血清尿酸水平與代謝綜合征間關系的性別差異_《華西醫學》

作者：

陳靜靜 , 何紅燕 , 萬里艷 , 李龍心 , 趙麗明 ,  陳曉平

四川大學華西臨床醫學院心內科（成都，610041）;

關鍵詞：

尿酸代謝綜合征性別差異

DOI：

10.7507/1002-0179.20130057

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目的　探討中老年人群血清尿酸水平與代謝綜合征（MS）及其各組分的關系。方法　采用橫斷面研究，對2007年49～80歲成都成華區711例人群進行調查，并測量身高、體重、血壓、空腹血糖、三酰甘油、高密度脂蛋白、低密度脂蛋白、血清尿酸等指標，采用SPSS 16.0軟件分析尿酸與MS及MS各組分之間的關系。結果　在中老年人群中，MS的發生率為25.60%，高尿酸血癥的發生率為21.24%。女性MS、腹型肥胖、高三酰甘油血癥和低高密度脂蛋白膽固醇血癥的發生率均明顯高于男性。尿酸與腰圍、收縮壓、三酰甘油、舒張壓、高密度脂蛋白水平的相關系數分別為0.311、0.140、0.118、0.106和?0.147，均有統計學意義（P＜0.05）。男、女性尿酸與腰圍的相關系數分別為0.173和?0.321，均有統計學意義（P＜0.05）。男、女性尿酸與空腹血糖的相關系數分別為?0.049和0.183，均有統計學意義（P＜0.05）。結論　血清尿酸水平與MS及其各組分關系密切，血清尿酸水平和MS及其各組分間的關系存在性別差異。

引用本文： 陳靜靜,何紅燕,萬里艷,李龍心,趙麗明,陳曉平. 血清尿酸水平與代謝綜合征間關系的性別差異. 華西醫學, 2013, 28(2): 175-178. doi: 10.7507/1002-0179.20130057 復制

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10.	Ebrahimpour P, Fakhrzadeh H, Heshmat R, et al. Serum uric acid levels and risk of metabolic syndrome in healthy adults[J]. Endocr Pract, 2008, 14(3): 298-304.
11.	Miao Z, Yan S, Wang J, et al. Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions[J]. Inflamm Res, 2009, 58(10): 659-668.
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1. 　Zhang W, Liang S, Wu J, et al. Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr-1+ myeloid-derived suppressor cells that promote long-term survival of allografts[J]. Transplantation, 2008, 86(8): 1125-1134.
2. 　熊建平, 歐利民, 譚學瑞. 尿酸及白細胞計數與代謝綜合征的相關性研究[J].熱帶醫學雜志, 2012, 12(2): 136-141.
3. 　Chiou WK, Wang MH, Huang DH, et al. The relationship between serum uric acid level and metabolic syndrome:difference by sex and age in Taiwanese[J]. J Epidemiol, 2010, 20(3): 219-224.
4. 　Onat A ,Uyarel H, Hergenc G, et al. Serum uric acid is a determinant of metabolic syndrome in a population-based study[J]. Am J Hypertens, 2006, 19(10 ): 1055-1062.
5. 　Yamada T，Fukatsu M, Suzuki S，et al．Elevated serum uric acid predicts impaired fasting glucose and type 2 diabetes only among Japanese women undergoing health checkups[J]. Diabetes Metab, 2011, 37(3): 252-258.
6. 　Tamba S, Nishizawa H, Funahashi T, et al. Relationship between the serum uric acid level ,visceral fat accumulation and serum adiponectin concentration in Japanese men[J]. Intern Med, 2008, 47(13): 1175-1180.
7. 　Bock G, Dalla C, Campioni M, et al. Pathog enesis of pre-diabetes mechanisms of fasting and postprandial hyperglycemia in people wit h impaired fasting glucose and/ or impaired glucose tolerance[J]. Diabetes, 2006, 55(11): 3536-3538.
8. 　龐建華, 周亞茹, 王戰建. 2型糖尿病與胰島素抵抗[J]. 河北醫藥, 2004, 26(4): 292.
9. 　張永能, 程繼東. 高尿酸血癥及相關代謝性疾病的病理生理學研究進展[J]. 廣東醫學, 2012, 33(1): 134-136.
10. 　Ebrahimpour P, Fakhrzadeh H, Heshmat R, et al. Serum uric acid levels and risk of metabolic syndrome in healthy adults[J]. Endocr Pract, 2008, 14(3): 298-304.
11. 　Miao Z, Yan S, Wang J, et al. Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions[J]. Inflamm Res, 2009, 58(10): 659-668.
12. 　Bedir A, Topbas M, Tanyeri F, et al．Leptin might be a regulator of serum uric acid concentrations in human[J]. Jpn Heart J, 2003, 44(4): 527-536.

《華西醫學》

血清尿酸水平與代謝綜合征間關系的性別差異

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《華西醫學》

血清尿酸水平與代謝綜合征間關系的性別差異

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