ω-3脂肪酸在胃腸道腫瘤患者中的臨床作用效果_《華西醫學》

作者：

胡艷杰 ^1,2 ,  李卡 ² , 黃明君 ² , 汪曉東 ²

四川大學（成都，610041）1 華西臨床醫學院，2 華西醫院胃腸外科中心;

關鍵詞：

ω-3脂肪酸胃腸道腫瘤免疫營養制劑

DOI：

10.7507/1002-0179.20130348

視頻：

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近年來，研究證明ω-3脂肪酸具有抑制炎癥反應、調節機體免疫功能、改善胃腸道術后患者肝功能損害及一定的抗腫瘤作用，這與其調節機體免疫因子、調控細胞內信號轉導途徑等有關。現就ω-3脂肪酸的來源、特點及在胃腸道腫瘤術前對患者機體的免疫營養作用、術后對患者肝功能恢復的臨床效果和抗腫瘤等方面的相關作用作一綜述。

引用本文： 胡艷杰,李卡,黃明君,汪曉東. ω-3脂肪酸在胃腸道腫瘤患者中的臨床作用效果. 華西醫學, 2013, 28(7): 1120-1122. doi: 10.7507/1002-0179.20130348 復制

1.	劉鑫, 辛福澤, 張彥波. ω-3魚油脂肪乳對胃腸道腫瘤患者術后免疫功能和炎性反應的影響[J]. 腸內與腸外營養, 2009, 16(5): 280-282.
2.	Pratt VC, Tredget EE, Clandinin MT, et al. Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans[J]. Crit Care Med, 2002, 30(8): 1753-1761.
3.	陳博, 伍曉汀. 腸內免疫營養及其臨床應用[J]. 中國普外基礎與臨床雜志, 2009, 16(12): 978-981.
4.	Calder PC. Immunomodulation by omega-3 fatty acids[J]. Prostag Leukotr Ess, 2007, 77(6): 327-335.
5.	Hofmanová J, Vaculová A, Kozubík A. Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis[J]. Cancer Lett, 2005, 218(1): 33-41.
6.	Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery[J]. Clin Nutr, 2004, 23(3): 325-330.
7.	Nakamura K, Kariyazono H, Komokata T, et al. Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for Cancer[J]. Nutrition, 2005, 21(6): 639-649.
8.	梁尚游, 徐亮, 余利堅, 等. 腸內免疫營養對創傷Wistar大鼠腸屏障功能的影響[J]. 現代醫藥衛生, 2008(20): 3013-3015.
9.	Braga M, Vignali A, Gianotti L, et al. Immune and nutrional effects of enteral nutrition after major abdominal operations[J]. Eur J Surg, 1996, 162(2): 105-112.
10.	Stehr SN, Heller AR. Omega-3 fatty acid effects on biochemical indices following Cancer surgery[J]. Clin Chim Acta, 2006, 373(1-2): 1-8.
11.	Caglayan K, Oner I, Gunerhan Y, et al. The impact of preoperative immunonutrition and other nutrition models on tumor infiltrative lymphocytes in colorectal Cancer patients[J]. Am J Surg, 2012, 204(4): 416-421.
12.	張斌, 姬社青, 陳小兵. ω-3脂肪酸對胃癌新輔助放化療患者術后康復的作用研究[J]. 中國當代醫藥, 2011, 18(25): 13-16.
13.	孟凡杰. ω-3魚油脂肪乳對惡性腫瘤術后的影響[J]. 醫藥論壇雜志, 2009, 30(21): 80-82.
14.	Galbán C, Montejo JC, Mesejo A, et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients[J]. Crit Care Med, 2000, 28(3): 643-648.
15.	Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects[J]. Br J Nutr, 2003, 89(5): 679-689.
16.	張維康, 龍躍平, 陳俊華. ω-3魚油脂肪乳對胃腸道惡性腫瘤患者術后恢復的作用[J]. 臨床外科雜志, 2007, 15(9): 606-608.
17.	Marciniak R, Majewski P, Biczysko M. Effects of gastrectomy or colectomy on liver metabolism and liver morphology in an experimental rat model[J]. Med Sci Monit, 2004, 10(2): 34-40.
18.	Giger U, Büchler M, Farhadi J, et al. Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study[J]. Ann Surg Oncol, 2007, 14(10): 2798-2806.
19.	Rhoden D, Matheson PJ, Carricato ND, et al. Immune-enhancing enteral diet selectively augments ileal blood flow in the rat[J]. J Surg Res, 2002, 106(1): 25-30.
20.	Kirimlioglu V, Kirimlioglu H, Yilmaz S, et al. Effect of fish oil, olive oil, and vitamin E on liver pathology, cell proliferation, and antioxidant defense system in rats subjected to partial hepatectomy[J]. Transplant Proc, 2006, 38(2): 564-567.
21.	Heller AR, Rössel T, Gottschlich B, et al. Omega-3 fatty acids improve liver and pancreas function in postoperative Cancer patients[J]. Int J Cancer, 2004, 111(4): 611-616.
22.	Parker HM, Johnson NA, Burdon CA, et al. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis[J]. J Hepatol, 2012, 56(4): 944-951.
23.	談談, 仇毓東, 王萌, 等. ω-3不飽和脂肪酸對肝部分切除大鼠殘肝的保護作用及機制[J]. 中國普通外科雜志, 2012, 21(1): 35-40.
24.	邱孝全, 沈月平. ω-3脂肪酸的抗癌研究[J]. 疾病控制雜志, 1997, 1(3): 211-213.
25.	Cockbain AJ, Toogood GJ, Hull MA. Omega-3 poly acids for the treatment and prevention of colorectal Cancer[J]. Gut, 2012, 61(1): 135-149.
26.	Fearon K. The anticancer and anticachectic effects of ω?3 fatty acids[J]. Clin Nutr, 2002, 21(sup2): 73-77.
27.	Latham P, Lund EK, Brown JC, et al. Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo[J]. Gut, 2001, 49(1): 97-105.
28.	Li M, Kong ZM, Liu ZL. Antioxidant enzyme activities and lipid peroxidation induced by eicosapentaenoic acid (EPA) in PC12 cells[J]. Cell Biol Toxicol, 2006, 22(5): 331-337.
29.	王向群, 陳麗娟. ω-3多不飽和脂肪酸抗腫瘤機制的研究進展[J]. 實用癌癥雜志, 2011, 26(3): 321-324.
30.	王席娟. ω-3多不飽和脂肪酸的腫瘤治療作用及其機制[J]. 腫瘤防治研究, 2010, 37(8): 967-970.
31.	Palmer AJ, Ho CK, Ajibola O, et al. The role of ω-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis[J]. Crit Care Med, 2013, 41(1): 307-316.

1. 　劉鑫, 辛福澤, 張彥波. ω-3魚油脂肪乳對胃腸道腫瘤患者術后免疫功能和炎性反應的影響[J]. 腸內與腸外營養, 2009, 16(5): 280-282.
2. 　Pratt VC, Tredget EE, Clandinin MT, et al. Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans[J]. Crit Care Med, 2002, 30(8): 1753-1761.
3. 　陳博, 伍曉汀. 腸內免疫營養及其臨床應用[J]. 中國普外基礎與臨床雜志, 2009, 16(12): 978-981.
4. 　Calder PC. Immunomodulation by omega-3 fatty acids[J]. Prostag Leukotr Ess, 2007, 77(6): 327-335.
5. 　Hofmanová J, Vaculová A, Kozubík A. Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis[J]. Cancer Lett, 2005, 218(1): 33-41.
6. 　Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery[J]. Clin Nutr, 2004, 23(3): 325-330.
7. 　Nakamura K, Kariyazono H, Komokata T, et al. Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for Cancer[J]. Nutrition, 2005, 21(6): 639-649.
8. 　梁尚游, 徐亮, 余利堅, 等. 腸內免疫營養對創傷Wistar大鼠腸屏障功能的影響[J]. 現代醫藥衛生, 2008(20): 3013-3015.
9. 　Braga M, Vignali A, Gianotti L, et al. Immune and nutrional effects of enteral nutrition after major abdominal operations[J]. Eur J Surg, 1996, 162(2): 105-112.
10. 　Stehr SN, Heller AR. Omega-3 fatty acid effects on biochemical indices following Cancer surgery[J]. Clin Chim Acta, 2006, 373(1-2): 1-8.
11. 　Caglayan K, Oner I, Gunerhan Y, et al. The impact of preoperative immunonutrition and other nutrition models on tumor infiltrative lymphocytes in colorectal Cancer patients[J]. Am J Surg, 2012, 204(4): 416-421.
12. 　張斌, 姬社青, 陳小兵. ω-3脂肪酸對胃癌新輔助放化療患者術后康復的作用研究[J]. 中國當代醫藥, 2011, 18(25): 13-16.
13. 　孟凡杰. ω-3魚油脂肪乳對惡性腫瘤術后的影響[J]. 醫藥論壇雜志, 2009, 30(21): 80-82.
14. 　Galbán C, Montejo JC, Mesejo A, et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients[J]. Crit Care Med, 2000, 28(3): 643-648.
15. 　Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects[J]. Br J Nutr, 2003, 89(5): 679-689.
16. 　張維康, 龍躍平, 陳俊華. ω-3魚油脂肪乳對胃腸道惡性腫瘤患者術后恢復的作用[J]. 臨床外科雜志, 2007, 15(9): 606-608.
17. 　Marciniak R, Majewski P, Biczysko M. Effects of gastrectomy or colectomy on liver metabolism and liver morphology in an experimental rat model[J]. Med Sci Monit, 2004, 10(2): 34-40.
18. 　Giger U, Büchler M, Farhadi J, et al. Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study[J]. Ann Surg Oncol, 2007, 14(10): 2798-2806.
19. 　Rhoden D, Matheson PJ, Carricato ND, et al. Immune-enhancing enteral diet selectively augments ileal blood flow in the rat[J]. J Surg Res, 2002, 106(1): 25-30.
20. 　Kirimlioglu V, Kirimlioglu H, Yilmaz S, et al. Effect of fish oil, olive oil, and vitamin E on liver pathology, cell proliferation, and antioxidant defense system in rats subjected to partial hepatectomy[J]. Transplant Proc, 2006, 38(2): 564-567.
21. 　Heller AR, Rössel T, Gottschlich B, et al. Omega-3 fatty acids improve liver and pancreas function in postoperative Cancer patients[J]. Int J Cancer, 2004, 111(4): 611-616.
22. 　Parker HM, Johnson NA, Burdon CA, et al. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis[J]. J Hepatol, 2012, 56(4): 944-951.
23. 　談談, 仇毓東, 王萌, 等. ω-3不飽和脂肪酸對肝部分切除大鼠殘肝的保護作用及機制[J]. 中國普通外科雜志, 2012, 21(1): 35-40.
24. 　邱孝全, 沈月平. ω-3脂肪酸的抗癌研究[J]. 疾病控制雜志, 1997, 1(3): 211-213.
25. 　Cockbain AJ, Toogood GJ, Hull MA. Omega-3 poly acids for the treatment and prevention of colorectal Cancer[J]. Gut, 2012, 61(1): 135-149.
26. 　Fearon K. The anticancer and anticachectic effects of ω?3 fatty acids[J]. Clin Nutr, 2002, 21(sup2): 73-77.
27. 　Latham P, Lund EK, Brown JC, et al. Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo[J]. Gut, 2001, 49(1): 97-105.
28. 　Li M, Kong ZM, Liu ZL. Antioxidant enzyme activities and lipid peroxidation induced by eicosapentaenoic acid (EPA) in PC12 cells[J]. Cell Biol Toxicol, 2006, 22(5): 331-337.
29. 　王向群, 陳麗娟. ω-3多不飽和脂肪酸抗腫瘤機制的研究進展[J]. 實用癌癥雜志, 2011, 26(3): 321-324.
30. 　王席娟. ω-3多不飽和脂肪酸的腫瘤治療作用及其機制[J]. 腫瘤防治研究, 2010, 37(8): 967-970.
31. 　Palmer AJ, Ho CK, Ajibola O, et al. The role of ω-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis[J]. Crit Care Med, 2013, 41(1): 307-316.

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ω-3脂肪酸在胃腸道腫瘤患者中的臨床作用效果

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《華西醫學》

ω-3脂肪酸在胃腸道腫瘤患者中的臨床作用效果

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