun NK, et al. Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells[J]. J Neurosci Res, 2003, 74(2): 248-254.
6.	Dent EW, Gertler FB. Cytoskeletal dynamics and transport in growth cone motility and axon guidance[J]. Neuron, 2003, 40(2): 209-227.
7.	Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics[J]. Science, 2009, 325(5943): 960-963.
8.	Chitu V, Stanley ER. Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions[J]. Trends Cell Biol, 2007, 17(3): 145-156.
9.	Tsujita K, Suetsugu S, Sasaki N, et al. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis[J]. JCB, 2006, 172(2): 269-279.
10.	Lippincott J, Li R. Involvement of PCH family proteins in cytokinesis and actin distribution[J]. Microsc Res Tech, 2000, 49(2): 168-172.
11.	Chitu V, Stanley ER. Pombe cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions[J]. Trends Cell Biol, 2007, 17(3):145-156.
12.	Aspenström P. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton[J]. Curr Biol, 1997, 7(7): 479-487.
13.	So CW, Lin M, Ayton PM, et al. Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias[J]. Cancer Cell, 2003, 4(2): 99-110.
14.	Tsujita K, Suetsugu S, Sasaki N, et al. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis[J]. J Cell Biol, 2006,172(2): 269-279.
15.	Henne WM, Kent HM, Ford MG, et al. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature[J]. Structure, 2007, 15(7): 839-852.
16.	Itoh T, Erdmann KS, Roux A, et al. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins[J]. Dev Cell, 2005, 9(6): 791-804.
17.	Shimada A, Niwa H, Tsujita K, et al. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis[J]. Cell, 2007, 129(4): 761-772.
18.	You JJ, Lin-Chao S. Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons[J]. J Biol Chem, 2010, 285(15): 11652-11666.
19.	Chao CC, Chang PY, Lu HH. Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth[J]. J Neurosci Res, 2005, 81(2): 153-162.
20.	She BR, Liou GG, Lin-Chao S. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth[J]. Exp Cell Res, 2002, 273(1): 34-44.
21.	Guerrier S, Coutinho-Budd J, Sassa T, et al. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis[J]. Cell, 2009, 138(5): 990-1004.
22.	Kakimoto T, Katoh H, Negishi M. Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination[J]. J Biol Chem, 2006, 281(39): 29042-29053.
23.	Akiyama H, Gotoh A, Shin RW, et al. A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease[J]. J Biol Chem, 2009, 284(47): 32695-32699.
24.	Uchida T, Akiyama H, Sakamoto W, et al. Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7[J]. J Mol Biol, 2009, 391(5): 849-857.
25.	Lortie K, Huang D, Chakravarthy B, et al. The gas7 protein potentiates NGF-mediated differentiation of PC12 cells[J]. Brain Res, 2005, 1036(1-2): 27-34.
26.	Huang BT, Chang PY, Su CH, et al. Gas7-deficient mouse reveals roles in motor function and muscle fiber composition during aging[J]. PLoS One, 2012, 7(5): 37702.
27.	Ebinger M, Senf L, Scheurlen W. Risk stratification in medulloblastoma: screening for molecular markers[J]. Klin Padiatr, 2006, 218(3): 139-142.
28.	Tseng RC, Hsieh FJ, Hsu HS, et al. Minimal deletion regions in lung squamous cell carcinoma: association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers[J]. Lung Cancer, 2008, 59(3): 332-329.
29.	Ebinger M, Senf L, Wachowski O, et al. Expression of GAS7 in childhood CNS tumors[J]. Pediatr Blood Cancer, 2006, 46(3): 325-328.
30.	Hung FC, Chao CC. Knockdown of growth-arrest-specific gene 7b (gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: Implications for preventing apoptosis of neurons[J]. J Neurosci Res, 2010, 88(16): 3578-3587.
31.	Ilsley JL, Sudol M, Winder SJ. The WW domain: linking cell signalling to the membrane cytoskeleton[J]. Cell Signal, 2002, 14(3): 183-189.
32.	Megonigal MD, Cheung NK, Rappaport EF, et al. Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors[J]. Proc Natl Acad Sci U S A, 2000, 97(6): 2814-2819.
33.	So CW, Karsunky H, Passegué E, et al. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice[J]. Cancer Cell, 2003, 3(2): 161-171.
34.	Zhou J, Dudley ME, Rosenberg SA, et al. Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy[J]. J Immunother, 2005, 28(1): 53-62.
35.	Lu PJ, Wulf G, Zhou XZ, et al. The prolyl isomerase Pin1 restores the function of alzheimer-associated phosphorylated tau protein[J]. Nature, 1999, 399(6738): 784-788.
36.	Smet C, Sambo AV, Wieruszeski JM, et al. The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau[J]. Biochemistry, 2004, 43(7): 2032-2040.
37.	Hung FC, Chang Y, Lin-Chao S, et al. Gas7 mediates the differentiation of human bone marrow-derived mesenchymal stem cells into functional osteoblasts by enhancing Runx2-dependent gene expression[J]. J Orthop Res, 2011, 29(10): 1528-1535.
38.	Chang Y, Ueng SW, Lin-Chao S, et al. Involvement of Gas7 along the ERK1/2 MAP kinase and SOX9 pathway in chondrogenesis of human marrow-derived mesenchymal stem cells[J]. Osteoarthritis Cartilage, 2008, 16(11): 1403-1412.

1. 　Brenner DG, Lin-Chao S, Cohen SN. Analysis of mammalian cell genetic regulation in situ by using retrovirus-derived “portable exons” carrying the Escherichia coli lacZ gene[J]. PNAS, 1989, 86(14): 5517-5521.
2. 　Lazakovitch EM, She BR, Lien CL, et al. The Gas7 gene encodes two protein isoforms differentially expressed within the brain[J]. Genomics, 1999, 61(3): 298-306.
3. 　Ju YT, Chang AC, She BR, et al. gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation[J]. PNAS, 1998, 95(19):11423-11428.
4. 　Moorthy PP, Kumar AA, Devaraj H. Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice[J]. Stem Cells Dev, 2005, 14(6): 664-670.
5. 　Chao CC, Su LJ, Sun NK, et al. Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells[J]. J Neurosci Res, 2003, 74(2): 248-254.
6. 　Dent EW, Gertler FB. Cytoskeletal dynamics and transport in growth cone motility and axon guidance[J]. Neuron, 2003, 40(2): 209-227.
7. 　Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics[J]. Science, 2009, 325(5943): 960-963.
8. 　Chitu V, Stanley ER. Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions[J]. Trends Cell Biol, 2007, 17(3): 145-156.
9. 　Tsujita K, Suetsugu S, Sasaki N, et al. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis[J]. JCB, 2006, 172(2): 269-279.
10. 　Lippincott J, Li R. Involvement of PCH family proteins in cytokinesis and actin distribution[J]. Microsc Res Tech, 2000, 49(2): 168-172.
11. 　Chitu V, Stanley ER. Pombe cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions[J]. Trends Cell Biol, 2007, 17(3):145-156.
12. 　Aspenström P. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton[J]. Curr Biol, 1997, 7(7): 479-487.
13. 　So CW, Lin M, Ayton PM, et al. Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias[J]. Cancer Cell, 2003, 4(2): 99-110.
14. 　Tsujita K, Suetsugu S, Sasaki N, et al. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis[J]. J Cell Biol, 2006,172(2): 269-279.
15. 　Henne WM, Kent HM, Ford MG, et al. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature[J]. Structure, 2007, 15(7): 839-852.
16. 　Itoh T, Erdmann KS, Roux A, et al. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins[J]. Dev Cell, 2005, 9(6): 791-804.
17. 　Shimada A, Niwa H, Tsujita K, et al. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis[J]. Cell, 2007, 129(4): 761-772.
18. 　You JJ, Lin-Chao S. Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons[J]. J Biol Chem, 2010, 285(15): 11652-11666.
19. 　Chao CC, Chang PY, Lu HH. Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth[J]. J Neurosci Res, 2005, 81(2): 153-162.
20. 　She BR, Liou GG, Lin-Chao S. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth[J]. Exp Cell Res, 2002, 273(1): 34-44.
21. 　Guerrier S, Coutinho-Budd J, Sassa T, et al. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis[J]. Cell, 2009, 138(5): 990-1004.
22. 　Kakimoto T, Katoh H, Negishi M. Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination[J]. J Biol Chem, 2006, 281(39): 29042-29053.
23. 　Akiyama H, Gotoh A, Shin RW, et al. A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease[J]. J Biol Chem, 2009, 284(47): 32695-32699.
24. 　Uchida T, Akiyama H, Sakamoto W, et al. Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7[J]. J Mol Biol, 2009, 391(5): 849-857.
25. 　Lortie K, Huang D, Chakravarthy B, et al. The gas7 protein potentiates NGF-mediated differentiation of PC12 cells[J]. Brain Res, 2005, 1036(1-2): 27-34.
26. 　Huang BT, Chang PY, Su CH, et al. Gas7-deficient mouse reveals roles in motor function and muscle fiber composition during aging[J]. PLoS One, 2012, 7(5): 37702.
27. 　Ebinger M, Senf L, Scheurlen W. Risk stratification in medulloblastoma: screening for molecular markers[J]. Klin Padiatr, 2006, 218(3): 139-142.
28. 　Tseng RC, Hsieh FJ, Hsu HS, et al. Minimal deletion regions in lung squamous cell carcinoma: association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers[J]. Lung Cancer, 2008, 59(3): 332-329.
29. 　Ebinger M, Senf L, Wachowski O, et al. Expression of GAS7 in childhood CNS tumors[J]. Pediatr Blood Cancer, 2006, 46(3): 325-328.
30. 　Hung FC, Chao CC. Knockdown of growth-arrest-specific gene 7b (gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: Implications for preventing apoptosis of neurons[J]. J Neurosci Res, 2010, 88(16): 3578-3587.
31. 　Ilsley JL, Sudol M, Winder SJ. The WW domain: linking cell signalling to the membrane cytoskeleton[J]. Cell Signal, 2002, 14(3): 183-189.
32. 　Megonigal MD, Cheung NK, Rappaport EF, et al. Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors[J]. Proc Natl Acad Sci U S A, 2000, 97(6): 2814-2819.
33. 　So CW, Karsunky H, Passegué E, et al. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice[J]. Cancer Cell, 2003, 3(2): 161-171.
34. 　Zhou J, Dudley ME, Rosenberg SA, et al. Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy[J]. J Immunother, 2005, 28(1): 53-62.
35. 　Lu PJ, Wulf G, Zhou XZ, et al. The prolyl isomerase Pin1 restores the function of alzheimer-associated phosphorylated tau protein[J]. Nature, 1999, 399(6738): 784-788.
36. 　Smet C, Sambo AV, Wieruszeski JM, et al. The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau[J]. Biochemistry, 2004, 43(7): 2032-2040.
37. 　Hung FC, Chang Y, Lin-Chao S, et al. Gas7 mediates the differentiation of human bone marrow-derived mesenchymal stem cells into functional osteoblasts by enhancing Runx2-dependent gene expression[J]. J Orthop Res, 2011, 29(10): 1528-1535.
38. 　Chang Y, Ueng SW, Lin-Chao S, et al. Involvement of Gas7 along the ERK1/2 MAP kinase and SOX9 pathway in chondrogenesis of human marrow-derived mesenchymal stem cells[J]. Osteoarthritis Cartilage, 2008, 16(11): 1403-1412.

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生長休止基因7及其產物的生理作用研究進展

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《華西醫學》

生長休止基因7及其產物的生理作用研究進展

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