先天性囊性腺瘤樣畸形_《華西醫學》

作者：

王妍亭 ,  楊小東 , 黃燕花 , 劉正滿

四川大學華西醫院呼吸內科（成都，610041）;

關鍵詞：

先天性囊性腺瘤樣畸形錯構瘤手術治療

DOI：

10.7507/1002-0179.20130157

視頻：

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目的　全面介紹先天性囊性腺瘤樣畸形(CCAM)其可能的病因，臨床、病理特點及診斷手段，循證探討針對CCAM的治療方法及預后。方法　對我院2011年11月收治的1例罕見的CCAM患者的臨床資料進行分析，并對相關文獻進行復習。結果　患者數次誤診后最終診斷為CCAM，予手術治療后痊愈，隨訪1年無復發。結論　 CCAM是一種少見的、非遺傳性的、錯構瘤樣的肺發育異常，為一種良性的肺部畸形，其特點是局部肺終末呼吸性細支氣管過度生長。CCAM多通過產前影像學檢查、活組織檢查或術后病檢診斷。手術為治愈該病的最根本、最重要措施。

引用本文： 王妍亭,楊小東,黃燕花,劉正滿. 先天性囊性腺瘤樣畸形. 華西醫學, 2013, 28(4): 489-493. doi: 10.7507/1002-0179.20130157 復制

1.	Ch’In K, Tang M. Congenital adenomatoid malformation of one lobe of a lung with general anasarca[J]. Arch Pathol (Chic), 1949, 48(3): 221-229.
2.	Laberge J, Flageole H, Pugash D, et al. Outcome of the prenatally diagnosed congenital cystic adenomatoid lung malformation: a Canadian experience[J]. Fetal Diagn Ther, 2001, 16(3): 178-186.
3.	Khan N, Jones M, Greaves M. Congenital cystic adenomatoid malformation of an entire lung in a 33-year-old man: a case report and review of the literature[J]. Br J Radiol, 2008, 81(971): 276-278.
4.	Cass DL, Quinn TM, Yang EY, et al. Increased cell proliferation and decreased apoptosis characterize congenital cystic adenomatoid malformation of the lung[J]. J Pediatr Surg, 1998, 33(7): 1043-1047.
5.	Berrocal T, Madrid C, Novo S, et al. Congenital Anomalies of the Tracheobronchial Tree, Lung, and Mediastinum: Embryology, Radiology, and Pathology1[J]. Radiographics, 2004, 24(1): 17-17.
6.	劉鍵平, 常曉燕, 陳杰, 等. 肺先天性囊性腺瘤樣畸形 4 例臨床病理分析[J]. 診斷病理學雜志, 2006, 13(4): 247-249.
7.	Stocker JT, Madewell JE, Drake RM. Congenital cystic adenomatoid malformation of the lung: classification and morphologic spectrum[J]. Hum Pathol, 1977, 8(2): 155-171.
8.	Lakhoo K. Management of congenital cystic adenomatous malformations of the lung[J]. Arch Dis Child Fetal Neonatal Ed, 2009, 94(1): 73-76.
9.	Patz Jr EF, Müller NL, Swensen SJ, et al. Congenital cystic adenomatoid malformation in adults: CT findings[J]. J Comput Assist Tomogr, 1995, 19(3): 361-364.
10.	Stanton M, Njere I, Ade-Ajayi N, et al. Systematic review and meta-analysis of the postnatal management of congenital cystic lung lesions[J]. J Pediatr Surg, 2009, 44(5): 1027-1033.
11.	Nasr A, Bass J. Thoracoscopic vs open resection of congenital lung lesions: a meta-analysis[J]. J Pediatr Surg, 2012, 47(5): 857-861.
12.	Colon N, Schlegel C, Pietsch J, et al. Congenital lung anomalies: can we postpone resection[J]. J Pediatr Surg, 2012, 47(1): 87-92.
13.	Nagata K, Masumoto K, Tesiba R, et al. Outcome and treatment in an antenatally diagnosed congenital cystic adenomatoid malformation of the lung[J]. Pediatr Surg Int, 2009, 25(9): 753-757.
14.	Conforti A, Aloi I, Trucchi A, et al. Asymptomatic congenital cystic adenomatoid malformation of the lung: Is it time to operate[J]. J Thorac Cardiovasc Surg, 2009, 138(4): 826-830.
15.	Sueyoshi R, Okazaki T, Urushihara N, et al. Managing prenatally diagnosed asymptomatic congenital cystic adenomatoid malformation[J]. Pediatr Surg Int, 2008, 24(10): 1111-1115.
16.	Wong A, Vieten D, Singh S, et al. Long-term outcome of asymptomatic patients with congenital cystic adenomatoid malformation[J]. Pediatr Surg Int, 2006, 25(6): 479-485.
17.	Kim YT, Kim JS, Park JD, et al. Treatment of congenital cystic adenomatoid malformation-does resection in the early postnatal period increase surgical risk?[J]. Eur Cardiothorac Surg, 2005, 27(4): 658-661.
18.	Khosa JK, Leong SL, Borzi PA. Congenital cystic adenomatoid malformation of the lung: indications and timing of surgery[J]. Pediatr Surg Int, 2004, 20(7): 505-508.
19.	Aziz D, Langer JC, Tuuha SE, et al. Perinatally diagnosed asymptomatic congenital cystic adenomatoid malformation: to resect or not?[J]. J Pediatr Surg, 2004, 39(3): 329-333.

1. 　Ch’In K, Tang M. Congenital adenomatoid malformation of one lobe of a lung with general anasarca[J]. Arch Pathol (Chic), 1949, 48(3): 221-229.
2. 　Laberge J, Flageole H, Pugash D, et al. Outcome of the prenatally diagnosed congenital cystic adenomatoid lung malformation: a Canadian experience[J]. Fetal Diagn Ther, 2001, 16(3): 178-186.
3. 　Khan N, Jones M, Greaves M. Congenital cystic adenomatoid malformation of an entire lung in a 33-year-old man: a case report and review of the literature[J]. Br J Radiol, 2008, 81(971): 276-278.
4. 　Cass DL, Quinn TM, Yang EY, et al. Increased cell proliferation and decreased apoptosis characterize congenital cystic adenomatoid malformation of the lung[J]. J Pediatr Surg, 1998, 33(7): 1043-1047.
5. 　Berrocal T, Madrid C, Novo S, et al. Congenital Anomalies of the Tracheobronchial Tree, Lung, and Mediastinum: Embryology, Radiology, and Pathology1[J]. Radiographics, 2004, 24(1): 17-17.
6. 　劉鍵平, 常曉燕, 陳杰, 等. 肺先天性囊性腺瘤樣畸形 4 例臨床病理分析[J]. 診斷病理學雜志, 2006, 13(4): 247-249.
7. 　Stocker JT, Madewell JE, Drake RM. Congenital cystic adenomatoid malformation of the lung: classification and morphologic spectrum[J]. Hum Pathol, 1977, 8(2): 155-171.
8. 　Lakhoo K. Management of congenital cystic adenomatous malformations of the lung[J]. Arch Dis Child Fetal Neonatal Ed, 2009, 94(1): 73-76.
9. 　Patz Jr EF, Müller NL, Swensen SJ, et al. Congenital cystic adenomatoid malformation in adults: CT findings[J]. J Comput Assist Tomogr, 1995, 19(3): 361-364.
10. 　Stanton M, Njere I, Ade-Ajayi N, et al. Systematic review and meta-analysis of the postnatal management of congenital cystic lung lesions[J]. J Pediatr Surg, 2009, 44(5): 1027-1033.
11. 　Nasr A, Bass J. Thoracoscopic vs open resection of congenital lung lesions: a meta-analysis[J]. J Pediatr Surg, 2012, 47(5): 857-861.
12. 　Colon N, Schlegel C, Pietsch J, et al. Congenital lung anomalies: can we postpone resection[J]. J Pediatr Surg, 2012, 47(1): 87-92.
13. 　Nagata K, Masumoto K, Tesiba R, et al. Outcome and treatment in an antenatally diagnosed congenital cystic adenomatoid malformation of the lung[J]. Pediatr Surg Int, 2009, 25(9): 753-757.
14. 　Conforti A, Aloi I, Trucchi A, et al. Asymptomatic congenital cystic adenomatoid malformation of the lung: Is it time to operate[J]. J Thorac Cardiovasc Surg, 2009, 138(4): 826-830.
15. 　Sueyoshi R, Okazaki T, Urushihara N, et al. Managing prenatally diagnosed asymptomatic congenital cystic adenomatoid malformation[J]. Pediatr Surg Int, 2008, 24(10): 1111-1115.
16. 　Wong A, Vieten D, Singh S, et al. Long-term outcome of asymptomatic patients with congenital cystic adenomatoid malformation[J]. Pediatr Surg Int, 2006, 25(6): 479-485.
17. 　Kim YT, Kim JS, Park JD, et al. Treatment of congenital cystic adenomatoid malformation-does resection in the early postnatal period increase surgical risk?[J]. Eur Cardiothorac Surg, 2005, 27(4): 658-661.
18. 　Khosa JK, Leong SL, Borzi PA. Congenital cystic adenomatoid malformation of the lung: indications and timing of surgery[J]. Pediatr Surg Int, 2004, 20(7): 505-508.
19. 　Aziz D, Langer JC, Tuuha SE, et al. Perinatally diagnosed asymptomatic congenital cystic adenomatoid malformation: to resect or not?[J]. J Pediatr Surg, 2004, 39(3): 329-333.

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