小細胞性骨肉瘤的診斷與治療_《華西醫學》

作者：

四川大學華西醫院腫瘤中心胸部腫瘤科（成都，610041）;

關鍵詞：

小細胞性骨肉瘤診斷治療

DOI：

10.7507/1002-0179.20130223

視頻：

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目的　總結小細胞性骨肉瘤的臨床特征及診治情況。方法　回顧性分析1995年12月－2012年6月收治的12例小細胞性骨肉瘤患者的臨床資料。結合文獻分析該病的診治特點。結果　全組患者手術11例，化學治療（化療）8例，術后輔助放射治療（放療）2例。隨訪截止時，全組患者總生存4～55個月。文獻回顧方面，通過檢索策略獲得探討相關治療方案的文獻8篇，涉及小細胞性骨肉瘤患者79例。治療方式以手術+輔助化療為主。結論　小細胞性骨肉瘤發病率低，預后較普通骨肉瘤更差。手術為主要治療方式，新輔助化療及輔助化療可能使患者進一步受益，放療的治療效果目前還不明確。

引用本文： 萬曉莉,周麟. 小細胞性骨肉瘤的診斷與治療. 華西醫學, 2013, 28(5): 715-718. doi: 10.7507/1002-0179.20130223 復制

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8.	Sipos EP, Tamargo RJ, Epstein JI, et al. Primary intracerebral small-cell osteosarcoma in an adolescent girl: Report of a case [J]. J Neurooncol, 1997, 32(2): 169-174.
9.	Park SH, Kim I. Small cell osteogenic sarcoma of the ribs: Cytological, immunohistochemical, and ultrastructural study with literature review [J]. Ultrastruct Pathol, 1999, 23(2): 133-140.
10.	Hameed M. Small round cell tumors of bone [J]. Arch Pathol Lab Med, 2007, 131(2): 192-204.
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12.	Machado I, Alberghini M, Giner F, et al. Histopathological characterization of small cell osteosarcoma with immuno-histochemistry and molecular genetic support. A study of 10 cases [J]. Histopathology, 2010, 57(1): 162-167.
13.	Bertoni F, Present D, Bacchini P, et al. The istituto rizzoli experience with small cell osteosarcoma [J]. Cancer, 1989, 64(12): 2591-2599.
14.	Devaney K, Vinh TN, Sweet DE. Small cell osteosarcoma of bone: An immunohistochemical study with differential diagnostic considerations [J]. Hum Pathol, 1993, 24(11): 1211-1225.
15.	徐萬鵬，李佛保. 骨與軟組織腫瘤學 [M] .北京：人民衛生出版社，2008: 451-452.
16.	吳文娟，張英澤. 骨與軟組織腫瘤 [M] .北京：人民衛生出版社，2009: 203.
17.	Noguera R, Navarro S, Triche TJ. Translocation (11;22) in small cell osteosarcoma [J]. Cancer Genet Cytogenet, 1990, 45(1): 121-124.
18.	Lee AF, Hayes MM, Lebrun D, et al. Fli-1 distinguishes ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma [J]. Appl Immunohistochem Mol Morphol, 2011, 19(3): 233-238.
19.	Stea B, Cavazzana A, Kinsella TJ. Small-cell osteosarcoma: Correlation of in vitro and clinical radiation response [J]. Int J Radiat Oncol Biol Phys, 1988, 15(5): 1233-1238.
20.	Todesco A, Carli M, Iacona I, et al. All-trans retinoic acid and interferon-alpha in the treatment of a patient with resistant metastatic osteosarcoma [J]. Cancer, 2000, 89(12): 2661-2666.
21.	Nakamura T, Ishimaru J, Mizui T, et al. Osteosarcoma metastatic to the mandible: A case report [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(4): 452-454.
22.	Kallel R, Ayadi L, Toumi N, et al. Small cell osteosarcoma: A case report [J]. Pathologica, 2009, 101(2): 101-104.
23.	Futani H, Fukunaga S, Tsukamoto Y, et al. Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin [J]. Anticancer Res, 2012, 32(3): 965-971.

1. 　McPherson F, Chamyan G, Gilbert-Barness E. Pathology quiz: Small cell osteosarcoma [J]. Pediatr Pathol Mol Med, 2001, 20(4): 345-348.
2. 　Kyriakos M, Gilula LA, Becich MJ, et al. Intracortical small cell osteosarcoma [J]. Clin Orthop Relat Res, 1992, (279): 269-280.
3. 　Sim FH, Unni KK, Beabout JW, et al. Osteosarcoma with small cells simulating ewing’s tumor [J]. J Bone Joint Surg Am, 1979, 61(2): 207-215.
4. 　Boldrini R, Devito R, Bosman C. Small-cell osteosarcoma[J]. Pathologica, 2000, 92: 133-134.
5. 　Tsuchiya H, Yasutake H, Yokogawa A, et al. Effect of chemotherapy combined with caffeine for osteosarcoma [J]. J Cancer Res Clin Oncol, 1992, 118(8): 567-569.
6. 　Nakajima H, Sim FH, Bond JR, et al. Small cell osteosarcoma of bone. Review of 72 cases [J]. Cancer, 1997, 79(11): 2095-2106.
7. 　Li SMD, Siegal GPMDP. Small cell tumors of bone. [review] [M]. Advances in Anatomic Pathology January, 2010, 17(1): 1-11.
8. 　Sipos EP, Tamargo RJ, Epstein JI, et al. Primary intracerebral small-cell osteosarcoma in an adolescent girl: Report of a case [J]. J Neurooncol, 1997, 32(2): 169-174.
9. 　Park SH, Kim I. Small cell osteogenic sarcoma of the ribs: Cytological, immunohistochemical, and ultrastructural study with literature review [J]. Ultrastruct Pathol, 1999, 23(2): 133-140.
10. 　Hameed M. Small round cell tumors of bone [J]. Arch Pathol Lab Med, 2007, 131(2): 192-204.
11. 　Ayala AG, Ro JY, Raymond AK, et al. Small cell osteosarcoma. A clinicopathologic study of 27 cases [J]. Cancer, 1989, 64(10): 2162-2173.
12. 　Machado I, Alberghini M, Giner F, et al. Histopathological characterization of small cell osteosarcoma with immuno-histochemistry and molecular genetic support. A study of 10 cases [J]. Histopathology, 2010, 57(1): 162-167.
13. 　Bertoni F, Present D, Bacchini P, et al. The istituto rizzoli experience with small cell osteosarcoma [J]. Cancer, 1989, 64(12): 2591-2599.
14. 　Devaney K, Vinh TN, Sweet DE. Small cell osteosarcoma of bone: An immunohistochemical study with differential diagnostic considerations [J]. Hum Pathol, 1993, 24(11): 1211-1225.
15. 　徐萬鵬，李佛保. 骨與軟組織腫瘤學 [M] .北京：人民衛生出版社，2008: 451-452.
16. 　吳文娟，張英澤. 骨與軟組織腫瘤 [M] .北京：人民衛生出版社，2009: 203.
17. 　Noguera R, Navarro S, Triche TJ. Translocation (11;22) in small cell osteosarcoma [J]. Cancer Genet Cytogenet, 1990, 45(1): 121-124.
18. 　Lee AF, Hayes MM, Lebrun D, et al. Fli-1 distinguishes ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma [J]. Appl Immunohistochem Mol Morphol, 2011, 19(3): 233-238.
19. 　Stea B, Cavazzana A, Kinsella TJ. Small-cell osteosarcoma: Correlation of in vitro and clinical radiation response [J]. Int J Radiat Oncol Biol Phys, 1988, 15(5): 1233-1238.
20. 　Todesco A, Carli M, Iacona I, et al. All-trans retinoic acid and interferon-alpha in the treatment of a patient with resistant metastatic osteosarcoma [J]. Cancer, 2000, 89(12): 2661-2666.
21. 　Nakamura T, Ishimaru J, Mizui T, et al. Osteosarcoma metastatic to the mandible: A case report [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(4): 452-454.
22. 　Kallel R, Ayadi L, Toumi N, et al. Small cell osteosarcoma: A case report [J]. Pathologica, 2009, 101(2): 101-104.
23. 　Futani H, Fukunaga S, Tsukamoto Y, et al. Small cell osteosarcoma successfully treated by high-dose ifosfamide and methotrexate, combined with carboplatin and pirarubicin [J]. Anticancer Res, 2012, 32(3): 965-971.

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《華西醫學》

小細胞性骨肉瘤的診斷與治療

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《華西醫學》

小細胞性骨肉瘤的診斷與治療

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