Research progress of epithelial-mesenchymal transition in age-related macular degeneration based on retinal pigment epithelial cells_Chinese Journal of Ocular Fundus Diseases

Authors：

Chen Chen , Hu Yingxue , Li Fei ,  Xu Xinrong

Department of Ophthalmology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China;

Corresponding?author：

Xu Xinrong, Email: xinrong_xu@aliyun.com

Keywords：

Age-related macular degeneration; Retinal pigment epithelium; Epithelial-mesenchymal transition; Fibrosis; Molecular mechanism; Review

DOI：

10.3760/cma.j.cn511434-20260120-00040

Video：

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Abstract Full text Figures/Tables Video References Cited by

Age-related macular degeneration (AMD) is one of the leading causes of irreversible visual impairment worldwide. At present, there is no effective treatment for advanced subretinal fibrosis in atrophic AMD and exudative AMD. Epithelial-mesenchymal transition of retinal pigment epithelial cells is a key pathological link connecting early damage and late atrophy and fibrosis of AMD. Microenvironmental factors such as oxidative stress and hypoxia trigger epithelial-mesenchymal transition, and a complex molecular regulatory network is formed by core signaling pathways such as transcription factors, transforming growth factor-β/SMAD and Wnt/β-catenin, epigenetic modification and autophagy mechanisms. Emerging therapeutic strategies such as targeted inhibition of oxidative stress, blocking of key signaling pathways and intervention based on non-coding RNA provide theoretical basis and new ideas for blocking the pathological process of AMD and clinical precision treatment. Future studies need to further clarify the specific molecular mechanisms of different stages of AMD in order to develop more accurate combined treatment options to effectively block the pathological process and save the patient's vision.

Citation： Chen Chen, Hu Yingxue, Li Fei, Xu Xinrong. Research progress of epithelial-mesenchymal transition in age-related macular degeneration based on retinal pigment epithelial cells. Chinese Journal of Ocular Fundus Diseases, 2026, 42(9): 813-821. doi: 10.3760/cma.j.cn511434-20260120-00040 Copy

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Chinese Journal of Ocular Fundus Diseases

Research progress of epithelial-mesenchymal transition in age-related macular degeneration based on retinal pigment epithelial cells

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