兒童視網膜血管炎3例_Chinese Journal of Ocular Fundus Diseases

Authors：

陸以凡 , 林媛媛 ,  宮媛媛

上海交通大學醫學院附屬第一人民醫院眼科, 上海 200080;

Corresponding?author：

宮媛媛, Email: gyydr@126.com

Keywords：

葡萄膜炎; 視網膜血管炎; 兒童; 病例報告

DOI：

10.3760/cma.j.cn511434-20250610-00260

Video：

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Citation： 陸以凡, 林媛媛, 宮媛媛. 兒童視網膜血管炎3例. Chinese Journal of Ocular Fundus Diseases, 2026, 42(8): 706-709. doi: 10.3760/cma.j.cn511434-20250610-00260 Copy

1.	Zheng XY, Xu J, Li W, et al. Frosted branch angiitis in pediatric dyskeratosis congenita: a case report[J/OL]. Medicine, 2016, 95(12): e3106[2016-03-01]. https://pubmed.ncbi.nlm.nih.gov/27015183/. DOI: 10.1097/MD.0000000000003106.
2.	Lee K, Jung S, Chin HS. Frosted branch angiitis; case series and literature review[J]. Ocul Immunol Inflamm, 2024, 32(1): 31-39. DOI: 10.1080/09273948.2022.2148112.
3.	Walker S, Iguchi A, Jones NP. Frosted branch angiitis: a review[J]. Eye (Lond), 2004, 18(5): 527-533. DOI: 10.1038/sj.eye.6700712.
4.	Kleiner RC. Frosted branch angiitis: clinical syndrome or clinical sign?[J]. Retina, 1997, 17(5): 370-371. DOI: 10.1097/00006982-199709000-00002.
5.	Luo Y, Acevedo D, Vlagea A, et al. Changes in treg and breg cells in a healthy pediatric population[J/OL]. Front Immunol, 2023, 14: 1283981[2023-11-21]. https://pubmed.ncbi.nlm.nih.gov/38077340/. DOI: 10.3389/fimmu.2023.1283981.
6.	Lai WC, Hsieh YC, Chen YC, et al. A potent antibody-secreting B cell response to mycoplasma pneumoniae in children with pneumonia[J]. J Microbiol Immunol Infect, 2022, 55(3): 413-420. DOI: 10.1016/j.jmii.2021.08.010.
7.	Aljasir MF, Alhamad DM, Alsubhi SS, et al. Sudden bilateral vision loss: a case report of frosted branch angiitis following pentavalent vaccination in a 2-year-old boy[J/OL]. J Ophthalmic Inflamm Infect, 2025, 15(1): 14[2025-02-26]. https://pubmed.ncbi.nlm.nih.gov/40009257/. DOI: 10.1186/s12348-025-00455-z.
8.	Zhang W, Chen C, Song Y, et al. A case of bartonella neuroretinitis presenting with concomitant frosted branch angiitis on long-term follow-up[J/OL]. Retin Cases Brief Rep, 2025, 2025: E1(2025-02-05)[2025-06-10]. https://pubmed.ncbi.nlm.nih.gov/39933158/. DOI: 10.1097/ICB.0000000000001730. [published online ahead of print].
9.	Alzuabi A, AlBloushi A. Unilateral frosted branch angiitis following COVID-19 disease: case report and literature review[J]. Keio J Med, 2025, 74(2): 101-105. DOI: 10.2302/kjm.2024-0010-CR.
10.	顧瑞平, 雷博雅, 舒秦蒙, 等. 鏈球菌感染后葡萄膜炎綜合征相關霜樣視網膜血管炎1例[J]. 中華眼底病雜志, 2024, 40(7): 547-549. DOI: 10.3760/cma.j.cn511434-20230705-00299.Gu RP, Lei BY, Shu QM, et al. One case of frosty retinal vasculitis associated with post-streptococcal uveitis syndrome[J]. Chin J Ocul Fundus Dis, 2024, 40(7): 547-549. DOI: 10.3760/cma.j.cn511434-20230705-00299.
11.	Li Y, Wu M, Liang Y, et al. Mycoplasma pneumoniae infection outbreak in Guangzhou, China after COVID-19 pandemic[J/OL]. Virol J, 2024, 21(1): 183[2024-08-11]. https://pubmed.ncbi.nlm.nih.gov/39129001/. DOI: 10.1186/s12985-024-02458-z.
12.	Li H, Li S, Yang H, et al. Resurgence of mycoplasma pneumonia by macrolide-resistant epidemic clones in China[J/OL]. Lancet Microbe, 2024, J5(6): e515[2024-01-17]. https://pubmed.ncbi.nlm.nih.gov/38244553/. DOI: 10.1016/S2666-5247(23)00405-6.
13.	Narita M. Classification of extrapulmonary manifestations due to mycoplasma pneumoniae infection on the basis of possible pathogenesis[J/OL]. Front Microbiol, 2016, 7: 23[2016-01-28]. https://pubmed.ncbi.nlm.nih.gov/26858701/. DOI: 10.3389/fmicb.2016.00023.
14.	Narita M. Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia[J]. J Infect Chemother, 2010, 16(3): 162-169. DOI: 10.1007/s10156-010-0044-x.
15.	Bai X, Chen Y, Hua R. Multimodal imaging findings in a patient with bilateral panuveitis secondary to Mycoplasma pneumoniae infection[J]. Quant Imaging Med Surg, 2023, 13(2): 1232-1234. DOI: 10.21037/qims-22-455.
16.	Dawidek GM. Anterior uveitis associated with mycoplasma pneumoniae pneumonia[J]. Postgrad Med J, 1991, 67(786): 380-382. DOI: 10.1136/pgmj.67.786.380.
17.	Di Maria A, Ruberto G, Redaelli C, et al. Anterior uveitis associated with Mycoplasma pneumoniae pneumonia: a case report[J]. Acta Ophthalmol Scand, 1999, 77(3): 349-350. DOI: 10.1034/j.1600-0420.1999.770322.x.
18.	Matsou A, Riga P, Samouilidou M, et al. Bilateral intermediate uveitis with appearance of frosted branch angiitis and association with Mycoplasma pneumoniae infection: case report and review of the literature[J]. J AAPOS, 2016, 20(4): 358-361. DOI: 10.1016/j.jaapos.2016.02.005.
19.	Yip IYM, Scotcher S. Raised intracranial pressure with bilateral anterior uveitis[J/OL]. BMJ Case Rep, 2018, 2018: bcr2017222504[2018-06-10]. https://pubmed.ncbi.nlm.nih.gov/29891509/. DOI: 10.1136/bcr-2017-222504.
20.	Wade CI, Earley KE, Justin GA, et al. Vogt-Koyanagi-Harada disease presenting secondary to a post-infectious Mycoplasma pneumoniae autoimmune response[J/OL]. Am J Ophthalmol Case Rep, 2020, 19: 100793[2020-06-22]. https://pubmed.ncbi.nlm.nih.gov/32613142/. DOI: 10.1016/j.ajoc.2020.100793.

1. Zheng XY, Xu J, Li W, et al. Frosted branch angiitis in pediatric dyskeratosis congenita: a case report[J/OL]. Medicine, 2016, 95(12): e3106[2016-03-01]. https://pubmed.ncbi.nlm.nih.gov/27015183/. DOI: 10.1097/MD.0000000000003106.
2. Lee K, Jung S, Chin HS. Frosted branch angiitis; case series and literature review[J]. Ocul Immunol Inflamm, 2024, 32(1): 31-39. DOI: 10.1080/09273948.2022.2148112.
3. Walker S, Iguchi A, Jones NP. Frosted branch angiitis: a review[J]. Eye (Lond), 2004, 18(5): 527-533. DOI: 10.1038/sj.eye.6700712.
4. Kleiner RC. Frosted branch angiitis: clinical syndrome or clinical sign?[J]. Retina, 1997, 17(5): 370-371. DOI: 10.1097/00006982-199709000-00002.
5. Luo Y, Acevedo D, Vlagea A, et al. Changes in treg and breg cells in a healthy pediatric population[J/OL]. Front Immunol, 2023, 14: 1283981[2023-11-21]. https://pubmed.ncbi.nlm.nih.gov/38077340/. DOI: 10.3389/fimmu.2023.1283981.
6. Lai WC, Hsieh YC, Chen YC, et al. A potent antibody-secreting B cell response to mycoplasma pneumoniae in children with pneumonia[J]. J Microbiol Immunol Infect, 2022, 55(3): 413-420. DOI: 10.1016/j.jmii.2021.08.010.
7. Aljasir MF, Alhamad DM, Alsubhi SS, et al. Sudden bilateral vision loss: a case report of frosted branch angiitis following pentavalent vaccination in a 2-year-old boy[J/OL]. J Ophthalmic Inflamm Infect, 2025, 15(1): 14[2025-02-26]. https://pubmed.ncbi.nlm.nih.gov/40009257/. DOI: 10.1186/s12348-025-00455-z.
8. Zhang W, Chen C, Song Y, et al. A case of bartonella neuroretinitis presenting with concomitant frosted branch angiitis on long-term follow-up[J/OL]. Retin Cases Brief Rep, 2025, 2025: E1(2025-02-05)[2025-06-10]. https://pubmed.ncbi.nlm.nih.gov/39933158/. DOI: 10.1097/ICB.0000000000001730. [published online ahead of print].
9. Alzuabi A, AlBloushi A. Unilateral frosted branch angiitis following COVID-19 disease: case report and literature review[J]. Keio J Med, 2025, 74(2): 101-105. DOI: 10.2302/kjm.2024-0010-CR.
10. 顧瑞平, 雷博雅, 舒秦蒙, 等. 鏈球菌感染后葡萄膜炎綜合征相關霜樣視網膜血管炎1例[J]. 中華眼底病雜志, 2024, 40(7): 547-549. DOI: 10.3760/cma.j.cn511434-20230705-00299.Gu RP, Lei BY, Shu QM, et al. One case of frosty retinal vasculitis associated with post-streptococcal uveitis syndrome[J]. Chin J Ocul Fundus Dis, 2024, 40(7): 547-549. DOI: 10.3760/cma.j.cn511434-20230705-00299.
11. Li Y, Wu M, Liang Y, et al. Mycoplasma pneumoniae infection outbreak in Guangzhou, China after COVID-19 pandemic[J/OL]. Virol J, 2024, 21(1): 183[2024-08-11]. https://pubmed.ncbi.nlm.nih.gov/39129001/. DOI: 10.1186/s12985-024-02458-z.
12. Li H, Li S, Yang H, et al. Resurgence of mycoplasma pneumonia by macrolide-resistant epidemic clones in China[J/OL]. Lancet Microbe, 2024, J5(6): e515[2024-01-17]. https://pubmed.ncbi.nlm.nih.gov/38244553/. DOI: 10.1016/S2666-5247(23)00405-6.
13. Narita M. Classification of extrapulmonary manifestations due to mycoplasma pneumoniae infection on the basis of possible pathogenesis[J/OL]. Front Microbiol, 2016, 7: 23[2016-01-28]. https://pubmed.ncbi.nlm.nih.gov/26858701/. DOI: 10.3389/fmicb.2016.00023.
14. Narita M. Pathogenesis of extrapulmonary manifestations of Mycoplasma pneumoniae infection with special reference to pneumonia[J]. J Infect Chemother, 2010, 16(3): 162-169. DOI: 10.1007/s10156-010-0044-x.
15. Bai X, Chen Y, Hua R. Multimodal imaging findings in a patient with bilateral panuveitis secondary to Mycoplasma pneumoniae infection[J]. Quant Imaging Med Surg, 2023, 13(2): 1232-1234. DOI: 10.21037/qims-22-455.
16. Dawidek GM. Anterior uveitis associated with mycoplasma pneumoniae pneumonia[J]. Postgrad Med J, 1991, 67(786): 380-382. DOI: 10.1136/pgmj.67.786.380.
17. Di Maria A, Ruberto G, Redaelli C, et al. Anterior uveitis associated with Mycoplasma pneumoniae pneumonia: a case report[J]. Acta Ophthalmol Scand, 1999, 77(3): 349-350. DOI: 10.1034/j.1600-0420.1999.770322.x.
18. Matsou A, Riga P, Samouilidou M, et al. Bilateral intermediate uveitis with appearance of frosted branch angiitis and association with Mycoplasma pneumoniae infection: case report and review of the literature[J]. J AAPOS, 2016, 20(4): 358-361. DOI: 10.1016/j.jaapos.2016.02.005.
19. Yip IYM, Scotcher S. Raised intracranial pressure with bilateral anterior uveitis[J/OL]. BMJ Case Rep, 2018, 2018: bcr2017222504[2018-06-10]. https://pubmed.ncbi.nlm.nih.gov/29891509/. DOI: 10.1136/bcr-2017-222504.
20. Wade CI, Earley KE, Justin GA, et al. Vogt-Koyanagi-Harada disease presenting secondary to a post-infectious Mycoplasma pneumoniae autoimmune response[J/OL]. Am J Ophthalmol Case Rep, 2020, 19: 100793[2020-06-22]. https://pubmed.ncbi.nlm.nih.gov/32613142/. DOI: 10.1016/j.ajoc.2020.100793.

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