分化抑制因子-1在肝細胞肝癌中的表達及與預后相關性的初步研究_《華西醫學》

作者：

鄧宏宇 , 朱杰 ,  楊麗

四川大學華西醫院金卡病房（成都，610041）;

關鍵詞：

分化抑制因子1 肝癌預后

DOI：

10.7507/1002-0179.20130273

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目的　檢測分化抑制因子1（Id-1）在肝細胞肝癌組織中和正常肝組織中的表達情況，了解Id-1與肝細胞肝癌患者預后關系。方法　對獲得的19例肝細胞肝癌組織標本和8例正常肝組織進行免疫組織化學染色，并對染色結果進行分級。借助SPSS軟件，分析肝細胞肝癌組織標本與正常肝組織標本中的Id-1表達強度區別，Id-1與甲胎蛋白（AFP）相關性，及Id-1表達強度與肝癌患者預后之間的關系。結果　免疫組織化學染色結果顯示所有標本均表達為陽性，其中3例（+），7例（++），10例（+++）7例（++++），肝細胞肝癌組織標本與正常肝組織標本差異有統計學意義（P＜0.05）；Id-1表達與血液中AFP水平相關不顯著（r=?0.121，P=0.621）；Spearman等級相關分析顯示患者生存時間與Id-1表達呈負相關（r=?0.567，P=0.011）。結論　Id-1在肝癌組織中表達增高，Id-1表達水平與生存時間呈負相關，但和AFP無明顯相關。

引用本文： 鄧宏宇,朱杰,楊麗. 分化抑制因子-1在肝細胞肝癌中的表達及與預后相關性的初步研究. 華西醫學, 2013, 28(6): 871-874. doi: 10.7507/1002-0179.20130273 復制

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7.	Le Jossic C, Ilyin GP, Loyer P, et al. Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture[J]. Cancer Res, 1994, 54(23): 6065-6068.
8.	Ohtani N, Zebedee Z, Huot TJ, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence[J]. Nature, 2001, 409(6823): 1067-1070.
9.	Lee TK, Man K, Ling MT, et al. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway[J]. Carcinogenesis, 2003, 24(11): 1729-1736.
10.	Alani RM, Young AZ, Shifflett CB. Id-1 regulation of cellular senescence through transcriptional repression of p16/Ink4a[J]. Proc Natl Acad Sci U S A, 2001, 98(14): 7812-7816.
11.	李曉軍, 秦浚川. 分化抑制因子的研究進展[J]. 生物化學與生物物理學進展, 2004, 31(10): 865-869.
12.	Ao J, Meng J, Zhu L, et al. Activation of androgen receptor induces Id-1 and promotes hepatocellular carcinoma cell migration and invasion[J]. Mol Oncol, 2012, 6(5): 507-515.
13.	Fong S, Debs RJ, Desprez PY. Id genes and proteins as promising targets in Cancer therapy[J]. Trends Mol Med, 2004, 10(8): 387-392.
14.	宋光, 劉晶, 張男. 甲胎蛋白(AFP)與原發性肝癌早期診斷的關系[J]. 人人健康·醫學導刊, 2008(5): 54-56.
15.	Forootan SS, Wong YC, Dodson A, et al. Increased Id-1 expression is significantly associated with poor survival of patients with prostate Cancer[J]. Hum Pathol, 2007, 38(9): 1321-1329.
16.	Perk J, Iavarone A, Benezra R, et al. Id family of helix-loop-helix proteins in Cancer[J]. Nat Rev Cancer, 2005, 5(8): 603-614.

1. 　Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012[J]. CA Cancer J Clin, 2012, 62(1): 10-29.
2. 　Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000. The global picture[J]. Eur J Cancer, 2001, 37(Supp18): 4-66.
3. 　Block TM, Mehta AS, Fimmel CJ, et al. Molecular viral oncology of hepatocellular carcinoma[J]. Oncogene, 2003, 22(33): 5093-5107.
4. 　Ruzinova MB, Benezra R. Id proteins in development, cell cycleand Cancer[J]. Trends Cell Biol, 2003, 13(8): 410-418.
5. 　Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis[J]. J Cell Sci, 2000, 113(22): 3897-3905.
6. 　Ding R, Han S, Lu Y, et al. Overexpressed Id-1 is associated with patient prognosis and HBx expression in hepatitis B virus-related hepatocellular carcinoma[J]. Cancer Biol Ther, 2010, 10(3): 299-307.
7. 　Le Jossic C, Ilyin GP, Loyer P, et al. Expression of helix-loop-helix factor Id-1 is dependent on the hepatocyte proliferation and differentiation status in rat liver and in primary culture[J]. Cancer Res, 1994, 54(23): 6065-6068.
8. 　Ohtani N, Zebedee Z, Huot TJ, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence[J]. Nature, 2001, 409(6823): 1067-1070.
9. 　Lee TK, Man K, Ling MT, et al. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway[J]. Carcinogenesis, 2003, 24(11): 1729-1736.
10. 　Alani RM, Young AZ, Shifflett CB. Id-1 regulation of cellular senescence through transcriptional repression of p16/Ink4a[J]. Proc Natl Acad Sci U S A, 2001, 98(14): 7812-7816.
11. 　李曉軍, 秦浚川. 分化抑制因子的研究進展[J]. 生物化學與生物物理學進展, 2004, 31(10): 865-869.
12. 　Ao J, Meng J, Zhu L, et al. Activation of androgen receptor induces Id-1 and promotes hepatocellular carcinoma cell migration and invasion[J]. Mol Oncol, 2012, 6(5): 507-515.
13. 　Fong S, Debs RJ, Desprez PY. Id genes and proteins as promising targets in Cancer therapy[J]. Trends Mol Med, 2004, 10(8): 387-392.
14. 　宋光, 劉晶, 張男. 甲胎蛋白(AFP)與原發性肝癌早期診斷的關系[J]. 人人健康·醫學導刊, 2008(5): 54-56.
15. 　Forootan SS, Wong YC, Dodson A, et al. Increased Id-1 expression is significantly associated with poor survival of patients with prostate Cancer[J]. Hum Pathol, 2007, 38(9): 1321-1329.
16. 　Perk J, Iavarone A, Benezra R, et al. Id family of helix-loop-helix proteins in Cancer[J]. Nat Rev Cancer, 2005, 5(8): 603-614.

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分化抑制因子-1在肝細胞肝癌中的表達及與預后相關性的初步研究

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分化抑制因子-1在肝細胞肝癌中的表達及與預后相關性的初步研究

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