血清胰島素生長因子-1和膠質纖維酸性蛋白在腦膠質瘤分級及預后評估中的臨床價值_《華西醫學》

作者：

張正保 ¹ , 覃川 ¹ , 晏怡 ² , 李柏成 ¹ , 張彪 ¹ , 胡建剛 ¹ ,  楊秀江 ¹

1 重慶大足區人民醫院神經外科（重慶， 402360）;2 重慶醫科大學附屬第一醫院神經外科;

關鍵詞：

胰島素生長因子-1 膠質纖維酸性蛋白腫瘤標志物腦膠質瘤臨床價值

DOI：

10.7507/1002-0179.20130003

視頻：

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目的　通過檢測腦膠質瘤患者血清中胰島素生長因子-1（IGF-1）和膠質纖維酸性蛋白（GFAP）的表達，探討其與膠質瘤分級及預后評估的關系。方法　2010年12月－2011年11月，采用雙抗體一步夾心法分別測定A、B兩組共40例不同級別腦膠質瘤患者術前、術后血清中IGF-1和GFAP濃度。結果　高級別膠質瘤患者組血清中IGF-1濃度顯著高于低級別膠質瘤組（P=0.009 0）；血清GFAP濃度顯著低于低級別膠質瘤組（P＜0.000 1）。經手術治療后且療效評價為有效的膠質瘤患者，其血清中IGF-1、GFAP濃度較術前水平顯著下降（P＜0.001 0）。結論　IGF-1、GFAP是兩種較好的腦膠質瘤血清標志物，在其分級及預后評估中具有重要的臨床應用價值。

引用本文： 張正保,覃川,晏怡,李柏成,張彪,胡建剛,楊秀江. 血清胰島素生長因子-1和膠質纖維酸性蛋白在腦膠質瘤分級及預后評估中的臨床價值. 華西醫學, 2013, 28(1): 11-13. doi: 10.7507/1002-0179.20130003 復制

1.	Ferguson SD. Malignant gliomas: diagnosis and treatment[J]. Dis Mon, 2011, 57(10): 558-569.
2.	張玉林. 對神經系統腫瘤的國際分類的新觀點[J]. 中國臨床神經科學, 2001, 9(1): 105-108.
3.	Jo H, Jia Y, Subramanian KK, et al. Cancer cell-derived clusterin modulates the phosphatidylinositol 3’-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation[J]. Mol Cell Biol, 2008, 28(13): 4285-4299.
4.	付鍇, 袁先厚, 江普查, 等. HIF-1α, IGF-1在人腦膠質瘤中的表達及意義[J]. 現代腫瘤醫學, 2005, 13(3): 317-319.
5.	Renehan AG, Zwahlen M, Minder C, et al. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis[J]. Lancet, 2004, 363(9418): 1346-1353.
6.	Godau J, Knauel K, Weber K, et al. Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson disease[J]. Arch Neurol, 2011, 68(7): 925-931.
7.	Rohrmann S, Linseisen J, Becker S, et al. Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition[J]. Cancer Epidemiol Biomarkers Prev, 2011, 20(10): 2174-2182.
8.	覃川, 黎成祿, 謝惠, 等. 膠質瘤患者血清IGF-1的表達及臨床意義[J]. 重慶醫學, 2009, 38(15): 1941-1942.
9.	陳忠平, 周旺寧. 我國膠質瘤診斷治療現狀和努力方向[J]. 中國腫瘤, 2005, 14(2): 78-81.
10.	Restrepo A, Smith CA, Agnihotri S, et al. Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas[J]. Neuro Oncol, 2011, 13(1): 42-50.
11.	Peraud A, Mondal S, Hawkins C, et al. Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades[J]. Brain Tumor Pathol, 2003, 20(2): 53-58.
12.	Brommeland T, Rosengren L, Fridlund S, et al. Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas[J]. Acta Neurol Scand, 2007, 116(6): 380-384.
13.	Murakami M, Dirks PB, Hubbard SL, et al. Cytoskeletal-induced alterations in the adhesion of HT-1080 fibrosarcoma cells to extracellular matrix[J]. Int J Oncol, 2001, 18(5): 1027-1033.
14.	Yusubalieva GM, Baklaushev VP, Gurina OI, et al. Immunochemical analysis of glial fibrillary acidic protein as a tool to assess astroglial reaction in experimental C6 glioma[J]. Bull Exp Biol Med, 2010, 149(1): 125-130.
15.	Condorelli DF, Dell’albani P, Conticello SG, et al. A neural-specific hypomethylated domain in the 5’ flanking region of the glial fibrillary acidic protein gene[J]. Dev Neurosci, 1997, 19(5): 446-456.

1. 　Ferguson SD. Malignant gliomas: diagnosis and treatment[J]. Dis Mon, 2011, 57(10): 558-569.
2. 　張玉林. 對神經系統腫瘤的國際分類的新觀點[J]. 中國臨床神經科學, 2001, 9(1): 105-108.
3. 　Jo H, Jia Y, Subramanian KK, et al. Cancer cell-derived clusterin modulates the phosphatidylinositol 3’-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation[J]. Mol Cell Biol, 2008, 28(13): 4285-4299.
4. 　付鍇, 袁先厚, 江普查, 等. HIF-1α, IGF-1在人腦膠質瘤中的表達及意義[J]. 現代腫瘤醫學, 2005, 13(3): 317-319.
5. 　Renehan AG, Zwahlen M, Minder C, et al. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis[J]. Lancet, 2004, 363(9418): 1346-1353.
6. 　Godau J, Knauel K, Weber K, et al. Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson disease[J]. Arch Neurol, 2011, 68(7): 925-931.
7. 　Rohrmann S, Linseisen J, Becker S, et al. Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition[J]. Cancer Epidemiol Biomarkers Prev, 2011, 20(10): 2174-2182.
8. 　覃川, 黎成祿, 謝惠, 等. 膠質瘤患者血清IGF-1的表達及臨床意義[J]. 重慶醫學, 2009, 38(15): 1941-1942.
9. 　陳忠平, 周旺寧. 我國膠質瘤診斷治療現狀和努力方向[J]. 中國腫瘤, 2005, 14(2): 78-81.
10. 　Restrepo A, Smith CA, Agnihotri S, et al. Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas[J]. Neuro Oncol, 2011, 13(1): 42-50.
11. 　Peraud A, Mondal S, Hawkins C, et al. Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades[J]. Brain Tumor Pathol, 2003, 20(2): 53-58.
12. 　Brommeland T, Rosengren L, Fridlund S, et al. Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas[J]. Acta Neurol Scand, 2007, 116(6): 380-384.
13. 　Murakami M, Dirks PB, Hubbard SL, et al. Cytoskeletal-induced alterations in the adhesion of HT-1080 fibrosarcoma cells to extracellular matrix[J]. Int J Oncol, 2001, 18(5): 1027-1033.
14. 　Yusubalieva GM, Baklaushev VP, Gurina OI, et al. Immunochemical analysis of glial fibrillary acidic protein as a tool to assess astroglial reaction in experimental C6 glioma[J]. Bull Exp Biol Med, 2010, 149(1): 125-130.
15. 　Condorelli DF, Dell’albani P, Conticello SG, et al. A neural-specific hypomethylated domain in the 5’ flanking region of the glial fibrillary acidic protein gene[J]. Dev Neurosci, 1997, 19(5): 446-456.

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血清胰島素生長因子-1和膠質纖維酸性蛋白在腦膠質瘤分級及預后評估中的臨床價值

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