阻塞性睡眠呼吸暫停低通氣綜合征與2型糖尿病的關系_《華西醫學》

作者：

1川北醫學院精神科（四川南充，637000）;2 綿陽市第三人民醫院精神科;

關鍵詞：

2型糖尿病阻塞性睡眠呼吸暫停低通氣綜合征

DOI：

10.7507/1002-0179.20130245

視頻：

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近年來越來越多的研究顯示睡眠參與了包括血糖調節在內的多種生理功能調節。作為常見睡眠疾患之一，阻塞性睡眠呼吸暫停低通氣綜合征不僅在2型糖尿病患者中有著較高的發病率，而且還可能直接促使了體內糖代謝異常的發生，有證據表明通過有效治療阻塞性睡眠呼吸暫停低通氣綜合征可以明顯改善患者血糖調節水平。

引用本文： 任蓉,黃國平. 阻塞性睡眠呼吸暫停低通氣綜合征與2型糖尿病的關系. 華西醫學, 2013, 28(5): 792-794. doi: 10.7507/1002-0179.20130245 復制

1.	Sicree RJ, Shaw J, Zimmet P. The global burden, diabetes and impaired glucose tolerance[M]. In: IDF diabetes atlas4th ed. Brussels: International Diabetes Federation, 2009: 1-105.
2.	Punjabi NM. The epidemiology of adult obstructive sleep apnea[J]. Proc Am Thorac Soc, 2008, 5(2): 136-143.
3.	Einhorn D, Stewart DA, Erman MK, et al. Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus[J]. Endocr Pract, 2007, 13(4): 355-362.
4.	Schober AK, Neurath MF, Harsch IA. Prevalence of sleep apnoea in diabetic patients[J]. Clin Respir J, 2011, 5(3): 165-172.
5.	Foster GD, Sanders MH, Millman R, et al. Obstructive sleep apnea among obese patients with type 2 diabetes[J]. Diabetes Care, 2009, 32(6): 1017-1019.
6.	Punjabi NM, Sorkin JD, Katzel LI, et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men[J]. Am J Respir Crit Care Med, 2002, 165(5): 677-682.
7.	Ip MS, Lam B, Ng MM, et al. Obstructive sleep apnea is independently associated with insulin resistance[J]. Am J Respir Crit Care Med, 2002, 165(5): 670-676.
8.	Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes[J]. Am J Med, 2009, 122(12): 1122-1127.
9.	Marshall NS, Wong KK, Phillips CL, et al. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the busselton health study?[J]. J Clin Sleep Med, 2009, 5(1): 15-20.
10.	Ronksley PE, Hemmelgarn BR, Heitman SJ, et al. Obstructive sleep apnoea is associated with diabetes in sleepy subjects[J]. Thorax, 2009, 64(10): 834-839.
11.	Aronsohn RS, Whitmore H, van Cauter E, et al. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes[J]. Am J Respir Crit Care Med, 2010, 181(5): 507-513.
12.	Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers[J]. J Appl Physiol, 2009, 106(5): 1538-1544.
13.	Iiyori N, Alonso LC, Li J, et al. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity[J]. Am J Respir Crit Care Med, 2007, 175(8): 851-857.
14.	Stamatakis KA, Punjabi NM. Effects of experimental sleep fragmentation on glucose metabolism in normal subjects[J]. Chest, 2010, 137(1): 95-101.
15.	Punjabi NM, Beamer BA. Alterations in glucose disposal in sleep-disordered breathing[J]. Am J Respir Crit Care Med .2009, 179(3): 235-240.
16.	Punjabi NM, Workshop Participants. Do sleep disorders and associated treatments impact glucose metabolism?[J]. Drugs, 2009, 69(suppl 2): 13-27.
17.	Lam JC, Lam B, Yao TJ, et al. A randomized controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnea[J]. Eur Respir J, 2010, 35(1): 138-145.
18.	Patruno V, Aiolfi S, Costantino G, et al. Fixed and autoadjusting continuous positive airway pressure treatments are not similar in educing cardiovascular risk factors in patients with obstructive sleep apnea[J]. Chest, 2007, 131(5): 1393-1399.
19.	魏翠英, 王慧玲 , 李靜, 等. CPAP治療對OSA HS合并糖尿病患者2 4小時動態血糖影響的初步研究[G]. 2008年中國睡眠研究會第五屆學術年會論文摘要匯編. 北京: 中國睡眠研究會, 2008.
20.	Coughlin SR, Mawdsley L, Mugarza JA, et al. Cardiovascularand metabolic effects of CPAP in obese males with OSA[J]. Eur Respir J, 2007, 29(4): 720-727.
21.	West SD, Nicoll DJ, Wallace TM, et al. Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes[J]. Thorax, 2007, 62(11): 969-974.
22.	Yang D, Liu Z, Yang H, et al. Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis[J]. Sleep Breath, 2013, 17(1): 33-38.
23.	Hecht L, Möhler R, Meyer G. Effects of CPAP-respiration on markers of glucose metabolism in patients with obstructive sleep apnoea syndrome: a systematic review and meta-analysis[J]. Ger Med Sci, 2011, 9: 20.
24.	Kosseifi S, Bailey B, Price R, et al. The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients[J]. Mil Med, 2010, 175(11): 913-916.

1. 　Sicree RJ, Shaw J, Zimmet P. The global burden, diabetes and impaired glucose tolerance[M]. In: IDF diabetes atlas4th ed. Brussels: International Diabetes Federation, 2009: 1-105.
2. 　Punjabi NM. The epidemiology of adult obstructive sleep apnea[J]. Proc Am Thorac Soc, 2008, 5(2): 136-143.
3. 　Einhorn D, Stewart DA, Erman MK, et al. Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus[J]. Endocr Pract, 2007, 13(4): 355-362.
4. 　Schober AK, Neurath MF, Harsch IA. Prevalence of sleep apnoea in diabetic patients[J]. Clin Respir J, 2011, 5(3): 165-172.
5. 　Foster GD, Sanders MH, Millman R, et al. Obstructive sleep apnea among obese patients with type 2 diabetes[J]. Diabetes Care, 2009, 32(6): 1017-1019.
6. 　Punjabi NM, Sorkin JD, Katzel LI, et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men[J]. Am J Respir Crit Care Med, 2002, 165(5): 677-682.
7. 　Ip MS, Lam B, Ng MM, et al. Obstructive sleep apnea is independently associated with insulin resistance[J]. Am J Respir Crit Care Med, 2002, 165(5): 670-676.
8. 　Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes[J]. Am J Med, 2009, 122(12): 1122-1127.
9. 　Marshall NS, Wong KK, Phillips CL, et al. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the busselton health study?[J]. J Clin Sleep Med, 2009, 5(1): 15-20.
10. 　Ronksley PE, Hemmelgarn BR, Heitman SJ, et al. Obstructive sleep apnoea is associated with diabetes in sleepy subjects[J]. Thorax, 2009, 64(10): 834-839.
11. 　Aronsohn RS, Whitmore H, van Cauter E, et al. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes[J]. Am J Respir Crit Care Med, 2010, 181(5): 507-513.
12. 　Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers[J]. J Appl Physiol, 2009, 106(5): 1538-1544.
13. 　Iiyori N, Alonso LC, Li J, et al. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity[J]. Am J Respir Crit Care Med, 2007, 175(8): 851-857.
14. 　Stamatakis KA, Punjabi NM. Effects of experimental sleep fragmentation on glucose metabolism in normal subjects[J]. Chest, 2010, 137(1): 95-101.
15. 　Punjabi NM, Beamer BA. Alterations in glucose disposal in sleep-disordered breathing[J]. Am J Respir Crit Care Med .2009, 179(3): 235-240.
16. 　Punjabi NM, Workshop Participants. Do sleep disorders and associated treatments impact glucose metabolism?[J]. Drugs, 2009, 69(suppl 2): 13-27.
17. 　Lam JC, Lam B, Yao TJ, et al. A randomized controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnea[J]. Eur Respir J, 2010, 35(1): 138-145.
18. 　Patruno V, Aiolfi S, Costantino G, et al. Fixed and autoadjusting continuous positive airway pressure treatments are not similar in educing cardiovascular risk factors in patients with obstructive sleep apnea[J]. Chest, 2007, 131(5): 1393-1399.
19. 　魏翠英, 王慧玲 , 李靜, 等. CPAP治療對OSA HS合并糖尿病患者2 4小時動態血糖影響的初步研究[G]. 2008年中國睡眠研究會第五屆學術年會論文摘要匯編. 北京: 中國睡眠研究會, 2008.
20. 　Coughlin SR, Mawdsley L, Mugarza JA, et al. Cardiovascularand metabolic effects of CPAP in obese males with OSA[J]. Eur Respir J, 2007, 29(4): 720-727.
21. 　West SD, Nicoll DJ, Wallace TM, et al. Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes[J]. Thorax, 2007, 62(11): 969-974.
22. 　Yang D, Liu Z, Yang H, et al. Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis[J]. Sleep Breath, 2013, 17(1): 33-38.
23. 　Hecht L, Möhler R, Meyer G. Effects of CPAP-respiration on markers of glucose metabolism in patients with obstructive sleep apnoea syndrome: a systematic review and meta-analysis[J]. Ger Med Sci, 2011, 9: 20.
24. 　Kosseifi S, Bailey B, Price R, et al. The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients[J]. Mil Med, 2010, 175(11): 913-916.

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阻塞性睡眠呼吸暫停低通氣綜合征與2型糖尿病的關系

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《華西醫學》

阻塞性睡眠呼吸暫停低通氣綜合征與2型糖尿病的關系

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